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Optimizing therapeutic drug monitoring of mirtazapine — applying therapeutic reference range, concentration–dose ratio/dose-related concentration, and metabolic ratio in a naturalistic setting
Optimizing therapeutic drug monitoring of mirtazapine — applying therapeutic reference range, concentration–dose ratio/dose-related concentration, and metabolic ratio in a naturalistic setting
Mirtazapine is a common antidepressant, regularly monitored through therapeutic drug monitoring. The previously published ...
The effect of coenzyme Q10 supplementation on depressive symptoms and anxiety: a systematic review and meta-analysis of randomized controlled trials
The effect of coenzyme Q10 supplementation on depressive symptoms and anxiety: a systematic review and meta-analysis of randomized controlled trials
Anxiety and depression are major global health concerns that can manifest as primary disorders or as comorbid symptoms alo...
GLP-1 receptor agonists: emerging therapeutic potential in psoriasis management — current evidence and future outlook
GLP-1 receptor agonists: emerging therapeutic potential in psoriasis management — current evidence and future outlook
Psoriasis is a chronic inflammatory skin disease driven by immune dysregulation and often exacerbated by metabolic comorbi...
Population pharmacokinetics and pharmacodynamics of meropenem in critically ill patients with renal impairment or on continuous renal replacement therapy
Population pharmacokinetics and pharmacodynamics of meropenem in critically ill patients with renal impairment or on continuous renal replacement therapy
This study aimed to characterize the pharmacokinetics (PK) of meropenem in patients with renal impairment or on continuous...
Validation of pharmacokinetic model for quizartinib quantified by UPLC-MS/MS in patients with FLT3-ITD negative newly diagnosed acute myeloid leukemia
Validation of pharmacokinetic model for quizartinib quantified by UPLC-MS/MS in patients with FLT3-ITD negative newly diagnosed acute myeloid leukemia
Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims ...
Oral Melatonin for Pain Relief During Venepuncture in Neonates– a Pilot Randomized Control Trial
Oral Melatonin for Pain Relief During Venepuncture in Neonates– a Pilot Randomized Control Trial
This study aims to compare the analgesic efficacy of oral melatonin with placebo in neonates during venepuncture. This ope...
Imeglimin systematic review: a novel therapeutic approach for type 2 diabetes—unveiling benefits on β-cell function, insulin sensitivity, and potential long-term glycaemic control (HbA1c)
Imeglimin systematic review: a novel therapeutic approach for type 2 diabetes—unveiling benefits on β-cell function, insulin sensitivity, and potential long-term glycaemic control (HbA1c)
The prevalence of diabetes mellitus has surged fourfold globally over the past 30 years, creating a major health ...
A real-world pharmacovigilance study of FDA Adverse Event Reporting System events for gefitinib and docetaxel
A real-world pharmacovigilance study of FDA Adverse Event Reporting System events for gefitinib and docetaxel
In recent years, gefitinib and docetaxel, as targeted and chemotherapeutic agents, respectively, have been widely used in ...
Safety and efficacy of fondaparinux use in hemodialysis patients with heparin-induced thrombocytopenia: a systematic review
Safety and efficacy of fondaparinux use in hemodialysis patients with heparin-induced thrombocytopenia: a systematic review
Heparin-induced thrombocytopenia (HIT) is a severe primary hypercoagulable disorder, particularly concerning in hemodialys...
Economic evaluation of antibody-drug conjugates (ADCs) in patients with breast cancer: systematic review
Economic evaluation of antibody-drug conjugates (ADCs) in patients with breast cancer: systematic review
Metastatic breast cancer (mBC) is a major global health challenge. Antibody-drug conjugates (ADCs), including trastuzumab ...
Hair analysis for monitoring adherence to inhaled respiratory medications: possibilities and limitations
Hair analysis for monitoring adherence to inhaled respiratory medications: possibilities and limitations
Non-adherence to inhaled medication poses a significant clinical and economic burden on patients with respiratory diseases...
β-blocker and clinical outcomes in patients after myocardial infarction: a systematic review and meta-analysis
β-blocker and clinical outcomes in patients after myocardial infarction: a systematic review and meta-analysis
While current clinical guidelines generally advocate for beta-blocker therapy following acute myocardial infarction (AMI),...
Efficacy and safety of nitazoxanide and escitalopram as adjuvant therapies in patients with rheumatoid arthritis: a randomized controlled study
Efficacy and safety of nitazoxanide and escitalopram as adjuvant therapies in patients with rheumatoid arthritis: a randomized controlled study
This research aimed at evaluating the effectiveness and safety of nitazoxanide and escitalopram as adjuvant therapies in p...
Influence of ultrafiltration conditions on the unbound fraction of phenytoin and valproic acid
Influence of ultrafiltration conditions on the unbound fraction of phenytoin and valproic acid
This study was designed to analyse the influence of temperature, pH and storage time on unbound fractions of PHT and VPA. ...
Population pharmacokinetic characteristics of tacrolimus in Chinese lung transplant recipients and optimisation of dosing regimen during the early post-transplantation phase
Population pharmacokinetic characteristics of tacrolimus in Chinese lung transplant recipients and optimisation of dosing regimen during the early post-transplantation phase
This study aimed to establish a population pharmacokinetic model and optimise tacrolimus dosing regimens in Chinese lung t...
Influence of genetic variants of imatinib on pharmacokinetics and recurrence-free survival in postoperative patients with gastrointestinal stromal tumor
Influence of genetic variants of imatinib on pharmacokinetics and recurrence-free survival in postoperative patients with gastrointestinal stromal tumor
Imatinib is the first-line therapy for gastrointestinal stromal tumor (GIST), significantly enhancing patient prognosis. H...
Optimizing acid-related disease management: insights into potassium-competitive acid blockers and proton pump inhibitors
Optimizing acid-related disease management: insights into potassium-competitive acid blockers and proton pump inhibitors
This narrative review evaluates the clinical value of key globally marketed potassium-competitive acid blockers (P-CABs) f...
Challenging the young and shaping the growth of clinical pharmacology: 10 years of the EACPT Early Career Clinical Pharmacologists (ECCP) working group
Challenging the young and shaping the growth of clinical pharmacology: 10 years of the EACPT Early Career Clinical Pharmacologists (ECCP) working group
Ethics approval Not applicable. ...
Prognostic value of IMDC score in non-small cell lung cancer receiving immunotherapy: old dog, new tricks?
Prognostic value of IMDC score in non-small cell lung cancer receiving immunotherapy: old dog, new tricks?
Although there are multiple treatment options, oncologists lack appropriate biomarkers for determining the efficacy and to...
Disproportionality analysis from World Health Organization data on migraine-specific medications and cerebrovascular diseases
Disproportionality analysis from World Health Organization data on migraine-specific medications and cerebrovascular diseases
Migraine is a major cause of population ill health, with an estimated global prevalence of approximately 14–15%. How...
Considerations of sex in bioequivalence assessments: does sex affect pharmacokinetic variability between evaluation formulations?
Considerations of sex in bioequivalence assessments: does sex affect pharmacokinetic variability between evaluation formulations?
Bioequivalence assessment determines the equivalence between drug formulations and is primarily used to demonstrate that a...
Antiretroviral drug exposure in pregnancy and risk of congenital anomalies: a European case/non-case malformed study
Antiretroviral drug exposure in pregnancy and risk of congenital anomalies: a European case/non-case malformed study
Antiretroviral drugs are recommended during pregnancy to achieve HIV viral suppression and reduce mother-to-child transmis...
Clinical pharmacology—how it shapes the drug development journey
Clinical pharmacology—how it shapes the drug development journey
Every drug development is a complex and long journey. Clinical pharmacology is an essential discipline in modern drug deve...
Unravelling the implementation of pharmacogenetic testing in Belgium
Unravelling the implementation of pharmacogenetic testing in Belgium
Although already a lot of research has been done on pharmacogenetic tests to inform the choice and/or dosing of medicines,...
The effect of colchicine on coagulation in patients with chronic coronary disease who use vitamin K antagonists
The effect of colchicine on coagulation in patients with chronic coronary disease who use vitamin K antagonists
Low-dose (0.5 mg/day) colchicine improves cardiovascular outcomes in patients with stable coronary disease. Around 10̵...
A narrative review of the placebo effect: historical roots, current applications, and emerging insights
A narrative review of the placebo effect: historical roots, current applications, and emerging insights
Placebo is a term to define physiologically inactive compounds used in treatment that causes physical and emotional change...
Era of surrogate endpoints and accelerated approvals: a comprehensive review on applicability, uncertainties, and challenges from regulatory, payer, and patient perspectives
Era of surrogate endpoints and accelerated approvals: a comprehensive review on applicability, uncertainties, and challenges from regulatory, payer, and patient perspectives
The regulatory landscape in rare diseases and oncology has evolved to address unmet medical needs by implementing expedite...
Evaluation of surrogate endpoints in phase III randomized control trials of advanced hepatocellular carcinoma treated with immune checkpoint inhibitors
Evaluation of surrogate endpoints in phase III randomized control trials of advanced hepatocellular carcinoma treated with immune checkpoint inhibitors
Overall survival (OS) is recommended as a gold standard endpoint but has some limitations. We aimed to finding more effect...
Prescribing patterns of glucagon-like peptide-1 receptor agonists in the Swedish capital region—a register-based cross-sectional study
Prescribing patterns of glucagon-like peptide-1 receptor agonists in the Swedish capital region—a register-based cross-sectional study
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained considerable media attention, but there is limited knowl...
Facilitators and barriers to generic and biosimilar medications in the Middle East and North Africa: insights from physicians and pharmacists—a systematic review
Facilitators and barriers to generic and biosimilar medications in the Middle East and North Africa: insights from physicians and pharmacists—a systematic review
The adoption of generic and biosimilar medications is crucial for improving healthcare accessibility and cost savings in t...
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