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Tumor-activated Theranostic Probe To Enhance Photodynamic Eradication of Solid Tumors by a Three-Pronged Strategy
Tumor-activated Theranostic Probe To Enhance Photodynamic Eradication of Solid Tumors by a Three-Pronged Strategy
Photodynamic therapy (PDT) has been widely deployed in clinical tumor treatment due to its light controllability and minim...
Solvent Polarity Matching for the Fabrication of Evenly Distributed Metal-Organic Framework Stationary Phases
Solvent Polarity Matching for the Fabrication of Evenly Distributed Metal-Organic Framework Stationary Phases
Stationary phase optimization is crucial for enhancing gas chromatography (GC) separation performance, yet coating process...
Cantilever-Enhanced Fiber-Optic Photoacoustic Micro-Water and Pressure Sensor for SF Insulation Equipment Monitoring
Cantilever-Enhanced Fiber-Optic Photoacoustic Micro-Water and Pressure Sensor for SF Insulation Equipment Monitoring
A miniature cantilever-enhanced fiber-optic photoacoustic sensor (FOPAS) is designed for micro-water and pressure measurem...
An Integrated Microfluidic Platform Possessing Uniform Tumor Spheroids for Evaluating Radio-Therapeutic Nanomaterials
An Integrated Microfluidic Platform Possessing Uniform Tumor Spheroids for Evaluating Radio-Therapeutic Nanomaterials
Abundant new nanomaterials are developed every year to enhance traditional radiotherapy by improving therapeutic response ...
Genetically Encoded Alkyne-Based Cross-linkable Probes
Genetically Encoded Alkyne-Based Cross-linkable Probes
The non-covalent interactions of ubiquitin/ubiquitin-like proteins (Ub/Ubls) with other proteins play a pivotal role in re...
Multiplex MicroRNA Profiling Using a Logic Nanodevice-Based Electrochemiluminescence Biosensor for the Rapid Diagnosis of Acute Myocardial Infarction
Multiplex MicroRNA Profiling Using a Logic Nanodevice-Based Electrochemiluminescence Biosensor for the Rapid Diagnosis of Acute Myocardial Infarction
Developing reliable biological computing circuit devices for microRNA (miRNA) assays is critical in facilitating the early...
One-Step In-Situ Synthesis of Porous AuRu Solid-Solution Alloy for Efficient Non-Enzymatic Glucose Sensing Application
One-Step In-Situ Synthesis of Porous AuRu Solid-Solution Alloy for Efficient Non-Enzymatic Glucose Sensing Application
The practicality of the non-enzymatic glucose sensing depends on the development of cost-effective, binder-free, and highl...
Density-Based Resampling Strategy Unveils Metabolic Heterogeneity and Subtypes in Liver Disease Progression
Density-Based Resampling Strategy Unveils Metabolic Heterogeneity and Subtypes in Liver Disease Progression
Metabolomics studies of heterogeneous diseases, such as hepatitis B virus (HBV) infection, liver cirrhosis (LC), and hepat...
Mass Spectrometry-Based Multi-Omics Integration Decodes Metabolic-Immune Crosstalk in Multifocal Breast Cancer Progression
Mass Spectrometry-Based Multi-Omics Integration Decodes Metabolic-Immune Crosstalk in Multifocal Breast Cancer Progression
The heterogeneity in the different primary tumor sites of metabolic-immune networks across multifocal tumors remains a cri...
Cell-Permeable Mitochondrial-Targeting Probes Enable Precise Tracking Via the Interplay between Electrostatic Interaction and Lipid-Tail Anchoring Mechanism
Cell-Permeable Mitochondrial-Targeting Probes Enable Precise Tracking Via the Interplay between Electrostatic Interaction and Lipid-Tail Anchoring Mechanism
Mitochondria constitute vital organelles in eukaryotic cells, essential not only for adenosine triphosphate (ATP) synthesi...
Decoding Soft Metals Multifunctional Fluorescent Probes for Selective Ag and Hg Sensing
Decoding Soft Metals Multifunctional Fluorescent Probes for Selective Ag and Hg Sensing
Ag+ and Hg2+ are soft, thiophilic cations of high environmental and biomedical relevance, yet their closely related coordi...
Portable Microfluidic Detection of via MOF-CRISPR–Cas12a Cascade Signal Amplification
Portable Microfluidic Detection of via MOF-CRISPR–Cas12a Cascade Signal Amplification
Mycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia, especially in children, but its early diag...
Real-Time Imaging of Pulmonary Inflammation and Smoke-Induced Lung Toxicity via a Near-Infrared Probe Targeting Butyrylcholinesterase Activity
Real-Time Imaging of Pulmonary Inflammation and Smoke-Induced Lung Toxicity via a Near-Infrared Probe Targeting Butyrylcholinesterase Activity
Monitoring pulmonary injury caused by environmental exposures remains a critical challenge in toxicological and diagnostic...
Comparative Evaluation of Three Serum Thawing Methods and Their Effects on Metabolome Integrity and Biomarker Discovery
Comparative Evaluation of Three Serum Thawing Methods and Their Effects on Metabolome Integrity and Biomarker Discovery
Serum samples are widely used in metabolomics studies and are typically stored at −80 °C after collect...
From Sensing to Prediction: A Machine Learning-Enhanced Electrochemical Platform for Ultrasensitive Monitoring of Bioactive Flavonoids
From Sensing to Prediction: A Machine Learning-Enhanced Electrochemical Platform for Ultrasensitive Monitoring of Bioactive Flavonoids
Rutin (Rt) and quercetin (Qt), two prominent bioactive flavonoids, are widely present in functional foods and beverages, o...
Highly Sensitive Analysis of Iodine in Seawater via Headspace Solid-Phase Microextraction Coupled with Gas Chromatography-Mass Spectrometry
Highly Sensitive Analysis of Iodine in Seawater via Headspace Solid-Phase Microextraction Coupled with Gas Chromatography-Mass Spectrometry
Monitoring iodine speciation in marine environments holds immense significance due to its profound implications for human ...
A Microcontroller-Integrated Multichannel Time Detector for Paper-Based Analytical Devices — Applications to Viscosity Measurements in Saliva Analysis and Protease-Activity Assays
A Microcontroller-Integrated Multichannel Time Detector for Paper-Based Analytical Devices — Applications to Viscosity Measurements in Saliva Analysis and Protease-Activity Assays
We designed and developed a microcontroller-integrated multichannel time detection system that uses a microfluidic paper-b...
Multiple miRNA Analysis Based on DNA Fiber Barcodes for Cell Typing
Multiple miRNA Analysis Based on DNA Fiber Barcodes for Cell Typing
Tumor cell subtyping is clinically critical for early cancer diagnosis and prognostic assessment. As key regulators of cel...
Peltier-Based Temperature Control Enables High-Bandwidth and Low-Noise Measurements with Solid-State Nanopores
Peltier-Based Temperature Control Enables High-Bandwidth and Low-Noise Measurements with Solid-State Nanopores
Temperature is a fundamental yet underexploited control parameter in nanopore-based single-molecule sensing, critically in...
Tailored Assembly of Electronically Engineered Gold Nanoclusters for On-Chip Visual Detection of Nitrogen-Rich Heterocyclic Explosives
Tailored Assembly of Electronically Engineered Gold Nanoclusters for On-Chip Visual Detection of Nitrogen-Rich Heterocyclic Explosives
Rapid and reliable detection of emerging nitrogen-rich heterocyclic explosives is essential for security and environmental...
Making movies with ultra-fast pair distribution functions
Making movies with ultra-fast pair distribution functions
Adam Sapnik details the importance of custom beamline detector setups at X-ray free electron lasers for ultra-fast scatter...
More than just a delivery system
More than just a delivery system
Lipid nanoparticle (LNP)-encapsulated messenger RNA (mRNA) vaccines proved highly effective during the COVID-19 pandemic, ...
Photochemical, electrochemical and electrophotochemical C−N bond-forming cross-coupling reactions
Photochemical, electrochemical and electrophotochemical C−N bond-forming cross-coupling reactions
Nitrogen-containing molecules are foundational to modern synthesis, spanning a wide range of pharmaceuticals, agrochemical...
Chemical heterogeneity for battery materials
Chemical heterogeneity for battery materials
Next-generation rechargeable batteries require materials that offer enhanced electrochemical capabilities. Achieving these...
Polarity promotes power production
Polarity promotes power production
Thermoelectrochemical hydrogels can generate voltages as the temperature rises, which is often due to multiple, coupled tr...
Molecular rotor-based probes for protein monitoring in biomedical research
Molecular rotor-based probes for protein monitoring in biomedical research
As the fundamental executors of biological function, proteins are frequently dysregulated or differentially expressed in d...
The chemistry of magnetoelectric multiferroics
The chemistry of magnetoelectric multiferroics
The development of magnetoelectric multiferroic materials, which combine and couple (ferro)magnetism and ferroelectricity ...
A life researching the path to better polymers
A life researching the path to better polymers
Ahead of his 70th birthday, Takuzo Aida, Group Director at RIKEN and Distinguished University Professor at the Un...
Transfer RNA deacylases as beacons for non-canonical amino acid biosynthesis
Transfer RNA deacylases as beacons for non-canonical amino acid biosynthesis
Non-canonical amino acids are important building blocks for natural products but finding them is nontrivial. Now, transfer...
De novo chemo-optogenetics through the rational design of photoresponsive molecules and selection of their artificial protein binding pairs
De novo chemo-optogenetics through the rational design of photoresponsive molecules and selection of their artificial protein binding pairs
Optical manipulation of proteins is central to probing and engineering cellular functions. However, existing optogenetic t...
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