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Synthesis and biological evaluation of Retro-2-based PROTACs reveal PEG-linker length and warhead impact on GSPT1 degradation
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Synthesis of potent human DHRS11 inhibitors and their efficacy against androgen-dependent proliferation and sensitivity to AKT inhibitor Capivasertib of triple-negative breast cancer cells
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Marine natural product-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivative CHNQD-01522: A novel anti-hepatocellular carcinoma agent targeting colchicine binding site of microtubule
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Structure-activity relationship of steroidal-nitroxide hybrids: Dual-modulators of glucocorticoid receptor signalling and cellular redox state
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Discovery of KRAS-G12D degraders via exploration of various E3 ligases
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Design and synthesis of novel triazole-metronidazole boswellic acid hybrids for ovarian cancer targeting
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Discovery of novel ENPP1 inhibitors with benzotriazole core for cancer immunotherapy
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Development of the first-in-class RNF4 PROTAC degrader as potential therapeutics for hepatocellular carcinoma
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Semi-rigid linkers improve the pharmacokinetic properties and therapeutic efficacy of BET PROTACs for cancer therapy
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New antitubercular pretomanid analogues as potent payloads in polymeric micelles: Leveraging zebrafish assays to accelerate lead optimisation
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Identification of a new protein-RNA interaction inhibitor targeting the KH34 region of the insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2/IMP2)
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Discovery of 9-arylamino-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline-8-carbonitriles: Potent inducers of immunogenic cell death via colchicine site-targeted microtubule polymerization inhibition
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Structural optimization of natural product honokiol to discover novel membrane-targeting antibacterial agents against Gram-positive bacteria
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Rational design of dual PB2/JAK2 inhibitors achieving balanced antiviral and host-directed immunomodulatory effects
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A combination of salinomycin or its C20 triphenylphosphonium-conjugated derivative with carboplatin leads to autophagy in ovarian cancer cells – An in vitro study
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N-terphenylpicolinamide derivatives designed to target PD-L1 increase activation and proliferation of T cells, and their cytotoxic properties toward cancer cells
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Hypoxia-activated dual donors of H2S and NO alleviate myocardial injury in coronary heart disease via synergistic mechanisms
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Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer's disease model
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Design, synthesis, and investigation of anti-Alzheimer's activity and molecular mechanisms of phosphatidylserine derivatives
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Tailoring cariprazine for dual disorders via secondary pharmacophore optimization
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Small molecular inhibitors targeting Janus kinases (JAKs) for the treatment of psoriasis
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Orphan GPCRs regulate the metabolic liver diseases through mediating the crosstalk between the liver and immune cells: Mechanisms and therapeutics
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Targeting p53 activation: Recent therapeutic advances in cancer and diabetic macular edema
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Recent advances in functional activatable probes for oncological surgery: Illuminating precision or hindering clinical translation?
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Discovery of thiazolylcyanovinyl benzopyridone acids: Potential new generation antibacterial oxacins?
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Discovery of novel hydrazinyl thiazole derivatives as potent anticancer agents by inhibiting eIF4E/eIF4G interactions
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Discovery of novel fluorescent amino-pyrazolines that detect and kill Mycobacterium tuberculosis
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Synthesis and evaluation of new 5-(1H-1,2,4-triazol-3-yl)-1,2,4-oxadiazole derivatives and their application as OXPHOS inhibitors
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Targeting dihydroorotate dehydrogenase (DHODH) for host-directed therapy: Discovery of a novel alkyne-based scaffold inhibitor effective against SARS-CoV-2
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Lead optimization of a CHI3L1 inhibitor for Glioblastoma: Enhanced target engagement, pharmacokinetics, and efficacy in 3D spheroid models
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