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Pan-H7 influenza human antibody virus neutralization depends on avidity and steric hindrance
Research ArticleImmunologyInfectious diseaseVirology Open Access | 10.1172/jci.insight.186182 ...
Cord blood proteomics identifies biomarkers of early-onset neonatal sepsis
Clinical Research and Public HealthImmunologyInfectious disease Open Access | 10.1172/jci.insight.193826 ...
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma
Sex as a biological variable. Male mice were specifically used when studying response to HDM as previous studies in our l...
Identification of bacteriophage DNA in human umbilical cord blood
Bacteriophage DNA is present in human umbilical cord blood. To test the hypothesis that the fetus is exposed to bacteriop...
Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice
GBA1 L444P PD patient-derived cortical neurons have increased total C16:1 and C18:1 fatty acid associating with decreased...
Polyfunctional T follicular helper cells drive checkpoint-inhibitor diabetes and are targeted by JAK inhibitor therapy
Research ArticleOncology Open Access | 10.1172/jci.insight.188843 Nicole L. Huang,1 Jessi...
Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia
Research ArticleInflammationMetabolism Open Access | 10.1172/jci.insight.191649 John Q. Yap,1...
High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19
Research ArticleCOVID-19Immunology Open Access | 10.1172/jci.insight.191314 Anita E. Qualls,1...
Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression
Sex as a biological variable. Sex was not considered as a biological variable in this study. Cell culture. THP-1 and Raw2...
A CARD9 deficiency mouse model recapitulates human chronic CNS candidiasis identifying defective monocytic cell responses in immunopathogenesis
Research ArticleGeneticsImmunology Open Access | 10.1172/jci.insight.176676 Marija Landekic,1...
Macrophage-derived Spp1 promotes intramuscular fat in dystrophic muscle
Research ArticleGeneticsMuscle biology Open Access | 10.1172/jci.insight.181946 Philip K. Far...
MTOR signaling regulates the development of airway mucous cell metaplasia associated with severe asthma
Research ArticleCell biologyPulmonology Open Access | 10.1172/jci.insight.187904 Katrina M. K...
Distinct cell types along thick ascending limb express pathways for monovalent and divalent cation transport
Research ArticleMetabolismNephrology Open Access | 10.1172/jci.insight.190992 Hasan Demirci,1...
Impact of the IL-15 superagonist N-803 on lymphatic reservoirs of HIV
Clinical Research and Public HealthAIDS/HIVInfectious disease Open Access | 10.1172/jci.insight.190831 ...
An amphiregulin reporter mouse enables transcriptional and clonal expansion analysis of reparative lung Tregs
The AregThy1.1 reporter mouse delineates active Areg production from Tregs during models of lung damage. Due to the inabi...
Label-free single-cell phenotyping to determine tumor cell heterogeneity in pancreatic cancer in real time
Research ArticleGastroenterologyOncology Open Access | 10.1172/jci.insight.169105 Katja Witte...
Opposing roles for myeloid and smooth muscle cell STING in pulmonary hypertension
Sex as a biological variable For studies using human and animal samples, sex is specified as appropriate to the design of...
Involvement of impaired carnitine-induced fatty acid oxidation in experimental and human diabetic kidney disease
Middle-to-long-chain Acyl-C and ectopic lipid accumulation are increased in patients with DKD. First, to investigate whet...
ADAR1 expression is associated with cervical cancer progression and negatively regulates NK cell activity
Research ArticleImmunologyInflammationOncology Open Access | 10.1172/jci.insight.190244 Valen...
NEXN regulates vascular smooth muscle cell phenotypic switching and neointimal hyperplasia
Research ArticleCell biologyVascular biology Open Access | 10.1172/jci.insight.190089 Zexuan ...
Detection of sequence-tagged sites to reveal mechanisms of multi-step mutations at multi-copy Y-STRs in father-son pairs
Detection of sequence-tagged sites to reveal mechanisms of multi-step mutations at multi-copy Y-STRs in father-son pairs
The case report demonstrates that co-examining various forensic markers with different technologies can strengthen the con...
Determination of normal post-mortem computed tomography (PMCT) parameters for the temporomandibular joint
Determination of normal post-mortem computed tomography (PMCT) parameters for the temporomandibular joint
Post-mortem radiology, particularly post-mortem computed tomography (PMCT), has become an important tool in forensic death...
Cardiac-specific troponin-I (cTnI) in a post-mortem setting
Cardiac-specific troponin-I (cTnI) in a post-mortem setting
Cardiac-specific troponin (cTn) is widely used in clinical medicine to support a diagnosis of acute myocardial infarction....
Automated identification of unknown decedents: matching postmortem CT images with clinical databases
Automated identification of unknown decedents: matching postmortem CT images with clinical databases
The maxillary sinus plays an important role in the forensic identification of unknown deceased individuals. This study aim...
Genital and anal injury in women after sexual assault: prevalence rates and associated risk factors in 294 cases
Genital and anal injury in women after sexual assault: prevalence rates and associated risk factors in 294 cases
To investigate the prevalence of, and risk factors for, genito-anal injury in females who attended a Sexual Assault Treatm...
Genealogically bewildered individuals and forensic identification: a review of current and emerging solutions
Genealogically bewildered individuals and forensic identification: a review of current and emerging solutions
The increasing use of assisted reproductive technologies (ART) with donor gametes is driven by rising infertility rates, d...
Assessment of cardiac biomarker “point-of-care” testing as postmortem diagnostic tool
Assessment of cardiac biomarker “point-of-care” testing as postmortem diagnostic tool
In cardiac death, some entities, such as arrhythmia or nonocclusive myocardial ischemia, are not associated with clear and...
CT of the medial clavicular epiphysis for forensic age estimation – raised arms position recommended
CT of the medial clavicular epiphysis for forensic age estimation – raised arms position recommended
To compare the effect of arm positioning on radiation dose, scan length, and image noise in computed tomography (CT) scans...
Post-mortem forensic application of proteomics on human ribs: Investigating the phenomenon of vital reaction
Post-mortem forensic application of proteomics on human ribs: Investigating the phenomenon of vital reaction
The research upon vital reactions is a hot topic in forensic pathology. However, there are very few studies which focus on...
DNA forensics at forty: the way forward
DNA forensics at forty: the way forward
Forensic DNA analysis has transformed criminal investigations since its inception in 1985. Over four decades, this field h...
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