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In-cell chemistry enables discovery of cyclic peptide transcription factor inhibitors
In-cell chemistry enables discovery of cyclic peptide transcription factor inhibitors
In this Tools of the Trade article, Brennan (Mason lab) describes a method that enables cyclization and screening of genet...
Prevailing views of cell senescence overlook its biological complexity
Although cell senescence is framed mainly as a stress response that promotes ageing, it is also programmed and evolutionar...
The PANoptosis hypothesis examined
The PANoptosis hypothesis examined
Danger signals have been reported to induce a PANoptosome complex, enabling the simultaneous induction of pyroptotic, apop...
The regulation, function and disease relevance of cytoplasmic tRNAs
The regulation, function and disease relevance of cytoplasmic tRNAs
Transfer RNAs (tRNAs) are core components of protein synthesis. Recent studies and technological advances have expanded ou...
Molecular mechanisms and biotechnology applications of CRISPR–Cas12a
Molecular mechanisms and biotechnology applications of CRISPR–Cas12a
CRISPR–Cas12a is a versatile RNA-guided nuclease that has rapidly gained prominence for its dual functionality in ge...
New developments and applications of human organoids
New developments and applications of human organoids
Organoid technology offers unique opportunities for studying human biology and disease in vitro. Organoids are self-organi...
RNA modifications: one ring to map them all
RNA modifications: one ring to map them all
Direct RNA sequencing by the Oxford nanopore technology enabled simultaneous mapping of different RNA modifications on the...
HAK-actin brings F-actin into focus in expansion microscopy
HAK-actin brings F-actin into focus in expansion microscopy
In this Tools of the Trade article, Mercey and Lemaitre (Hamel and Guichard lab) present an actin-labelling probe compatib...
The role of the lymphatic system in musculoskeletal system health and disease: research progress and future directions
The role of the lymphatic system in musculoskeletal system health and disease: research progress and future directions
The lymphatic system is widely distributed in skeletal muscles, joints, and skeletal tissues and plays a key role in maint...
Bone sialoprotein: a multifunctional regulator of bone remodelling and tumour progression
Bone sialoprotein: a multifunctional regulator of bone remodelling and tumour progression
Bone sialoprotein (BSP) is a major non-collagenous protein of the bone extracellular matrix and an important regulator of ...
Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization
Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization
Thrombospondin 1 and 2 (TSP1 and TSP2) are critical regulators of extracellular matrix (ECM) interactions, influencing cel...
Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration
Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration
Nociceptive pain is a cardinal feature of traumatic and inflammatory bone diseases. However, whether and how nociceptors a...
PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice
PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice
During aging, the spine undergoes degenerative changes, particularly with vertebral endplate bone expansion and sclerosis,...
Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing
Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing
Advanced age impairs bone fracture healing; the underlying mechanism of this phenomenon remains unknown. We determined tha...
Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging
Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging
Osteoarthritis (OA) is a degenerative skeletal condition marked by the loss of articular cartilage and changes to subchond...
Microenvironmental stiffness directs microtubule perturbation in chondrocyte mitosis via ILK-refilinB/Smad3 axis
Microenvironmental stiffness directs microtubule perturbation in chondrocyte mitosis via ILK-refilinB/Smad3 axis
Cells actively sense and transduce microenvironmental mechanical inputs into chemical signals via cytoskeletal rearrangeme...
Review of Disruptive Technologies in 3D Bioprinting
Review of Disruptive Technologies in 3D Bioprinting
The purpose of this review is to share insights from recognized experts in 3D biopriniting on the recent advances in these...
Protein Crystallization in Microgravity: Commercialization and the Next Chapter
Protein Crystallization in Microgravity: Commercialization and the Next Chapter
The purpose of this review is to describe the benefit of growing crystals in a microgravity environment and the changes we...
New Disruptive Technologies: Early-Stage Funding and Investment Trends
New Disruptive Technologies: Early-Stage Funding and Investment Trends
This paper provides a discussion of the investment climate in the life sciences industry. The authors explore recent and l...
Physiological Relevant 3D Biomanufacturing of Pluripotent Stem Cells for Regenerative Medicine
Physiological Relevant 3D Biomanufacturing of Pluripotent Stem Cells for Regenerative Medicine
Regenerative medicine is transforming modern healthcare by offering personalized approaches to the treatment of diseases a...
Artificial Intelligence in Biotechnology and Pharmaceuticals: Evolution, Applications, and Regulatory Frontiers
Artificial Intelligence in Biotechnology and Pharmaceuticals: Evolution, Applications, and Regulatory Frontiers
This review aims to examine how Artificial Intelligence (AI) is revolutionizing the biotechnology and pharmaceutical indus...
Denosumab Withdrawal and Rebound Bone Resorption: Molecular Mechanisms and Approaches for Treatment
Denosumab Withdrawal and Rebound Bone Resorption: Molecular Mechanisms and Approaches for Treatment
Denosumab (Dmab) is a human monoclonal anti-RANKL antibody that inhibits osteoclast-mediated bone resorption and sequentia...
From Brain Organoids to Organoid Intelligence. Benefits and Ethical-Moral Framework
From Brain Organoids to Organoid Intelligence. Benefits and Ethical-Moral Framework
Organoid intelligence (OI) is an emerging field in biological computing that integrates brain organoids with external inte...
The hunter becomes the hunted in target-directed microRNA degradation
The hunter becomes the hunted in target-directed microRNA degradation
Two 2010 papers showed that microRNA interactions with certain RNAs result not in target destruction but in the decay of t...
Mechanisms of human germ cell development
Mechanisms of human germ cell development
Human germ cells are the foundation of human reproduction and development, ensuring heredity and contributing to genetic d...
AI will create the next generation of user-friendly interfaces
AI will create the next generation of user-friendly interfaces
Artificial intelligence (AI) will enable scientists to interact with computational tools in plain language, increasing the...
Turning the replisome around
A 2017 cryo-electron microscopy structure that resolved the orientation of the replicative helicase CMG at the DNA replica...
Tissue injury leads to the accumulation of somatic mtDNA mutations
Tissue injury leads to the accumulation of somatic mtDNA mutations
Acute kidney injury induces somatic mitochondrial DNA mutations that impair energy metabolism and the resilience of kidney...
Visions of the future of molecular cell biology
Visions of the future of molecular cell biology
To celebrate the journal’s 25th anniversary, we asked 13 researchers to offer a glimpse of what their research field...
Coordination of cardiogenesis in vivo and in vitro
Coordination of cardiogenesis in vivo and in vitro
Heart development has been extensively explored on the anatomical, cellular and molecular levels. Yet, the intricate inter...
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