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Novel peptaibiotics identified from clade
Novel peptaibiotics identified from clade
This study focuses on the peptaibiome produced by different species of Trichoderma belonging to clade Viride: T. koningii ...
Initial shoot regeneration in the selenium hyperaccumulator and in vitro test system for selenium tolerance and accumulation
Initial shoot regeneration in the selenium hyperaccumulator and in vitro test system for selenium tolerance and accumulation
The trace element selenium is essential for human nutrition but is distributed unevenly in soils worldwide with&a...
Ginkgetin from : mechanistic insights into anticancer efficacy
Ginkgetin from : mechanistic insights into anticancer efficacy
The extraction of anticancer agents from medicinal plants represents a highly promising research frontier. Ginkgetin, a na...
Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives
Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives
Natural product tanshinone I exhibits weak potency and poor drug-like properties, which have restricted its clinical devel...
Harnessing Actinobacteria secondary metabolites for tuberculosis drug discovery: Historical trends, current status and future outlooks
Harnessing Actinobacteria secondary metabolites for tuberculosis drug discovery: Historical trends, current status and future outlooks
Tuberculosis (TB) is a leading infectious disease killer and one of the major causes of deaths worldwide. Although TB is a...
Correction: Xiaoyankangjun tablet alleviates dextran sulfate sodium‑induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway
Correction: Xiaoyankangjun tablet alleviates dextran sulfate sodium‑induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Concise syntheses of natural diarylheptanoids containing a 1,4‑pentadiene unit
Correction: Concise syntheses of natural diarylheptanoids containing a 1,4‑pentadiene unit
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy
Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy
Modern pharmacology has found that both Realgar and Coptis chinensis can induce apoptosis in tumor cells, and traditional ...
Senkyunolide H reverses depression-induced breast cancer progression by regulating CXCR2
Senkyunolide H reverses depression-induced breast cancer progression by regulating CXCR2
Depression promotes breast cancer progression. Given the lack of specific targets for depression-associated breast cancer,...
(+)-/(−)-Ormohenins A and B, two pairs of ormosanine-type enantiomers and their derivatives with neuroprotective activity from Prain
(+)-/(−)-Ormohenins A and B, two pairs of ormosanine-type enantiomers and their derivatives with neuroprotective activity from Prain
Two pairs of undescribed alkaloid enantiomers, (+)-/(−)-ormohenins A (1) and B (2), were isolated from the seeds of ...
Correction: New acetogenin katsuurallene from collected from Katsuura, Japan
Correction: New acetogenin katsuurallene from collected from Katsuura, Japan
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
A novel polysaccharide in : structure elucidation, the activities of anti-inflammatory and the regulation of gut microbiota in vitro
A novel polysaccharide in : structure elucidation, the activities of anti-inflammatory and the regulation of gut microbiota in vitro
Polysaccharides are the primary active constituents of Polygonatum kingianum Coll. et Hemsl. However, the comprehensive ch...
Stingless bee propolis: a comprehensive review of chemical constituents and health efficacy
Stingless bee propolis: a comprehensive review of chemical constituents and health efficacy
Propolis, consisting of plant-derived materials, wax, and bee secretions, is abundant in bioactive constituents like flavo...
Nidulin stimulates glucose uptake in myotubes through the IRS-AKT pathway and alters redox balance and intracellular calcium
Nidulin stimulates glucose uptake in myotubes through the IRS-AKT pathway and alters redox balance and intracellular calcium
Nidulin is a secondary metabolite of the depsidone family produced by Aspergillus spp., and has shown promises in pharmaco...
Chalasoergodimers A–E, heterodimers with multiple polymerization modes from a marine-derived sp. fungus
Chalasoergodimers A–E, heterodimers with multiple polymerization modes from a marine-derived sp. fungus
Five new heterodimers, chalasoergodimers A–E (1–5), and three known heterodimers (6–8), along with four ...
Kaemphenolide: a cyclobutane-bearing phenylpropanoid from L. with nitric oxide inhibitory activity
Kaemphenolide: a cyclobutane-bearing phenylpropanoid from L. with nitric oxide inhibitory activity
An undescribed phenylpropanoid dimer featuring a rare cyclobutane ring was isolated from the rhizomes of Kaempferia galang...
Mechanisms underlying the dynamic changes in tannins associated with food processing and plant growth
Mechanisms underlying the dynamic changes in tannins associated with food processing and plant growth
This review describes the chemical mechanisms behind the structural changes in selected tannins associated with food proce...
Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor
Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor
Pulmonary hypertension is a disease characterized by complex diagnosis, challenging treatment, and a shortage of clinical ...
Traditional medicine meets modern science: Halofuginone’s role in combating autoimmune diseases
Traditional medicine meets modern science: Halofuginone’s role in combating autoimmune diseases
Dichroa febrifuga Lour., a traditional Chinese medicinal herb historically used for malaria treatment, contains the active...
Anti-cancer activity of the glycyrrhetinic acid derivatives with an inhibitory inflammatory microenvironment
Anti-cancer activity of the glycyrrhetinic acid derivatives with an inhibitory inflammatory microenvironment
The tumor inflammatory microenvironment plays an important role in tumor development, and the compounds which modulate tum...
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression
Atractylodin (ATR) is a natural sesquiterpene compound primarily isolated from the rhizomes of Atractylodes, a plant of th...
Metabolite derived from green tea polyphenol increases and activates plasmacytoid dendritic cells
Metabolite derived from green tea polyphenol increases and activates plasmacytoid dendritic cells
The immune system plays a crucial role in protecting the body from harmful bacterial, viral infections and vital for cance...
Drimane sesquiterpenoids from cultures of basidiomycete
Drimane sesquiterpenoids from cultures of basidiomycete
Nine previously undescribed drimane sesquiterpenoids, ganoresinosins A–I (1–9), were isolated from cultures of...
Ameliorative role of leaf extract in aluminum chloride-induced neurotoxicity flies possibly mediated by -methyl--aspartate receptor antagonistic and anticholinesterase active compounds
Ameliorative role of leaf extract in aluminum chloride-induced neurotoxicity flies possibly mediated by -methyl--aspartate receptor antagonistic and anticholinesterase active compounds
Polyscias fruticosa leaves have been used in traditional medicine to aid in the therapy of brain and nerve-related disorde...
Apoptosis-inducing activity of a steroidal glycoside from G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress
Apoptosis-inducing activity of a steroidal glycoside from G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress
A saponin fraction from Allium chinense G. Don. bulbs has previously been reported to exhibit cytotoxicity against melanom...
ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation
ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation
Research context reveals that major depressive disorder (MDD), as a prevalent chronic relapsing psychiatric condition affe...
Advanced multidimensional quality evaluation of encapsulated peppermint oil products in various formulas
Advanced multidimensional quality evaluation of encapsulated peppermint oil products in various formulas
We investigated the actual label indications and quality of encapsulated peppermint oil (PO) products marketed as medicina...
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway
Osteoarthritis (OA) is the most common degenerative musculoskeletal disorder worldwide. Diosmetin is the aglycone of diosm...
Anti-allergic actions and pharmacokinetics of orally administered 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in mice
Anti-allergic actions and pharmacokinetics of orally administered 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in mice
In this study, we explored the anti-allergic actions of 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acids (18...
Unprecedented triterpenes with anti-inflammatory activity from
Unprecedented triterpenes with anti-inflammatory activity from
Four triterpenes with the unprecedented pentacyclic skeletons were isolated from Limax maximus, the traditional medicine o...
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