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The hunter becomes the hunted in target-directed microRNA degradation
The hunter becomes the hunted in target-directed microRNA degradation
Two 2010 papers showed that microRNA interactions with certain RNAs result not in target destruction but in the decay of t...
Mechanisms of human germ cell development
Mechanisms of human germ cell development
Human germ cells are the foundation of human reproduction and development, ensuring heredity and contributing to genetic d...
AI will create the next generation of user-friendly interfaces
AI will create the next generation of user-friendly interfaces
Artificial intelligence (AI) will enable scientists to interact with computational tools in plain language, increasing the...
Turning the replisome around
A 2017 cryo-electron microscopy structure that resolved the orientation of the replicative helicase CMG at the DNA replica...
Tissue injury leads to the accumulation of somatic mtDNA mutations
Tissue injury leads to the accumulation of somatic mtDNA mutations
Acute kidney injury induces somatic mitochondrial DNA mutations that impair energy metabolism and the resilience of kidney...
Visions of the future of molecular cell biology
Visions of the future of molecular cell biology
To celebrate the journal’s 25th anniversary, we asked 13 researchers to offer a glimpse of what their research field...
Coordination of cardiogenesis in vivo and in vitro
Coordination of cardiogenesis in vivo and in vitro
Heart development has been extensively explored on the anatomical, cellular and molecular levels. Yet, the intricate inter...
The emergence of MARUbe — a hybrid ADP-ribose–ubiquitin modification
Evidence is mounting that crosstalk between ubiquitylation and ADP-ribosylation is crucial for maintaining proteostasis. R...
AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition
AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition
Debate regarding the premature aging of knee joints in acquired immune deficiency syndrome (AIDS) patients has remained co...
Current cutting-edge omics techniques on musculoskeletal tissues and diseases
Current cutting-edge omics techniques on musculoskeletal tissues and diseases
Musculoskeletal disorders, including osteoarthritis, rheumatoid arthritis, osteoporosis, bone fracture, intervertebral dis...
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Itaconate, a macrophage-specific anti-inflammatory metabolite, has recently emerged as a critical regulator in rheumatoid ...
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease in which synovial fibroblasts (SFs) maintain chronic inflammati...
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory p...
Different role of the gut microbiota in postmenopausal and senile osteoporosis
Different role of the gut microbiota in postmenopausal and senile osteoporosis
Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55–71 (2021).Art...
Pathophysiology of Myopenia in rheumatoid arthritis
Pathophysiology of Myopenia in rheumatoid arthritis
Rheumatoid arthritis (RA) is a prevalent and debilitating inflammatory disease that significantly impairs functional capac...
Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Membrane-initiated estrogen receptor α (mERα) signaling has been shown to affect bone mass in murine models. How...
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches
Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches
Spina bifida (SB) is a severe birth defect that affects 1400 newborns annually in the USA. SB is often diagnosed before ir...
TRASCET—Transamniotic Stem Cell Therapy
TRASCET—Transamniotic Stem Cell Therapy
This is an overview of the current state of development of transamniotic stem cell therapy (TRASCET) as an emerging therap...
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
The maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a cor...
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Prenatal intervention for congenital diseases could potentially halt or reverse devastating co-morbidities. Particle-based...
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
There is an urgent unmet clinical need for effective therapies for obstetric complications such as fetal growth restrictio...
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
This concise review delves into the pivotal role of three-dimensional (3D) nanostructured scaffolds in fostering mesenchym...
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of t...
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
To review recent research using various stem cell-related therapies, including bone marrow, adipose tissue, hematopoietic ...
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Mesenchymal Stromal/Stem Cells (MSCs) include a population of cells that are predominantly stromal cells with a small frac...
Human Induced Pluripotent Stem Cells for Advancing Regenerative Medicine in Space
Human Induced Pluripotent Stem Cells for Advancing Regenerative Medicine in Space
Space medicine research investigates the effects of microgravity on physiological systems to improve both astronaut health...
Role of Mesenchymal Stem Cells in Skin Aging and Damage: Insights from Recent Preclinical and Clinical Studies
Role of Mesenchymal Stem Cells in Skin Aging and Damage: Insights from Recent Preclinical and Clinical Studies
As interest in healthy lifestyles and youthfulness grows, anti-aging research has become increasingly popular among health...
Microenvironmental determinants of endothelial cell heterogeneity
Microenvironmental determinants of endothelial cell heterogeneity
During development, endothelial cells (ECs) undergo an extraordinary specialization by which generic capillary microcircul...
The centromere as a tag of self-DNA
The centromere as a tag of self-DNA
Intriguing findings in yeast suggested that centromeres ‘tag’ DNA as self and allow its condensation during mi...
Silencing centromeres with age
Silencing centromeres with age
Centromeres are silenced in aged cells by the epigenetic downregulation of centromere transcription.
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