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Impact testing as a new approach to determine mechanical strength of pharmaceutical tablets
Impact testing as a new approach to determine mechanical strength of pharmaceutical tablets
Oral solid dosage (OSD) forms continue to be the preferred route of drug administration for patients, healthcare providers...
Diabetic wound healing function of PCL/cellulose acetate nanofiber engineered with chitosan/cerium oxide nanoparticles
Diabetic wound healing function of PCL/cellulose acetate nanofiber engineered with chitosan/cerium oxide nanoparticles
As the body's largest vital organ, skin is vulnerable to injuries that can compromise its integrity and cause skin wounds ...
A self-assembly active nanomodulator based on berberine for photothermal immunotherapy of breast cancer via dual regulation of immune suppression
A self-assembly active nanomodulator based on berberine for photothermal immunotherapy of breast cancer via dual regulation of immune suppression
Breast cancer (BC), comprising for 23 % of female cancers, stands as a prevalent and widespread malignant disease (Loibl e...
Core-shell nanofibers containing L-arginine stimulates angiogenesis and full thickness dermal wound repair
Core-shell nanofibers containing L-arginine stimulates angiogenesis and full thickness dermal wound repair
Wound healing is one of the major challenges in medicine. Wound care aims to accelerate wound healing and relieve pain. Ne...
Doxorubicin loaded octacalcium phosphate particles as controlled release drug delivery systems: Physico-chemical characterization, in vitro drug release and evaluation of cell death pathway
Doxorubicin loaded octacalcium phosphate particles as controlled release drug delivery systems: Physico-chemical characterization, in vitro drug release and evaluation of cell death pathway
Mastering new and efficient ways to obtain successful drug delivery systems (DDS) with controlled release became a paramou...
Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics
Estimation of the concentration boundary layer adjacent to a flat surface using computational fluid dynamics
Dissolution-permeation (D/P) experiments are widely used during preclinical development due to producing results with bett...
Numerical and experimental evaluation of nasopharyngeal aerosol administration methods in children with adenoid hypertrophy
Numerical and experimental evaluation of nasopharyngeal aerosol administration methods in children with adenoid hypertrophy
Administering aerosol drugs through the nasal pathway is a common early treatment for children with adenoid hypertrophy (A...
Selenium nanoparticles/carboxymethyl chitosan/alginate antioxidant hydrogel for treating steroid-induced osteonecrosis of the femoral head
Selenium nanoparticles/carboxymethyl chitosan/alginate antioxidant hydrogel for treating steroid-induced osteonecrosis of the femoral head
Steroid-induced osteonecrosis of the femoral head (SONFH), a serious disease caused by excessive glucocorticoid use, can i...
A quality-by-design strategic approach for the development of bedaquiline-pretomanid nanoparticles as inhalable dry powders for TB treatment
A quality-by-design strategic approach for the development of bedaquiline-pretomanid nanoparticles as inhalable dry powders for TB treatment
Tuberculosis (TB) is a global infectious disease caused by Mycobacterium tuberculosis (M.tb) and ranks as the second leadi...
Impact of dry coating lactose as a brittle excipient on multi-component blend processability
Impact of dry coating lactose as a brittle excipient on multi-component blend processability
Tablets have long been preferred as a solid dosage form for drug delivery due to their stability, cost-effectiveness, ease...
Systematic screening of photopolymer resins for stereolithography (SLA) 3D printing of solid oral dosage forms: Investigation of formulation factors on printability outcomes
Systematic screening of photopolymer resins for stereolithography (SLA) 3D printing of solid oral dosage forms: Investigation of formulation factors on printability outcomes
Pharmaceutical three-dimensional printing (3DP) is now in its golden age. Recent years have seen a dramatic increase in th...
Visualization and correlation of drug release of risperidone/clozapine microspheres in vitro and in vivo based on FRET mechanism
Visualization and correlation of drug release of risperidone/clozapine microspheres in vitro and in vivo based on FRET mechanism
Long-acting injectable dosage forms represent innovative and practical drug preparations for achieving extended drug relea...
Development of samarium-doped phosphate glass microspheres for internal radiotheranostic applications
Development of samarium-doped phosphate glass microspheres for internal radiotheranostic applications
In 2020, over 900,000 new cases of liver cancer (Hepatocellular carcinoma - HCC), including both primary and metastatic, w...
Wound recovery efficacy of retinol based-micellar formulations in an organotypic skin wound model
Wound recovery efficacy of retinol based-micellar formulations in an organotypic skin wound model
Impairment of the skin's structural integrity initially results in acute wounds which can become chronic if timely wound c...
Calreticulin P-domain-derived “Eat-me” peptides for enhancing liposomal uptake in dendritic cells
Calreticulin P-domain-derived “Eat-me” peptides for enhancing liposomal uptake in dendritic cells
Calreticulin (CRT) is a ubiquitously expressed and evolutionarily conserved protein primarily located in the endoplasmic r...
Feature extraction of particle morphologies of pharmaceutical excipients from scanning electron microscope images using convolutional neural networks
Feature extraction of particle morphologies of pharmaceutical excipients from scanning electron microscope images using convolutional neural networks
KeywordsConvolutional neural networksMachine learningClusteringScanning electron microscopeRaw materials databasePowderAbb...
Dual centrifugation as a novel and efficient method for the preparation of lipodisks
Dual centrifugation as a novel and efficient method for the preparation of lipodisks
Polyethylene glycol (PEG)-stabilized lipodisks have emerged as innovatiive, promising nanocarriers for several classes of ...
Conjugation to gold nanoparticles of methionine gamma-lyase, a cancer-starving enzyme. Physicochemical characterization of the nanocomplex for prospective nanomedicine applications
Conjugation to gold nanoparticles of methionine gamma-lyase, a cancer-starving enzyme. Physicochemical characterization of the nanocomplex for prospective nanomedicine applications
The pyridoxal 5′-dependent enzyme methionine γ-lyase (MGL) catalyzes the degradation of methionine. This activity has been...
Novel nano-encapsulated limonene: Utilization of drug-in-cyclodextrin-in-liposome formulation to improve the stability and enhance the antioxidant activity
Novel nano-encapsulated limonene: Utilization of drug-in-cyclodextrin-in-liposome formulation to improve the stability and enhance the antioxidant activity
Several naturally occurring nanofoods and their modified products serve as excellent carriers for the nanoencapsulation of...
Industrializable approach for preparing hydrogel microneedles and their application in melanoma treatment
Industrializable approach for preparing hydrogel microneedles and their application in melanoma treatment
The emergence of MNs technology has changed the situation of traditional transdermal formulations limited by physicochemic...
Smart biodegradable hydrogels: Drug-delivery platforms for treatment of chronic ophthalmic diseases affecting the back of the eye
Smart biodegradable hydrogels: Drug-delivery platforms for treatment of chronic ophthalmic diseases affecting the back of the eye
The growing incidence of chronic ophthalmic diseases reported in developed countries in recent decades is mainly due to in...
Near-infrared imaging of in vivo performance of orally administered solid forms to rats: Feasibility study with indocyanine green
Near-infrared imaging of in vivo performance of orally administered solid forms to rats: Feasibility study with indocyanine green
Solid formulations, such as tablets and capsules, undergo disintegration after administration as a function of formulation...
Synergistic effects of multidrug/material combination deliver system for anti-mutidrug-resistant tumor
Synergistic effects of multidrug/material combination deliver system for anti-mutidrug-resistant tumor
Multidrug resistance (MDR) is a major factor contributing to the failure of cancer therapy and is a public health issue of...
Prolonging the stability of cetuximab (Erbitux®) and panitumumab (Vectibix®): An orthogonal assessment of physicochemical, biological and microbiological properties of original opened glass vials and diluted saline preparations
Prolonging the stability of cetuximab (Erbitux®) and panitumumab (Vectibix®): An orthogonal assessment of physicochemical, biological and microbiological properties of original opened glass vials and diluted saline preparations
The two anti-epidermal growth factor receptor monoclonal antibodies (mAbs) cetuximab and panitumumab are the pillars for t...
Simple elaboration of drug-SPION nanocapsules (hybridosomes®) by solvent shifting: Effect of the drug molecular structure and concentration
Simple elaboration of drug-SPION nanocapsules (hybridosomes®) by solvent shifting: Effect of the drug molecular structure and concentration
The design of nanocapsules with a controlled architecture remains a major scientific and technological objective to this d...
Enzymatic prodrug degradation in the fasted and fed small intestine: In vitro studies and interindividual variability in human aspirates
Enzymatic prodrug degradation in the fasted and fed small intestine: In vitro studies and interindividual variability in human aspirates
The interactions of oral drugs with the complex environment of the gastrointestinal tract (GIT) may cause issues with drug...
pH-sensitive niosomes for ATRA delivery: A promising approach to inhibit Pin1 in high-grade serous ovarian cancer
pH-sensitive niosomes for ATRA delivery: A promising approach to inhibit Pin1 in high-grade serous ovarian cancer
The peptidyl-prolyl cis/trans isomerase Pin1 positively regulates numerous cancer-driving pathways, and it is overexpresse...
Impact of the crystal size of crystalline active pharmaceutical compounds on loading into microneedles
Impact of the crystal size of crystalline active pharmaceutical compounds on loading into microneedles
Microneedles (MNs) have emerged as a simple technology that overcame several obstacles of the conventional drug delivery s...
PEG-modified nano liposomes co-deliver Apigenin and RAGE-siRNA to protect myocardial ischemia injury
PEG-modified nano liposomes co-deliver Apigenin and RAGE-siRNA to protect myocardial ischemia injury
Ischemic heart disease is a serious threat to human health and one of the leading causes of death worldwide (Nowbar et al....
Enhancing osteosarcoma therapy through aluminium hydroxide nanosheets-enabled macrophage modulation
Enhancing osteosarcoma therapy through aluminium hydroxide nanosheets-enabled macrophage modulation
Osteosarcoma is the most common primary bone cancer, manifesting in the distal femur with hallmarks such as pain and bone ...
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