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Medics for Rare Disease: advocating for rare disease training
Rare cardiovascular diseases affect 5% of the world’s population. Rare disease training for clinicians is essential ...
Fibrosis-targeted, immunosuppressive dendritic cells mitigate cardiac adverse remodelling
Engineered immunosuppressive and fibrosis-targeted dendritic cells protect against pathological cardiac remodelling in ani...
Stenting for post-thrombotic syndrome
In the C-TRACT trial involving patients with post-thrombotic syndrome, the addition of endovascular treatment to standard ...
Local calcium dynamics and signalling in cardiomyocytes
Local calcium dynamics and signalling in cardiomyocytes
Calcium (Ca²⁺) signalling is essential for cardiomyocyte function, regulating excitation–contraction coup...
Base editing and silencing of PCSK9 shows clinical promise in humans
Base editing and silencing of PCSK9 shows clinical promise in humans
Base editing therapies to silence PCSK9 have entered clinical trials, and early results show promise for a durable ‘...
Digital screening and decision-support tools in equitable preventive cardiology
Nguyen and Vinh discuss the insights from the Apple Heart Study on digital screening for atrial fibrillation and highlight...
The weekend effect in atrial fibrillation hospitalizations: a nationwide analysis of outcomes and interventions
The weekend effect in atrial fibrillation hospitalizations: a nationwide analysis of outcomes and interventions
Previous studies have suggested that patients admitted on the weekend may experience worse outcomes compared to weekday ad...
The SLCO1B1 c.521 T>C variant (rs4149056) is not associated with muscular symptoms or PCSK9-inhibitor prescription in patients with severe hypercholesterolemia and contemporary lipid lowering therapy
The SLCO1B1 c.521 T>C variant (rs4149056) is not associated with muscular symptoms or PCSK9-inhibitor prescription in patients with severe hypercholesterolemia and contemporary lipid lowering therapy
The SLCO1B1 c.521 T > C variant, which reduces hepatic statin uptake, has been linked to an in...
Post-pulmonary embolism cardiac impairment and chronic thromboembolic pulmonary hypertension after ultrasound-assisted catheter-directed thrombolysis for acute pulmonary embolism
Post-pulmonary embolism cardiac impairment and chronic thromboembolic pulmonary hypertension after ultrasound-assisted catheter-directed thrombolysis for acute pulmonary embolism
Sparse data are available on the long-term course of acute pulmonary embolism (PE) after ultrasound-assisted catheter-dire...
Impact of the invasively measured flow-gradient pattern on clinical outcomes and ventricular remodeling after transcatheter aortic valve implantation in patients with severe aortic stenosis and preserved ejection fraction
Impact of the invasively measured flow-gradient pattern on clinical outcomes and ventricular remodeling after transcatheter aortic valve implantation in patients with severe aortic stenosis and preserved ejection fraction
To investigate clinical outcomes and cardiac remodeling according to cardiac magnetic resonance (CMR) of the invasively me...
Impact of catheter ablation for atrial fibrillation on cardiac ventricular electrical activity: assessment of premature ventricular complex burden
Impact of catheter ablation for atrial fibrillation on cardiac ventricular electrical activity: assessment of premature ventricular complex burden
Data on premature ventricular complex (PVC) burden after pulmonary vein isolation (PVI) for atrial fibrillation (AF) are i...
Head-to-head comparison of non-invasive markers of atrial cardiomyopathy and their association with arrhythmia recurrence after atrial fibrillation ablation
Head-to-head comparison of non-invasive markers of atrial cardiomyopathy and their association with arrhythmia recurrence after atrial fibrillation ablation
Atrial cardiomyopathy (AtCM) represents an important substrate underlying atrial fibrillation (AF), increased arrhythmia r...
Impact of residential noise pollution on early-onset myocardial infarction risk results from the DECIBEL-MI (Determination of Environmental CIty-noise's Burden, Exposure, and Link to Myocardial Infarction) study
Impact of residential noise pollution on early-onset myocardial infarction risk results from the DECIBEL-MI (Determination of Environmental CIty-noise's Burden, Exposure, and Link to Myocardial Infarction) study
Noise pollution is increasingly recognized as a cardiovascular hazard, yet its contribution to early-onset myocardia...
Preprocedural Systemic Immune-Inflammation Index as a marker of risk for major adverse cardiac events and stroke after transcatheter aortic valve implantation
Preprocedural Systemic Immune-Inflammation Index as a marker of risk for major adverse cardiac events and stroke after transcatheter aortic valve implantation
The Systemic Immune-Inflammation Index (SII), calculated as neutrophils × platelets / lymphocytes, reflec...
Pulsed electric field and radiofrequency ablation for paroxysmal supraventricular tachycardia: a propensity score-matched comparison (PFA-SVT study)
Pulsed electric field and radiofrequency ablation for paroxysmal supraventricular tachycardia: a propensity score-matched comparison (PFA-SVT study)
Preliminary studies have demonstrated the feasibility of pulsed field ablation (PFA) for the treatment of paroxysmal supra...
Decreasing radiation exposure in interventional pediatric cardiology: a 10-year European single-center analysis of 3683 procedures
Decreasing radiation exposure in interventional pediatric cardiology: a 10-year European single-center analysis of 3683 procedures
To evaluate radiation exposure during pediatric cardiac catheterization over a 10-year period at a central European tertia...
Early safety and efficacy of intra-annular versus supra-annular self-expanding transcatheter heart valves
Early safety and efficacy of intra-annular versus supra-annular self-expanding transcatheter heart valves
Comparative data on safety and efficacy of intra- and supra-annular self-expanding heart valves (THV) for transcatheter ao...
In-hospital outcomes and cost-effectiveness of transcatheter aortic valve replacement among younger patients: a double/debiased machine learning approach using electronic health records in Germany
In-hospital outcomes and cost-effectiveness of transcatheter aortic valve replacement among younger patients: a double/debiased machine learning approach using electronic health records in Germany
The prevalence of severe symptomatic aortic stenosis is increasing with population aging. Although surgical aortic valve r...
The ABC of sealing following left atrial appendage closure
The ABC of sealing following left atrial appendage closure
Peri-device leak (PDL) following left atrial appendage closure (LAAC) can be diagnosed by both transesophageal echocardiog...
Cardiac biomarkers in women with high-risk pregnancies: short-term outcomes from the Heidelberg Cardio-Obstetrics Registry
Cardiac biomarkers in women with high-risk pregnancies: short-term outcomes from the Heidelberg Cardio-Obstetrics Registry
Pregnancy leads to profound physiological changes within the cardiovascular system. However, in women with pre-existing or...
Type 1 and type 2 NSTEMI in atrial fibrillation: insights from the HERA-FIB registry
Type 1 and type 2 NSTEMI in atrial fibrillation: insights from the HERA-FIB registry
Differentiating type 1 from type 2 non–ST-elevation myocardial infarction (NSTEMI) is clinically challenging, partic...
Mechanical thrombectomy improves left ventricular filling in intermediate-high risk pulmonary embolism: the role of ventricular interdependence
Mechanical thrombectomy improves left ventricular filling in intermediate-high risk pulmonary embolism: the role of ventricular interdependence
Acute pulmonary embolism (PE) is the third most common acute cardiovascular condition and remains associated with high mor...
T-T interval predicts VT inducibility in arrhythmogenic mitral valve prolapse syndrome
T-T interval predicts VT inducibility in arrhythmogenic mitral valve prolapse syndrome
Mitral valve prolapse (MVP) is commonly benign, but an arrhythmic phenotype (AMVP) with increased risk for sudden cardiac ...
Hospitalization profiles and complications across ICD and CRT-D implantations in Germany: data from the VIDEO study
Hospitalization profiles and complications across ICD and CRT-D implantations in Germany: data from the VIDEO study
Implantable cardioverter-defibrillator (ICD) is a cornerstone therapy for the prevention of sudden cardiac death. However,...
Intraprocedural atrial tachycardia during ablation of paroxysmal atrial fibrillation: incidence, mechanisms, and clinical outcomes
BackgroundRadiofrequency catheter ablation (RFCA) is the mainstay treatment for paroxysmal atrial fibrillation (PAF). Howe...
miR-181a post-transcriptionally targets GRK2 to limit maladaptive signaling in cardiomyocytes
BackgroundPathological upregulation of G protein-coupled receptor kinase 2 (GRK2) is a hallmark of heart failure and contr...
Empagliflozin attenuates elaidic acid-exacerbated cardiac dysfunction post-myocardial infarction via suppression of the NF-κB/NLRP3 pathway
ObjectiveMyocardial infarction leads to heart failure greatly increasing the risk of adverse cardiovascular events. Empagl...
Predictive value of ALBI score in assessing prognosis of NSTEMI: a retrospective cohort study
ObjectiveThis study aims to evaluate the predictive value of the albumin-bilirubin (ALBI) score for mortality risk in pati...
Recurrent myocarditis in a young female with a desmoplakin gene variant: a case report and literature review
BackgroundRecurrent myocarditis is commonly associated with infectious or immune etiologies. This case suggests a potentia...
Polygenic risk modulates myocardial repolarization and T-wave geometry in congenital long-QT syndrome type 1: evidence from digital ECG phenotyping
IntroductionCongenital long-QT syndrome type 1 (LQT1), one of the major LQTS subtypes caused by pathogenic variants in the...
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