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Social media recruitment enhances participant diversity in dermatology clinical trial: findings from the SAFA trial
Social media recruitment enhances participant diversity in dermatology clinical trial: findings from the SAFA trial
Recruitment and retention of participants remain critical challenges in clinical trials, often requiring innovative approa...
Optimizing pharmacologic treatment for neonatal opioid withdrawal syndrome (OPTimize NOW): a symptom-based dosing approach study protocol for a multi-center, cluster crossover design randomized controlled trial
Optimizing pharmacologic treatment for neonatal opioid withdrawal syndrome (OPTimize NOW): a symptom-based dosing approach study protocol for a multi-center, cluster crossover design randomized controlled trial
Opioid use and misuse during pregnancy rose from 1.5 to 6.5 per 1000 deliveries between 1999 and 2014 and continues as a s...
Effects of a transitional care programme for elderly patients with osteoporotic fracture living in a rural community: a randomized controlled trial
Effects of a transitional care programme for elderly patients with osteoporotic fracture living in a rural community: a randomized controlled trial
Patients with osteoporotic fracture (OF) after discharge to home represent a vulnerable population who are susceptible to ...
The “SleepWell” intervention for patients with insomnia and persistent pain: a study protocol for a randomised waiting-list controlled trial of a cognitive behavioural group therapy programme
The “SleepWell” intervention for patients with insomnia and persistent pain: a study protocol for a randomised waiting-list controlled trial of a cognitive behavioural group therapy programme
Patients with persistent pain and comorbid insomnia often experience a dual burden with significant day- and nighttime imp...
Pan-H7 influenza human antibody virus neutralization depends on avidity and steric hindrance
Research ArticleImmunologyInfectious diseaseVirology Open Access | 10.1172/jci.insight.186182 ...
Cord blood proteomics identifies biomarkers of early-onset neonatal sepsis
Clinical Research and Public HealthImmunologyInfectious disease Open Access | 10.1172/jci.insight.193826 ...
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma
Sex as a biological variable. Male mice were specifically used when studying response to HDM as previous studies in our l...
Identification of bacteriophage DNA in human umbilical cord blood
Bacteriophage DNA is present in human umbilical cord blood. To test the hypothesis that the fetus is exposed to bacteriop...
Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice
GBA1 L444P PD patient-derived cortical neurons have increased total C16:1 and C18:1 fatty acid associating with decreased...
Polyfunctional T follicular helper cells drive checkpoint-inhibitor diabetes and are targeted by JAK inhibitor therapy
Research ArticleOncology Open Access | 10.1172/jci.insight.188843 Nicole L. Huang,1 Jessi...
Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia
Research ArticleInflammationMetabolism Open Access | 10.1172/jci.insight.191649 John Q. Yap,1...
High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19
Research ArticleCOVID-19Immunology Open Access | 10.1172/jci.insight.191314 Anita E. Qualls,1...
Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression
Sex as a biological variable. Sex was not considered as a biological variable in this study. Cell culture. THP-1 and Raw2...
A CARD9 deficiency mouse model recapitulates human chronic CNS candidiasis identifying defective monocytic cell responses in immunopathogenesis
Research ArticleGeneticsImmunology Open Access | 10.1172/jci.insight.176676 Marija Landekic,1...
Macrophage-derived Spp1 promotes intramuscular fat in dystrophic muscle
Research ArticleGeneticsMuscle biology Open Access | 10.1172/jci.insight.181946 Philip K. Far...
MTOR signaling regulates the development of airway mucous cell metaplasia associated with severe asthma
Research ArticleCell biologyPulmonology Open Access | 10.1172/jci.insight.187904 Katrina M. K...
Distinct cell types along thick ascending limb express pathways for monovalent and divalent cation transport
Research ArticleMetabolismNephrology Open Access | 10.1172/jci.insight.190992 Hasan Demirci,1...
Impact of the IL-15 superagonist N-803 on lymphatic reservoirs of HIV
Clinical Research and Public HealthAIDS/HIVInfectious disease Open Access | 10.1172/jci.insight.190831 ...
An amphiregulin reporter mouse enables transcriptional and clonal expansion analysis of reparative lung Tregs
The AregThy1.1 reporter mouse delineates active Areg production from Tregs during models of lung damage. Due to the inabi...
Label-free single-cell phenotyping to determine tumor cell heterogeneity in pancreatic cancer in real time
Research ArticleGastroenterologyOncology Open Access | 10.1172/jci.insight.169105 Katja Witte...
Opposing roles for myeloid and smooth muscle cell STING in pulmonary hypertension
Sex as a biological variable For studies using human and animal samples, sex is specified as appropriate to the design of...
Involvement of impaired carnitine-induced fatty acid oxidation in experimental and human diabetic kidney disease
Middle-to-long-chain Acyl-C and ectopic lipid accumulation are increased in patients with DKD. First, to investigate whet...
ADAR1 expression is associated with cervical cancer progression and negatively regulates NK cell activity
Research ArticleImmunologyInflammationOncology Open Access | 10.1172/jci.insight.190244 Valen...
NEXN regulates vascular smooth muscle cell phenotypic switching and neointimal hyperplasia
Research ArticleCell biologyVascular biology Open Access | 10.1172/jci.insight.190089 Zexuan ...
Detection of sequence-tagged sites to reveal mechanisms of multi-step mutations at multi-copy Y-STRs in father-son pairs
Detection of sequence-tagged sites to reveal mechanisms of multi-step mutations at multi-copy Y-STRs in father-son pairs
The case report demonstrates that co-examining various forensic markers with different technologies can strengthen the con...
Determination of normal post-mortem computed tomography (PMCT) parameters for the temporomandibular joint
Determination of normal post-mortem computed tomography (PMCT) parameters for the temporomandibular joint
Post-mortem radiology, particularly post-mortem computed tomography (PMCT), has become an important tool in forensic death...
Cardiac-specific troponin-I (cTnI) in a post-mortem setting
Cardiac-specific troponin-I (cTnI) in a post-mortem setting
Cardiac-specific troponin (cTn) is widely used in clinical medicine to support a diagnosis of acute myocardial infarction....
Automated identification of unknown decedents: matching postmortem CT images with clinical databases
Automated identification of unknown decedents: matching postmortem CT images with clinical databases
The maxillary sinus plays an important role in the forensic identification of unknown deceased individuals. This study aim...
Genital and anal injury in women after sexual assault: prevalence rates and associated risk factors in 294 cases
Genital and anal injury in women after sexual assault: prevalence rates and associated risk factors in 294 cases
To investigate the prevalence of, and risk factors for, genito-anal injury in females who attended a Sexual Assault Treatm...
Genealogically bewildered individuals and forensic identification: a review of current and emerging solutions
Genealogically bewildered individuals and forensic identification: a review of current and emerging solutions
The increasing use of assisted reproductive technologies (ART) with donor gametes is driven by rising infertility rates, d...
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