SCI Abstract

search
+
Pathology-directed drug delivery strategies: How to overcome blood–brain barrier for the treatment of brain diseases
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
Immunocyte reprogramming empowers live-cell drug delivery: Mechanistic insights, delivery strategies, and clinical perspectives
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
Photoimmunological hydrogel vaccine creates a supportive immune niche to promote antigen cross-presentation cascade and cancer-immunity cycle progression
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
Targeting glial cells: Unveiling the neuroprotective mechanisms of Ginseng in the brain microenvironment
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
Palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
REEP6 promotes colorectal cancer glycolysis and tumorigenesis through PRMT5-mediated PGAM1 arginine methylation
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
Interleukin 12-tethered nano-aluminum adjuvant orchestrates environmental immunomodulation to empower cytotoxic T cells against solid tumors
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
Progress in peptide and protein therapeutics: Challenges and strategies
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
Structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c2...
Fluorescence bioimaging of drug nanocarriers based on Förster resonance energy transfer, aggregation-induced emission and aggregation-caused quenching
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c1...
Probiotic living microneedles designed by interbacterial competition for accelerated infected wound healing
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c1...
Rifamycin O as a novel CRBN ligand for targeted degradation of IKZF1/3 proteins in hematopoietic malignancies
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c1...
Omics-based large language models: A new engine for drug discovery innovation
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c1...
FAP-targeted radionuclide therapy induces ferroptosis in cancer-associated fibroblasts via disrupting iron homeostasis and redox balance
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c1...
In situ rewiring TAMs as annihilators by “Spark-Relay” nanoinitiator with flexible reactant ratio for amplifying solid tumor immunotherapy
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c1...
DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi, targeting IMPDH2 to inhibit triple-negative breast cancer
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c1...
LSD1 inhibition sensitizes anti-PD1 blockade immunotherapy by inhibiting the long-range attack of tumor-derived extracellular vesicles
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c1...
Computational approaches to druggable site identification: Current status and future perspective
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 996c1...
Possible Interaction of Suramin with Thalamic P2X Receptors and NLRP3 Inflammasome Activation Alleviates Reserpine-Induced Fibromyalgia-Like Symptoms
Possible Interaction of Suramin with Thalamic P2X Receptors and NLRP3 Inflammasome Activation Alleviates Reserpine-Induced Fibromyalgia-Like Symptoms
The high pain sensitivity in fibromyalgia (FM) is processed by the thalamus that presents as a key component in the pain p...
HucMSCs-Derived Extracellular Vesicles Deliver RPS27A Protein to Manipulate the MDM2-P53 Axis and Ameliorate Neurological Dysfunction in Parkinson’s Disease
HucMSCs-Derived Extracellular Vesicles Deliver RPS27A Protein to Manipulate the MDM2-P53 Axis and Ameliorate Neurological Dysfunction in Parkinson’s Disease
Extracellular vesicles released from mesenchymal stem cells (MSCs-EV) have shown anti-inflammatory effects in Parkinson...
Protective Effect of HMG-CoA Reductase Inhibitor Rosuvastatin on Doxorubicin-Induced Cognitive Impairment, Oxidative Stress and Neuroinflammation: Possible Role of CREB, ERK1/2, and BDNF
Protective Effect of HMG-CoA Reductase Inhibitor Rosuvastatin on Doxorubicin-Induced Cognitive Impairment, Oxidative Stress and Neuroinflammation: Possible Role of CREB, ERK1/2, and BDNF
During or after chemotherapy, cognitive impairments characterized by forgetfulness, difficulty concentrating, and depressi...
COP1 Overexpression Attenuates Nociceptive Behaviors and Neuroinflammation in Cancer-Induced Bone Pain by Suppressing c/EBPβ
COP1 Overexpression Attenuates Nociceptive Behaviors and Neuroinflammation in Cancer-Induced Bone Pain by Suppressing c/EBPβ
Patients with advanced cancer often have bone metastases, causing bone destruction and cancer-induced bone pain (CIBP). Th...
Limettin and PD98059 Mitigated Alzheimer’s Disease Like Pathology Induced by Streptozotocin in Mouse Model: Role of -ERK1/2/GSK-3β/CREB/BDNF Pathway
Limettin and PD98059 Mitigated Alzheimer’s Disease Like Pathology Induced by Streptozotocin in Mouse Model: Role of -ERK1/2/GSK-3β/CREB/BDNF Pathway
Sporadic Alzheimer’s disease (SAD) represents one of the major memory deficits that is characterized by tau hyperpho...
Clonidine Ameliorates Neuroinflammation in the Rat Model of Tourette Syndrome
Clonidine Ameliorates Neuroinflammation in the Rat Model of Tourette Syndrome
Neuroinflammation plays a vital role in the etiology and pathogenesis of Tourette syndrome (TS). The postmortem report of ...
Exploring Dapagliflozin’s Influence on Autophagic Flux in Mania-like Behaviour: Insights from the LKB1/AMPK/LC3 Pathway in a Mouse Model
Exploring Dapagliflozin’s Influence on Autophagic Flux in Mania-like Behaviour: Insights from the LKB1/AMPK/LC3 Pathway in a Mouse Model
Mania-like episodes are neuropsychiatric disturbances associated with bipolar disorder (BD). Autophagic flux disturbance e...
COVID-19 Alters Inflammatory, Mitochondrial, and Protein Clearance Pathway Genes: Potential Implications for New-onset Parkinsonism in Patients
COVID-19 Alters Inflammatory, Mitochondrial, and Protein Clearance Pathway Genes: Potential Implications for New-onset Parkinsonism in Patients
Several preclinical and clinical studies have shown that SARS-CoV-2 infection is associated with new-onset Parkinson’...
RIPK1: A Promising Target for Intervention Neuroinflammation
RIPK1: A Promising Target for Intervention Neuroinflammation
Necroptosis is a novel mode of cell death that differs from traditional apoptosis, characterized by distinct molecular mec...
TNF-Stimulated Gene-6, Part of Extracellular Vesicles in Adipose Tissue-Derived Mesenchymal Stem Cell Concentrated Conditioned Medium, Affects Microglial Activity
TNF-Stimulated Gene-6, Part of Extracellular Vesicles in Adipose Tissue-Derived Mesenchymal Stem Cell Concentrated Conditioned Medium, Affects Microglial Activity
Identifying the specific bioactive molecules produced by mesenchymal stem cells (MSCs) and the signaling pathways and cell...
Load More
format_indent_increase