SCI Abstract

search
+
Brain Delivery of a Kv1.3-Blocking Peptide is not Enhanced by Conjugation to Blood–Brain Barrier Shuttle Peptides
Brain Delivery of a Kv1.3-Blocking Peptide is not Enhanced by Conjugation to Blood–Brain Barrier Shuttle Peptides
The voltage-gated potassium channel KV1.3 is upregulated on pro-inflammatory microglia, and its blockade is effective in r...
De Novo Transcriptome Analysis of Primed Canine Umbilical Cord Derived Mesenchymal Stem Cells Uncovers a Collection of Antimicrobial Peptides
De Novo Transcriptome Analysis of Primed Canine Umbilical Cord Derived Mesenchymal Stem Cells Uncovers a Collection of Antimicrobial Peptides
Antimicrobial peptides (AMPs), produced constitutively by all living organisms serve as critical components of the innate ...
Anti-melanogenesis and Anti-wrinkle Effects of Novel Peptides Derived from L. (mealworm) Expressed by Gamma-Irradiation
Anti-melanogenesis and Anti-wrinkle Effects of Novel Peptides Derived from L. (mealworm) Expressed by Gamma-Irradiation
This study aimed to investigate the effects of gamma-irradiation on mealworm (Tenebrio molitor L.) proteins and to identif...
Biotinylated Heptapeptides Containing -amino Acids as Potential Anti-allergic Agents Targeting Cysteinyl Leukotrienes
Biotinylated Heptapeptides Containing -amino Acids as Potential Anti-allergic Agents Targeting Cysteinyl Leukotrienes
Cysteinyl leukotrienes (cysLTs) are secreted by mast cells and represent key lipid mediators in allergic airway inflammati...
Peptide-Based Strategies for Pancreatic Cancer: From Discovery Platforms to Theranostic and Immunopeptidomic Frontiers
Peptide-Based Strategies for Pancreatic Cancer: From Discovery Platforms to Theranostic and Immunopeptidomic Frontiers
Pancreatic cancer exhibits high mortality due to its aggressive nature, late-stage detection, and dense desmoplastic strom...
Mass Spectrometry-Guided Library Preparation of Peptides as Metabolic Enzyme Natural Inhibitors for the Management of Obesity and Diabetes
Mass Spectrometry-Guided Library Preparation of Peptides as Metabolic Enzyme Natural Inhibitors for the Management of Obesity and Diabetes
Goat whey protein (GWP) is recognized as a valuable source of bioactive peptides with significant health-promoting propert...
Incorporation of D-amino Acids and Ornithines into Tirzepatide by Biosynthesis in
Incorporation of D-amino Acids and Ornithines into Tirzepatide by Biosynthesis in
Tirzepatide is an effective dual GLP-1 and GIP receptor agonist for type 2 diabetes and obesity but faces challenges with ...
Bikaneri Camel Milk-Derived Low-Molecular-Weight Peptides as a Novel Therapeutic Approach for Diabetes
Bikaneri Camel Milk-Derived Low-Molecular-Weight Peptides as a Novel Therapeutic Approach for Diabetes
This study provides the first systematic identification of antidiabetic peptides from Bikaneri camel milk (Indian camel br...
Relationship Between GLP-1 Concentration and Protein Kinase Activation in Isolated Rat Hearts Under Physiological Conditions
Relationship Between GLP-1 Concentration and Protein Kinase Activation in Isolated Rat Hearts Under Physiological Conditions
Although glucagon-like peptide-1 (GLP-1), a hormone secreted by intestinal endocrine L cells, exerts cardioprotective effe...
Bacteriophage-Based Vaccine Platform for Next Generation Vaccine Development Against Bovine Tuberculosis and Other Pulmonary Diseases of Animals
Bacteriophage-Based Vaccine Platform for Next Generation Vaccine Development Against Bovine Tuberculosis and Other Pulmonary Diseases of Animals
Infectious respiratory diseases remain a major constraint to livestock productivity and animal health worldwide. Conventio...
Neprilysin, a Multifunctional Peptidase: Molecular Functions and Roles in Human Disease
Neprilysin, a Multifunctional Peptidase: Molecular Functions and Roles in Human Disease
Neprilysin (NEP) is a multifunctional, therapeutically relevant, zinc-dependent membrane endopeptidase with significant im...
Investigating the Role of Insulin and Its Analogs in Breast Cancer Proliferation
Investigating the Role of Insulin and Its Analogs in Breast Cancer Proliferation
The global demand for recombinant human insulin and its analogs has increased markedly due to the rising prevalence of typ...
Fast Atom Bombardment-Mass Spectrometry for Counting Disulfide Bonds in Cyclic Oligopeptides: Silica-Gel-Promoted Reduction on a Thin-Layer Chromatography Plate
Fast Atom Bombardment-Mass Spectrometry for Counting Disulfide Bonds in Cyclic Oligopeptides: Silica-Gel-Promoted Reduction on a Thin-Layer Chromatography Plate
Fast atom bombardment-mass spectrometry (FAB-MS) measurement using a thiol-containing matrix such as α-thioglycerol (...
Dual Redox-Apoptotic Mechanism of Cyclo(Pro-Tyr): A Marine-Derived Anticancer Peptide Targeting Mitochondrial Dysfunction in Breast Cancer Cells
Dual Redox-Apoptotic Mechanism of Cyclo(Pro-Tyr): A Marine-Derived Anticancer Peptide Targeting Mitochondrial Dysfunction in Breast Cancer Cells
Breast cancer remains the leading malignancy due to frequent development of acquired resistance to endocrine therapies, wh...
-CBP-PepIII Changes the Proteomic Profile of Gastric Cancer Cells, Induces Membrane Pore Formation, and ROS Overaccumulation
-CBP-PepIII Changes the Proteomic Profile of Gastric Cancer Cells, Induces Membrane Pore Formation, and ROS Overaccumulation
Synthetic peptides have gained prominence due to their potential structural alterations and selective toxicity. In this co...
Improvements in Scalp Elasticity and Hair Properties Following Supplementation with Low-Molecular-Weight Porcine Placental Peptides (Placenderm®): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Improvements in Scalp Elasticity and Hair Properties Following Supplementation with Low-Molecular-Weight Porcine Placental Peptides (Placenderm®): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
The aging of scalp and hair is a complex biological process characterized by reduced biomechanical elasticity and degradat...
Prophylactic Effects of Ghrelin on Behavioral and Biochemical Outcomes in Male Mice Exposed to Lipopolysaccharide-Induced Inflammation
Prophylactic Effects of Ghrelin on Behavioral and Biochemical Outcomes in Male Mice Exposed to Lipopolysaccharide-Induced Inflammation
Depression, as a common and disabling disorder globally, leads to both mental and physical alterations that negatively imp...
Co-administration of Antimicrobial Peptides: A Promising Strategy to Broaden Antibacterial Activity and Minimize Hemolysis
Co-administration of Antimicrobial Peptides: A Promising Strategy to Broaden Antibacterial Activity and Minimize Hemolysis
Antimicrobial resistance (AMR) remains a major challenge in the treatment ofwound infections, particularly those involving...
Eradication Efficacy of Antimicrobial Peptide CRAMP-34 Against Mixed-Species Biofilms Formed by and
Eradication Efficacy of Antimicrobial Peptide CRAMP-34 Against Mixed-Species Biofilms Formed by and
To investigate the efficacy of antimicrobial peptide CRAMP-34 against mono- and mixed-species biofilms formed by Staphyloc...
Molecular and Functional Characterization of Kalata-Type Cyclotides from L. (Rubiaceae)
Molecular and Functional Characterization of Kalata-Type Cyclotides from L. (Rubiaceae)
The present study aimed to examine the occurrence of cyclotides in Oldenlandia umbellata L. and to characterize peptide co...
LC-QTOF Analysis for Characterization of Degradation Products of Ganirelix Acetate: Exploration of Degradation Pathways and In Silico Toxicity Predictions
LC-QTOF Analysis for Characterization of Degradation Products of Ganirelix Acetate: Exploration of Degradation Pathways and In Silico Toxicity Predictions
Ganirelix acetate (GAN) is a third-generation gonadotropin-releasing hormone (GnRH) antagonist with high antagonistic acti...
Rational Design of Novel Anti-Staphylococcal Peptides Using Machine Learning-Guided QSAR Modeling and Experimental Validation
Rational Design of Novel Anti-Staphylococcal Peptides Using Machine Learning-Guided QSAR Modeling and Experimental Validation
The global health crisis of antibiotic-resistant infections, particularly in chronic wounds, demands innovative therapeuti...
Research Advancements in Peptides for Promoting Reparative Dentin Regeneration in Direct Pulp Capping: A Narrative Review
Research Advancements in Peptides for Promoting Reparative Dentin Regeneration in Direct Pulp Capping: A Narrative Review
Direct pulp capping is an extensively used procedure in clinical practice for preserving pulp vitality and promoting denti...
Bioactive Peptides from Microalgae and Cyanobacteria and Their Possible Mechanisms of Action
Bioactive Peptides from Microalgae and Cyanobacteria and Their Possible Mechanisms of Action
Currently, microalgae and cyanobacteria thrill the researchers with their wide range of applications and diverse health be...
Assessment of the Antimicrobial Efficacy of a Novel Peptide Against : An in Silico and in Vitro Investigation
Assessment of the Antimicrobial Efficacy of a Novel Peptide Against : An in Silico and in Vitro Investigation
P. gingivalis is a significant pathogen in periodontal disease, a chronic inflammatory condition disturbing tooth-supporti...
Functional Peptides in Targeted Cancer Therapy: Mechanisms, Delivery Strategies, and Clinical Perspectives
Functional Peptides in Targeted Cancer Therapy: Mechanisms, Delivery Strategies, and Clinical Perspectives
This review aims to provide a comprehensive analysis of the role of functional peptides in targeted cancer therapy, with a...
Antimicrobial Peptides (AMPs): A Breakthrough Approach for Wound Healing and Infection Control
Antimicrobial Peptides (AMPs): A Breakthrough Approach for Wound Healing and Infection Control
Chronic wounds, such as diabetic ulcers, pressure sores, and burns, remain a global healthcare burden due to the rising th...
Antimicrobial Peptide -Crustin as a Therapeutic Agent against WSSV Infection in Culture System, Conferring Better Protection and Survival
Antimicrobial Peptide -Crustin as a Therapeutic Agent against WSSV Infection in Culture System, Conferring Better Protection and Survival
White Spot Syndrome Virus (WSSV) is a major viral pathogen in shrimp aquaculture, causing high mortality and economic loss...
Enteral Lactoferrin Mitigates Myocardial ischemia-reperfusion Injury Via Enteral Lactoferrin-induced glucagon-like peptide-1 in Isolated Rat Heart Model
Enteral Lactoferrin Mitigates Myocardial ischemia-reperfusion Injury Via Enteral Lactoferrin-induced glucagon-like peptide-1 in Isolated Rat Heart Model
Lactoferrin (LF) administered enterally increases serum glucagon-like peptide-1 (GLP-1) levels, showing cardioprotective e...
A Photolabile Backbone Amide Linker for the Solid-Phase Synthesis of Cyclic Peptides and C-terminal Thioesters
A Photolabile Backbone Amide Linker for the Solid-Phase Synthesis of Cyclic Peptides and C-terminal Thioesters
A new backbone amide linker has been developed for the synthesis of cyclic and C-terminally modified peptides that permits...
Load More
format_indent_increase