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Structural modeling and functional characterization of a novel gain-of-function TLR8 variant causing severe inflammatory syndrome
Research ArticleGeneticsImmunologyInfectious disease Open Access | 10.1172/jci.insight.187422 ...
Single-cell capture of on-ART SIV transcription reveals TGF-β–mediated metabolic control of viral latency
Research ArticleAIDS/HIVImmunologyMetabolism Open Access | 10.1172/jci.insight.198810 Romaila...
Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 mediator kinase inhibition
Research ArticleCell biologyOncology Open Access | 10.1172/jci.insight.192113 Mehri Monavaria...
IL-21 enhances the cytotoxicity of intratumoral CD8+ T cells, improving radiation efficacy
Sex as a biological variable. Human samples were deliberately sourced from male and female individuals. For mouse experim...
Dose-dependent IFN programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination
Clinical Research and Public HealthImmunologyPublic Health Open Access | 10.1172/jci.insight.199245 ...
SARS-CoV-2 antibody–dependent enhancement of infection depends on antibody binding to both ACE2 and Fc receptors
Research ArticleImmunologyVirology Open Access | 10.1172/jci.insight.197773 Natalia A. Kuzmin...
HDAC1 modulates sepsis-induced immunosuppression by driving the exhaustion of CD8+ T cells
Research ArticleImmunologyInfectious diseaseInflammation Open Access | 10.1172/jci.insight.197224 ...
New approaches to uncover COPD pathobiology and develop therapies
Review Open Access | 10.1172/jci.insight.199693 Yohannes Tesfaigzi,1 Ali Önder Yildirim,2...
Pathophysiological and therapeutic implications of C-type natriuretic peptide/cyclic GMP signaling in pulmonary fibrosis
Among various types of lung cells, GC-B expression is greatest in fibroblasts. The CNP receptor, GC-B, is expressed in se...
Characteristics of anti–integrin αvβ6 autoantibodies in patients with ulcerative colitis
Sex as a biological variable. This study included samples from 4 male and 3 female patients with UC. Sex was not consider...
IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies
Research ArticleHepatologyMetabolism Open Access | 10.1172/jci.insight.183247 Wen Gu,1 Ni...
Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling
scRNA-Seq captures muscle-resident SCs across healthy and denervated muscles. SC regenerative responses are activated by ...
Erythropoietin alleviates syndrome-associated intellectual disability and autism-like behavior in Zbtb20-haploinsufficient Primrose syndrome mouse model
Research ArticleClinical ResearchNeuroscience Open Access | 10.1172/jci.insight.200021 Martin...
A porcine commotio retinae model for preclinical evaluation of posttraumatic photoreceptor degeneration
Research ArticleNeuroscienceOphthalmology Open Access | 10.1172/jci.insight.192799 Juan Amara...
Characterization of the clonal hierarchy and immunophenotype of PTPN11 mutations in acute myeloid leukemia
Research ArticleHematologyOncology Open Access | 10.1172/jci.insight.193779 Sydney Fobare,1,2...
Pyruvate kinase deficiency modifies sickle hemoglobin carrier and sickle cell disease phenotypes in mice
AA, AS, and SS Townes mice with Pklr-null mutations are viable, lack PKR expression, and have intact expression of other ...
Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin
Sex as a biological variable. Sex was not considered as a biological variable. Both male and female mice were used in thi...
Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb coinfection in macaques
Research ArticleAIDS/HIVImmunologyInfectious disease Open Access | 10.1172/jci.insight.199314 ...
Phosphoproteomics identification of ERK-dependent activation of Rps6kb1 in cardiac hypertrophy
Research ArticleCardiologyCell biology Open Access | 10.1172/jci.insight.190760 Chao Li,1,2 ...
Unbiased cleavage site prediction uncovers viral antagonism of host innate immunity by SARS-CoV-2 3C-like protease
Research ArticleCOVID-19Virology Open Access | 10.1172/jci.insight.185739 Nora Yucel,1 Si...
Comparative accuracy of telecytology and in-person rapid on-site evaluation by specimen source: A multi-campus analysis
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
The diagnostic utility and frequency of CD56 expression in plasma cell myeloma
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Clinicopathological features of hepatic Langerhans cell histiocytosis: report of ten cases and review of the literature
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Spread through air spaces (STAS) in lung adenocarcinoma: Prognostic impact of morphologic patterns, density, and extent
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Clinicopathological characterization of gastric amphicrine carcinoma: A case series
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Pulmonary intravascular mononuclear cell accumulation in cases of mechanical asphyxia due to external neck compression
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Interval appendicitis
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Novel RUNX1/2 fusions in unclassified cystic squamous salivary gland tumors: Possible expansion of the keratocystoma family
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Diagnostic value of dystrophin immunostaining for histopathologic diagnosis of uterine smooth muscle tumors
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
From the archives of MD Anderson Cancer Center: Paraneoplastic autoimmune multiorgan syndrome (PAMS) associated with stroma-rich Castleman disease
All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
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