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Advancing hepatotoxicity assessment: current advances and future directions

During drug development, it is crucial to ensure that a drug exhibits effective activity in its target cells and organs. H...

Toxicological Research

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Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study

Red yeast rice (RYR) is commonly used as colouring and flavouring agent in foods throughout East Asia. RYR contains monaco...

Toxicological Research

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Artificial intelligence‑based quantitative analysis of hepatic fibrosis in carbon tetrachloride-induced mouse model of metabolic dysfunction-associated steatohepatitis

Liver fibrosis, a major histopathological indicator of chronic liver injury, is also a key feature of metabolic dysfunctio...

Toxicological Research

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Validation of a B cell acute lymphoblastic leukemia xenograft rat model for integrated efficacy, pharmacokinetics and safety of CD19 CAR-T

In preclinical studies of B cell acute lymphoblastic leukemia (B-ALL), mouse models have limitations related to their smal...

Toxicological Research

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Molecular modulation of cholinergic and neuromuscular signaling following long-term acetaminophen administration

Acetaminophen is widely used as an analgesic and antipyretic; however, its long-term neurochemical actions remain incomple...

Toxicological Research

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The oncogenic signalosome: SQSTM1/p62 as a master integrator of signaling, metabolism, and autophagy in cancer

Sequestosome 1 (SQSTM1/p62), long established as a selective autophagy receptor and ubiquitin-binding scaffold, is now rec...

Toxicological Research

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Development of in vitro skin corrosion test using KeraSkin™

Skin corrosion and irritation are critical local toxicological endpoints associated with chemical exposure. OECD has appro...

Toxicological Research

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Skin absorption and metabolism of [C]-labeled C12-benzalkonium chloride (C12-BKC) in ex vivo porcine ear skin using UPLC-β-RAM analysis

Benzalkonium chloride is a quaternary ammonium disinfectant widely used in pharmaceutical, cosmetic, and household product...

Toxicological Research

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Neuronal safety of Kv11.1 blockers: Patch-clamp and in vitro evaluation with physiologically based pharmacokinetic (PBPK) modeling

Toxicology Reports

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Comparative analysis of test tube and volumetric drinking monitor methods in voluntary ethanol consumption in female mice for prenatal alcohol exposure

Toxicology Reports

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Comprehensive sub-chronic toxicological profiling of illegal artisanal small-scale mining-polluted river bodies in four regions of Ghana

Toxicology Reports

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Safety evaluation of an effervescent curcuminoids–ascorbic acid–polysaccharide–β-cyclodextrin (CUR-A-Poly-β-CD) inclusion complex powder in healthy volunteers: A non-placebo-controlled pilot study

Toxicology Reports

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Establishment of the Kuwait Poison Control Center: From concept to operations

Toxicology Reports

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Risk assessment of Cd exposure through consumption of jasmine rice

Toxicology Reports

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National survey of Dutch emergency physicians on pharmacological sedation practices for extreme agitation

Toxicology Reports

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Toxicological profile of anti-diabetic drugs and emerging measures to reduce the toxic burden

Toxicology Reports

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Unravelling the multi-target mechanism of methoxylated flavonoids in Parkinson's disease: Insights from network pharmacology and molecular dynamics

Toxicology Reports

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Ethylene glycol toxicity presenting as a rapidly deteriorating focal neurological exam and reversible cerebral herniation syndrome

Toxicology Reports

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Repeated oral administration of gamma-aminobutyric acid (GABA) does not cause reproductive or developmental toxicity in rats

Toxicology Reports

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Mycoflora, mycotoxin exposure and cancer risk assessment in Tuo-Zaafi, a fermented cereal meal consumed in northern Ghana

Toxicology Reports

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Regulatory integration of new approach methodologies for human-relevant developmental and reproductive toxicity (DART) assessment: A systematic cross-sector review

Toxicology Reports

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In vitro studies on curcumin-chitosan-Multiwalled Carbon Nanotubes (MWCNT) cytotoxicity against A549 (lung cancer cell line) HCT 116 (colorectal cancer cell line) and PANC1 (pancreatic cancer cell line)

Toxicology Reports

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Self-nanoemulsifying drug delivery system (SNEDDS) enhances the antidiabetic potential of Averrhoa bilimbi L. leaf extract: Integrated LC–MS/MS metabolomics, network pharmacology, and alpha-amylase inhibition

Toxicology Reports

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Acute 2,4-dichlorophenoxyacetic acid herbicide poisoning in rural India: clinical spectrum, multiorgan toxicity, and outcomes in an eight-patient observational study

Toxicology Reports

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Presence of glyphosate in endometrial cancer tissue: A cross-sectional study

Toxicology Reports

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In silico evaluation of soursop (Annona muricata) leaf compound interactions with CYP450 and their potential impact on systemic cancer therapies

Toxicology Reports

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Toxicological evaluation of bioengineered salidroside produced by a novel method

Toxicology Reports

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Characteristics and prognostic factors of adult poisoning patients in the intensive care unit: A retrospective cohort study using the Japanese intensive care patient database

Toxicology Reports

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Assessment of Tap Water Quality and Health Risks in Mymensingh City, Bangladesh

medRxiv - the preprint server for biology, operated by openRxiv, a nonprofit organization dedicated to advancing scientifi...

Medrxiv - Toxicology

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Prenatal Exposure to Emerging Pesticides and Childhood Allergy Risk: A First Mixture Assessment in an Urban Cohort

medRxiv - the preprint server for biology, operated by openRxiv, a nonprofit organization dedicated to advancing scientifi...

Medrxiv - Toxicology

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