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Small molecular inhibitors targeting Janus kinases (JAKs) for the treatment of psoriasis
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Orphan GPCRs regulate the metabolic liver diseases through mediating the crosstalk between the liver and immune cells: Mechanisms and therapeutics
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Targeting p53 activation: Recent therapeutic advances in cancer and diabetic macular edema
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Recent advances in functional activatable probes for oncological surgery: Illuminating precision or hindering clinical translation?
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Discovery of thiazolylcyanovinyl benzopyridone acids: Potential new generation antibacterial oxacins?
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Discovery of novel hydrazinyl thiazole derivatives as potent anticancer agents by inhibiting eIF4E/eIF4G interactions
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Discovery of novel fluorescent amino-pyrazolines that detect and kill Mycobacterium tuberculosis
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Synthesis and evaluation of new 5-(1H-1,2,4-triazol-3-yl)-1,2,4-oxadiazole derivatives and their application as OXPHOS inhibitors
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Targeting dihydroorotate dehydrogenase (DHODH) for host-directed therapy: Discovery of a novel alkyne-based scaffold inhibitor effective against SARS-CoV-2
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Lead optimization of a CHI3L1 inhibitor for Glioblastoma: Enhanced target engagement, pharmacokinetics, and efficacy in 3D spheroid models
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Discovery of novel thiazolylhydrazone derivatives as potent anti-cancer agents inducing ferroptosis via direct NRF2 inhibition
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Synthesis and evaluation of lactam and maleimide derivatives of 16-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide from Polyalthia longifolia as potential anticancer agents
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Discovery of a novel Genipin derivative targeting YB-1 to enhance the P-glycoprotein-mediated paclitaxel sensitivity of paclitaxel-resistant non-small cell lung cancer
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1,3-Thiazole nucleus as promising molecular platform against antimicrobial resistance: a recent overview in drug discovery
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Discovery of SA-8 as a potent SHP2-AUTAC degrader in cancer therapy
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Recent advance of hypoxia-inducible factor prolyl hydroxylases inhibitors for anemia therapy
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Local enhancement of cationic charge density via polyamine side chain incorporation improves the selectivity of antimicrobial peptoids
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Design and synthesis of Riluzole-Ciprofloxacin hybrids as selective MST3 inhibitors for cancer treatment
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Highly potent dipeptidyl peptidase 8/9 (DPP8/9) inhibitors designed via relative binding free energy calculations
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Discovery of 3,4-dihydroisoquinoline-2(1H)-carboxamide STING inhibitors as anti-inflammatory agents
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Design, synthesis and antitumor activity study of tubulin/HDAC6 dual targeting inhibitor
Design, synthesis and antitumor activity study of tubulin/HDAC6 dual targeting inhibitor
Cancer combination therapy is a novel strategy to circumvent drug resistance in highly metastatic and advanced malignancie...
Pharmacological significance of palbociclib and its derivatives in cancer treatment and prevention: an update
Pharmacological significance of palbociclib and its derivatives in cancer treatment and prevention: an update
Palbociclib is a selective cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor that emerged as a significant therapeutic a...
Exploring putative histone deacetylase inhibitors with antiproliferative activity of chrysin derivatives
Exploring putative histone deacetylase inhibitors with antiproliferative activity of chrysin derivatives
Thirty-three derivatives of chrysin were designed and synthesized to evaluate biological activities. All compounds were ch...
Design and synthesis of novel 1-1,2,3-triazolecarbohydrazides and 1,2,4-triazoloazines based on them for anticancer drug discovery
Design and synthesis of novel 1-1,2,3-triazolecarbohydrazides and 1,2,4-triazoloazines based on them for anticancer drug discovery
The synthesis of (1H-1,2,3-triazol-4-yl)-1,2,4-triazolazine derivatives was achieved via a multi-step synthesis starting f...
Discovery of a novel selenamide derivative as potent activator of aldehyde dehydrogenase 2 for cardioprotective applications
Discovery of a novel selenamide derivative as potent activator of aldehyde dehydrogenase 2 for cardioprotective applications
Aldehyde dehydrogenase 2 (ALDH2), a mitochondrial enzyme, plays a pivotal role in the metabolism of endogenous reactive al...
Benzoxa-[2,1,3]-diazole substituted amino acid hydrazides as therapeutics for drug-resistant
Benzoxa-[2,1,3]-diazole substituted amino acid hydrazides as therapeutics for drug-resistant
The global burden of tuberculosis is on the rise and continues to be alarmingly high, with a notable prevalence of multidr...
Development of novel caffeic acid derivatives as multifunctional agents for the treatment of AD
Development of novel caffeic acid derivatives as multifunctional agents for the treatment of AD
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder for which the multi-target-directed ligand (MTD...
Design and discovery of POLQ helicase domain inhibitors by virtual screening and machine learning
Design and discovery of POLQ helicase domain inhibitors by virtual screening and machine learning
DNA polymerase theta (Polθ or POLQ) is an attractive target for treating BRCA-deficient cancers. In the present work,...
Nanosensing doxorubicin: a new frontier in medicinal chemistry
Nanosensing doxorubicin: a new frontier in medicinal chemistry
The advent of nanosensing technologies marks a significant advancement in medicinal chemistry, particularly in the detecti...
The inhibition of monoamine oxidase by 2-methylbenzo[]oxazole derivatives
The inhibition of monoamine oxidase by 2-methylbenzo[]oxazole derivatives
The monoamine oxidase (MAO) enzymes metabolise neurotransmitter amines and are drug targets for the treatment of neuropsyc...
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