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Prognostic value of IMDC score in non-small cell lung cancer receiving immunotherapy: old dog, new tricks?
Prognostic value of IMDC score in non-small cell lung cancer receiving immunotherapy: old dog, new tricks?
Although there are multiple treatment options, oncologists lack appropriate biomarkers for determining the efficacy and to...
Disproportionality analysis from World Health Organization data on migraine-specific medications and cerebrovascular diseases
Disproportionality analysis from World Health Organization data on migraine-specific medications and cerebrovascular diseases
Migraine is a major cause of population ill health, with an estimated global prevalence of approximately 14–15%. How...
Considerations of sex in bioequivalence assessments: does sex affect pharmacokinetic variability between evaluation formulations?
Considerations of sex in bioequivalence assessments: does sex affect pharmacokinetic variability between evaluation formulations?
Bioequivalence assessment determines the equivalence between drug formulations and is primarily used to demonstrate that a...
Antiretroviral drug exposure in pregnancy and risk of congenital anomalies: a European case/non-case malformed study
Antiretroviral drug exposure in pregnancy and risk of congenital anomalies: a European case/non-case malformed study
Antiretroviral drugs are recommended during pregnancy to achieve HIV viral suppression and reduce mother-to-child transmis...
Clinical pharmacology—how it shapes the drug development journey
Clinical pharmacology—how it shapes the drug development journey
Every drug development is a complex and long journey. Clinical pharmacology is an essential discipline in modern drug deve...
Unravelling the implementation of pharmacogenetic testing in Belgium
Unravelling the implementation of pharmacogenetic testing in Belgium
Although already a lot of research has been done on pharmacogenetic tests to inform the choice and/or dosing of medicines,...
The effect of colchicine on coagulation in patients with chronic coronary disease who use vitamin K antagonists
The effect of colchicine on coagulation in patients with chronic coronary disease who use vitamin K antagonists
Low-dose (0.5 mg/day) colchicine improves cardiovascular outcomes in patients with stable coronary disease. Around 10̵...
A narrative review of the placebo effect: historical roots, current applications, and emerging insights
A narrative review of the placebo effect: historical roots, current applications, and emerging insights
Placebo is a term to define physiologically inactive compounds used in treatment that causes physical and emotional change...
Era of surrogate endpoints and accelerated approvals: a comprehensive review on applicability, uncertainties, and challenges from regulatory, payer, and patient perspectives
Era of surrogate endpoints and accelerated approvals: a comprehensive review on applicability, uncertainties, and challenges from regulatory, payer, and patient perspectives
The regulatory landscape in rare diseases and oncology has evolved to address unmet medical needs by implementing expedite...
Evaluation of surrogate endpoints in phase III randomized control trials of advanced hepatocellular carcinoma treated with immune checkpoint inhibitors
Evaluation of surrogate endpoints in phase III randomized control trials of advanced hepatocellular carcinoma treated with immune checkpoint inhibitors
Overall survival (OS) is recommended as a gold standard endpoint but has some limitations. We aimed to finding more effect...
Prescribing patterns of glucagon-like peptide-1 receptor agonists in the Swedish capital region—a register-based cross-sectional study
Prescribing patterns of glucagon-like peptide-1 receptor agonists in the Swedish capital region—a register-based cross-sectional study
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained considerable media attention, but there is limited knowl...
Facilitators and barriers to generic and biosimilar medications in the Middle East and North Africa: insights from physicians and pharmacists—a systematic review
Facilitators and barriers to generic and biosimilar medications in the Middle East and North Africa: insights from physicians and pharmacists—a systematic review
The adoption of generic and biosimilar medications is crucial for improving healthcare accessibility and cost savings in t...
Unveiling cardiovascular and respiratory toxicities with monoclonal antibodies in multiple myeloma: disproportionality analysis from the FDA Adverse Event Reporting System
Unveiling cardiovascular and respiratory toxicities with monoclonal antibodies in multiple myeloma: disproportionality analysis from the FDA Adverse Event Reporting System
Monoclonal antibodies (mAbs) have revolutionized the treatment of multiple myeloma (MM), demonstrating remarkable effectiv...
Influence of cigarette smoking on drugs’ metabolism and effects: a systematic review
Influence of cigarette smoking on drugs’ metabolism and effects: a systematic review
Cigarette smoke continues to be widely used around the world and it contains several substances that can affect the pharma...
Genome-wide association study of direct oral anticoagulants and their relation to bleeding
Genome-wide association study of direct oral anticoagulants and their relation to bleeding
Direct oral anticoagulants (DOACs) are used to prevent and treat thromboembolic events in adults. We aimed to investigate ...
Exploring the comprehensive factors influencing tacrolimus pharmacokinetics in early renal transplant recipients: A population pharmacokinetic analysis
Exploring the comprehensive factors influencing tacrolimus pharmacokinetics in early renal transplant recipients: A population pharmacokinetic analysis
To establish a population pharmacokinetic (PopPK) model of tacrolimus in the early stages after renal transplantation and ...
Psychotropic polypharmacy impairs walking independence in post-stroke patients
Psychotropic polypharmacy impairs walking independence in post-stroke patients
Psychotropic drugs are associated with adverse outcomes in older adults. However, evidence on the effect of psychotropic u...
Effects of oral antidiabetic agents on the renin–angiotensin–aldosterone system
Effects of oral antidiabetic agents on the renin–angiotensin–aldosterone system
The renin-angiotensin-aldosterone system (RAAS) is a vital endocrine system that plays a crucial role in maintaining homeo...
Effect of dapagliflozin on malignant ventricular arrhythmias in elderly after acute myocardial infarction: a propensity score-matched cohort study
Effect of dapagliflozin on malignant ventricular arrhythmias in elderly after acute myocardial infarction: a propensity score-matched cohort study
This study aims to evaluate the effect of dapagliflozin (DAPA) on malignant ventricular arrhythmias (MVA) after acute myoc...
Challenges of pediatric pharmacotherapy: A narrative review of pharmacokinetics, pharmacodynamics, and pharmacogenetics
Challenges of pediatric pharmacotherapy: A narrative review of pharmacokinetics, pharmacodynamics, and pharmacogenetics
Personalized pharmacotherapy, including for the pediatric population, provides optimal treatment and has emerged as a majo...
Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases
Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases
Selective androgen receptor modulators (SARMs) have demonstrated agonist activity on the androgen receptor in various tiss...
Correction to: Empagliflozin and colchicine in patients with reduced left ventricular ejection fraction following ST-elevation myocardial infarction: a randomized, double-blinded, three-arm parallel-group, controlled trial
Correction to: Empagliflozin and colchicine in patients with reduced left ventricular ejection fraction following ST-elevation myocardial infarction: a randomized, double-blinded, three-arm parallel-group, controlled trial
Cite this articleKhiali, S., Taban-Sadeghi, M., Sarbakhsh, P. et al. Correction to: Empagliflozin and colchicine in patien...
Pharmacokinetics of oral spironolactone in infants up to 2 years of age
Pharmacokinetics of oral spironolactone in infants up to 2 years of age
Spironolactone is a potassium sparing diuretic used for decades. Until now, pharmacokinetic (PK) studies of spironolactone...
Serotonin syndrome: A pharmacovigilance comparative study of drugs affecting serotonin levels
Serotonin syndrome: A pharmacovigilance comparative study of drugs affecting serotonin levels
Serotonin syndrome is a rare and potentially fatal adverse drug reaction caused by serotonergic drugs and is due to an inc...
Effect of azilsartan on myocardial remodeling after acute myocardial infarction
Effect of azilsartan on myocardial remodeling after acute myocardial infarction
To investigate the effect of azilsartan on myocardial remodeling after acute myocardial infarction (AMI). A total of 200 A...
Antidepressant use and the risk of seizure: a meta-analysis of observational studies
Antidepressant use and the risk of seizure: a meta-analysis of observational studies
The association between antidepressant use and the risk of seizures remains controversial. Therefore, this meta-analysis e...
Direct oral anticoagulants and the risk of adverse clinical outcomes among patients with different body weight categories: a large hospital-based study
Direct oral anticoagulants and the risk of adverse clinical outcomes among patients with different body weight categories: a large hospital-based study
Through predictable pharmacokinetics—including a convenient fixed-dose regimen, direct oral anticoagulants (DOACs) a...
Untapped options to reduce waste from blister packaging for tablets and capsules
Untapped options to reduce waste from blister packaging for tablets and capsules
In Europe, most medicines are taken orally and primarily packaged as single solid oral dosage forms (SODF) in blister cham...
The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review
The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review
This study intends to assess the reference range of lamotrigine concentration for treating childhood epilepsy. PubMed, Ovi...
Area under the curve of tacrolimus using microsampling devices: towards precision medicine in solid organ transplantation?
Area under the curve of tacrolimus using microsampling devices: towards precision medicine in solid organ transplantation?
Therapeutic drug monitoring of tacrolimus using trough concentration (Cmin) is mandatory to ensure drug efficacy and safet...
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