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Synthetic oleanolic acid derivative, RTA-408, overcome in TMZ-resistant glioblastoma cells by inducing apoptosis and G1 cell cycle arrest
Synthetic oleanolic acid derivative, RTA-408, overcome in TMZ-resistant glioblastoma cells by inducing apoptosis and G1 cell cycle arrest
Glioblastoma is the most malignant primary brain tumor. It is characterized by high cellular heterogeneity, which contribu...
Integrating scRNA-seq and spatial transcriptomics to explore the implication of G6PD on immune microenvironment in lymphatic metastasis of breast cancer
Integrating scRNA-seq and spatial transcriptomics to explore the implication of G6PD on immune microenvironment in lymphatic metastasis of breast cancer
Breast cancer is among the most prevalent malignancies, with lymph node metastasis strongly linked to worse prognostic out...
Epigenetic dysregulation in cancer: mechanisms, diagnostic biomarkers and therapeutic strategies
Epigenetic dysregulation in cancer: mechanisms, diagnostic biomarkers and therapeutic strategies
The disruption of the epigenetic patterns and its impact on gene expression is recognized as a critical factor in the init...
Analysis of possible effects of recombinant antimicrobial peptide TP4 on colon cancer line HT-29
Analysis of possible effects of recombinant antimicrobial peptide TP4 on colon cancer line HT-29
Tilapia piscidin 4 (TP4) is a 25-amino-acid cationic antimicrobial peptide derived from Nile tilapia (Oreochromis...
Ursolic acid affects autophagy and apoptosis of breast cancer through PLK1 via AKT/mTOR signaling pathway
Ursolic acid affects autophagy and apoptosis of breast cancer through PLK1 via AKT/mTOR signaling pathway
Breast cancer poses a significant threat to women's health globally, exhibiting the greatest incidence and fatality ra...
Noncoding RNAs as mechanistic regulators and therapeutic modulators of YAP/TAZ signaling in colorectal cancer
Noncoding RNAs as mechanistic regulators and therapeutic modulators of YAP/TAZ signaling in colorectal cancer
Colorectal cancer (CRC) continues to represent a significant global health challenge due to its high incidence and mortali...
Targeted therapy of papillary craniopharyngioma
Targeted therapy of papillary craniopharyngioma
This review provide a comprehensive overview of the molecular biology and therapeutic advances regarding papillary craniop...
Therapeutic exploration of novel reactive oxygen species-mediated anti-cancer mechanism by modulating electron transfer in respiratory complex III
Therapeutic exploration of novel reactive oxygen species-mediated anti-cancer mechanism by modulating electron transfer in respiratory complex III
Reactive oxygen species (ROS) are by-products of cellular aerobic metabolism, playing a crucial role in the development of...
Computational biology meets oncology: designing custom protein and peptide binders to outsmart cancer
Computational biology meets oncology: designing custom protein and peptide binders to outsmart cancer
Cancer remains one of the most formidable global health challenges, with conventional therapies often limited by off-targe...
ULK2 promotes migration and invasion of colorectal cancer cells via MCT4-mediated lactate export
ULK2 promotes migration and invasion of colorectal cancer cells via MCT4-mediated lactate export
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy worldwide. Despite significant advancements in CRC...
Quercetin as a multi-targeted therapeutic agent in breast cancer: molecular targets and therapeutic potential
Quercetin as a multi-targeted therapeutic agent in breast cancer: molecular targets and therapeutic potential
Breast cancer is a worldwide serious health issue with constantly recurring issues of drug resistance, toxicity, and recur...
Duloxetine inhibits breast cancer progression by suppressing AKT signaling and inducing Bax/Bcl-2-mediated apoptosis
Duloxetine inhibits breast cancer progression by suppressing AKT signaling and inducing Bax/Bcl-2-mediated apoptosis
Depressive symptoms are recognized contributors to breast cancer progression; while previous studies have investigated the...
Combination of PSMA targeting alpha-emitting radioligand [Pb]Pb-AB001 with BET bromodomain inhibitors in in vitro prostate cancer models
Combination of PSMA targeting alpha-emitting radioligand [Pb]Pb-AB001 with BET bromodomain inhibitors in in vitro prostate cancer models
The alpha-emitting radioligand [212Pb]Pb-AB001, targeting prostate-specific membrane antigen (PSMA), is a promising therap...
Efficacy analysis of targeted P53 therapy in solid tumors
Efficacy analysis of targeted P53 therapy in solid tumors
Mutations in the oncogene p53 are present in nearly all types of carcinomas and are commonly inactivated in certain tumor ...
Natural bioactive compounds as notch signaling modulators: cutting-edge strategies for cancer therapy
Natural bioactive compounds as notch signaling modulators: cutting-edge strategies for cancer therapy
Natural bioactive compounds have demonstrated potential in altering the Notch signaling system, a crucial regulator of can...
Investigation of the effect of C-phycocyanin on sonic hedgehog pathway-related Gli1 and Bcl-2 gene expression in MKN45 gastric cancer cells
Investigation of the effect of C-phycocyanin on sonic hedgehog pathway-related Gli1 and Bcl-2 gene expression in MKN45 gastric cancer cells
Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. Many traditional treatments for this...
Epigenetic reprogramming of mast and cancer cells modifies tumor-promoting cytokine networks
Epigenetic reprogramming of mast and cancer cells modifies tumor-promoting cytokine networks
Mast cells (MC) play a crucial role in the tumor microenvironment (TME) by promoting tumor progression and immune evasion ...
ROCK inhibition suppresses glioblastoma via a PTEN-associated reduction in PI3K/AKT signaling
ROCK inhibition suppresses glioblastoma via a PTEN-associated reduction in PI3K/AKT signaling
Glioblastoma is the most common primary malignant brain tumor. It is aimed to elucidate the role of ROCK in the regulation...
Metabolic reprogramming and functional crosstalk within the tumor microenvironment (TME) and A Multi-omics anticancer approach
Metabolic reprogramming and functional crosstalk within the tumor microenvironment (TME) and A Multi-omics anticancer approach
Tumors are characterized by a complex interplay of various cell types, each contributing to the unique metabolic landscape...
Red wavelength-induced photobiomodulation enhances indocyanine green-based anticancer photodynamic therapy
Red wavelength-induced photobiomodulation enhances indocyanine green-based anticancer photodynamic therapy
Cancer is a global concern worldwide. Prostate cancer has high prevalence and mortality rates among men. Photodynamic ther...
Targeting the mevalonate pathway enhances the efficacy of 5-fluorouracil by regulating pyroptosis
Targeting the mevalonate pathway enhances the efficacy of 5-fluorouracil by regulating pyroptosis
The 5-fluorouracil (5-FU)-based chemotherapy regimen is a primary strategy for treating pancreatic cancer (PC). However, c...
Dual roles of extracellular vesicles in acute lymphoblastic leukemia: implications for disease progression and theranostic strategies
Dual roles of extracellular vesicles in acute lymphoblastic leukemia: implications for disease progression and theranostic strategies
Acute Lymphoblastic Leukemia (ALL) is a heterogeneous blood cancer characterized by the uncontrolled growth of immature ly...
N6-methyladenosine RNA modification in head and neck squamous cell carcinoma (HNSCC): current status and future insights
N6-methyladenosine RNA modification in head and neck squamous cell carcinoma (HNSCC): current status and future insights
N6-methyladenosine (m6A) plays a pivotal role in regulating epitranscriptomic mechanisms and is closely linked to the norm...
An overview on the interaction between non-coding RNAs and CTLA-4 gene in human diseases
An overview on the interaction between non-coding RNAs and CTLA-4 gene in human diseases
Cytotoxic T lymphocyte antigen 4 (CTLA-4), in conjunction with PD-1 and CD28, plays a pivotal role in the modulation of T-...
Exploring the role of antigen-presenting cancer-associated fibroblasts and CD74 on the pancreatic ductal adenocarcinoma tumor microenvironment
Exploring the role of antigen-presenting cancer-associated fibroblasts and CD74 on the pancreatic ductal adenocarcinoma tumor microenvironment
Pancreatic ductal adenocarcinoma (PDAC) has proven to be a formidable cancer primarily due to its tumor microenvironment (...
Telomerase inhibition in breast cancer and breast cancer stem cells: a brief review
Telomerase inhibition in breast cancer and breast cancer stem cells: a brief review
Breast cancer is a major health problem, accounting for one third of all cancers in women. There is no definitive treatmen...
Associations between the life’s essential 8, genetic risk and breast cancer incidence in premenopausal and postmenopausal women: a prospective study in UK Biobank
Associations between the life’s essential 8, genetic risk and breast cancer incidence in premenopausal and postmenopausal women: a prospective study in UK Biobank
The combined effect of cardiovascular risk factors on breast cancer in women is unknown. The relationship between genetic ...
Exosomes in esophageal cancer: function and therapeutic prospects
Exosomes in esophageal cancer: function and therapeutic prospects
Esophageal cancer (EC) is one of the most common malignant tumors worldwide. Exosomes are a type of extracellular vesicles...
The AXL-mediated modulation of myeloid-derived suppressor cells (MDSC) in nasopharyngeal carcinoma
The AXL-mediated modulation of myeloid-derived suppressor cells (MDSC) in nasopharyngeal carcinoma
AXL has ubiquitous expression in multiple cancers, and is strongly linked to both tumor progression, metastasis, and poor ...
Investigation of anticancer potential of a novel bioactive molecule from Trichosporon asahii VITSTB1 in breast cancer cell lines: an in vitro study
Investigation of anticancer potential of a novel bioactive molecule from Trichosporon asahii VITSTB1 in breast cancer cell lines: an in vitro study
The current study investigates the anticancer activity of protein derived from yeast against breast cancer. Yeast-derived ...
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