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GNPS2 molecular networking reveals metabolic diversity in fungi isolated from protease-rich fruits
GNPS2 molecular networking reveals metabolic diversity in fungi isolated from protease-rich fruits
Fungi are a rich source of chemical diversity for bioprospecting, yet most of their metabolic potential remains unexplored...
Limonene and its metabolite perillyl alcohol inhibit Chlamydia trachomatis growth by altering host isoprenoid metabolism
Limonene and its metabolite perillyl alcohol inhibit Chlamydia trachomatis growth by altering host isoprenoid metabolism
The obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial sexually transmitted infection glo...
Deacetylforskolin ameliorates bleomycin-induced pulmonary fibrosis by suppressing inflammation and TGF-β1-induced epithelial–mesenchymal transition
Deacetylforskolin ameliorates bleomycin-induced pulmonary fibrosis by suppressing inflammation and TGF-β1-induced epithelial–mesenchymal transition
Pulmonary fibrosis (PF) is a chronic, progressive and irreversible inflammatory disease with limited therapeutic methods i...
Sophflarines F–K: matrine-based alkaloids with a rare aromatic system from and their anti-inflammatory and synergistic antibacterial effects
Sophflarines F–K: matrine-based alkaloids with a rare aromatic system from and their anti-inflammatory and synergistic antibacterial effects
Six new matrine-based alkaloids, sophflarines F–K (1–6), featuring a rare aromatic system, were obtained from ...
Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase
Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase
Peptides from natural sources have often served as valuable leads in drug discovery. Plant-derived protease inhibitors are...
Artificial intelligence-based screening of phytochemicals for targeted cancer therapy
Artificial intelligence-based screening of phytochemicals for targeted cancer therapy
Cancer remains one of the leading causes of death worldwide and continues to pose a serious public health challenge. The l...
Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in
Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in
Oxidative stress (OS) is a major contributor to aging and the pathogenesis of numerous conditions, including diabetes, neu...
Prenylated acylphloroglucinols from the fruits of
Prenylated acylphloroglucinols from the fruits of
Twenty-eight prenylated acylphloroglucinols, including the new hypulatones C–F (1–4), have been isolated from ...
Diversity of oligosaccharides in lipooligosaccharides of and its anti-atherosclerotic activity
Diversity of oligosaccharides in lipooligosaccharides of and its anti-atherosclerotic activity
As an important and beneficial gut commensal, Akkermansia muciniphila plays a crucial role in regulating host metabolism a...
Cytotoxic trichothecene derivatives from sp. DWS815
Cytotoxic trichothecene derivatives from sp. DWS815
Ten novel trichothecene sesquiterpenoids including two new seco-trichothecenes, trichotheciumones A (1) and B (2), a new t...
Facile synthesis and biological evaluation of glomuferrin and rhizoferrin as ferroptosis inhibitors in rice blast disease
Facile synthesis and biological evaluation of glomuferrin and rhizoferrin as ferroptosis inhibitors in rice blast disease
Iron homeostasis has recently emerged as a key determinant in the early stages of plant–pathogen interactions, parti...
Mechanistic insights into polyphenolic constituents from traditional Chinese medicines in inhibiting colorectal cancer metastasis
Mechanistic insights into polyphenolic constituents from traditional Chinese medicines in inhibiting colorectal cancer metastasis
Colorectal cancer (CRC) is the third most predominant cancer caused by genetic, environmental and nutritional factors and ...
First total synthesis of (±)-spirobroussonin B via electromediated oxidative coupling for constructing spirodienone ring
First total synthesis of (±)-spirobroussonin B via electromediated oxidative coupling for constructing spirodienone ring
An electromediated oxidative coupling strategy for constructing spirodienone fragment has been developed and applied as th...
Four new Cyclohexenone with antibacterial activity from the coral-derived fungus
Four new Cyclohexenone with antibacterial activity from the coral-derived fungus
Marine fungus-derived natural products are an important source of new drugs and lead compounds. In this study, guided by t...
New patchoulol- and guaiane-type sesquiterpenoids from with anti-melanogenic activity
New patchoulol- and guaiane-type sesquiterpenoids from with anti-melanogenic activity
Twelve new sesquiterpenoids, sanguisorbaols A–L (1–12), along with twenty-five known compounds (13–37), ...
Distribution and bioactivities of tirucallane-type triterpenoids from Meliaceae family
Distribution and bioactivities of tirucallane-type triterpenoids from Meliaceae family
Tirucallane-type triterpenoids are one of the most structurally diverse classes of secondary metabolites in Meliaceae fami...
Exploring the global mosaic of medicinal plant databases: unveiling nature’s pharmacopoeia
Exploring the global mosaic of medicinal plant databases: unveiling nature’s pharmacopoeia
Medicinal plants have long served as an important asset in the treatment of diseases. Recent developments in computer scie...
Elucidating therapeutic mechanisms of naringin and phloridzin on ulcerative colitis mice by metabolomics-based comparative analysis
Elucidating therapeutic mechanisms of naringin and phloridzin on ulcerative colitis mice by metabolomics-based comparative analysis
Naringin and phloridzin are structurally similar flavonoids with anti-inflammatory, antioxidant, and antimicrobial propert...
Rapid exploration of anti-MRSA components from plants of
Rapid exploration of anti-MRSA components from plants of
Plants of Salvia are frequently used for treatment infections of boils and sores in Traditional Chinese medicine, which mi...
Sesamol derivatives bearing a quinazolin moiety: synthesis, antifungal efficacy against tea plant pathogens, and mechanistic insights
Sesamol derivatives bearing a quinazolin moiety: synthesis, antifungal efficacy against tea plant pathogens, and mechanistic insights
Pestalotiopsis sp. and Colletotrichum camelliae are two devastating fungal pathogens that cause significant yield losses a...
Prognostic Value of Natriuretic Peptides for Delayed Cerebral Ischemia and Outcomes After Aneurysmal Subarachnoid Hemorrhage: An Updated-Systematic Review and Meta-Analysis
Prognostic Value of Natriuretic Peptides for Delayed Cerebral Ischemia and Outcomes After Aneurysmal Subarachnoid Hemorrhage: An Updated-Systematic Review and Meta-Analysis
Aneurysmal subarachnoid hemorrhage (aSAH) is a type of hemorrhagic stroke with high morbidity and mortality, with life-thr...
Data technologies in robotic sealing: a systematic review on inspection and quality control
Data technologies in robotic sealing: a systematic review on inspection and quality control
The application of sealants and adhesives is a critical step in modern manufacturing, essential for the structural and fun...
Geochemically aware domain adaptation (GADA) for real-time fluoride inference in heterogeneous aquifers of Tamil nadu, India
Geochemically aware domain adaptation (GADA) for real-time fluoride inference in heterogeneous aquifers of Tamil nadu, India
Groundwater fluoride contamination in Tamil Nadu’s geochemically diverse aquifers necessitates high-fidelity, cost-e...
Ultimate Tensile Strength Prediction and Modeling System for High-Strength Steel Welded Joints Based on Interpretable Machine Learning
Ultimate Tensile Strength Prediction and Modeling System for High-Strength Steel Welded Joints Based on Interpretable Machine Learning
The ultimate tensile strength (UTS) of high-strength steel (HSS) welded joints is a key indicator in welding procedure qua...
Simulation of transit-oriented development impacts on travel carbon and air pollutant emissions
Simulation of transit-oriented development impacts on travel carbon and air pollutant emissions
Rapid motorization poses challenges to transport decarbonization and air quality in China. The built environment shapes tr...
MnO nanoparticles supported on g-CN-M for the selective oxidation of cumene to 2-phenyl-2-propanol
MnO nanoparticles supported on g-CN-M for the selective oxidation of cumene to 2-phenyl-2-propanol
The synergistic interaction between carbon materials and metals has been widely utilized in industrial selective hydrocarb...
Interdisciplinary, community-engaged training on endocrine-disrupting chemicals: bridging science, communication, justice and policy for environmental health
Interdisciplinary, community-engaged training on endocrine-disrupting chemicals: bridging science, communication, justice and policy for environmental health
Endocrine-disrupting chemicals (EDCs) pose urgent threats to public and environmental health, disproportionately affecting...
Numerical investigation and acoustic detection of flow boiling regimes in a helical tube
Numerical investigation and acoustic detection of flow boiling regimes in a helical tube
Boiling acoustics (BA) offers a noninvasive approach for two-phase flow regime identification, yet its correlation with sp...
A decade after the Fundão Dam collapse: key findings from studies in the Doce River basin and adjacent coastal and marine environments
A decade after the Fundão Dam collapse: key findings from studies in the Doce River basin and adjacent coastal and marine environments
The Fundão tailings dam marks its 10th year of disaster in 2025, underscoring the need for a critical assessment of t...
Physics and chemistry perspectives on three unsolved problems in glass science
Physics and chemistry perspectives on three unsolved problems in glass science
The study of glasses and glass formation is a rich and technologically important area of research. This Perspective review...
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