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Apoptotic and combinatorial potential of processed Mica via inhibition of CCR4-NOT transcription complex subunit 2/c-Myc and production of reactive oxygen species in non-small cell lung cancer cells
Apoptotic and combinatorial potential of processed Mica via inhibition of CCR4-NOT transcription complex subunit 2/c-Myc and production of reactive oxygen species in non-small cell lung cancer cells
Though Mica has been used for dysentery, bleeding and inflammation in Ayurveda medicine along with recent evidence on anti...
Chili pepper leaves extract induced antitumor effect via inhibition of NFkB/METTL1 mediated glycolysis in hepatocellular carcinoma cells
Chili pepper leaves extract induced antitumor effect via inhibition of NFkB/METTL1 mediated glycolysis in hepatocellular carcinoma cells
In the current work, we investigated the antitumor effects of a 30% ethanol extract of chili pepper leaves (Capsicum annum...
Antiarthritic property and toxicological evaluation of the tea prepared from barks
Antiarthritic property and toxicological evaluation of the tea prepared from barks
Ximenia americana L. (Olacaceae), popularly known as wild plum, northern plum or Brazilian plum, is used in the folk medic...
Mapping the scientific landscape of preksha dhyana: a bibliometric analysis
Mapping the scientific landscape of preksha dhyana: a bibliometric analysis
Preksha Dhyana (PD), a Jain meditation practice, shows growing interdisciplinary interest. This study presents the first b...
A twenty-year retrospective analysis on sepsis and septic shock incidence and mortality
A twenty-year retrospective analysis on sepsis and septic shock incidence and mortality
Sepsis and septic shock are major causes of global mortality. Analyzing trends in incidence, in-hospital mortality (IHM), ...
Porcine placental extract enhances social behavior and alleviates anxiety-like responses in a zebrafish model
Porcine placental extract enhances social behavior and alleviates anxiety-like responses in a zebrafish model
The symptoms of mental disorders are diverse, with prominent examples including impaired social behavior and heightened an...
AhR inhibition promotes axon regeneration
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Remodelling complex macrocycles
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Dual-vector gene therapy for hearing loss secures first FDA approval
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First-in-class HIV drug nabs approval
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The landscape for therapeutic cancer vaccines
The landscape for therapeutic cancer vaccines
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Shifts in pharma’s therapeutic area focus
Shifts in pharma’s therapeutic area focus
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Novel opioid provides cleaner pain relief
Novel opioid provides cleaner pain relief
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Bridging boundaries: making drug repurposing the new normal
The potential for drug repurposing to provide faster, cost-effective ways to address unmet medical needs remains to be ful...
Circadian Rhythm and Efficacy of Argatroban in Ischemic Stroke with Alteplase: A Post Hoc Analysis of the ARAIS Trial
Circadian Rhythm and Efficacy of Argatroban in Ischemic Stroke with Alteplase: A Post Hoc Analysis of the ARAIS Trial
The Argatroban Plus Recombinant Tissue-Type Plasminogen Activator for Acute Ischemic Stroke (ARAIS) trial did not show the...
Pathological Protein Targets in Parkinson’s Disease: Progress Towards the Development of Disease-Modifying Therapies
Pathological Protein Targets in Parkinson’s Disease: Progress Towards the Development of Disease-Modifying Therapies
Parkinson’s disease (PD) is a common neurodegenerative movement disorder that currently has no disease-modifying the...
Hepatic Safety of Adjunctive High-Dose Melatonin in Participants Receiving Ocrelizumab for Primary Progressive Multiple Sclerosis: Liver Toxicity Findings from a Phase I/II Randomised Clinical Trial (MELATOMS-1)
Hepatic Safety of Adjunctive High-Dose Melatonin in Participants Receiving Ocrelizumab for Primary Progressive Multiple Sclerosis: Liver Toxicity Findings from a Phase I/II Randomised Clinical Trial (MELATOMS-1)
Based on melatonin’s neuroprotective effects in pre-clinical multiple sclerosis models, the MELATOMS-1 study was des...
TRPV1 Receptor Modulators: Emerging Therapies for Neuropathic, Osteoarthritic, and Perioperative Pain
TRPV1 Receptor Modulators: Emerging Therapies for Neuropathic, Osteoarthritic, and Perioperative Pain
Capsaicin has proven itself to be a valuable addition to the pain therapeutic toolbox, but the development of other transi...
Efficacy and Safety of Cannabinoids for Neuropsychiatric Symptoms of Dementia: A Systematic Review with Meta-analysis
Efficacy and Safety of Cannabinoids for Neuropsychiatric Symptoms of Dementia: A Systematic Review with Meta-analysis
Neuropsychiatric symptoms (NPS) are highly prevalent in persons with dementia and have been associated with adverse health...
Therapeutic Potential of PCSK9 Inhibitors in Regulating Neuroinflammation in Acute Ischemic Stroke
Therapeutic Potential of PCSK9 Inhibitors in Regulating Neuroinflammation in Acute Ischemic Stroke
Acute ischemic stroke (AIS) poses a substantial risk of permanent disability and death globally, with neuroinflammation be...
Multiple Adverse Outcomes Associated with Risperidone in People with Dementia: An Individual Participant Data Meta-Analysis
Multiple Adverse Outcomes Associated with Risperidone in People with Dementia: An Individual Participant Data Meta-Analysis
Risperidone has modest efficacy for behaviours and psychological symptoms of dementia and is associated with many adverse ...
Seletracetam Revisited: A Missed Opportunity for Effective Epilepsy Therapy
Seletracetam Revisited: A Missed Opportunity for Effective Epilepsy Therapy
Seletracetam (SEL) is a second-generation racetam derivative of the benchmark antiseizure medication (ASM) levetiracetam, ...
Effectiveness and Safety of Low-Sodium Oxybate in Participants with Idiopathic Hypersomnia: Primary Results from the DUET Study
Effectiveness and Safety of Low-Sodium Oxybate in Participants with Idiopathic Hypersomnia: Primary Results from the DUET Study
Jazz DUET (Develop hypersomnia Understanding by Evaluating low-sodium oxybate Treatment) was a phase 4, prospective, multi...
Intranasal 5-MeO-DMT Concomitant with SSRI for Treatment-Resistant Depression: A Proof-of-Concept Trial
Intranasal 5-MeO-DMT Concomitant with SSRI for Treatment-Resistant Depression: A Proof-of-Concept Trial
Epidemiological data indicate that up to 60% of patients with major depressive disord...
Pharmacotherapy in Disorders of Consciousness: A Mechanism-Based Review
Pharmacotherapy in Disorders of Consciousness: A Mechanism-Based Review
Disorders of consciousness pose major therapeutic challenges owing to the complexity of underlying brain dysfunctions. Cur...
Correction: An Open‑Label Extension Study Assessing the Long‑Term Safety and Efficacy of Viloxazine Extended‑Release Capsules in Adults with Attention‑Deficit/Hyperactivity Disorder
Correction: An Open‑Label Extension Study Assessing the Long‑Term Safety and Efficacy of Viloxazine Extended‑Release Capsules in Adults with Attention‑Deficit/Hyperactivity Disorder
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 Internationa...
Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru, vs an Oil-Based Formulation, Epidyolex, Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study
Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru, vs an Oil-Based Formulation, Epidyolex, Under Fasted and Fed Conditions in Healthy Participants: A Randomized Open-Label Cross-Over Phase I Study
Emerging evidence indicates that cannabidiol (CBD) may offer meaningful therapeutic benefits across neurological, pain, an...
Comparative Mortality Risk of Aripiprazole, Olanzapine, Quetiapine, and Risperidone in Alzheimer’s Disease: A Real‑World Retrospective Cohort Study with Treatment Effect Heterogeneity Analysis
Comparative Mortality Risk of Aripiprazole, Olanzapine, Quetiapine, and Risperidone in Alzheimer’s Disease: A Real‑World Retrospective Cohort Study with Treatment Effect Heterogeneity Analysis
Second-generation antipsychotics (SGAs) are frequently used off-label to manage behavioral symptoms in Alzheimer’s d...
The Complexity and Challenges of Developing Effective Epilepsy Therapies: Lessons to be Learned from Comparing Cenobamate, Carisbamate, and Padsevonil
The Complexity and Challenges of Developing Effective Epilepsy Therapies: Lessons to be Learned from Comparing Cenobamate, Carisbamate, and Padsevonil
Most of the about 30 clinically approved antiseizure medications (ASMs) have been discovered using animal seizure models. ...
Preserving Neurological Function in People at High and Low Risk of Aggressive Multiple Sclerosis: An Observational Cohort Study
Preserving Neurological Function in People at High and Low Risk of Aggressive Multiple Sclerosis: An Observational Cohort Study
Patients aged ≥ 35 years at multiple sclerosis (MS) symptom onset with an Expanded Disability Status Scale ...
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