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Using Medication Dispensation Data to Identify Clusters with Similar Prescribing Patterns in Older Adults Living with Dementia

Older adults living with dementia are a heterogeneous group, which can make studying optimal medication management challen...

Drugs & Aging

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Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population

Managing diabetes in older adults requires balancing long-term glycaemic control with the prevention of hypoglycaemia, to ...

Drugs & Aging

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Reduced-Dose Edoxaban in Patients Aged ≥ 80 Years: A Single-Center Real-World Analysis

Optimal anticoagulation strategies in octogenarians remain controversial owing to age-related risks of thromboembolism and...

Drugs & Aging

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Characteristics of Late-Onset Systemic Lupus Erythematosus: Clinical Manifestations and Diagnostic and Treatment Challenges

Systemic lupus erythematosus (SLE) is widely recognized as a systemic autoimmune disease predominantly affecting young wom...

Drugs & Aging

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Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke

Acute ischemic stroke (AIS) is a significant cause of morbidity and mortality among older adults, with its incidence, seve...

Drugs & Aging

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Association of Antipsychotic Dose with Surrogate Efficacy and Safety Outcomes in Hospitalized Older Adults: A Retrospective Cohort Study

Antipsychotics are frequently used in hospitalized older adults to manage agitation and delirium, despite limited supporti...

Drugs & Aging

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Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies

Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes...

Drugs & Aging

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Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age

Chronic pain is a prevalent and disabling condition whose management becomes increasingly complex with aging and frailty. ...

Drugs & Aging

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Anti-hypertensive Drug Classes and Risk of New-Onset Atrial Fibrillation in Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial

Prior studies have suggested potential benefits of antihypertensive medication (AHM) in preventing atrial fibrillation. It...

Drugs & Aging

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Patterns and Characteristics of Gabapentin Use Among Medicare Beneficiaries

Gabapentin is increasingly prescribed to older adults, yet prescribing patterns and characteristics of gabapentin initiato...

Drugs & Aging

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Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial

More than one in three older adults use potentially inappropriate medications (PIMs), and those with chronic conditions ar...

Drugs & Aging

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Trends and Guideline Adherence in Gabapentinoid Use among Geriatric Outpatients: A Retrospective Cross-Sectional Study at a Falls Clinic

With pain treatment shifting away from opioids, alternative analgesics—such as gabapentinoids—are increasingly...

Drugs & Aging

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Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward

Early-phase clinical trials (EPCTs) are critical for evaluating the safety, tolerability, efficacy and pharmacokinetics of...

Drugs & Aging

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Initial Real-World Evidence for Lecanemab in the United States

Lecanemab is the first anti-amyloid monoclonal antibody with full approval in the US for the treatment of early Alzheimer&...

Drugs & Aging

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Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke

Stroke is the second leading cause of mortality and the leading cause of adult disability worldwide. Neuroinflammation is ...

Acta Pharmacologica Sinica

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Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2

Cite this articleHan, Yt., Chen, Xh., Gao, H. et al. Retraction Note: Physcion inhibits the metastatic potential of human ...

Acta Pharmacologica Sinica

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Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis

Breast cancer liver metastasis (BCLM) is characterized by high incidence and poor prognosis, lacking effective therapeutic...

Acta Pharmacologica Sinica

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Lung memory B cells ameliorate Alzheimer’s disease-like pathology in 5×FAD mice through the CXCL12-CXCR4 axis

Although most AD-related pathological studies are limited to the brain, increasing evidence has demonstrated the contribut...

Acta Pharmacologica Sinica

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Zinc pyrithione functions as a small-molecule STING agonist to exert antitumor immunotherapy effects

The stimulator of interferon genes (STING) is a crucial pattern recognition receptor that activates innate immunity, parti...

Acta Pharmacologica Sinica

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Next-generation topical antifungal therapy: Biocompatible voriconazole nanostructured lipid carriers with enhanced skin penetration for cutaneous candidiasis