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Transfer RNA deacylases as beacons for non-canonical amino acid biosynthesis
Transfer RNA deacylases as beacons for non-canonical amino acid biosynthesis
Non-canonical amino acids are important building blocks for natural products but finding them is nontrivial. Now, transfer...
De novo chemo-optogenetics through the rational design of photoresponsive molecules and selection of their artificial protein binding pairs
De novo chemo-optogenetics through the rational design of photoresponsive molecules and selection of their artificial protein binding pairs
Optical manipulation of proteins is central to probing and engineering cellular functions. However, existing optogenetic t...
Two-dimensional metal–organic frameworks offer all-in-one cocatalysts for photocatalytic overall water splitting
Two-dimensional metal–organic frameworks offer all-in-one cocatalysts for photocatalytic overall water splitting
Photocatalytic overall water splitting holds great promise for sustainable hydrogen production. For overall water splittin...
Single-crystal to single-crystal editing of metal–organic frameworks via ligand removal
Single-crystal to single-crystal editing of metal–organic frameworks via ligand removal
Accessing metal–organic frameworks (MOFs) with wide mesopores or specific topologies sometimes requires the use of a...
A Cu(I)-catalysed click reaction generates ROS-triggered cleavable linkages in aqueous media
A Cu(I)-catalysed click reaction generates ROS-triggered cleavable linkages in aqueous media
Click reactions that form functional linkages are rare. Among the few catalytic options, none directly delivers a cleavabl...
Reactions of diazoboranes with oxygen enables the synthesis and isolation of dioxaboriranes
Reactions of diazoboranes with oxygen enables the synthesis and isolation of dioxaboriranes
Cyclic peroxides are highly reactive oxygen-containing species that play important roles in chemical synthesis, yet, aside...
Small-molecule binding-site discovery using silyl ether-enabled chemoproteomics
Small-molecule binding-site discovery using silyl ether-enabled chemoproteomics
For chemical probe and drug discovery campaigns, the pairing of mass spectrometry-based chemoproteomics with photoaffinity...
Understanding low-pressure CO2 insertion chemistry in epoxide–CO2 copolymerization catalysis
Understanding low-pressure CO2 insertion chemistry in epoxide–CO2 copolymerization catalysis
Despite many CO2 use strategies being reliant on fast and selective CO2 insertion reactions into metal-alkoxide bonds, in-...
Repurposing magnetic hyperthermia therapy to control biosynthesis in synthetic cells
Repurposing magnetic hyperthermia therapy to control biosynthesis in synthetic cells
The programmability of synthetic cells facilitates their application as drug delivery devices, but on-demand biosynthesis ...
Interfacial solvation pre-organizes the transition state of the oxygen evolution reaction
Interfacial solvation pre-organizes the transition state of the oxygen evolution reaction
The sluggish kinetics of the oxygen evolution reaction are an energetic bottleneck for green hydrogen production via water...
A label-free method for measuring the composition of multicomponent biomolecular condensates
A label-free method for measuring the composition of multicomponent biomolecular condensates
Many subcellular compartments are biomolecular condensates made of multiple components, often including several distinct p...
Future-proofing calcium fluoride
Future-proofing calcium fluoride
Thomas Schlatzer and Véronique Gouverneur discuss why the chemistry of calcium fluoride is challenging, and how imagi...
Agree to disagree
Agree to disagree
Science is about discovering new knowledge, so, logically, there will be disagreement. Shira Joudan contemplates how disag...
Organocatalysed three-component modular synthesis of BN isosteres and BN-2,1-azaboranaphthalenes via Wolff-type rearrangement
Organocatalysed three-component modular synthesis of BN isosteres and BN-2,1-azaboranaphthalenes via Wolff-type rearrangement
[2,1]-Azaboranaphthalenes represent unique boron–nitrogen (BN) isosteres of naphthalenes, attracting interest for th...
Isotope-dependent Tafel analysis probes proton transfer kinetics during electrocatalytic water splitting
Isotope-dependent Tafel analysis probes proton transfer kinetics during electrocatalytic water splitting
Proton transfer plays an important role in both hydrogen and oxygen evolution reactions during electrocatalytic water spli...
Reserved charges in a long-lived NiOOH phase drive catalytic water oxidation
Reserved charges in a long-lived NiOOH phase drive catalytic water oxidation
Although NiOOH has been widely studied as a water oxidation catalyst, its active structure and catalytic mechanism under o...
Author Correction: Cytoskeleton-functionalized synthetic cells with life-like mechanical features and regulated membrane dynamicity
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 ...
Publisher Correction: Protocells by spontaneous reaction of cysteine with short-chain thioesters
Publisher Correction: Protocells by spontaneous reaction of cysteine with short-chain thioesters
Author notesYei-Chen LaiPresent address: Department of Chemistry, National Chung Hsing University, Taichung City, TaiwanTh...
Mesoporous single-crystal metal–organic frameworks
Mesoporous single-crystal metal–organic frameworks
The structural diversity of mesoporous metal–organic frameworks (MOFs) is limited, and known examples are typically ...
Coacervating proteins stick like a tick
Coacervating proteins stick like a tick
Ticks secrete a protein-based saliva that hardens into a cement, ensuring that they firmly attach to their host. Now, insi...
Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks
Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks
Protein catalysis and allostery require the atomic-level orchestration and motion of residues and ligand, solvent and prot...
A living library concept to capture the dynamics and reactivity of mixed-metal clusters for catalysis
A living library concept to capture the dynamics and reactivity of mixed-metal clusters for catalysis
The exploration of ligated metal clusters’ chemical space is challenging, partly owing to an insufficiently targeted...
Supramolecular dyads as photogenerated qubit candidates
Supramolecular dyads as photogenerated qubit candidates
Molecular spin qubits have the advantages of synthetic flexibility and amenability to be tailored to specific applications...
Enantioselective synthesis of 2-substituted bicyclo[1.1.1]pentanes via sequential asymmetric imine addition of bicyclo[1.1.0]butanes and skeletal editing
Enantioselective synthesis of 2-substituted bicyclo[1.1.1]pentanes via sequential asymmetric imine addition of bicyclo[1.1.0]butanes and skeletal editing
The substitution of an aromatic ring with a C(sp3)-rich bicyclic hydrocarbon, known as bioisosteric replacement, plays a c...
Electrochemical labelling of hydroxyindoles with chemoselectivity for site-specific protein bioconjugation
Electrochemical labelling of hydroxyindoles with chemoselectivity for site-specific protein bioconjugation
Electrochemistry has recently emerged as a powerful approach in small-molecule synthesis owing to its numerous attractive ...
Modular α-tertiary amino ester synthesis through cobalt-catalysed asymmetric aza-Barbier reaction
Modular α-tertiary amino ester synthesis through cobalt-catalysed asymmetric aza-Barbier reaction
Unnatural chiral α-tertiary amino acids containing two different carbon-based substituents at the α-carbon centr...
Organocatalytic aromatization-promoted umpolung reaction of imines
Organocatalytic aromatization-promoted umpolung reaction of imines
The umpolung functionalization of imines bears vast synthetic potential, but polarity inversion is less efficient compared...
Artificial cell synthesis using biocatalytic polymerization-induced self-assembly
Artificial cell synthesis using biocatalytic polymerization-induced self-assembly
Artificial cells are biomimetic microstructures that mimic functions of natural cells, can be applied as building blocks f...
Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases
Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases
Many peptide-derived natural products are produced by non-ribosomal peptide synthetases (NRPSs) in an assembly-line fashio...
Air- and photo-stable luminescent carbodicarbene-azaboraacenium ions
Air- and photo-stable luminescent carbodicarbene-azaboraacenium ions
Substitution of a C=C bond by an isoelectronic B–N bond is a well-established strategy to alter the electronic struc...
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