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Phase change nanodroplets: Challenges and clinical potential

Dual-driven by regulatory science and policy reconstruction: Traditional Chinese medicine (TCM) new drugs accelerate development—A critical review of highlights in registration and regulation of TCM and natural medicine new drugs in China (2021–2025)

Acta Pharmaceutica Sinica B

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Exendin-4 alleviates anxiety-like behaviors in chronic restraint stress mice via regulating BLA GLP-1R/BDNF signaling

Acta Pharmaceutica Sinica B

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Glutaminolysis inhibition boosts cuproptosis to eliminate breast cancer stem cells

Acta Pharmaceutica Sinica B

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Inhaled collagenase I liposomes reverse pulmonary fibrosis via local collagen degradation

Acta Pharmaceutica Sinica B

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Universal off-the-shelf TGF-β1-knockout whole-tumor cell vaccine overcomes immunotherapy resistance in pMMR/MSS tumors

Acta Pharmaceutica Sinica B

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Double coordination-driven Fe–DOX synergy enhances ferroptosis and immunogenic cancer therapy

Acta Pharmaceutica Sinica B

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Hepatokine FGL1 drives endothelial injury and atherogenesis via integrin β1-mediated endothelial–mesenchymal transition

Acta Pharmaceutica Sinica B

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Neutralizing dentin sialophosphoprotein facilitates tumor vascular normalization in colorectal cancer by blocking the crosstalk between tumor cells and endothelial cells

Acta Pharmaceutica Sinica B

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Novel circUnc79 regulates morphine-induced reward memory via the miR-149-3p/EAAT2 axis and glutamatergic plasticity

Acta Pharmaceutica Sinica B

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IFI30 reprograms glioblastoma-associated macrophage and induces immune evasion by MAFF/PTGS2 pathway

Acta Pharmaceutica Sinica B

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Tuning protein corona on nucleic acid nanodrugs for targeted delivery

Acta Pharmaceutica Sinica B

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Sequential mRNA vaccine-enabled quadruple therapy induces functional cure of HBV in rAAV8-1.3HBV carrier mice

Acta Pharmaceutica Sinica B

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Learn from nature, surpass nature: Bionic immune cell engineering—A new paradigm for unlocking the dual “delivery-activation” code in cancer therapy

Acta Pharmaceutica Sinica B

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Cytoplasmic relocation of nuclear Ku70 by Bruceine A augments cGAS–STING pathway-mediated anti-tumor immunity

Acta Pharmaceutica Sinica B

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Dual-modal tumor-selective Benzofuran tracer integrating real-time imaging and anticancer effects

Acta Pharmaceutica Sinica B

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Antihypertensive drug-induced liver injury is rare, but strongly associated with HLA-B*35:01

Acta Pharmaceutica Sinica B

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Emerging organoids and organoids-on-chip platforms for translational development of antibody‒drug conjugates and next-generation bioconjugates

Acta Pharmaceutica Sinica B

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Rhynchophylline rewires DLAT lipoylation via conformational control to reverse mitochondrial bioenergetic collapse against dopaminergic neuronal injury

Acta Pharmaceutica Sinica B

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Nanobodies targeting SARS-CoV-2 variants

Acta Pharmaceutica Sinica B

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Allelopathic effects of four spontaneous plants from arid regions on the germination and growth of selected weeds and crops

The study investigates the allelopathic potential of the aqueous extracts of four plants species; Cleome arabica L., Diplo...

Frontiers In Pharmacology

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Polyphyllin B induces ferroptosis in triple-negative breast cancer by inactivating NRF2

BackgroundTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC) and lacks effective tr...

Frontiers In Pharmacology

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Cost-utility analysis of add-on ezetimibe to moderate-intensity statin versus moderate-intensity statin alone for secondary prevention in patients with acute coronary syndrome intolerant to high-intensity statin therapy in Thailand

BackgroundAlthough high-intensity statin therapy is recommended for the secondary prevention of acute coronary syndrome (A...

Frontiers In Pharmacology

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Predicting affinity and potency of new psychoactive substances at cannabinoid 1 receptor with explainable artificial intelligence

Introduction Binding affinity and functional potency are two distinct but pharmacologically related properties in ligand-r...

Frontiers In Pharmacology

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Incidence and risk factors of venous and arterial thromboembolism events in lung cancer patients treated with immune checkpoint inhibitors

BackgroundThromboembolism (TE), which comprises venous thromboembolism (VTE) and arterial thromboembolism (ATE), represent...

Frontiers In Pharmacology

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Original research a real-world study of adverse events of nafamostat mesylate and sodium citrate based on the world health organization-VigiAccess database

AimsWhile nafamostat mesylate (NM) and sodium citrate serve as commonly used extracorporeal anticoagulants in clinical pra...

Frontiers In Pharmacology

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A rationally designed 18-amino acid peptide with potential as GLP-1 receptor agonist

IntroductionDiabetes mellitus (DM) is a multifaceted disease etiologically characterised by dysregulation in glucose homeo...

Frontiers In Pharmacology

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Association between terbutaline sulfate plus ambroxol hydrochloride and clinical outcomes, pulmonary function, and inflammatory biomarkers in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

BackgroundAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) are characterized by airflow limitation an...

Frontiers In Pharmacology

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Alkaloids from Fritillariae Cirrhosae Bulbus - progress on their pharmacological activities

Fritillariae Cirrhosae Bulbus is a valuable and authentic medicinal material widely used in traditional Chinese medicine t...

Frontiers In Pharmacology

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Dual BAFF/APRIL inhibition with telitacicept in systemic lupus erythematosus and IgA nephropathy: pharmacological rationale, clinical efficacy, and safety on female fertility preservation

BackgroundSystemic lupus erythematosus (SLE) and IgA nephropathy (IgAN) are immune-mediated renal disorders characterized ...

Frontiers In Pharmacology

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