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Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer
Ferroptosis induced by ferrous ions (Fe2+) and lipid peroxidation accumulation is a novel form of regulated cell death tha...
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations
Transferrin receptor 1 (TfR1), a widely expressed type II transmembrane glycoprotein located on the plasma membrane, is we...
A novel peptide 66CTG stabilizes Myc proto-oncogene protein to promote triple-negative breast cancer growth
A novel peptide 66CTG stabilizes Myc proto-oncogene protein to promote triple-negative breast cancer growth
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer that lacks reliable targets for diagno...
Glioblastoma at the crossroads: current understanding and future therapeutic horizons
Glioblastoma at the crossroads: current understanding and future therapeutic horizons
Glioblastoma (GBM) remains the most aggressive and lethal brain tumor in adults and poses significant challenges to patien...
Long-term consequences of cancer therapy: cognitive impairment following CAR T cell therapy
Long-term consequences of cancer therapy: cognitive impairment following CAR T cell therapy
Competing interests K.G. reports no conflicts of interest. S.K. has receiv...
Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair
Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair
Chemoresistance remains the major barrier to cancer treatment. Metabolic and epigenetic reprogramming are involved in this...
Targeting CD155 in lung adenocarcinoma: A5 nanobody-based therapeutics for precision treatment and enhanced drug delivery
Targeting CD155 in lung adenocarcinoma: A5 nanobody-based therapeutics for precision treatment and enhanced drug delivery
This study presents a novel approach targeting CD155, an overexpressed protein in lung adenocarcinoma (LUAD), using nanobo...
Pattern recognition receptors: function, regulation and therapeutic potential
Pattern recognition receptors: function, regulation and therapeutic potential
Pattern recognition receptors (PRRs) are sensors in the immune system, detecting pathogen-associated molecular patterns (P...
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encomp...
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with autism spectrum disorder (ASD), an...
NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal ...
New clinical trial design in precision medicine: discovery, development and direction
New clinical trial design in precision medicine: discovery, development and direction
In the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex ...
Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis
Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis
Temozolomide (TMZ) represents a standard-of-care chemotherapeutic agent in glioblastoma (GBM). However, the development of...
Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma
Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma
Natural killer T cell lymphoma (NKTCL) is highly aggressive, with advanced stage patients poorly responding to intensive c...
Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer
Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer
Despite the successful application of immune checkpoint therapy, no response or recurrence is typical in lung cancer. Canc...
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
In a recent Science article, Wang and colleagues showed that the dipeptidyl peptidase 4 (DPP4) enzyme...
IgE-Mast cell mediated allergy: a sensor of food quality
IgE-Mast cell mediated allergy: a sensor of food quality
In two recent studies published in Nature, Florsheim et al. and Plum et al. reported that allergic-sp...
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, ...
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other cell death modes, p...
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
In a recent article published in Cancer Discovery, Guirguis et al. demonstrated that enzymatic inhibi...
Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to...
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study
This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and niv...
Gut liver brain axis in diseases: the implications for therapeutic interventions
Gut liver brain axis in diseases: the implications for therapeutic interventions
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and...
Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets
Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets
The coronavirus disease 2019 (COVID-19) pandemic has been looming globally for three years, yet the diagnostic and treatme...
Going only half the way: cell cycle exit after the G1 restriction point
Going only half the way: cell cycle exit after the G1 restriction point
In a recent article published in Nature, James A. Cornwell et al. describe that cyclin A2 levels dete...
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
In recent studies published in Nature and Lancet Infectious Diseases,1,2 SARS-CoV-2 Omicron subvarian...
Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy
Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy
Despite the remarkable success of immune checkpoint inhibitors (ICIs), primary resistance to ICIs causes only subsets of p...
γδ T cells: origin and fate, subsets, diseases and immunotherapy
γδ T cells: origin and fate, subsets, diseases and immunotherapy
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the...
Multifunctional mesoporous silica nanoparticles for biomedical applications
Multifunctional mesoporous silica nanoparticles for biomedical applications
Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field...
Correction: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L
Correction: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
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