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The versatile interplay between steatotic liver disease and liver cancer
The versatile interplay between steatotic liver disease and liver cancer
Steatotic liver diseases (SLDs), including metabolic dysfunction-associated steatotic liver disease (MASLD; formerly known...
vCATCH enables body-wide in vivo drug distribution mapping
In this Tools of the Trade article, Zhengyuan Pang describes the development and use of volumetric clearing-assisted tissu...
Microbiota and immune-related adverse events in cancer immunotherapy
Microbiota and immune-related adverse events in cancer immunotherapy
In response to treatment with immune checkpoint inhibitors (ICIs), patients with cancer can develop immune-related adverse...
Advancing AI for multi-omics and clinical data integration in basic and translational cancer research
Advancing AI for multi-omics and clinical data integration in basic and translational cancer research
The extensive heterogeneity of cancer across biological scales necessitates a holistic approach beyond single-analyte meth...
Cancer risk in children with congenital anomalies
The established link between congenital anomalies and cancer could lead to improved surveillance and therapeutic strategie...
Context-dependent synthetic lethality — an emerging precision therapeutic approach
Context-dependent synthetic lethality — an emerging precision therapeutic approach
Context-dependent synthetic lethality offers a promising strategy for expanding the scope of precision oncology beyond dir...
The sleeping threat: targeting cancer dormancy to transform metastasis therapy
The sleeping threat: targeting cancer dormancy to transform metastasis therapy
Metastatic cancer cell dormancy, wherein disseminated cancer cells (DCCs) persist in a quiescent state before reactivating...
Enhancer and metabolic rewiring by KMT2C–COMPASS or KMT2D–COMPASS family loss in cancer creates druggable vulnerabilities
Enhancer and metabolic rewiring by KMT2C–COMPASS or KMT2D–COMPASS family loss in cancer creates druggable vulnerabilities
Many epigenetic regulatory factors are targets of the somatic mutations found in patient tumours. Amongst the family of ep...
OS benefit with first-line datopotamab deruxtecan in advanced-stage TNBC
Chemotherapy-based regimens remain the standard-of-care first-line treatment for the large proportion of patients with adv...
Spectrum, pathobiology, mechanistic insights and diagnostic challenges of post-CAR T cell therapy lymphoproliferative disorders
Spectrum, pathobiology, mechanistic insights and diagnostic challenges of post-CAR T cell therapy lymphoproliferative disorders
Chimeric antigen receptor (CAR) T cell therapy is now widely used for the treatment of various haematological malignancies...
Time as an unmeasured ‘dose’ in oncology: introducing time budgeting as a design principle for cancer care
The burden of cancer therapy on patients’ time is often overlooked. Building on the ‘time toxicity’ lite...
Systemic induction therapy and the expanding frontier of bladder preservation in MIBC
Two recent phase II trials, INDIBLADE and SURE-02, challenge the long-standing paradigm of mandatory radical local therapy...
Did ATOMIC really improve on the standard of care for mismatch repair-deficient colon cancer?
The ATOMIC trial has been widely celebrated as providing a positive result. However, when viewed with a lens of critical a...
Emerging trends in the global burden of colorectal cancer
Emerging trends in the global burden of colorectal cancer
Globally, colorectal cancer (CRC) is the third most frequently diagnosed cancer and the second leading cause of cancer-rel...
The clinical landscape of HIF2α inhibitors in oncology
The clinical landscape of HIF2α inhibitors in oncology
Hypoxia-inducible factor 2α (HIF2α; also known as endothelial PAS domain-containing protein 1) had long been con...
Synergistic integration of regional and systemic therapies in uveal melanoma
Treatments for metastatic uveal melanoma utilize various liver-directed strategies, yet optimal integration with systemic ...
Sarcomatoid carcinoma of the common bile duct: A case report and review of the literature
Sarcomatoid carcinoma of the common bile duct: A case report and review of the literature
Sarcomatoid carcinoma of the common bile duct is an exceptionally rare malignancy, with only eight cases previously report...
A case of poorly differentiated thyroid carcinoma harboring an mutation
A case of poorly differentiated thyroid carcinoma harboring an mutation
SWItch/sucrose non-fermentable (SWI/SNF) chromatin-remodeling complexes regulate nucleosome positioning. Its involvement h...
Pregnancy after fertility preservation and multimodal therapy including intensity-modulated radiotherapy for recurrent vulvar cancer: A case report
Pregnancy after fertility preservation and multimodal therapy including intensity-modulated radiotherapy for recurrent vulvar cancer: A case report
Advanced or recurrent vulvar cancer in women of reproductive age is extremely rare, and the effects of radiotherapy (RT) o...
Unique pattern of endometrial invasion in gastric-type adenocarcinoma of the uterine cervix: a report of two cases
Unique pattern of endometrial invasion in gastric-type adenocarcinoma of the uterine cervix: a report of two cases
Gastric-type cervical adenocarcinoma (GAS), the most prevalent subtype of human papillomavirus (HPV)-independent cervical ...
Severe nail toxicity induced by FGFR inhibitor in -rearranged cholangiocarcinoma
Severe nail toxicity induced by FGFR inhibitor in -rearranged cholangiocarcinoma
FGFR2 gene fusions are identified in approximately 10–16% of patients with intrahepatic cholangiocarcinoma and are t...
Combination of re-irradiation and bevacizumab for recurrent adult histological pineoblastoma: a case report
Combination of re-irradiation and bevacizumab for recurrent adult histological pineoblastoma: a case report
Adult pineoblastoma is an uncommon malignant neoplasm. Relevant literature, particularly regarding its recurrence, is limi...
Ewing sarcoma of the frontal sinus in an elderly patient: a case report and review
Ewing sarcoma of the frontal sinus in an elderly patient: a case report and review
Ewing sarcoma is a malignant small round cell tumor with an aggressive clinical course that typically arises in the extrem...
Rapidly progressive synchronous multifocal gastrointestinal stenoses in bladder cancer: diagnostic challenges and clinical implications
Rapidly progressive synchronous multifocal gastrointestinal stenoses in bladder cancer: diagnostic challenges and clinical implications
Gastrointestinal involvement by bladder cancer is rare and typically presents as localized invasion. We report an exceptio...
A case of advanced esophagogastric junction cancer in which comprehensive genomic profiling by liquid biopsy led to the diagnosis of a second primary hepatocellular carcinoma
A case of advanced esophagogastric junction cancer in which comprehensive genomic profiling by liquid biopsy led to the diagnosis of a second primary hepatocellular carcinoma
The primary objective of comprehensive genomic profiling (CGP) is to identify actionable genomic alterations. We report a ...
Palliative total kidney irradiation for acute kidney injury caused by bilateral renal infiltration of chemotherapy-resistant mantle cell lymphoma: a case report
Palliative total kidney irradiation for acute kidney injury caused by bilateral renal infiltration of chemotherapy-resistant mantle cell lymphoma: a case report
Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphoma, and acute kidney injury (AKI) from direct ren...
Maintaining complete response to avelumab for lung metastases from native ureteral cancer after kidney transplantation: a case report
Maintaining complete response to avelumab for lung metastases from native ureteral cancer after kidney transplantation: a case report
We report the first case of metastatic urothelial carcinoma (mUC) in a kidney transplant recipient who was successfully tr...
A case of successful combined intensity-modulated radiation therapy and hyperthermia for a large, drug-resistant chest wall recurrence of breast cancer
A case of successful combined intensity-modulated radiation therapy and hyperthermia for a large, drug-resistant chest wall recurrence of breast cancer
Chest wall recurrence (CWR) of breast cancer that is large and resistant to multiple systemic therapies requires rapid and...
Two successful deliveries following fertility-sparing treatment for synchronous endometrial and ovarian cancer: a case report and literature review
Two successful deliveries following fertility-sparing treatment for synchronous endometrial and ovarian cancer: a case report and literature review
Fertility-sparing treatment is a viable treatment option for selected patients with endometrial or ovarian cancer. However...
A giant testicular tumor requiring skin valvuloplasty
A giant testicular tumor requiring skin valvuloplasty
Giant testicular tumors, typically defined as those with volumes exceeding ten times the normal testicular volume, are ext...
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