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Microenvironmental determinants of endothelial cell heterogeneity
Microenvironmental determinants of endothelial cell heterogeneity
During development, endothelial cells (ECs) undergo an extraordinary specialization by which generic capillary microcircul...
The centromere as a tag of self-DNA
The centromere as a tag of self-DNA
Intriguing findings in yeast suggested that centromeres ‘tag’ DNA as self and allow its condensation during mi...
Silencing centromeres with age
Silencing centromeres with age
Centromeres are silenced in aged cells by the epigenetic downregulation of centromere transcription.
Expanding the genetic code for site-specific lysine lactylation
Expanding the genetic code for site-specific lysine lactylation
In this Tools of the Trade article, Zong (Zhou lab) describes how using genetic code expansion enabled the precise incorpo...
The bystander effect of pyroptosis
The bystander effect of pyroptosis
This study uncovered how extracellular vesicles carrying gasdermin D pores propagate pyroptosis between cells, exacerbatin...
Unravelling the complexity of gene regulation through multiplexed protein mapping
Unravelling the complexity of gene regulation through multiplexed protein mapping
In this Tools of the Trade article, Goronzy (Guttman lab) describes the development of ChIP-DIP, a high-throughput, split-...
Regulation and function of insulin and insulin-like growth factor receptor signalling
Regulation and function of insulin and insulin-like growth factor receptor signalling
Receptors of insulin and insulin-like growth factors (IGFs) are receptor tyrosine kinases whose signalling controls multip...
The molecular basis of translation initiation and its regulation in eukaryotes
The molecular basis of translation initiation and its regulation in eukaryotes
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional regulation of gene expressi...
Does species-specific alternative splicing make us human?
Florian Heyd describes a paper that pointed towards alternative splicing as a driver of human cognitive abilities.
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdow...
Local and systemic mechanisms that control the hair follicle stem cell niche
Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregul...
Extended heterochronic parabiosis as an approach to study rejuvenation
In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis...
Senescent cells support limb regeneration
Yu et al. identify senescent cells as important players in the regeneration of complex structures.
The nuance in DNA and transcription factor interactions
The nuance in DNA and transcription factor interactions
Emily Wong describes a study that provided a quantitative methodology for analyzing ChIP experiments and shifted ...
Probing cytoskeletal remodelling by cutting and marking filaments
In this Tools of the Trade article, Manuela Richter (Dumont lab) describes a method to probe mechanisms of cytoskeletal ne...
The molecular basis for cellular function of intrinsically disordered protein regions
The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable...
Mechanisms of SNARE proteins in membrane fusion
Mechanisms of SNARE proteins in membrane fusion
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of small conserved eukaryotic...
Challenges and opportunities in macromolecular structure determination
Embedded within the complexity of biological systems lies a formidable task: deciphering the intricate architecture of mac...
Mechanism of sperm mtDNA elimination
Mechanism of sperm mtDNA elimination
Phosphorylation of the mitochondrial DNA (mtDNA) maintenance factor TFAM during spermatogenesis prevents its import into m...
ERMES — from myths to molecules
Ernst and Renne highlight two papers, one that discovered and another that structurally defined the ER–mitochondria ...
Activation of human endogenous retroviruses and its physiological consequences
Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the human genome as remnants of ancient r...
Base editing of organellar DNA with programmable deaminases
Base editing of organellar DNA with programmable deaminases
Mitochondria and chloroplasts are organelles that include their own genomes, which encode key genes for ATP production and...
Gene silencing during oocyte specification requires heterochromatin and nucleoporins
Gene silencing during oocyte specification requires heterochromatin and nucleoporins
Sarkar et al. identify a feedback loop between the methyltransferase SETDB1 and nuclear pore complexes that ensures silenc...
mTOR inhibits starvation-induced nuclear export of the proteasome
mTOR inhibits starvation-induced nuclear export of the proteasome
mTOR inhibition by deprivation of the amino acids Tyr, Trp and Phe promotes the translocation of the 26S proteasome from t...
Identification of phase separating proteins associated with human disease
In this Tools of the Trade article, Christine Lim and Alicia González Díaz (Vendruscolo lab) describe a pipeline...
Mechanisms and regulation of human mitochondrial transcription
Mechanisms and regulation of human mitochondrial transcription
The expression of mitochondrial genes is regulated in response to the metabolic needs of different cell types, but the bas...
Mechanisms controlling cellular and systemic iron homeostasis
Mechanisms controlling cellular and systemic iron homeostasis
In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital processes such as mitochon...
Lasker Award for AlphaFold
Congratulations to John Jumper and Demis Hassabis for winning the 2023 Albert Lasker Basic Medical Research Award.
Mitochondrial proteome research: the road ahead
Mitochondrial proteome research: the road ahead
Mitochondria are multifaceted organelles with key roles in anabolic and catabolic metabolism, bioenergetics, cellular sign...
A quick guide to (transmembrane) planar cell polarity mouse strains
In this Tools of the Trade article, Sarah Paramore (from the Devenport and Nelson labs) discusses the use of mouse strains...
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