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Editorial: Unraveling enzyme-substrate dynamics in protein acylation and disease implications
Notably, the study revealed that these ubiquitination changes extensively affect not only immune-related pathways like aut...
Editorial: Clinical molecular biological characteristics of malignant tumors
In the context of biomarker discovery for common solid tumors, several contributions identified specific genetic and prote...
Preksha Dhyana meditation modulates the serum metabolome in healthy and meditation-naïve participants
Preksha Dhyana meditation modulates the serum metabolome in healthy and meditation-naïve participants
The impact of various meditation interventions on modifying human health outcomes has been demonstrated at both cognitive ...
Editorial: Exploring miRNA roles in cancer pathogenesis and treatment, volume III
they function as oncogenes or tumor suppressors to shape tumor initiation, progression, metastasis, and therapy resistance...
Correction: A comprehensive review of diagnostic approaches for hepatitis D
• Please read through all the templates before choosing • Pick the most relevant text template(s) from the following page ...
Oxidative stress mechanisms and potential biomarkers of methyl acetate poisoning: a urinary metabolomics study in rat model and human occupational cohort
BackgroundMethyl acetate (MA) is a common industrial solvent that causes rapid blindness in large exposures. Its toxicolog...
Functional and genomic characterization of LCN2-deficient PC-3 cells reveals insights into prostate cancer progression
IntroductionProstate Cancer-3 (PC-3) cells, commonly used as a model for aggressive, androgen-independent prostate cancer,...
Comparative proteomic analysis of colorectal cancer stem cells reveals potential biomarkers and altered pathways
BackgroundColorectal cancer (CRC) initiating/stem cells (CICs/CSCs) represent a rare tumor subpopulation with self-renewal...
Exome sequencing-based identification of DNAAF1 variants implicated in male infertility and primary ciliary dyskinesia
Primary ciliary dyskinesia (PCD) is a rare, autosomal recessive disorder caused by impaired cilia and flagella function. D...
Translational insights into miR-126 and miR-423: biomarkers and therapeutic targets in cancer, cardiovascular, metabolic and kidney diseases
MicroRNAs (miRNAs) are key post-transcriptional regulators that orchestrate complex gene regulatory networks controlling e...
Editorial: Advances on molecular mechanisms regulating reproduction - from gametogenesis to fertilization
CD52 as a key mediator of the immunosuppressive activity of human seminal fluid, potentially protecting sperm from immune ...
The “cutting edge” of non-canonical RNA splicing
Splicing, including alternative splicing, is a fundamental post-transcriptional mechanism in eukaryotes that generates fun...
Research progress of surface-enhanced Raman scattering technology in tumor liquid biopsy
Surface-Enhanced Raman Scattering technology has shown broad application potential in tumor diagnosis due to its excellent...
Exploring the role of adenosine deaminase in esophageal cancer and its potential for traditional Chinese medicine intervention
IntroductionThis study aims to systematically elucidate the association of adenosine deaminase with esophageal cancer from...
Predictive value of preoperative serum thyroglobulin and anti-thyroglobulin antibodies for central compartment lymph node metastasis in cN0 papillary thyroid carcinoma
ObjectiveTo investigate the predictive value of preoperative serum thyroglobulin (Tg) and anti-thyroglobulin antibodies (T...
Recent insights into HSP70: proteostasis and beyond
Since the 1980s, 70 kDa heat shock proteins (HSP70s) have been recognized as central regulators of proteostasis, with dive...
Genetic screening and response to drug therapy in familial hypercholesterolemia
ObjectivesFamilial hypercholesterolemia (FH) is an autosomal genetic disorder, which is significantly underdiagnosed. Here...
Analysis of proteins by a radical-free and highly reducing method of two-dimensional polyacrylamide gel electrophoresis
Kaltschmidt and Wittmann made significant advances in protein separation techniques by pioneering the two-dimensional poly...
Variant allele frequency as a predictor of treatment response to osimertinib in EGFR-mutated NSCLC
BackgroundOsimertinib has been approved as a treatment option for epidermal growth factor receptor (EGFR) mutated non-smal...
Editorial: Transcriptional and post-transcriptional regulatory networks in cellular homeostasis and stress response
The exposure to certain stimuli induces a dynamic regulation of transcription, which can modulate 39 cellular responses to...
Lipopolysaccharide affects metabolic processes and energy homeostasis in the corpus luteum
1 IntroductionThe corpus luteum (CL) is a heterogeneous endocrine gland that arises cyclically from the follicular cells o...
Dissecting the biophysical mechanisms of oleate hydratase association with membranes
1 IntroductionMembrane-targeting domains are essential for recruiting signaling molecules to membranes, and protein associ...
Artificial molecular motors in biological applications
1 IntroductionNatural molecular motors are integral to the proper functioning of living organisms, facilitating fundamenta...
Deciphering olfactory receptor binding mechanisms: a structural and dynamic perspective on olfactory receptors
1 IntroductionOlfactory receptors are classified as a subset of G-protein coupled receptors (GPCRs), which are integral to...
Identification of crucial pathways and genes linked to endoplasmic reticulum stress in PCOS through combined bioinformatic analysis
1 BackgroundPolycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder among women of reproductive age, aff...
Recent advances of lysine lactylation in prokaryotes and eukaryotes
1 IntroductionLysine lactylation is an emerging post-translational modification (PTM) that influences a variety of cellula...
Enhanced intestinal epithelial co-culture model with orbital mechanical stimulation: a proof-of-concept application in food nanotoxicology
1 IntroductionThe human intestinal epithelium functions as a critical interface between the body and external environment,...
Metabolomics insights into doxorubicin and 5-fluorouracil combination therapy in triple-negative breast cancer: a xenograft mouse model study
1 IntroductionBreast cancer (BCa) is the most prevalent cancer among women worldwide and a leading cause of death. In 2020...
First-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls
IntroductionGestational diabetes mellitus (GDM) defined as hyperglycemia first recognised in pregnancy (World Health Organ...
Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines
1 IntroductionColorectal cancer (CRC) is one of the most prevalent and deadly cancers worldwide, accounting for approximat...
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