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Double negative T cells (CD4-/CD8-) are associated with Trypanosoma cruzi persistence in the mouse colon during chronic Chagas disease
IntroductionChagas disease (CD), caused by the blood borne parasite Trypanosoma cruzi, affects 6–8 million people primaril...
Multi-omics and experimental validation identify USP54 as a prognostic deubiquitinase promoting pancreatic ductal adenocarcinoma progression within the immune microenvironment
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a complex tumor ecosystem that contri...
Deciphering the interferon gene signature spectrum: association with the clinical heterogeneity of Sjögren’s disease
PurposeThis study aimed to identify interferon (IFN)-related key genes in patients with Sjögren’s Disease (SjD) and to elu...
Hepatitis C virus core protein-induced myeloid-derived suppressor cells promote hepatic fibrosis by regulating hepatic stellate cell function via TGF-β
Background and objectiveMyeloid-derived suppressor cells (MDSCs) constitute a population of cells with immunosuppressive f...
Multidimensional regulatory mechanisms and translational potential of epigenetic networks in the rheumatoid arthritis disease course
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis that may progress to irreversible jo...
Dual effects of JAK vs TNF inhibitors on osteoporosis, fractures and mortality in rheumatoid arthritis: a real-world cohort study
PurposeThis real-world study compared the effects of JAK inhibitors (JAKi) versus TNF inhibitors (TNFi) on bone health and...
Gut microbiota alliance to shape sceneries of familial Mediterranean fever: a scoping review detailing difference between children and adults
Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide and a key-model to illu...
Overcoming multidimensional immunotherapy resistance in PDAC: from microenvironment to clinic
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with immunotherapy yielding
Case Report: A case of severe hypotension induced by nimotuzumab in a nasopharyngeal carcinoma patient
Nimotuzumab, a humanized immunoglobulin G1 monoclonal antibody, is mainly used in combination with radiotherapy for the tr...
[18F]-FDG-PET/CT detects subclinical optic nerve inflammation in giant cell arteritis
ObjectiveVision loss is a feared complication in giant cell arteritis (GCA). However, imaging data characterizing intraorb...
Intact lymph node homing and CD8+ T-cell priming abilities of Sprouty2-deficient dendritic cells
Sprouty2 (Spry2) acts as a modulator of the MAPK-ERK signaling pathway by exerting both positive and negative regulation i...
Correction: Long pentraxin 3 (PTX3) regulates IL-17A-mediated secondary immunity to Leishmania major infection in mice
Adding/removing text [ "In the published article, there was a mistake as we have missed including a sentence in the I...
Unraveling the indolence of papillary thyroid carcinoma: an exploratory study on B-cell subsets based on genetic predisposition and tumor immunity
BackgroundActive surveillance for low-risk papillary thyroid carcinoma (PTC) is hampered by the lack of reliable biomarker...
Incomplete B-cell reconstitution in ART-treated people living with HIV is associated with EBV-linked lymphoma progression
BackgroundDespite the widespread use of antiretroviral therapy (ART), people living with HIV continue to exhibit persisten...
Evaluation of the trypanocidal and immunomodulatory effects of LDT409, a cardanol derivative from cashew nut shell liquid
IntroductionChagas disease (CD), caused by Trypanosoma cruzi, is a neglected tropical illness with significant public heal...
Neuronal intranuclear inclusion disease with initial manifestation of intractable nausea and vomiting responsive to corticosteroids: a case report
Neuronal intranuclear inclusion disease (NIID) can initially present with gastrointestinal symptoms as the sole or primary...
Reinventing malaria control: hierarchical intervention strategies for African settings based on the microbiota-barrier-innate immunity axis
Malaria control is challenged by parasite drug resistance and inadequate vaccine protection. Although mosquito gut microbe...
Lymphocyte function inhibition and exhaustion in sepsis: mechanisms and applications
Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to infection and is charact...
Natural killer cell dysfunction in glioma: from immune evasion to immunotherapy
Natural killer (NK) cells, critical components of innate immunity, possess the ability to eliminate tumor cells without pr...
Combined use of Bumetanide and MGE cell transplantation alleviates neuropathic pain and its mechanism after spinal cord injury in mice
IntroductionNeuropathic pain (NP) after spinal cord injury (SCI) is intractable with limited efficacy of single treatments...
Two decades of mucormycosis: molecular epidemiology and antifungal susceptibility trends in Türkiye
BackgroundMucormycosis is a life-threatening invasive fungal infection that mainly affects individuals with weakened immun...
Inflammatory biomarkers and physiological reserve: an explainable machine learning model for predicting postoperative pulmonary complications in elderly laparoscopic surgery
IntroductionPostoperative pulmonary complications (PPCs) significantly impact the prognosis of elderly patients undergoing...
Low levels of the second messenger c-di-GMP enhance tolerance and resistance to meropenem in Pseudomonas aeruginosa
BackgroundThe carbapenem antibiotic meropenem is often used to treat life-threatening infections caused by Pseudomonas aer...
Systemic inflammation, multi-organ injury, and acute kidney risk in psittacosis pneumonia: a biomarker-driven clinical characterization
BackgroundPsittacosis pneumonia, which is caused by Chlamydia psittaci, is a systemic inflammatory disease that often resu...
Pathobiology of ESKAPE Biofilms in implant infections: current understanding and implications for future therapeutic strategies
In the modern era, the expanding demand for implants has transformed the healthcare system by restoring and enhancing the ...
Temporal dynamics of gut microbiota and virome in preterm infants: insights from longitudinal metagenomic analysis
IntroductionPreterm infants exhibit heightened vulnerability to morbidity and mortality due to their underdeveloped immune...
From proteomics to colloidal gold tests for urinary thrombomodulin: a prospective cohort study on accurate sepsis screening
BackgroundTo develop a new non-invasive screening method for sepsis by detecting urine samples.MethodsA prospective study ...
Carbapenem-resistant Salmonella Derby harboring a plasmid carrying blaNDM-1 from a clinical case in China
ObjectiveThe increasing antimicrobial resistance in non-typhoidal Salmonella (NTS) poses a growing challenge to clinical t...
An exhaustive cell-based screen coupled with an intracellular-induced lux-based reporter identified bioactive molecules that inhibit host cell infection by intracellular pathogens
IntroductionAntibiotic resistance poses a critical and escalating global health crisis, leading to higher morbidity and mo...
Candida albicans metabolic adaptation gene SFU1 regulates dual-species biofilm with Streptococcus mutans
ObjectiveTo investigate the role of the iron-sulfur cluster assembly factor SFU1 in the virulence-related traits of Candid...
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