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The role of the lymphatic system in musculoskeletal system health and disease: research progress and future directions
The role of the lymphatic system in musculoskeletal system health and disease: research progress and future directions
The lymphatic system is widely distributed in skeletal muscles, joints, and skeletal tissues and plays a key role in maint...
Bone sialoprotein: a multifunctional regulator of bone remodelling and tumour progression
Bone sialoprotein: a multifunctional regulator of bone remodelling and tumour progression
Bone sialoprotein (BSP) is a major non-collagenous protein of the bone extracellular matrix and an important regulator of ...
Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization
Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization
Thrombospondin 1 and 2 (TSP1 and TSP2) are critical regulators of extracellular matrix (ECM) interactions, influencing cel...
Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration
Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration
Nociceptive pain is a cardinal feature of traumatic and inflammatory bone diseases. However, whether and how nociceptors a...
PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice
PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice
During aging, the spine undergoes degenerative changes, particularly with vertebral endplate bone expansion and sclerosis,...
Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing
Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing
Advanced age impairs bone fracture healing; the underlying mechanism of this phenomenon remains unknown. We determined tha...
Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging
Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging
Osteoarthritis (OA) is a degenerative skeletal condition marked by the loss of articular cartilage and changes to subchond...
Microenvironmental stiffness directs microtubule perturbation in chondrocyte mitosis via ILK-refilinB/Smad3 axis
Microenvironmental stiffness directs microtubule perturbation in chondrocyte mitosis via ILK-refilinB/Smad3 axis
Cells actively sense and transduce microenvironmental mechanical inputs into chemical signals via cytoskeletal rearrangeme...
AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition
AIDS patients suffer higher risk of advanced knee osteoarthritis progression due to lopinavir-induced Zmpste24 inhibition
Debate regarding the premature aging of knee joints in acquired immune deficiency syndrome (AIDS) patients has remained co...
Current cutting-edge omics techniques on musculoskeletal tissues and diseases
Current cutting-edge omics techniques on musculoskeletal tissues and diseases
Musculoskeletal disorders, including osteoarthritis, rheumatoid arthritis, osteoporosis, bone fracture, intervertebral dis...
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis
Itaconate, a macrophage-specific anti-inflammatory metabolite, has recently emerged as a critical regulator in rheumatoid ...
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease in which synovial fibroblasts (SFs) maintain chronic inflammati...
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration
Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory p...
Different role of the gut microbiota in postmenopausal and senile osteoporosis
Different role of the gut microbiota in postmenopausal and senile osteoporosis
Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55–71 (2021).Art...
Pathophysiology of Myopenia in rheumatoid arthritis
Pathophysiology of Myopenia in rheumatoid arthritis
Rheumatoid arthritis (RA) is a prevalent and debilitating inflammatory disease that significantly impairs functional capac...
Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Membrane-initiated estrogen receptor α (mERα) signaling has been shown to affect bone mass in murine models. How...
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral nerve end...
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent tr...
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as ...
A new perspective on intervertebral disc calcification—from bench to bedside
A new perspective on intervertebral disc calcification—from bench to bedside
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to unders...
The role and applications of extracellular vesicles in osteoporosis
The role and applications of extracellular vesicles in osteoporosis
Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture...
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized ...
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but ...
Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues, including cartilage, bone, sy...
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amou...
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Bone formation is a highly energy-demanding process that can be impacted by metabolic disorders. Glucose has been consider...
Structure and function of the membrane microdomains in osteoclasts
Structure and function of the membrane microdomains in osteoclasts
The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed ...
Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways
Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways
Hand osteoarthritis is a common heterogeneous joint disorder with unclear molecular mechanisms and no disease-modifying dr...
Spatial transcriptomic interrogation of the murine bone marrow signaling landscape
Spatial transcriptomic interrogation of the murine bone marrow signaling landscape
Self-renewal and differentiation of skeletal stem and progenitor cells (SSPCs) are tightly regulated processes, with SSPC ...
Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization
Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization
Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic calcification and pathological calcif...
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