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Metabolism-related proteins as biomarkers for predicting prognosis in polycystic ovary syndrome

The study aimed to explore the role of metabolism-related proteins and their correlation with clinical data in predicting ...

Proteome Science

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$MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway$

MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway

Diabetic encephalopathy (DE) is considered as one of the complications of diabetes,which is associated with cognitive impa...

Proteome Science

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Identification of proteome-wide and functional analysis of lysine crotonylation in multiple organs of the human fetus

Lysine crotonylation (Kcr) is a novel post-translational modification that is important in functional studies. However, ou...

Proteome Science

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Identification of noval diagnostic biomarker for HFpEF based on proteomics and machine learning

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome that currently lacks effective biomarkers for...

Proteome Science

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Plasma proteome analysis of rheumatic patients reveals differences in fingerprints based on cardiovascular history: a pilot study

The risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) is much higher than that in the genera...

Proteome Science

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Editorial Note: Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways applying Petri net formalism and <i>in silico</i> knockout analysis

After publication of this article [1], concerns were raised about the replicability of the results ...

Plos Computational Biology

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Correction: Mathematical modeling suggests heterogeneous replication of <i>Mycobacterium tuberculosis</i> in rabbits

In the Funding statement, the grant number of the author Selvakumar Subbian (SS) is listed incorrec...

Plos Computational Biology

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A hemicyanine-based dual-responsive fluorescent sensor for the detection of lithium and cyanide ions: application in living cells

A hemicyanine-based colorimetric and fluorometric sensor, 2-(2-(2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododeci...

Analytical And Bioanalytical Chemistry

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Dual DNA recycling amplification-assisted CRISPR/Cas12a cleavage for dual-channel ratiometric fluorescence biosensing of kanamycin antibiotic

Fluorescence biosensors hold significant importance for testing antibiotic residues which seriously endanger public health...

Analytical And Bioanalytical Chemistry

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$Comprehensive characterization of sulfur compounds in the diesel fraction using methylation/demethylation derived separation and GC × GC–MS/FID analysis$

Comprehensive characterization of sulfur compounds in the diesel fraction using methylation/demethylation derived separation and GC × GC–MS/FID analysis

Comprehensive characterization of petroleum-derived sulfur compounds is crucial for researching and developing desulfuriza...

Analytical And Bioanalytical Chemistry

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Identification and characterization of chiral vitamin C using ion mobility and theoretical calculation

Vitamin C (L-( +)-ascorbic acid, L-AA) is an essential micronutrient. Its diastereoisomer, D-(-)-isoascorbic acid (D...

Analytical And Bioanalytical Chemistry

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Bimetallic-doped carbon quantum dots with enhanced photoluminescence and peroxidase-mimicking activity for dual-mode colorimetric and ratiometric fluorescence assay of alendronate

Carbon quantum dots (CQDs) are powerful signal transducers in dual-mode assays while still being challenged by their poor ...

Analytical And Bioanalytical Chemistry

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In-depth characterization of acylcarnitines: utilizing nitroxide radical–directed dissociation in tandem mass spectrometry

Acylcarnitines (ACs) are metabolic intermediates of fatty acids playing important roles in regulating cellular energy and ...

Analytical And Bioanalytical Chemistry

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Quantitative detection of rubella virus IgM antibodies using inductively coupled plasma mass spectrometry with elemental labeling: a new clinical application of mass spectrometry

Rubella is a virus that can cause severe complications, such as congenital rubella syndrome, in pregnant women and newborn...

Analytical And Bioanalytical Chemistry

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Novel chlorinated phospholipids—possible biomarkers of chlorine gas exposure

Biomarkers are needed to verify suspected exposure to chlorine gas in chemical attacks. Here, we aimed to expand upon the ...

Analytical And Bioanalytical Chemistry

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Laser-generated Pt/Ni nanocatalysts-carbon nanofibers enabling self-calibrated enzyme-free glucose detection at physiological pH

We propose a bimetallic alloy composed of Pt and Ni embedded within laser-induced carbon nanofibers (Pt/Ni-LCNFs) as an en...

Analytical And Bioanalytical Chemistry

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A colorimetric sandwich assay based on magnetic separation of Brevinin-1BW-functionalized magnetic beads and porcine IgG for the detection of

A novel strategy integrating Brevinin-1BW (BW)-functionalized magnetic bead-based separation with a colorimetric ...

Analytical And Bioanalytical Chemistry

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Study of sampling phases for body odor sampling prior to analysis by TD-GC×GC/ToFMS

Body odor consists of a complex matrix of volatile organic compounds (VOCs), which has garnered increasing interest in fie...

Analytical And Bioanalytical Chemistry

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Aptamer-based microfluidics for the detection of cancer biomarkers

Early diagnosis of cancer is a major concern in clinical medicine. Recently, aptamer-based microfluidics have off...

Analytical And Bioanalytical Chemistry

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Enzymatic digestion of hair increases extraction yields of cortisol: a novel two-dimensional liquid chromatography-tandem mass spectrometry method for hair cortisol analysis

Hair cortisol concentration is a retrospective, long-term measure of cortisol secretion, often used as a biomarker for chr...

Analytical And Bioanalytical Chemistry

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Determination of cyclopiazonic acid in food samples by using molecularly imprinted polymers based on magnetic halloysite nanotubes

A fast, accurate, and simple method of molecularly imprinted solid-phase extraction from magnetic molecularly imprinted po...

Analytical And Bioanalytical Chemistry

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A sensitive method for simultaneous screening exposure to 14 alkylating agents based on tripeptide adducts: an efficient approach for chemical weapon verification and chemical impurity profiling in plasma samples

For the implementation of the Chemical Weapons Convention, the Organisation for Prohibition of Chemical Weapons (OPCW) des...

Analytical And Bioanalytical Chemistry

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Quality evaluation of metabolite annotation based on comprehensive simulation of MS/MS data from high-resolution mass spectrometry (HRMS) and similarity scoring

Metabolite annotation is a critical step in discovery metabolomics, but remains a significant challenge. In this study, th...

Analytical And Bioanalytical Chemistry

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Identification of small covalent inhibitors targeting DsbA using virtual screening, covalent docking, and molecular dynamics simulations