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Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation
Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation
The catabolism of glutamine is essential for living organisms, so that its first step, driven by glutaminase 1 (GLS1), gen...
Ubiquitination at pericentromeric regions: directing heterochromatin reassembly during cell division
Ubiquitination at pericentromeric regions: directing heterochromatin reassembly during cell division
In a recent study published in Nature, Huang, Wong and their colleagues iden...
Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer
Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer
From a neuroscience perspective, cancer neuroscience has emerged as a subfield of cancer research. Presumable mechanisms u...
Parathyroid hormone–related protein is a therapeutic target in idiopathic pulmonary fibrosis
Parathyroid hormone–related protein is a therapeutic target in idiopathic pulmonary fibrosis
The crosstalk between immune or alveolar epithelial cells and fibroblasts mediated by paracrine signaling molecules is ass...
Stilbenoid gaylussacin modulates particulate matter-induced chromatin remodeling in macrophages to suppress chronic obstructive pulmonary disease
Stilbenoid gaylussacin modulates particulate matter-induced chromatin remodeling in macrophages to suppress chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD), a leading cause of mortality w...
Coronary atherosclerotic plaque intervention with Tongxinluo capsule (TXL-CAP): a multicenter, randomized, double-blind and placebo-controlled study
Coronary atherosclerotic plaque intervention with Tongxinluo capsule (TXL-CAP): a multicenter, randomized, double-blind and placebo-controlled study
Clinical evidence of traditional Chinese medicine Tongxinluo capsule therapy on coronary plaque vulnerability is lacking. ...
Concordance analysis of DNA and RNA profiling: The MD Anderson IMPACT2 study in precision oncology
Concordance analysis of DNA and RNA profiling: The MD Anderson IMPACT2 study in precision oncology
DNA profiling is an established method for cancer treatment selection, while RNA profiling remains investigational. We exp...
Antiviral drug discovery and development: challenges and future directions
Antiviral drug discovery and development: challenges and future directions
The coronavirus disease 2019 (COVID-19) pandemic has stimulated extensive endeavors toward the development of therapeutic ...
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer
Ferroptosis induced by ferrous ions (Fe2+) and lipid peroxidation accumulation is a novel form of regulated cell death tha...
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations
Transferrin receptor 1 (TfR1), a widely expressed type II transmembrane glycoprotein located on the plasma membrane, is we...
A novel peptide 66CTG stabilizes Myc proto-oncogene protein to promote triple-negative breast cancer growth
A novel peptide 66CTG stabilizes Myc proto-oncogene protein to promote triple-negative breast cancer growth
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer that lacks reliable targets for diagno...
Glioblastoma at the crossroads: current understanding and future therapeutic horizons
Glioblastoma at the crossroads: current understanding and future therapeutic horizons
Glioblastoma (GBM) remains the most aggressive and lethal brain tumor in adults and poses significant challenges to patien...
Long-term consequences of cancer therapy: cognitive impairment following CAR T cell therapy
Long-term consequences of cancer therapy: cognitive impairment following CAR T cell therapy
Competing interests K.G. reports no conflicts of interest. S.K. has receiv...
Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair
Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair
Chemoresistance remains the major barrier to cancer treatment. Metabolic and epigenetic reprogramming are involved in this...
Targeting CD155 in lung adenocarcinoma: A5 nanobody-based therapeutics for precision treatment and enhanced drug delivery
Targeting CD155 in lung adenocarcinoma: A5 nanobody-based therapeutics for precision treatment and enhanced drug delivery
This study presents a novel approach targeting CD155, an overexpressed protein in lung adenocarcinoma (LUAD), using nanobo...
Pattern recognition receptors: function, regulation and therapeutic potential
Pattern recognition receptors: function, regulation and therapeutic potential
Pattern recognition receptors (PRRs) are sensors in the immune system, detecting pathogen-associated molecular patterns (P...
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encomp...
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with autism spectrum disorder (ASD), an...
NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB in biology and targeted therapy: new insights and translational implications
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal ...
New clinical trial design in precision medicine: discovery, development and direction
New clinical trial design in precision medicine: discovery, development and direction
In the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex ...
Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis
Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis
Temozolomide (TMZ) represents a standard-of-care chemotherapeutic agent in glioblastoma (GBM). However, the development of...
Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma
Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma
Natural killer T cell lymphoma (NKTCL) is highly aggressive, with advanced stage patients poorly responding to intensive c...
Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer
Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer
Despite the successful application of immune checkpoint therapy, no response or recurrence is typical in lung cancer. Canc...
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
In a recent Science article, Wang and colleagues showed that the dipeptidyl peptidase 4 (DPP4) enzyme...
IgE-Mast cell mediated allergy: a sensor of food quality
IgE-Mast cell mediated allergy: a sensor of food quality
In two recent studies published in Nature, Florsheim et al. and Plum et al. reported that allergic-sp...
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, ...
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other cell death modes, p...
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
In a recent article published in Cancer Discovery, Guirguis et al. demonstrated that enzymatic inhibi...
Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to...
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study
This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and niv...
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