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The hunter becomes the hunted in target-directed microRNA degradation
The hunter becomes the hunted in target-directed microRNA degradation
Two 2010 papers showed that microRNA interactions with certain RNAs result not in target destruction but in the decay of t...
Mechanisms of human germ cell development
Mechanisms of human germ cell development
Human germ cells are the foundation of human reproduction and development, ensuring heredity and contributing to genetic d...
AI will create the next generation of user-friendly interfaces
AI will create the next generation of user-friendly interfaces
Artificial intelligence (AI) will enable scientists to interact with computational tools in plain language, increasing the...
Turning the replisome around
A 2017 cryo-electron microscopy structure that resolved the orientation of the replicative helicase CMG at the DNA replica...
Tissue injury leads to the accumulation of somatic mtDNA mutations
Tissue injury leads to the accumulation of somatic mtDNA mutations
Acute kidney injury induces somatic mitochondrial DNA mutations that impair energy metabolism and the resilience of kidney...
Visions of the future of molecular cell biology
Visions of the future of molecular cell biology
To celebrate the journal’s 25th anniversary, we asked 13 researchers to offer a glimpse of what their research field...
Coordination of cardiogenesis in vivo and in vitro
Coordination of cardiogenesis in vivo and in vitro
Heart development has been extensively explored on the anatomical, cellular and molecular levels. Yet, the intricate inter...
The emergence of MARUbe — a hybrid ADP-ribose–ubiquitin modification
Evidence is mounting that crosstalk between ubiquitylation and ADP-ribosylation is crucial for maintaining proteostasis. R...
Microenvironmental determinants of endothelial cell heterogeneity
Microenvironmental determinants of endothelial cell heterogeneity
During development, endothelial cells (ECs) undergo an extraordinary specialization by which generic capillary microcircul...
The centromere as a tag of self-DNA
The centromere as a tag of self-DNA
Intriguing findings in yeast suggested that centromeres ‘tag’ DNA as self and allow its condensation during mi...
Silencing centromeres with age
Silencing centromeres with age
Centromeres are silenced in aged cells by the epigenetic downregulation of centromere transcription.
Expanding the genetic code for site-specific lysine lactylation
Expanding the genetic code for site-specific lysine lactylation
In this Tools of the Trade article, Zong (Zhou lab) describes how using genetic code expansion enabled the precise incorpo...
The bystander effect of pyroptosis
The bystander effect of pyroptosis
This study uncovered how extracellular vesicles carrying gasdermin D pores propagate pyroptosis between cells, exacerbatin...
Unravelling the complexity of gene regulation through multiplexed protein mapping
Unravelling the complexity of gene regulation through multiplexed protein mapping
In this Tools of the Trade article, Goronzy (Guttman lab) describes the development of ChIP-DIP, a high-throughput, split-...
Regulation and function of insulin and insulin-like growth factor receptor signalling
Regulation and function of insulin and insulin-like growth factor receptor signalling
Receptors of insulin and insulin-like growth factors (IGFs) are receptor tyrosine kinases whose signalling controls multip...
The molecular basis of translation initiation and its regulation in eukaryotes
The molecular basis of translation initiation and its regulation in eukaryotes
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional regulation of gene expressi...
Does species-specific alternative splicing make us human?
Florian Heyd describes a paper that pointed towards alternative splicing as a driver of human cognitive abilities.
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdow...
Local and systemic mechanisms that control the hair follicle stem cell niche
Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregul...
Extended heterochronic parabiosis as an approach to study rejuvenation
In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis...
Senescent cells support limb regeneration
Yu et al. identify senescent cells as important players in the regeneration of complex structures.
The nuance in DNA and transcription factor interactions
The nuance in DNA and transcription factor interactions
Emily Wong describes a study that provided a quantitative methodology for analyzing ChIP experiments and shifted ...
Probing cytoskeletal remodelling by cutting and marking filaments
In this Tools of the Trade article, Manuela Richter (Dumont lab) describes a method to probe mechanisms of cytoskeletal ne...
The molecular basis for cellular function of intrinsically disordered protein regions
The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable...
Mechanisms of SNARE proteins in membrane fusion
Mechanisms of SNARE proteins in membrane fusion
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of small conserved eukaryotic...
Challenges and opportunities in macromolecular structure determination
Embedded within the complexity of biological systems lies a formidable task: deciphering the intricate architecture of mac...
Mechanism of sperm mtDNA elimination
Mechanism of sperm mtDNA elimination
Phosphorylation of the mitochondrial DNA (mtDNA) maintenance factor TFAM during spermatogenesis prevents its import into m...
ERMES — from myths to molecules
Ernst and Renne highlight two papers, one that discovered and another that structurally defined the ER–mitochondria ...
Activation of human endogenous retroviruses and its physiological consequences
Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the human genome as remnants of ancient r...
Base editing of organellar DNA with programmable deaminases
Base editing of organellar DNA with programmable deaminases
Mitochondria and chloroplasts are organelles that include their own genomes, which encode key genes for ATP production and...
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