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Annexin A1-FPR1 Interaction in dendritic cells promotes immune microenvironment modulation in Thyroid Cancer
Annexin A1-FPR1 Interaction in dendritic cells promotes immune microenvironment modulation in Thyroid Cancer
Thyroid cancer (THCA) is profoundly influenced by its immune microenvironment, with dendritic cells (DCs) serving as key m...
Loss of YTHDF1 suppresses the progression of malignant rhabdoid tumor of the kidney by regulating Glutathione S-transferase Mu 2 (GSTM2)
Loss of YTHDF1 suppresses the progression of malignant rhabdoid tumor of the kidney by regulating Glutathione S-transferase Mu 2 (GSTM2)
Malignant rhabdoid tumor of the kidney (MRTK) is a rare renal tumor with poor prognosis. While germline mutations of SMARC...
Dissecting the METTL3/STC2 axis in colorectal cancer: implications for drug resistance and metastasis
Dissecting the METTL3/STC2 axis in colorectal cancer: implications for drug resistance and metastasis
In recent years, the role of epigenetic modifications, especially N6-methyladenosine (m6A) modifications, in the occurrenc...
Correction to: Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue
Correction to: Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
SENP3 alleviates osteoporosis via promoting SIRT3 transcription through the increase of DLX2 stability via SUMO2/3
SENP3 alleviates osteoporosis via promoting SIRT3 transcription through the increase of DLX2 stability via SUMO2/3
Recent studies have indicated a close relationship between SENP3 and osteoporosis. However, the detailed molecular mechani...
Oral squamous cell carcinoma: Insights into cellular heterogeneity, drug resistance, and evolutionary trajectories
Oral squamous cell carcinoma: Insights into cellular heterogeneity, drug resistance, and evolutionary trajectories
Oral squamous cell carcinoma (OSCC) can lead to metastasis and high mortality rates known for its aggressive and invasive ...
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance
This research investigates how the SERPINE1-associated tumor microenvironment influences anti-PD-1 treatment response in g...
GelMA hydrogel-loaded extracellular vesicles derived from keratinocytes promote skin microvasculature regeneration and wound healing in diabetic mice through activation of the PDGF-induced PI3K/AKT pathway
GelMA hydrogel-loaded extracellular vesicles derived from keratinocytes promote skin microvasculature regeneration and wound healing in diabetic mice through activation of the PDGF-induced PI3K/AKT pathway
This study explores how extracellular vesicles (EVs) derived from keratinocytes cultured in Gelatin Methacryloyl (GelMA) h...
From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics
From neurotoxicity to neuroprotection: Rethinking GABAR-targeting anesthetics
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened sy...
Single-cell spatial proteomics of non-relapse small cell lung cancer identifies tumor microenvironment determinants of survival
Single-cell spatial proteomics of non-relapse small cell lung cancer identifies tumor microenvironment determinants of survival
Small cell lung cancer (SCLC) is characterized by high malignancy and early propensity for metastasis, and modest response...
The role of lncRNA in androgen metabolism and follicle growth arrest in polycystic ovary syndrome
The role of lncRNA in androgen metabolism and follicle growth arrest in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and follicular growth arrest. This study investigate...
ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling
ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling
Early studies indicated that the androgen-deprivation-therapy with antiandrogen Enzalutamide (Enz) could increase prostate...
Therapeutic targeting of PRSS3 to alleviate kidney damage in DKD
Therapeutic targeting of PRSS3 to alleviate kidney damage in DKD
As a primary contributor to end-stage renal disease, diabetic kidney disease (DKD) is characterized by metabolic and infla...
KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression
KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression
Collagen is a central component of the extracellular matrix (ECM) in tissues, and ECM can promote tumor cell immune evasio...
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through mA-dependent binding
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through mA-dependent binding
The rapid escalation of oxidative and nitrosative stress during ischemia/reperfusion (I/R) triggers neuronal damage, leadi...
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension
Based on bioinformatics insights, this study investigates the functions of lysophosphatidic acid receptor 3 (LPAR3) and TE...
NGR-modified curcumin nanovesicles reverse immunotherapy resistance in triple-negative breast cancer via TLR9 and mTOR pathway modulation
NGR-modified curcumin nanovesicles reverse immunotherapy resistance in triple-negative breast cancer via TLR9 and mTOR pathway modulation
Curcumin (Cur), a natural bioactive compound extracted from Curcuma longa, has garnered extensive interest due to its modu...
cGAS-STING targeting offers novel therapeutic regimen in sepsis-associated organ dysfunction
cGAS-STING targeting offers novel therapeutic regimen in sepsis-associated organ dysfunction
Sepsis is clinically defined as a life-threatening syndrome characterized by dysregulated host responses to infection, cul...
Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathy
Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathy
Neuropathic pain triggered by chemotherapy poses a significant clinical challenge. Investigating cell type-specific altera...
Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers
Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers
Hybrid hydrogels have emerged as multifunctional biomaterials for targeted drug delivery and tissue engineering in gynecol...
Electricity inaccessibility across historically redlined and present-day disadvantaged areas in New York City
Electricity inaccessibility across historically redlined and present-day disadvantaged areas in New York City
Electricity is crucial in sustaining livelihoods from turning the lights on at night, keeping the refrigerator running to ...
Longitudinal association of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) exposure with lipid traits, in a healthy unselected population
Longitudinal association of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) exposure with lipid traits, in a healthy unselected population
Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic Acid (PFOS) are synthetic substances with long half-lives. Their...
Can a single pollen measurement site provide exposure information for health research across an entire state? Results from a study of allergic-type asthma associated with thunderstorms (2007–2018)
Can a single pollen measurement site provide exposure information for health research across an entire state? Results from a study of allergic-type asthma associated with thunderstorms (2007–2018)
Thunderstorm asthma is an increase in severe asthma following thunderstorm events during high pollen conditions. However, ...
Air pollution and preterm birth: comparing trimester average and repeated threshold exposure metrics in a North Carolina birth cohort, 2003–2015
Air pollution and preterm birth: comparing trimester average and repeated threshold exposure metrics in a North Carolina birth cohort, 2003–2015
Exposures to ambient air pollutants during pregnancy are associated with preterm birth (PTB) in studies that evaluate aver...
Review of volatile organic compound (VOC) emissions from desktop 3D printers and associated health implications
Three-dimensional (3D) printing is a technique by which materials are continually added in layers to form structures. The ...
Associations between neighborhood greenery and birth outcomes in a North Carolina cohort
Associations between neighborhood greenery and birth outcomes in a North Carolina cohort
Higher levels of neighborhood greenery have been associated with improved birth outcomes. However, many studies use metric...
Statement in support of exposure science and the scientists that make America healthy
The health of every nation depends on the quality of its environment. Toxic chemicals in food, soil, water, and air are in...
Associations of climatic factors with pregnancy loss in Nicosia, Cyprus
Associations of climatic factors with pregnancy loss in Nicosia, Cyprus
While ambient climatic factors are linked to adverse pregnancy outcomes, only a few studies examine the risk of pregnancy ...
The neuroprotective potential of in a neuronal demyelination rat model through the modulation of interleukins, cyclooxygenase and tumor necrosis factor-α
The neuroprotective potential of in a neuronal demyelination rat model through the modulation of interleukins, cyclooxygenase and tumor necrosis factor-α
Multiple sclerosis is characterized by the demyelination of neurons, which is a chronic inflammatory disease of the centra...
From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management
From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management
The use of natural compounds as effective therapeutic agents is an expanding area of health and disease research. Curcumin...
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