SCI Abstract

search
+
Health economic evaluation of Mirvetuximab soravtansine for the treatment of FRα-positive, platinum resistant ovarian cancer in Germany
Health economic evaluation of Mirvetuximab soravtansine for the treatment of FRα-positive, platinum resistant ovarian cancer in Germany
Mirvetuximab soravtansine (MIRV) is an antibody–drug conjugate targeting the folate receptor α (FRα), appr...
Correlation of preoperative radiological lymph node assessment with pathological nodal and tumor findings in tongue and oral floor squamous cell carcinoma
Correlation of preoperative radiological lymph node assessment with pathological nodal and tumor findings in tongue and oral floor squamous cell carcinoma
Preoperative imaging is central to cervical lymph node staging in oral squamous cell carcinoma (OSCC). However, the pathol...
Years of life lost in cutaneous squamous cell carcinoma: analysis of a prospective cohort of 1400 patients
Years of life lost in cutaneous squamous cell carcinoma: analysis of a prospective cohort of 1400 patients
Cutaneous squamous cell carcinoma (cSCC) occurs predominantly in older adults. Disease-specific mortality is low, but conv...
Diagnostic performance and clinical limitations of sentinel lymph node biopsy in head and neck melanoma: a 20-year retrospective cohort study
Diagnostic performance and clinical limitations of sentinel lymph node biopsy in head and neck melanoma: a 20-year retrospective cohort study
Sentinel lymph node biopsy (SLNB) is a standard procedure for nodal staging in cutaneous melanoma. However, its diagnostic...
Residential radon exposure and lung cancer histology and stage: a population-based ecological study in Central Germany
Residential radon exposure and lung cancer histology and stage: a population-based ecological study in Central Germany
Residential radon exposure is recognised as one of the leading environmental risk factors for lung cancer and acts synergi...
Investigation of a GPC1-targeted and LIFU-responsive nanoplatform with ADV effect for visualized chemo-sonodynamic therapy against pancreatic ductal adenocarcinoma
Investigation of a GPC1-targeted and LIFU-responsive nanoplatform with ADV effect for visualized chemo-sonodynamic therapy against pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. Regardless of surgical resection, che...
Photon counting computed tomography in head and neck squamous cell carcinoma: iodine concentration and histopathological features
Photon counting computed tomography in head and neck squamous cell carcinoma: iodine concentration and histopathological features
Head and neck squamous cell carcinoma (HNSCC) is a common malignancy with increasing relevance in oncologic imaging. Photo...
Antibody-Drug Conjugates Reshape the Landscape of Cancer Therapy: Evolution, Challenges and Future Perspectives from the Concept of “Magic Bullet” to Clinical Application
Antibody-Drug Conjugates Reshape the Landscape of Cancer Therapy: Evolution, Challenges and Future Perspectives from the Concept of “Magic Bullet” to Clinical Application
Antibody-drug conjugates (ADCs), generated by covalently linking tumor-targeted monoclonal antibodies to highly potent cyt...
Artificial Intelligence in Lung Cancer: From Early Detection to Personalized Therapy
Artificial Intelligence in Lung Cancer: From Early Detection to Personalized Therapy
This review highlights recent advances in the use of artificial intelligence (AI) for lung cancer screening, risk stratifi...
Unveiling the Intricate Dance: Signaling Pathways in Liver Cancer Metabolism and Immunity
Unveiling the Intricate Dance: Signaling Pathways in Liver Cancer Metabolism and Immunity
Hepatocellular carcinoma is a type of cancer with high rates of occurrence and death worldwide. Recently, the marked incre...
Clinical Development of Novel-Novel Multi-Company Combination Therapies in Oncology
Clinical Development of Novel-Novel Multi-Company Combination Therapies in Oncology
Most novel anti-cancer therapies involve combining multiple immuno-oncology and/or targeted drugs. The historical paradigm...
Malignant Fungating Wounds in Advanced Cancer: Pathophysiology, Odor Control, and Dignity-Centered Management
Malignant Fungating Wounds in Advanced Cancer: Pathophysiology, Odor Control, and Dignity-Centered Management
Malignant fungating wounds (MFWs) represent a profoundly distressing complication of advanced cancer, affecting an estimat...
Physicians’ Knowledge and Experiences of Counseling on Complementary, Alternative, and Integrative Medicine in Cancer Care: a Qualitative Systematic Review
Physicians’ Knowledge and Experiences of Counseling on Complementary, Alternative, and Integrative Medicine in Cancer Care: a Qualitative Systematic Review
The increasing use of complementary, alternative, and integrative medicine (CAIM) among patients with cancer raises questi...
Immunological Drug–Drug Interactions in Immune Checkpoint Inhibitor Therapy: Mechanisms, Clinical Evidence, and Artificial Intelligence
Immunological Drug–Drug Interactions in Immune Checkpoint Inhibitor Therapy: Mechanisms, Clinical Evidence, and Artificial Intelligence
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, producing durable responses across multiple malignanc...
Mind-Body Therapies for Depression and Anxiety Symptoms in People with Cancer: A Systematic Review with Network Meta-Analysis
Mind-Body Therapies for Depression and Anxiety Symptoms in People with Cancer: A Systematic Review with Network Meta-Analysis
Mind-body therapies (MBTs) are promising forms of treatment for depression and anxiety symptoms in people with cancer, how...
Impact of 18-FDG PET/CT on Multidisciplinary Decision-Making and Management in Abdominal Malignancies: A Systematic Review and Meta-Analysis
Impact of 18-FDG PET/CT on Multidisciplinary Decision-Making and Management in Abdominal Malignancies: A Systematic Review and Meta-Analysis
To systematically review and assess the impact of 18 F-FDG PET/CT on multidisciplinary team (MDT) decision-making...
Preventive and Therapeutic Interventions for Anticancer Drug-induced Dermatologic Toxicities: a Scoping Review
Preventive and Therapeutic Interventions for Anticancer Drug-induced Dermatologic Toxicities: a Scoping Review
Anticancer drug-induced dermatologic toxicities frequently compromise quality of life and treatment adherence. While diver...
Targeting GD2 with CAR-T Cell Therapy in Neuroblastoma: Updates, Challenges, and Future Perspectives
Targeting GD2 with CAR-T Cell Therapy in Neuroblastoma: Updates, Challenges, and Future Perspectives
High-risk neuroblastoma remains a challenging pediatric cancer, with survival rates lagging despite advances in multimodal...
Advancing Systemic Treatment beyond First Line for Advanced Hepatocellular Carcinoma
Advancing Systemic Treatment beyond First Line for Advanced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) ranks among the most prevalent solid malignancies worldwide. A substantial proportion of pa...
Microbiome in Gastrointestinal Tumors: Implications in Oncogenesis and Therapeutic Response
Microbiome in Gastrointestinal Tumors: Implications in Oncogenesis and Therapeutic Response
To provide an updated overview of the role of the human microbiome in the initiation, progression, and therapeutic respons...
Liquid Biopsy in Modern Oncology: Advances, Challenges, and Future Perspectives in Early Cancer Detection, Minimal Residual Disease, and Dynamic Patient Monitoring
Liquid Biopsy in Modern Oncology: Advances, Challenges, and Future Perspectives in Early Cancer Detection, Minimal Residual Disease, and Dynamic Patient Monitoring
Liquid biopsy has emerged as a minimally invasive approach to overcome the limitations of tissue biopsy in oncology. This ...
Regimen-Related Oral Mucosal Injury: Pathobiology, Clinical Consequences and Rationale for Intervention Across Cancer Treatment Modalities
Regimen-Related Oral Mucosal Injury: Pathobiology, Clinical Consequences and Rationale for Intervention Across Cancer Treatment Modalities
Mucosal injury of the alimentary tract (mucositis) has been a consistent, markedly symptomatic, and clinically disruptive ...
Plant-Derived Diterpenoids as Potential Chemotherapeutics for Gastric Cancer
Plant-Derived Diterpenoids as Potential Chemotherapeutics for Gastric Cancer
Gastric cancer remains a leading contributor to cancer-related mortality worldwide despite its declining incidence, with p...
Decoding the 2023 FIGO Staging System in Endometrial Cancer: A Practical, Visually Guided Framework for Molecular Risk-Adapted Care Incorporating the 2025 Risk Group Update
Decoding the 2023 FIGO Staging System in Endometrial Cancer: A Practical, Visually Guided Framework for Molecular Risk-Adapted Care Incorporating the 2025 Risk Group Update
The FIGO staging system for endometrial cancer has evolved substantially over the past five decades, progressing from the ...
PARP Inhibitors as Radiosensitizers: Current Evidence and Future Directions
PARP Inhibitors as Radiosensitizers: Current Evidence and Future Directions
Radiotherapy remains a fundamental pillar of cancer treatment, however its efficacy is still often limited by tumor radior...
Immunological outcomes of a bespoke DNA cancer vaccine in glioblastoma
Immunological outcomes of a bespoke DNA cancer vaccine in glioblastoma
We report the results of a phase 1 clinical trial (NCT04015700) evaluating the safety and immunogenicity of GNOS-PV01, a p...
Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance
Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance
‘Emergency’ myelopoiesis usually occurs to facilitate malignancy progression. Immunosuppressive neutrophils, a...
Coupling dead cell recognition to Fcγ receptors augments anticancer immunity
Coupling dead cell recognition to Fcγ receptors augments anticancer immunity
Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells (APCs) for cross-priming of CD8+ T cells agai...
Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases
Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases
Metastatic solid tumors remain the principal cause of cancer mortality worldwide. High tumor burden impairs responses to c...
Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity
Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity
The nutrient-sparse cerebrospinal fluid (CSF) poses a major challenge to spreading cancer cells. Despite this challenge, l...
Load More
format_indent_increase