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The prelimbic prefrontal cortex mediates the development of lasting social avoidance as a consequence of social threat conditioning
The prelimbic prefrontal cortex mediates the development of lasting social avoidance as a consequence of social threat conditioning
Social avoidance is highly detrimental for natural behavior. Despite much research on this topic, the mechanisms underlyin...
The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior
The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior
Bipolar disorder (BD) is a severe psychiatric disorder characterized by alternating manic and depressive episodes. The mol...
Connectome-based predictive modeling of early and chronic psychosis symptoms
Connectome-based predictive modeling of early and chronic psychosis symptoms
Previous research indicates that early (EP) and chronic (CP) psychosis share brain correlates and symptoms. However, notab...
Central Executive Network drives delta-9-tetrahydrocannabinol (THC)-induced nonlinear changes in large-scale functional connectivity in adolescent nonhuman primates
Central Executive Network drives delta-9-tetrahydrocannabinol (THC)-induced nonlinear changes in large-scale functional connectivity in adolescent nonhuman primates
Adolescent cannabinoid exposure has been implicated in enduring modifications to adult brain circuitry; however, well-cont...
A new module in the drug development process: preclinical multi-center randomized controlled trial of R-ketamine on alcohol relapse
A new module in the drug development process: preclinical multi-center randomized controlled trial of R-ketamine on alcohol relapse
The drug development process in psychiatry faces significant challenges due to low reproducibility rates in animal testing...
IN MEMORIAM: Floyd E. Bloom, M.D
IN MEMORIAM: Floyd E. Bloom, M.D
On January 8, 2025, the ACNP lost one of its guiding lights, Floyd E. Bloom,...
Persistent brain network signatures in psychosis: implications for diagnosis, prognosis, and treatment
This work was supported by the following sources: Northwell Health Advancing Women in Science and Medicine (Career Develop...
Paternal heroin self-administration in rats increases drug-seeking behavior in male offspring via miR-19b downregulation in the nucleus accumbens
Paternal heroin self-administration in rats increases drug-seeking behavior in male offspring via miR-19b downregulation in the nucleus accumbens
Accumulating evidence indicates that drug addiction may lead to adaptive behavioral changes in offspring, potentially due ...
Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters
Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters
Though vaping likely represents a safer alternative to smoking, it is not without risks, many of which are not well unders...
Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia
Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia
One of the critical unmet medical needs in schizophrenia is the treatment for cognitive deficits. However, the neural circ...
Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease
Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease
Cognitive deterioration and memory decline associated with the progression of Alzheimer’s disease (AD) primarily res...
Greater subjective effects of a low dose of LSD in participants with depressed mood
Greater subjective effects of a low dose of LSD in participants with depressed mood
Recent studies and anecdotal reports suggest that psychedelics can improve mood states, even at low doses. However, few pl...
Correction: Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes
Authors and AffiliationsDepartment of Neuroscience, University of Kentucky, Lexington, KY, USAMengfan Xia, Tanner L. Ander...
ACNP 62nd Annual Meeting: Poster Abstracts P1 – P250
Sanjay Mathew*, Andrew J. Cutler, Nicole C. Visitacion, Michael Gold, Jason Yuan, Bill AuroraBaylor College of Medicine, H...
ACNP 62nd Annual Meeting: Author Index
First Name Last Name Submission Number(s)Scott Aaronson P249, P323, P327Mahmood Y. Abdelkader P186She...
ACNP 62nd Annual Meeting: Poster Abstracts P251 – P500
Aki Tsuchiyagaito, Rayus Kuplicki, Ryan Smith, Masaya Misaki, Noah Philip, Martin Paulus, Salvador Guinjoan*Laureate Insti...
ACNP 62nd Annual Meeting: Keyword Index
Key Word Submission Number(s)(2R,6R)-hydroxynorketamine P354(R,S)-ketamine P250, P354, P365, P726(R,S...
ACNP 62nd Annual Meeting: Poster Abstracts P501 – P753
Johanna Seitz-Holland*, Cornelius Berberich, Nora Penzel, Kevin Cho Kang-Ik, Ofer Pasternak, Suheyla Cetin-Karayumak, Yoge...
ACNP 62nd Annual Meeting: Panels, Mini-Panels and Study Groups
Dong-Jing FuJanssen Research and Development, LLC, Titusville, New Jersey, United StatesBackground: Regulatory agency appr...
Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer’s disease in mice
Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer’s disease in mice
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with cognitive dysfunction as its major clinical...
Correction: Neutralization of tumor necrosis factor-related apoptosis-inducing ligand reduces spinal cord injury damage in mice
Correction: Neutralization of tumor necrosis factor-related apoptosis-inducing ligand reduces spinal cord injury damage in mice
Authors and AffiliationsDepartment of Experimental and Clinical Pharmacology, University of Catania School of Medicine, Ca...
To lump or to split: cognitive impairment across mood and psychotic disorders
Wenzel J, Badde L, Haas SS, Bonivento C, Van Rheenen TE, Antonucci LA, et al. Transdiagnostic subgroups of cognitive impai...
Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insula...
Sex differences in offspring risk and resilience following 11β-hydroxylase antagonism in a rodent model of maternal immune activation
Sex differences in offspring risk and resilience following 11β-hydroxylase antagonism in a rodent model of maternal immune activation
Maternal immune activation (MIA) puts offspring at greater risk for neurodevelopmental disorders associated with impaired ...
The role of endogenous opioids in mindfulness and sham mindfulness-meditation for the direct alleviation of evoked chronic low back pain: a randomized clinical trial
The role of endogenous opioids in mindfulness and sham mindfulness-meditation for the direct alleviation of evoked chronic low back pain: a randomized clinical trial
Chronic low back pain (cLBP) is the most prevalent chronic pain condition. There are no treatments that haven been found t...
A double-blind, randomized controlled study of the effects of celecoxib on clinical symptoms and cognitive impairment in patients with drug-naïve first episode schizophrenia: pharmacogenetic impact of cyclooxygenase-2 functional polymorphisms
A double-blind, randomized controlled study of the effects of celecoxib on clinical symptoms and cognitive impairment in patients with drug-naïve first episode schizophrenia: pharmacogenetic impact of cyclooxygenase-2 functional polymorphisms
Chronic low-grade peripheral and central nervous system inflammation may have a role in the pathogenesis of schizophrenia ...
Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making
Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making
Serotonin is critical for adapting behavior flexibly to meet changing environmental demands. Cognitive flexibility is impo...
IN MEMORIAM: John A. Sweeney, Ph.D.
IN MEMORIAM: John A. Sweeney, Ph.D.
John Sweeney, PhD left us unexpectedly on September 10, 2023, at the age of 71, s...
Disrupted brain state dynamics in opioid and alcohol use disorder: attenuation by nicotine use
Disrupted brain state dynamics in opioid and alcohol use disorder: attenuation by nicotine use
Substance use disorder (SUD) is a chronic relapsing disorder with long-lasting changes in brain intrinsic networks. While ...
Should we embrace the term ‘preaddiction’?
McLellan AT, Koob GF, Volkow ND. Preaddiction—A Missing Concept for Treating Substance Use Disorders. JAMA Psychiatry. 202...
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