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Allelopathic effects of four spontaneous plants from arid regions on the germination and growth of selected weeds and crops
The study investigates the allelopathic potential of the aqueous extracts of four plants species; Cleome arabica L., Diplo...
Polyphyllin B induces ferroptosis in triple-negative breast cancer by inactivating NRF2
BackgroundTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC) and lacks effective tr...
Cost-utility analysis of add-on ezetimibe to moderate-intensity statin versus moderate-intensity statin alone for secondary prevention in patients with acute coronary syndrome intolerant to high-intensity statin therapy in Thailand
BackgroundAlthough high-intensity statin therapy is recommended for the secondary prevention of acute coronary syndrome (A...
Predicting affinity and potency of new psychoactive substances at cannabinoid 1 receptor with explainable artificial intelligence
Introduction Binding affinity and functional potency are two distinct but pharmacologically related properties in ligand-r...
Incidence and risk factors of venous and arterial thromboembolism events in lung cancer patients treated with immune checkpoint inhibitors
BackgroundThromboembolism (TE), which comprises venous thromboembolism (VTE) and arterial thromboembolism (ATE), represent...
Original research a real-world study of adverse events of nafamostat mesylate and sodium citrate based on the world health organization-VigiAccess database
AimsWhile nafamostat mesylate (NM) and sodium citrate serve as commonly used extracorporeal anticoagulants in clinical pra...
A rationally designed 18-amino acid peptide with potential as GLP-1 receptor agonist
IntroductionDiabetes mellitus (DM) is a multifaceted disease etiologically characterised by dysregulation in glucose homeo...
Association between terbutaline sulfate plus ambroxol hydrochloride and clinical outcomes, pulmonary function, and inflammatory biomarkers in elderly patients with acute exacerbation of chronic obstructive pulmonary disease
BackgroundAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) are characterized by airflow limitation an...
Alkaloids from Fritillariae Cirrhosae Bulbus - progress on their pharmacological activities
Fritillariae Cirrhosae Bulbus is a valuable and authentic medicinal material widely used in traditional Chinese medicine t...
Dual BAFF/APRIL inhibition with telitacicept in systemic lupus erythematosus and IgA nephropathy: pharmacological rationale, clinical efficacy, and safety on female fertility preservation
BackgroundSystemic lupus erythematosus (SLE) and IgA nephropathy (IgAN) are immune-mediated renal disorders characterized ...
Adverse neurological events associated with bispecific T cell engagers in oncology: a real-world study
BackgroundWith the increasing use of bispecific T cell engagers (BiTEs) in anti-tumor immunotherapy, the associated advers...
Real-world evaluation of attention deficit hyperactivity disorder symptoms and side effects in patients prescribed serdexmethylphenidate/dexmethylphenidate or other stimulants
BackgroundSerdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) (Azstarys®) is an FDA-approved treatment for ADHD in patien...
Thrombocytopenia and anemia associated with piperacillin-tazobactam: integrating clinical case series with FAERS disproportionality analysis
BackgroundPiperacillin-tazobactam (TZP) is a commonly used broad-spectrum antibiotic in clinical practice; however, its ha...
Factors associated with non-adherence to antihypertensive therapy and blood pressure control in Iraq
Background/ObjectivesHypertension is a major global public health concern, affecting approximately 1.28 billion people wor...
Hydroxysafflor yellow a attenuates oxygen-glucose deprivation/ reoxygenation induced endothelial pyroptosis via PARP-1/NLRP3 pathway
IntroductionDysfunction of brain microvascular endothelial cells (BMECs) induced by oxidative stress represents a critical...
Pretreatment of trans-ferulic acid improved neurotoxicity in a thioacetamide-induced hepatic encephalopathy rat model; participation of the MAPK/NF-κb signaling pathway
AimTrans-ferulic acid (TFA), a naturally occurring phenolic compound, has attracted significant attention due to its stron...
Adjuvant therapeutic effects and mechanisms of Yinchenhao decoction in obstructive jaundice: a narrative review
Yinchenhao Decoction (YCHD) is a classic traditional Chinese medicine (TCM) formula composed of three botanical drugs: Art...
Angiotensin II type 1 and type 2 receptors modulate TWIK1 channel expression and pain sensitivity in a rat model of neuropathic pain
BackgroundThe renin–angiotensin system (RAS) contributes to inflammatory and neuropathic pain, but whether its primary rec...
A narrative review of PCSK9 inhibitors: from evolocumab to novel discoveries
The application of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors represents a crucial milestone in the ...
Efficacy and safety of anisodine hydrobromide injection in acute ischemic stroke—a multicenter real-world observational study
ObjectiveTo evaluate the efficacy and safety of anisodine hydrobromide injection in patients with acute ischemic stroke in...
Activation of µ-δ Opioid Receptor Heteromer Attenuates Chemotherapy-Induced Neuropathic Pain in Mice
Activation of µ-δ Opioid Receptor Heteromer Attenuates Chemotherapy-Induced Neuropathic Pain in Mice
Chemotherapy-induced neuropathic pain (CINP) affects up to 80% of cancer patients treated with cytostatic drugs like pacli...
Neuroprotective Effects of Glucosamine in Huntington’s Disease Through NLRP3 Inflammasome Inhibition
Neuroprotective Effects of Glucosamine in Huntington’s Disease Through NLRP3 Inflammasome Inhibition
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the hunting...
The Ubiquitin–Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers
The Ubiquitin–Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers
Ubiquitination is a key enzymatic process where ubiquitin molecules covalently attach to substrate proteins, regulating th...
The Small Molecule Compound Eupalinolide B Alleviates Neuropathic Pain by Regulating the USP7/Keap1/Nrf2 Pathway
The Small Molecule Compound Eupalinolide B Alleviates Neuropathic Pain by Regulating the USP7/Keap1/Nrf2 Pathway
Neuropathic pain is a chronic pain condition characterized by complex pathogenesis and poor prognosis. EB (Eupalinolide B)...
Bradykinin Type 2 Receptor Deficiency Reshapes Acute Neuroinflammation and Improves Cell Survival after Ischemic Stroke in Diabetic Mice
Bradykinin Type 2 Receptor Deficiency Reshapes Acute Neuroinflammation and Improves Cell Survival after Ischemic Stroke in Diabetic Mice
Diabetes mellitus exacerbates cerebral ischemic damage by potentiating neuroinflammation. We hypothesized that activation ...
Fisetin Mitigates Ferroptosis and Promotes Remyelination in a Cuprizone Model of Multiple Sclerosis
Fisetin Mitigates Ferroptosis and Promotes Remyelination in a Cuprizone Model of Multiple Sclerosis
Multiple sclerosis (MS) is a long-lasting autoimmune condition characterized by myelin destruction and neurodegeneration. ...
Ameliorative Effect of Vitamin C Against Tramadol-Induced Learning and Memory Impairment in Juvenile Rat Via Attenuation of Oxidative Stress and Dysfunctional Synaptic Plasticity
Ameliorative Effect of Vitamin C Against Tramadol-Induced Learning and Memory Impairment in Juvenile Rat Via Attenuation of Oxidative Stress and Dysfunctional Synaptic Plasticity
Tramadol (TM) abuse negatively affects the central nervous system, especially brain regions like the hippocampus involved ...
Histamine H3 Receptor Antagonist, Thioperamide, Improves Behavioral and Neuropathological Changes Associated with Subclinical Hypersensitivity to a Cow’s Milk Allergen
Histamine H3 Receptor Antagonist, Thioperamide, Improves Behavioral and Neuropathological Changes Associated with Subclinical Hypersensitivity to a Cow’s Milk Allergen
Mood and behavior-related comorbidities are often reported with food allergies, an atopic condition that elevates histamin...
Telitacicept as a New Therapeutic Avenue for Generalized Myasthenia Gravis and Thymoma-Associated Myasthenia Gravis
Telitacicept as a New Therapeutic Avenue for Generalized Myasthenia Gravis and Thymoma-Associated Myasthenia Gravis
Generalized myasthenia gravis (gMG) is an antibody mediated autoimmune neuromuscular junction disorder characterized by mu...
Modulation of Cognitive Function by TRPM3 Channels in the Dentate Gyrus of a Menopausal Rat Model: Effects of Naringenin Treatment and Ciliary Neurotrophic Factor
Modulation of Cognitive Function by TRPM3 Channels in the Dentate Gyrus of a Menopausal Rat Model: Effects of Naringenin Treatment and Ciliary Neurotrophic Factor
Although transient receptor potential melastatin 3 (TRPM3) channels are primarily known for their role in spinal nocicepti...
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