Abramczyk R et al (2020) Diabetes and psoriasis: different sides of the same prism. Diabetes Metab Syndr Obes 13:3571–3577
Article CAS PubMed PubMed Central Google Scholar
Armstrong AW et al (2021) Psoriasis prevalence in adults in the United States. JAMA Dermatol 157(8):940–946
Haran K et al (2024) Impact of GLP-1 receptor agonists on psoriasis and cardiovascular comorbidities: a narrative review. Psoriasis (Auckl) 14:143–152
Takeshita J et al (2017) Psoriasis and comorbid diseases: epidemiology. J Am Acad Dermatol 76(3):377–390
Article PubMed PubMed Central Google Scholar
Wu JJ et al (2022) Psoriasis and metabolic syndrome: implications for the management and treatment of psoriasis. J Eur Acad Dermatol Venereol 36(6):797–806
Article CAS PubMed PubMed Central Google Scholar
Karacabeyli D et al (2024) Mortality and major adverse cardiovascular events after glucagon-like peptide-1 receptor agonist initiation in patients with immune-mediated inflammatory diseases and type 2 diabetes: a population-based study. PLoS One 19(8)
Article CAS PubMed PubMed Central Google Scholar
Shaefer CF Jr., Kushner P, Aguilar R (2015) User’s guide to mechanism of action and clinical use of GLP-1 receptor agonists. Postgrad Med 127(8):818–826
Cerillo JL, Parmar M (2025) Liraglutide. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island
Brandfon S et al (2023) Advances in anti-obesity pharmacotherapy: current treatments, emerging therapies, and challenges. Cureus 15(10)
PubMed PubMed Central Google Scholar
Miranda S et al (2025) Impact of semaglutide on lipid profiles in overweight and obese non-diabetic adults: a systematic review and meta-analysis of randomized controlled trials. Eur J Pharmacol 1003
Article CAS PubMed Google Scholar
Burshtein J et al (2025) The association between obesity and efficacy of psoriasis therapies: an expert consensus panel. J Am Acad Dermatol 92(4):807–815
Article CAS PubMed Google Scholar
Faurschou A et al (2014) Improvement in psoriasis after treatment with the glucagon-like peptide-1 receptor agonist liraglutide. Acta Diabetol 51(1):147–150
Article CAS PubMed Google Scholar
Ramakrishnan S et al (2020) Remarkable improvement in plaque psoriasis with a 4 week short course liraglutide therapy in an obese type 2 DM patient. J Endocrinol Sci. https://doi.org/10.29245/2767-5157/2020/1.1106
Buysschaert M, Tennstedt D, Preumont V (2012) Improvement of psoriasis during exenatide treatment in a patient with diabetes. Diabetes Metab 38(1):86–88
Article CAS PubMed Google Scholar
Hogan AE et al (2011) Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis. Diabetologia 54(11):2745–2754
Article CAS PubMed PubMed Central Google Scholar
Malavazos AE, Meregalli C, Sorrentino F, Vignati A, Dubini C, Scravaglieri V, Basilico S, Boniardi F, Spagnolo P, Malagoli P, Romanelli P, Secchi F, Iacobellis G (2023) Semaglutide therapy decreases epicardial fat inflammation and improves psoriasis severity in patients affected by abdominal obesity and type-2 diabetes. Endocrinol Diabetes Metab Case Rep 2023(3):23–0017. https://doi.org/10.1530/EDM-23-0017
Costanzo G et al (2021) Two birds one stone: semaglutide is highly effective against severe psoriasis in a type 2 diabetic patient. Endocrinol Diabetes Metab Case Rep 2021:21-0007
Nowowiejska J, Baran A, Flisiak I (2023) The first case of psoriatic skin lesions exacerbation after liraglutide. Pol Arch Intern Med 133(7–8):165–27
Petkovic-Dabic J et al (2025) Effects of semaglutide treatment on psoriatic lesions in obese patients with type 2 diabetes mellitus: an open-label, randomized clinical trial. Biomolecules 15(1):46
Lin L et al (2022) Glucagon-like peptide-1 receptor agonist liraglutide therapy for psoriasis patients with type 2 diabetes: a randomized-controlled trial. J Dermatolog Treat 33(3):1428–1434
Article CAS PubMed Google Scholar
Faurschou A et al (2015) Lack of effect of the glucagon-like peptide-1 receptor agonist liraglutide on psoriasis in glucose-tolerant patients–a randomized placebo-controlled trial. J Eur Acad Dermatol Venereol 29(3):555–559
Article CAS PubMed Google Scholar
Nicolau J et al (2023) Effects of liraglutide among patients living with psoriasis and obesity. Med Clin (Barc) 161(7):293–296
Article CAS PubMed Google Scholar
Xu X et al (2019) Treatment with liraglutide, a glucagon-like peptide-1 analogue, improves effectively the skin lesions of psoriasis patients with type 2 diabetes: a prospective cohort study. Diabetes Res Clin Pract 150:167–173
Article CAS PubMed Google Scholar
Ahern T et al (2013) Glucagon-like peptide-1 analogue therapy for psoriasis patients with obesity and type 2 diabetes: a prospective cohort study. J Eur Acad Dermatol Venereol 27(11):1440–1443
Article CAS PubMed Google Scholar
Buysschaert M et al (2014) Improvement of psoriasis during glucagon-like peptide-1 analogue therapy in type 2 diabetes is associated with decreasing dermal gammadelta T-cell number: a prospective case-series study. Br J Dermatol 171(1):155–161
Article CAS PubMed Google Scholar
Yang J, Wang Z, Zhang X (2019) GLP-1 receptor agonist impairs keratinocytes inflammatory signals by activating AMPK. Exp Mol Pathol 107:124–128
Article CAS PubMed Google Scholar
Faurschou A et al (2013) Increased expression of glucagon-like peptide-1 receptors in psoriasis plaques. Exp Dermatol 22(2):150–152
Article CAS PubMed Google Scholar
Jensen P, Skov L (2016) Psoriasis and obesity. Dermatology 232(6):633–639
Hogan AE et al (2014) Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetologia 57(4):781–784
Article CAS PubMed Google Scholar
Mahase E (2024) GLP-1 agonists: US sees 700% increase over four years in number of patients without diabetes starting treatment. BMJ 386:q1645. https://doi.org/10.1136/bmj.q1645
Harris E (2024) Poll: roughly 12% of US adults have used a GLP-1 drug, even if unaffordable. JAMA 332(1):8. https://doi.org/10.1001/jama.2024.10333
Laurindo LF et al (2022) GLP-1a: going beyond traditional use. Int J Mol Sci. https://doi.org/10.3390/ijms23020739
Article PubMed PubMed Central Google Scholar
Elmets CA et al (2021) Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with topical therapy and alternative medicine modalities for psoriasis severity measures. J Am Acad Dermatol 84(2):432–470
Menter A et al (2019) Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics. J Am Acad Dermatol 80(4):1029–1072
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