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A practical guide to identifying associations between tandem repeats and complex human traits using consensus genotypes from multiple tools
A practical guide to identifying associations between tandem repeats and complex human traits using consensus genotypes from multiple tools
Tandem repeats (TRs) are highly variable loci in the human genome that are linked to various human phenotypes. Accurate an...
Synthesis of transition metal-sensitized lanthanide near-infrared luminescent nanoparticles
Synthesis of transition metal-sensitized lanthanide near-infrared luminescent nanoparticles
The versatility of lanthanide-doped near-infrared (NIR, 700–1,700 nm) luminescent nanoparticles makes them valuable ...
Quantitative mapping of smooth topographic landscapes generated using thermal scanning-probe lithography
Quantitative mapping of smooth topographic landscapes generated using thermal scanning-probe lithography
Scanning probe microscopy (SPM) is a powerful technique for mapping nanoscale surface properties through tip–sample ...
A versatile toolkit for drug metabolism studies with GNPS2: from drug development to clinical monitoring
A versatile toolkit for drug metabolism studies with GNPS2: from drug development to clinical monitoring
Metabolism is a fundamental process that shapes the pharmacological and toxicological profiles of drugs, making metabolite...
Purifying recombinant proteins from Nicotiana benthamiana for structural studies
Purifying recombinant proteins from Nicotiana benthamiana for structural studies
Structural biology is fundamental to understanding the molecular basis of biological processes. While machine learning-bas...
Dual AAV vectors for efficient delivery of large transgenes
Dual AAV vectors for efficient delivery of large transgenes
Despite their limited cargo capacity (<5 kb), adeno-associated viral (AAV) vectors remain the gold standard for in ...
Generating structurally and functionally programmable hydrogels by biological membrane hybridization
Generating structurally and functionally programmable hydrogels by biological membrane hybridization
Hydrogels, as 3D cross-linked hydrophilic networks that exhibit favorable flexibility, cargo loading and release abilities...
Labeling, isolation and characterization of cell-type-specific exosomes derived from mouse skin tissue
Labeling, isolation and characterization of cell-type-specific exosomes derived from mouse skin tissue
Extracellular vesicles are a heterogeneous group of membrane-bound vesicles involved in cell–cell communication, for...
Fabrication of high-performance tin halide perovskite thin-film transistors via chemical solution-based composition engineering
Fabrication of high-performance tin halide perovskite thin-film transistors via chemical solution-based composition engineering
Metal halide perovskite semiconductors have attracted considerable attention because they enable the development of device...
PEPPI-MS: gel-based sample pre-fractionation for deep top-down and middle-down proteomics
PEPPI-MS: gel-based sample pre-fractionation for deep top-down and middle-down proteomics
Top-down analysis of intact proteins and middle-down analysis of proteins subjected to limited digestion require efficient...
An accessible workflow for high-sensitivity proteomics using parallel accumulation–serial fragmentation (PASEF)
An accessible workflow for high-sensitivity proteomics using parallel accumulation–serial fragmentation (PASEF)
Deep and accurate proteome analysis is crucial for understanding cellular processes and disease mechanisms; however, it is...
Generating allogeneic CAR-NKT cells for off-the-shelf cancer immunotherapy with genetically engineered HSP cells and feeder-free differentiation culture
Generating allogeneic CAR-NKT cells for off-the-shelf cancer immunotherapy with genetically engineered HSP cells and feeder-free differentiation culture
The clinical potential of current chimeric antigen receptor-engineered T (CAR-T) cell therapy is hampered by its autologou...
Fabrication of nonplanar tapered fibers to integrate optical and electrical signals for neural interfaces in vivo
Fabrication of nonplanar tapered fibers to integrate optical and electrical signals for neural interfaces in vivo
Implantable multifunctional probes have transformed neuroscience research, offering access to multifaceted brain activity ...
Photothermal nanofiber-mediated photoporation for gentle and efficient intracellular delivery of macromolecules
Photothermal nanofiber-mediated photoporation for gentle and efficient intracellular delivery of macromolecules
Photoporation with free photothermal nanoparticles (NPs) is a promising technology for gentle delivery of functional bioma...
A multifunctional sensor for cell traction force, matrix remodeling and biomechanical assays in self-assembled 3D tissues in vitro
A multifunctional sensor for cell traction force, matrix remodeling and biomechanical assays in self-assembled 3D tissues in vitro
Cell–matrix interactions, mediated by cellular force and matrix remodeling, result in dynamic reciprocity that drive...
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice
Establishing reliable intravenous catheterization in mice with optical implants allows the combination of neural manipulat...
In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation
In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation
The central nervous system (CNS) comprises diverse and morphologically complex cells. To understand the molecular basis of...
Synthesis and functionalization of scalable and versatile 2D protein films via amyloid-like aggregation
Synthesis and functionalization of scalable and versatile 2D protein films via amyloid-like aggregation
Two-dimensional (2D) protein films can be used to modify the properties of surfaces, and find applications predominantly i...
Small RNA structural biochemistry in a post-sequencing era
Small RNA structural biochemistry in a post-sequencing era
High-throughput sequencing has had an enormous impact on small RNA research during the past decade. However, sequencing on...
Spatiotemporal control of RNA metabolism and CRISPR–Cas functions using engineered photoswitchable RNA-binding proteins
Spatiotemporal control of RNA metabolism and CRISPR–Cas functions using engineered photoswitchable RNA-binding proteins
RNA molecules perform various crucial roles in diverse cellular processes, from translating genetic information to decodin...
Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst
Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst
The tail-to-head terpene (THT) cyclization is a biochemical process that gives rise to many terpene natural product skelet...
A platform for whole-genome speed introgression from Aegilops tauschii to wheat for breeding future crops
A platform for whole-genome speed introgression from Aegilops tauschii to wheat for breeding future crops
Breeding new and sustainable crop cultivars of high yields and desirable traits has been a major challenge for ensuring fo...
CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction
CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction
Intratumor heterogeneity provides the fuel for the evolution and selection of subclonal tumor cell populations. However, a...
Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input
Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input
These authors contributed equally: Tetsuya Handa, Akihito Harada, Kazumitsu Maehara.Cell Biology Center, Institute of Inno...
Reproducible strategy for excisional skin-wound-healing studies in mice
Reproducible strategy for excisional skin-wound-healing studies in mice
Wound healing is a complex physiological process involving various cell types and signaling pathways. The capability to ob...
Robust scoring of selective drug responses for patient-tailored therapy selection
Robust scoring of selective drug responses for patient-tailored therapy selection
Most patients with advanced malignancies are treated with severely toxic, first-line chemotherapies. Personalized treatmen...
Analyzing somatic mutations by single-cell whole-genome sequencing
Analyzing somatic mutations by single-cell whole-genome sequencing
Somatic mutations are the cause of cancer and have been implicated in other, noncancerous diseases and aging. While clonal...
Ultra-fast supercritically solvothermal polymerization for large single-crystalline covalent organic frameworks
Ultra-fast supercritically solvothermal polymerization for large single-crystalline covalent organic frameworks
Crystalline polymer materials, e.g., hyper-crosslinked polystyrene, conjugate microporous polymers and covalent organic fr...
High-throughput identification and quantification of bacterial cells in the microbiota based on 16S rRNA sequencing with single-base accuracy using BarBIQ
High-throughput identification and quantification of bacterial cells in the microbiota based on 16S rRNA sequencing with single-base accuracy using BarBIQ
Bacteria often function as a community, called the microbiota, consisting of many different bacterial species. The accurat...
Fabrication of angstrom-scale two-dimensional channels for mass transport
Fabrication of angstrom-scale two-dimensional channels for mass transport
Fluidic channels at atomic scales regulate cellular trafficking and molecular filtration across membranes, and thus play c...
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