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Combination of sodium pentaborate pentahydrate, curcumin and piperine treatment induces ferroptosis in hepatocellular carcinoma cells by regulating iron homeostasis and ROS activity
Combination of sodium pentaborate pentahydrate, curcumin and piperine treatment induces ferroptosis in hepatocellular carcinoma cells by regulating iron homeostasis and ROS activity
Hepatocellular carcinoma (HCC) is one of the most prevalent solid cancers with the highest mortality rate, despite various...
MicroRNA mediated signaling and metabolic reprogramming in oral squamous cell carcinoma
MicroRNA mediated signaling and metabolic reprogramming in oral squamous cell carcinoma
Oral Squamous Cell Carcinoma (OSCC) is the most aggressive oral cancer type, with minimal survival rates resulting from me...
A randomized clinical trial assessing the efficacy of vitamin B prophylaxis in attenuating paclitaxel-induced neuropathy and the imperative use of gabapentin in diabetic ovarian cancer patients
A randomized clinical trial assessing the efficacy of vitamin B prophylaxis in attenuating paclitaxel-induced neuropathy and the imperative use of gabapentin in diabetic ovarian cancer patients
Paclitaxel being an effective treatment for ovarian cancer, presents one of the most critical toxicities; peripheral neuro...
CD168 in lung adenocarcinoma: prognostic relevance, immune feature associations, and MAPK/ERK pathway enrichment
CD168 in lung adenocarcinoma: prognostic relevance, immune feature associations, and MAPK/ERK pathway enrichment
Lung adenocarcinoma (LUAD), the predominant non-small cell lung cancer (NSCLC) subtype, faces major clinical challenges in...
Gecko protein F2 inhibits tumor angiogenesis by suppressing the VEGF/MAPK/ERK signaling pathway
Gecko protein F2 inhibits tumor angiogenesis by suppressing the VEGF/MAPK/ERK signaling pathway
The anti-tumor clinical effect of traditional Chinese medicine gecko is very prominent. A novel anti-tumor protein compone...
Smart covalent organic frameworks in cancer sensing and imaging: opportunities, challenges, and translational prospects
Smart covalent organic frameworks in cancer sensing and imaging: opportunities, challenges, and translational prospects
Covalent organic frameworks (COFs) represent a rapidly expanding class of porous crystalline materials with exceptional po...
A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression
A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression
Prostate cancer (PCa) is one of the most prevalent malignant tumors among men globally, with limited treatment options, es...
Structural and functional insights into CD3 bispecific antibodies targeting DLL3 in cancer immunotherapy
Structural and functional insights into CD3 bispecific antibodies targeting DLL3 in cancer immunotherapy
CD3 bispecific antibodies (BsAbs) targeting delta-like ligand 3 (DLL3) have emerged as promising candidates in cancer immu...
Investigating the effects of platelets, platelet releasate and aspirin on colorectal cancer cell proliferation, migration and invasion
Investigating the effects of platelets, platelet releasate and aspirin on colorectal cancer cell proliferation, migration and invasion
The aims of this study were to investigate the binding of platelets to colorectal cancer (CRC) cells, platelet activation ...
Hippo-YAP/TAZ signaling in gastric cancer: molecular pathogenesis and emerging therapeutic horizons
Hippo-YAP/TAZ signaling in gastric cancer: molecular pathogenesis and emerging therapeutic horizons
Gastric cancer remains a significant global health challenge, ranking as the 5th most common cancer worldwide with high mo...
Natural simple coumarins and their interaction with AKR1C3: implications for overcoming chemoradioresistance in gastrointestinal carcinomas
Natural simple coumarins and their interaction with AKR1C3: implications for overcoming chemoradioresistance in gastrointestinal carcinomas
Gastrointestinal (GI) carcinomas are among the leading cause of cancer-related deaths worldwide, and chemoradioresistance ...
Phytochemical and pharmacological elucidation of (L.) fourr. essential oil: a promising therapeutic source against inflammation and cancer
Phytochemical and pharmacological elucidation of (L.) fourr. essential oil: a promising therapeutic source against inflammation and cancer
The growing demand for natural therapeutics with safer pharmacological profiles has renewed interest in aromatic plants tr...
Pharmacological modulation of Ca²⁺ signaling by calycosin promotes glioblastoma cell death
Pharmacological modulation of Ca²⁺ signaling by calycosin promotes glioblastoma cell death
Flavonoids are plant-derived polyphenols widely found in fruits, vegetables, and herbs, and have attracted growing interes...
Bio-mediated synthesis of zinc oxide nanoparticles from leaves: A potent inducer of apoptosis in lung cancer cells
Bio-mediated synthesis of zinc oxide nanoparticles from leaves: A potent inducer of apoptosis in lung cancer cells
Zinc oxide nanoparticles (ZnO-NPs) have gained attention as potential anticancer agents due to their selective cytotoxicit...
Engineered mesenchymal stem cells expressing CXCR4 and LIGHT enhance Anti-Tumor activity in a subcutaneous gastric cancer xenograft model
Engineered mesenchymal stem cells expressing CXCR4 and LIGHT enhance Anti-Tumor activity in a subcutaneous gastric cancer xenograft model
Gastric cancer remains a leading cause of cancer-related mortality, with limited treatment options and a poor prognosis. M...
Maleimide-substituted 1,4-naphthoquinone flaviolin mimetic (FM) induces S-phase arrest and mitochondria-mediated apoptosis in multiple myeloma cells
Maleimide-substituted 1,4-naphthoquinone flaviolin mimetic (FM) induces S-phase arrest and mitochondria-mediated apoptosis in multiple myeloma cells
Effective treatment for multiple myeloma remains a significant clinical challenge due to multidrug resistance and the side...
Loss of junctional plakoglobin (JUP) activates PI3K/AKT signaling in head and neck squamous cell carcinoma
Loss of junctional plakoglobin (JUP) activates PI3K/AKT signaling in head and neck squamous cell carcinoma
Head and neck squamous cell carcinomas (HNSCC) are characterized by poor prognosis, primarily due to early metastatic spre...
Elbasvir triggers ferroptosis in esophageal squamous cell carcinoma through NCOA4-mediated ferritinophagy
Elbasvir triggers ferroptosis in esophageal squamous cell carcinoma through NCOA4-mediated ferritinophagy
Esophageal squamous cell carcinoma (ESCC) remains treatment-resistant; we explored Elbasvir, an NS5A inhibitor, as a ferro...
Synthetic oleanolic acid derivative, RTA-408, overcome in TMZ-resistant glioblastoma cells by inducing apoptosis and G1 cell cycle arrest
Synthetic oleanolic acid derivative, RTA-408, overcome in TMZ-resistant glioblastoma cells by inducing apoptosis and G1 cell cycle arrest
Glioblastoma is the most malignant primary brain tumor. It is characterized by high cellular heterogeneity, which contribu...
Integrating scRNA-seq and spatial transcriptomics to explore the implication of G6PD on immune microenvironment in lymphatic metastasis of breast cancer
Integrating scRNA-seq and spatial transcriptomics to explore the implication of G6PD on immune microenvironment in lymphatic metastasis of breast cancer
Breast cancer is among the most prevalent malignancies, with lymph node metastasis strongly linked to worse prognostic out...
Epigenetic dysregulation in cancer: mechanisms, diagnostic biomarkers and therapeutic strategies
Epigenetic dysregulation in cancer: mechanisms, diagnostic biomarkers and therapeutic strategies
The disruption of the epigenetic patterns and its impact on gene expression is recognized as a critical factor in the init...
Analysis of possible effects of recombinant antimicrobial peptide TP4 on colon cancer line HT-29
Analysis of possible effects of recombinant antimicrobial peptide TP4 on colon cancer line HT-29
Tilapia piscidin 4 (TP4) is a 25-amino-acid cationic antimicrobial peptide derived from Nile tilapia (Oreochromis...
Ursolic acid affects autophagy and apoptosis of breast cancer through PLK1 via AKT/mTOR signaling pathway
Ursolic acid affects autophagy and apoptosis of breast cancer through PLK1 via AKT/mTOR signaling pathway
Breast cancer poses a significant threat to women's health globally, exhibiting the greatest incidence and fatality ra...
Noncoding RNAs as mechanistic regulators and therapeutic modulators of YAP/TAZ signaling in colorectal cancer
Noncoding RNAs as mechanistic regulators and therapeutic modulators of YAP/TAZ signaling in colorectal cancer
Colorectal cancer (CRC) continues to represent a significant global health challenge due to its high incidence and mortali...
Targeted therapy of papillary craniopharyngioma
Targeted therapy of papillary craniopharyngioma
This review provide a comprehensive overview of the molecular biology and therapeutic advances regarding papillary craniop...
Therapeutic exploration of novel reactive oxygen species-mediated anti-cancer mechanism by modulating electron transfer in respiratory complex III
Therapeutic exploration of novel reactive oxygen species-mediated anti-cancer mechanism by modulating electron transfer in respiratory complex III
Reactive oxygen species (ROS) are by-products of cellular aerobic metabolism, playing a crucial role in the development of...
Computational biology meets oncology: designing custom protein and peptide binders to outsmart cancer
Computational biology meets oncology: designing custom protein and peptide binders to outsmart cancer
Cancer remains one of the most formidable global health challenges, with conventional therapies often limited by off-targe...
ULK2 promotes migration and invasion of colorectal cancer cells via MCT4-mediated lactate export
ULK2 promotes migration and invasion of colorectal cancer cells via MCT4-mediated lactate export
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy worldwide. Despite significant advancements in CRC...
Quercetin as a multi-targeted therapeutic agent in breast cancer: molecular targets and therapeutic potential
Quercetin as a multi-targeted therapeutic agent in breast cancer: molecular targets and therapeutic potential
Breast cancer is a worldwide serious health issue with constantly recurring issues of drug resistance, toxicity, and recur...
Duloxetine inhibits breast cancer progression by suppressing AKT signaling and inducing Bax/Bcl-2-mediated apoptosis
Duloxetine inhibits breast cancer progression by suppressing AKT signaling and inducing Bax/Bcl-2-mediated apoptosis
Depressive symptoms are recognized contributors to breast cancer progression; while previous studies have investigated the...
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