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Structural basis of phosphodiesterase-5 conformational organization revealed by a PDE6/PDE5 chimera
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Slow PPi release enhances fidelity of the SARS-CoV-2 RNA dependent RNA polymerase
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Electrostatic tuning of the pyridoxal-5′-phosphate cofactor site defines pH dependence in type I cystathionine β-lyases
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Identification of novel ubiquitin receptors on the 26S proteasome by photo-crosslinking mass spectrometry
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Structure and enzymology of glutaminase S482C and H461L variants associated with excess brain glutamate and neurological disease
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Molecular insights into juvenile hormone maturation by juvenile hormone acid methyltransferase
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Structural basis of the protein kinase PKN1 HR1 domain oligomerization and differential regulation by RhoA and Rac1
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Calcium-loaded acylated segment controls membrane penetration capacity of repeats-in-toxin cytolysins
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Platelet CLEC-2 activation leads to GPIb⍺ shedding: Implications for doxorubicin chemotherapy and thrombosis
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The dynamic pool of Rec8-cohesin is crucial for meiotic recombination and transcription regulation in the yeast Saccharomyces cerevisiae
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P4HA3 is dispensable for prolyl 4-hydroxylation of type I collagen during mouse development
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Minor hemolysin-coregulated proteins (Hcp) form heteromeric complexes and mediate effector secretion in Bacteroidales type VI secretion systems
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Binding of RbFox proteins at weak 5’splice site of A2 induces its alternative splicing in non-muscle myosin heavy-chain IIA mRNA
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A dileucine motif in TMEM163 is essential for its binding with both AP-3 and BLOC-1 complex
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Zinc-induced exposure of an LxL motif drives clathrin-mediated endocytosis of the zinc transceptor ZIP4
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Deletion of mitochondrial calcium uniporter enhances calcium signals by slowing calcium clearance and triggers adaptive transcriptomic remodeling
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Correction: GPR39-mediated molecular signaling by bile acids
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Correction: The necessity of multi-parameter normalization in cyanobacterial research: A case study of the PsbU in Synechocystis sp. PCC 6803 using CRISPRi
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Correction: PKM2 inhibitor suppresses kidney fibrogenesis by disrupting YAP-TEAD-CCN2 transcriptional signaling following ischemia–reperfusion injury
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Correction: Acylation of Lysine 983 Is Sufficient for Toxin Activity of Bordetella pertussis Adenylate Cyclase
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AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and neuroinflammation in a microbiota disruption model
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Inhibition of ESCRT-III activates alternative pathways for protein degradation and secretion
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GABAergic neuronal ontogeny in the central nervous system of the viviparous teleost Poecilia sphenops
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Inhibition of S100A9 mitigates aging-related mitochondrial dysfunction and neurodegeneration in Parkinson's disease
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IL-33/ST2 deficiency induces depression-like behaviors through neuroinflammation in the medial prefrontal cortex and hippocampus
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Overexpression of Thioredoxin-1 alleviates morphine-induced neuroinflammation in BV-2 cells and the ventral tegmental area of mice
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Microglia beyond boundaries: Paradigm shifts in origin, distribution, state diversity, and therapeutic regeneration
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Parkinson's disease as a disorder of synaptic raft integrity: A unified explanation for motor subtypes and non-motor symptoms
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Nature-origin phthalides for Parkinson's disease drug development
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Elamipretide (SS-31) promotes recovery by preserving mitochondrial bioenergetics and neural remodeling after spinal cord injury
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