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The neuroprotective potential of in a neuronal demyelination rat model through the modulation of interleukins, cyclooxygenase and tumor necrosis factor-α

Multiple sclerosis is characterized by the demyelination of neurons, which is a chronic inflammatory disease of the centra...

Inflammopharmacology

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From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management

The use of natural compounds as effective therapeutic agents is an expanding area of health and disease research. Curcumin...

Inflammopharmacology

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Gut microbiota and Parkinson’s Disease: a new frontier in understanding neurological health

Increasingly recognized as a neurodegenerative disease with motor manifestations and progressive cognitive decline, PD has...

Inflammopharmacology

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The presumable combined effects of hydroxychloroquine and its metabolites on the blood lipids and glucose in the treatment of rheumatoid arthritis

To explore the potential combined effects of hydroxycholoroquine (HCQ) and its metabolites on blood lipids and glucose in ...

Inflammopharmacology

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Can pyridoxine function as an anti-pyroptosis agent? A narrative review

Pyroptosis, a highly inflammatory form of programmed cell death, plays a key role in diseases such as sepsis, rheumatoid a...

Inflammopharmacology

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Phytochemical analysis of leaf extract of and investigation of its biological activities

This study investigates the phytoconstituents of the less explored leaf of Piper nigrum, a common ethnomedicinal plant as ...

Inflammopharmacology

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The role of Ergothioneine in cognition and age-related neurodegenerative disease: a systematic review

Ergothioneine (ET) is an under recognised diet-derived compound which has the potential to be a “longevity vitamin&#...

Inflammopharmacology

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Deciphering the role of cell signaling pathways in gout pathogenesis and the therapeutic potential of phytoconstituents in their modulation

Gout, a type of inflammatory arthritis, arises from the accumulation of monosodium urate crystals in joints, leading to se...

Inflammopharmacology

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Impact of corticoid receptors on Alzheimer’s disease: a neuroendocrine perspective

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that has been strongly associated with changes in...

Inflammopharmacology

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Exploring the therapeutic potential of NLRP3 inhibitors in Parkinson's Disease: a systematic review of in-vivo studies

Parkinson's disease is a progressive neurodegenerative disorder characterized by motor symptoms such as tremors, rigid...

Inflammopharmacology

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Ocimene mitigates pyroptosis through TLR4/NLRP3-mediated mechanisms in CFA-induced inflammation

The monocyclic monoterpenoid ocimene (OC) has undergone pharmacological testing as a possible inhibitor of pyroptosis trig...

Inflammopharmacology

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Voclosporin promotes neurological function recovery by inhibiting inflammation and maintaining blood–brain barrier integrity following rtPA reperfusion after MCAO in mice

Hemorrhagic transformation (HT) is the most serious complication after rtPA thrombolytic therapy in patients with acute is...

Inflammopharmacology

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Tetrylpyamethrazine alleviates hepatic fibrosis induced by experimental mansonic schistosomiasis

Hepatic fibrosis resulting from human mansonic schistosomiasis significantly impairs liver function and contributes substa...

Inflammopharmacology

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NSAID-encapsulated nanoparticles as a targeted therapeutic platform for modulating chronic inflammation and inhibiting cancer progression: a review

Recent advancements in nanotechnology have significantly advanced nanocarrier-mediated drug delivery systems, promoting th...

Inflammopharmacology

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Role of TRPV1 and TRPA1 nociceptive neurons in delayed-onset muscle soreness: inhibition by hesperidin methyl chalcone

Delayed-onset muscle soreness (DOMS) is a type of pain caused by muscle injury provoked by eccentric, high intensity, or l...

Inflammopharmacology

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fruit pulp extracts mitigate collagen-induced arthritis via regulation of oxidative stress and inflammation

Rheumatoid arthritis (RA) is an autoimmune inflammation disorder affecting the joints, it has a complex pathophysiology in...

Inflammopharmacology

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Molecular mechanisms and treatment strategies for estrogen deficiency-related and glucocorticoid-induced osteoporosis: a comprehensive review

Osteoporosis, a debilitating condition characterized by reduced bone mass and increased fracture risk, is notably influenc...

Inflammopharmacology

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The effect of methylation and hydroxymethylation of cytosine on activity and fidelity of Pol λ and Pol β

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Dna Repair

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Targeting dePARylation in cancer therapy

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Dna Repair

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Role of NEIL1 in genome maintenance

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Dna Repair

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The hidden elephant: Modified abasic sites and their consequences

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Dna Repair

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Repair pathway coordination from gap filling by polβ and subsequent nick sealing by LIG1 or LIG3α governs BER efficiency at the downstream steps

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Dna Repair

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Obituary: Francis Fabre (1940–2024): Yeast geneticist that contributed to our understanding of the control of homologous recombination