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Synthesis and optimization of fluoxetine-loaded polymeric nanoparticles for dual therapeutic applications in cancer and depression
Synthesis and optimization of fluoxetine-loaded polymeric nanoparticles for dual therapeutic applications in cancer and depression
Fluoxetine, an antidepressant, has shown potential anticancer effects. However, its therapeutic efficacy is limited by its...
Profiling metoprolol enantiomers in urine of hypertensive patients
Profiling metoprolol enantiomers in urine of hypertensive patients
Metoprolol, a widely used β-blocker, is administered as a racemic mixture, with (S)-metoprolol being more pharmacolog...
Cleaning validation in pharmaceutical quality control laboratories: a structured protocol for contamination risk mitigation
Cleaning validation in pharmaceutical quality control laboratories: a structured protocol for contamination risk mitigation
Cleaning activities are critical in pharmaceutical manufacturing to prevent cross-contamination of Active Pharmaceutical I...
Glucocorticoid withdrawal syndrome: Disproportionality analysis of cases using VigiBase data
Glucocorticoid withdrawal syndrome: Disproportionality analysis of cases using VigiBase data
Glucocorticoids are associated with withdrawal syndrome, but specific glucocorticoid types that cause severe conditions re...
Efficacy of dostarlimab in recurrent or advanced mismatch Repair-Deficient endometrial Cancer as a Single-Agent therapy: A systematic review and Meta-Analysis
Efficacy of dostarlimab in recurrent or advanced mismatch Repair-Deficient endometrial Cancer as a Single-Agent therapy: A systematic review and Meta-Analysis
The effectiveness of PD-1 inhibitors for treating endometrial cancer (EC) remains a topic of debate. Guidelines lack consi...
Drug repositioning: examining antipsychotic drugs and their anticancer effects
Drug repositioning: examining antipsychotic drugs and their anticancer effects
Cancer leads the list of causes of death worldwide, and the search for new and rapid treatment options for this disease ha...
Pre-emptive hydrocortisone therapy in early septic shock: a double-blind, allocation-concealed, pilot randomized controlled trial
Pre-emptive hydrocortisone therapy in early septic shock: a double-blind, allocation-concealed, pilot randomized controlled trial
Sepsis, a major global health issue, often progresses to septic shock with high morbidity and mortality. Corticosteroids e...
The effect of FeO biosynthesized through the green synthesis of and HA in the targeted delivery of 5-Fluorouracil to HCT116 cell line
The effect of FeO biosynthesized through the green synthesis of and HA in the targeted delivery of 5-Fluorouracil to HCT116 cell line
The administration of 5-FU as the first chemotherapeutic agent for colorectal cancer, showed difficulties including short ...
In vitro evaluation of CeO nanoparticles on doxorubicin induced cardiotoxicity: focused on oxidative stress, inflammation, apoptosis, and mitochondrial function
In vitro evaluation of CeO nanoparticles on doxorubicin induced cardiotoxicity: focused on oxidative stress, inflammation, apoptosis, and mitochondrial function
Doxorubicin (Dox) is a chemotherapy medication used in the therapy of cancers. However, despite its killing of cancer cell...
Innovative triamcinolone acetonide microsuspension for Non-Invasive ocular management of inflammation
Innovative triamcinolone acetonide microsuspension for Non-Invasive ocular management of inflammation
Enhancing the bioavailability of insoluble active agents in the eye through topical administration is a key focus in formu...
Relieving postherpetic neuralgia pain via gabapentin-loaded bigels as an auspicious topical drug delivery system
Relieving postherpetic neuralgia pain via gabapentin-loaded bigels as an auspicious topical drug delivery system
Over the past decades, a substantial portion of the population worldwide has been infected with varicella zoster and most ...
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
Rhinovirus (RV) infection is a major cause of common colds and asthma exacerbations, with no antiviral drug available. Cur...
Pharmacogenetic DPYD allele variant frequencies: A comprehensive analysis across an ancestrally diverse Iranian population
Pharmacogenetic DPYD allele variant frequencies: A comprehensive analysis across an ancestrally diverse Iranian population
Cancer treatment has improved over the past decades, but many cancer patients still experience adverse drug reactions (ADR...
Therapeutic role of erythropoietin in methanol induced optic neuropathy: a systematic review
Therapeutic role of erythropoietin in methanol induced optic neuropathy: a systematic review
Despite various therapeutic attempts, an approved treatment for Methanol-induced optic neuropathy (MION), a sight-threaten...
Advances in artificial intelligence-based technologies for increasing the quality of medical products
Advances in artificial intelligence-based technologies for increasing the quality of medical products
Artificial intelligence (AI) is a technology that combines machine learning (ML) and deep learning. It has numerous usages...
Cellular and molecular aspects of drug resistance in cancers
Cellular and molecular aspects of drug resistance in cancers
Cancer drug resistance is a multifaceted phenomenon. The present review article aims to comprehensively analyze the cellul...
Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery
Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery
Amphotericin B (AMB) is a drug used to treat vulvovaginal candidiasis (VVC), which is a fungal infection affecting the vag...
Trends analysis and future study of the pharmaceutical industry field: a scoping review
Trends analysis and future study of the pharmaceutical industry field: a scoping review
The main aim of this study was to explore and understand the emerging developments, changes, and patterns shaping the futu...
Electroceuticals: Unlocking the promise of therapies
Electroceuticals: Unlocking the promise of therapies
Electroceuticals refers to the constantly growing disciplines of bioelectric and bioelectronic medication. These include a...
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test
High-performance liquid chromatography (HPLC) has emerged as a highly sensitive and versatile analytical technique for qua...
and assessment of curcumin loaded bile salt stabilized nanovesicles for oral delivery
and assessment of curcumin loaded bile salt stabilized nanovesicles for oral delivery
Bile salts enriched nanovesicles (bilosomes) have been attention worthy in the past few years due to their distinctive eff...
The effect of biosynthesized zinc oxide nanoparticles on gene expression and apoptosis in triple-negative breast cancer cells
The effect of biosynthesized zinc oxide nanoparticles on gene expression and apoptosis in triple-negative breast cancer cells
Some forms of breast cancer such as triple-negative phenotype, are serious challenge because of high metastatic cases, hig...
Evaluation of the consumption pattern and efficacy of Linezolid in COVID-19 hospitalized patients in a hospital in Tehran-Iran
Evaluation of the consumption pattern and efficacy of Linezolid in COVID-19 hospitalized patients in a hospital in Tehran-Iran
The inappropriate use of antibiotics increases the costs of treatment, antibiotic resistance, increased disease length and...
Vancomycin- induced leukocytoclastic vasculitis in a patient with end-stage renal disease: a case report and literature review
Vancomycin- induced leukocytoclastic vasculitis in a patient with end-stage renal disease: a case report and literature review
Leukocytoclastic vasculitis (LCV) is a small-vessel inflammatory condition that can rarely occur as an adverse drug reacti...
Efficacy and safety of different dosages of rituximab for myasthenia gravis: a single-arm meta-analysis
Efficacy and safety of different dosages of rituximab for myasthenia gravis: a single-arm meta-analysis
Rituximab (RTX) is one of the treatment options for refractory myasthenia gravis (MG), yet the optimal dosing schedule rem...
The impact of Mill. on gastrointestinal disorders: a comprehensive analysis through clinical trials, systematic review, and meta-analysis
The impact of Mill. on gastrointestinal disorders: a comprehensive analysis through clinical trials, systematic review, and meta-analysis
Rosa damascena Mill. has been studied in clinical trials for the treatment of diverse gastrointestinal diseases. The aim o...
Stearyl amine tailored spanlastics embedded within tetronic nanogel for boosting the repurposed anticancer potential of mebendazole: formulation, in vitro profiling, cytotoxicity assessment, and in vivo permeation analysis
Stearyl amine tailored spanlastics embedded within tetronic nanogel for boosting the repurposed anticancer potential of mebendazole: formulation, in vitro profiling, cytotoxicity assessment, and in vivo permeation analysis
Mebendazole (MBZ) is an anthelmintic drug that was repurposed as an anti-cancer agent. This study aimed at formulating MBZ...
Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
Alzheimer’s disease (AD) is a neurological disease that causes memory loss over time. Current therapies are limited ...
Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation
Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation
In this study, a combination of nanotechnology, organic synthesis and radiochemistry were utilized in order to design an e...
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review
Fruit vinegar is one of the most famous fruit byproducts worldwide with several unique properties. There are two types of ...
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