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The methylation-expression correlation of autophagy-related genes in colorectal cancer patients from southern Iran

Colorectal cancer (CRC), which has high mortality and increasing morbidity is a major concern worldwide. The autophagy pat...

Molecular Biology Research Communications

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A systematic in-silico functional and structural analysis reveals deleterious nsSNPs in the Human CSF1R Gene

Colony Stimulating Factor-1 Receptor (CSF1R) is a tyrosine kinase transmembrane receptor that plays a vital role in innate...

Molecular Biology Research Communications

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SPIN.DOC induces cellular transformation of NIH3T3 normal mouse fibroblast cells

SPIN.DOC was discovered as a transcriptional co-repressor of wingless related integration site (WNT) pathway. However, it ...

Molecular Biology Research Communications

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In silico exploring of the epigenetic factors in teratozoospermia: A focus on IGF2BP2

Teratozoospermia is an abnormal sperm morphology that is a common cause of male infertility. Epigenetic factors have been ...

Molecular Biology Research Communications

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Molecular identification of KRAS, BRAF, and PIK3CA mutations in colorectal cancer patients from the Kurdistan region of Iraq

Colorectal cancer (CRC) emerged due to genetic mutations that fuel tumor development and influence patient outcomes. This ...

Molecular Biology Research Communications

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Role of VOPP1 in regulation of Paclitaxel response and EMT process during ovarian tumor progression

Ovarian cancer (OC) is one of the most common malignancies of the genitourinary system in women that has a high mortality ...

Molecular Biology Research Communications

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Integrative computational approach to farnesyltransferase inhibition toward anti-liver cancer drug candidate from Syzygium cumini essential oils

Farnesyltransferase plays a critical role in the post-translational modification of mammalian proteins, including the Ras ...

Molecular Biology Research Communications

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Molecular dynamics simulation of thermal activation of human TRPV1

TRPV1 (Transient Receptor Potential Vanilloid 1) is a non-selective ion channel that responds to various thermal, chemical...

Molecular Biology Research Communications

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Wharton's jelly mesenchymal stem cell-derived conditioned media inhibits colon cancer cells via activating AMPK/mTOR-mediated autophagy

Prior studies have shown that conditioned media derived from Wharton's jelly mesenchymal stem cells (WJ-CM) have anti...

Molecular Biology Research Communications

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Analysis of amino acid residues affecting the transcriptional activity of nuclear factor Ya

Nuclear factor Y (NF-Y) is a heterotrimeric transcription factor essential for regulating genes involved in lipid metaboli...

Molecular Biology Research Communications

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CPUK02 sensitizes U87 glioblastoma cell lines to TMZ treatment via autophagy flux inhibition

Adjuvant chemotherapy with TMZ (Temozolomide) does not improve the survival of patients suffering from GBM (Glioblastoma)....

Molecular Biology Research Communications

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The possibility of prognostic and functional values of the 8q24 and 20q13 chromosomal bands in colorectal cancer

Colorectal cancer (CRC) remains a major global health concern, especially given its increasing incidence among younger ind...

Molecular Biology Research Communications

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Artificial intelligence and genomic data privacy: Balancing innovation with security

Artificial intelligence (AI) has emerged as one of the most transformative technologies in contemporary medicine and biolo...

Molecular Biology Research Communications

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A systematic comparison of in-house prepared transfection reagents in the delivery of mRNA or DNA to a wide range of cultured cells