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In-cell chemistry enables discovery of cyclic peptide transcription factor inhibitors
In-cell chemistry enables discovery of cyclic peptide transcription factor inhibitors
In this Tools of the Trade article, Brennan (Mason lab) describes a method that enables cyclization and screening of genet...
Prevailing views of cell senescence overlook its biological complexity
Although cell senescence is framed mainly as a stress response that promotes ageing, it is also programmed and evolutionar...
The PANoptosis hypothesis examined
The PANoptosis hypothesis examined
Danger signals have been reported to induce a PANoptosome complex, enabling the simultaneous induction of pyroptotic, apop...
The regulation, function and disease relevance of cytoplasmic tRNAs
The regulation, function and disease relevance of cytoplasmic tRNAs
Transfer RNAs (tRNAs) are core components of protein synthesis. Recent studies and technological advances have expanded ou...
Molecular mechanisms and biotechnology applications of CRISPR–Cas12a
Molecular mechanisms and biotechnology applications of CRISPR–Cas12a
CRISPR–Cas12a is a versatile RNA-guided nuclease that has rapidly gained prominence for its dual functionality in ge...
New developments and applications of human organoids
New developments and applications of human organoids
Organoid technology offers unique opportunities for studying human biology and disease in vitro. Organoids are self-organi...
RNA modifications: one ring to map them all
RNA modifications: one ring to map them all
Direct RNA sequencing by the Oxford nanopore technology enabled simultaneous mapping of different RNA modifications on the...
HAK-actin brings F-actin into focus in expansion microscopy
HAK-actin brings F-actin into focus in expansion microscopy
In this Tools of the Trade article, Mercey and Lemaitre (Hamel and Guichard lab) present an actin-labelling probe compatib...
The hunter becomes the hunted in target-directed microRNA degradation
The hunter becomes the hunted in target-directed microRNA degradation
Two 2010 papers showed that microRNA interactions with certain RNAs result not in target destruction but in the decay of t...
Mechanisms of human germ cell development
Mechanisms of human germ cell development
Human germ cells are the foundation of human reproduction and development, ensuring heredity and contributing to genetic d...
AI will create the next generation of user-friendly interfaces
AI will create the next generation of user-friendly interfaces
Artificial intelligence (AI) will enable scientists to interact with computational tools in plain language, increasing the...
Turning the replisome around
A 2017 cryo-electron microscopy structure that resolved the orientation of the replicative helicase CMG at the DNA replica...
Tissue injury leads to the accumulation of somatic mtDNA mutations
Tissue injury leads to the accumulation of somatic mtDNA mutations
Acute kidney injury induces somatic mitochondrial DNA mutations that impair energy metabolism and the resilience of kidney...
Visions of the future of molecular cell biology
Visions of the future of molecular cell biology
To celebrate the journal’s 25th anniversary, we asked 13 researchers to offer a glimpse of what their research field...
Coordination of cardiogenesis in vivo and in vitro
Coordination of cardiogenesis in vivo and in vitro
Heart development has been extensively explored on the anatomical, cellular and molecular levels. Yet, the intricate inter...
The emergence of MARUbe — a hybrid ADP-ribose–ubiquitin modification
Evidence is mounting that crosstalk between ubiquitylation and ADP-ribosylation is crucial for maintaining proteostasis. R...
Microenvironmental determinants of endothelial cell heterogeneity
Microenvironmental determinants of endothelial cell heterogeneity
During development, endothelial cells (ECs) undergo an extraordinary specialization by which generic capillary microcircul...
The centromere as a tag of self-DNA
The centromere as a tag of self-DNA
Intriguing findings in yeast suggested that centromeres ‘tag’ DNA as self and allow its condensation during mi...
Silencing centromeres with age
Silencing centromeres with age
Centromeres are silenced in aged cells by the epigenetic downregulation of centromere transcription.
Expanding the genetic code for site-specific lysine lactylation
Expanding the genetic code for site-specific lysine lactylation
In this Tools of the Trade article, Zong (Zhou lab) describes how using genetic code expansion enabled the precise incorpo...
The bystander effect of pyroptosis
The bystander effect of pyroptosis
This study uncovered how extracellular vesicles carrying gasdermin D pores propagate pyroptosis between cells, exacerbatin...
Unravelling the complexity of gene regulation through multiplexed protein mapping
Unravelling the complexity of gene regulation through multiplexed protein mapping
In this Tools of the Trade article, Goronzy (Guttman lab) describes the development of ChIP-DIP, a high-throughput, split-...
Regulation and function of insulin and insulin-like growth factor receptor signalling
Regulation and function of insulin and insulin-like growth factor receptor signalling
Receptors of insulin and insulin-like growth factors (IGFs) are receptor tyrosine kinases whose signalling controls multip...
The molecular basis of translation initiation and its regulation in eukaryotes
The molecular basis of translation initiation and its regulation in eukaryotes
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional regulation of gene expressi...
Does species-specific alternative splicing make us human?
Florian Heyd describes a paper that pointed towards alternative splicing as a driver of human cognitive abilities.
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling through macromolecular breakdow...
Local and systemic mechanisms that control the hair follicle stem cell niche
Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregul...
Extended heterochronic parabiosis as an approach to study rejuvenation
In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis...
Senescent cells support limb regeneration
Yu et al. identify senescent cells as important players in the regeneration of complex structures.
The nuance in DNA and transcription factor interactions
The nuance in DNA and transcription factor interactions
Emily Wong describes a study that provided a quantitative methodology for analyzing ChIP experiments and shifted ...
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