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Surface-Enhanced Raman Scattering to Improve the Sensitivity of the MTT Assay
Surface-Enhanced Raman Scattering to Improve the Sensitivity of the MTT Assay
Currently, empirical therapy regimens are often used in the treatment of infectious diseases that are not based on data on...
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
SKP2 gene is an independent prognostic factor in some diseases and a potential oncogene. The molecular mechanism underlyin...
Cytotoxic Effects of the Combination of Pam3CSK4 with Carfilzomib, Ixazomib, and Venetoclax in Human Multiple Myeloma Cells
Cytotoxic Effects of the Combination of Pam3CSK4 with Carfilzomib, Ixazomib, and Venetoclax in Human Multiple Myeloma Cells
Proteasome inhibitors (PIs) are effective in the treatment of multiple myeloma (MM), which is a plasma cell malignancy. Di...
Unraveling Cancer Progression in Oral Squamous Cell Carcinoma through Regulatory Network Analysis; miRNA-Target Gene Interaction
Unraveling Cancer Progression in Oral Squamous Cell Carcinoma through Regulatory Network Analysis; miRNA-Target Gene Interaction
Dysregulation of microRNAs (miRs) plays an essential role in tumor progression of oral squamous cell carcinoma (OSCC) thro...
Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1
Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Considerable research...
Toxicity Study of the Pharmacological Pair of Encapsulated Citrobacter freundii C115H Methionine γ-Lyase/Methiin
Toxicity Study of the Pharmacological Pair of Encapsulated Citrobacter freundii C115H Methionine γ-Lyase/Methiin
Acute and subchronic toxicity of the pharmacological pair based on encapsulated Citrobacter freundii C115H methionine ^...
History of the Creation of a New Generation of Antibiotics of the Group of Polycyclic Glycopeptides
History of the Creation of a New Generation of Antibiotics of the Group of Polycyclic Glycopeptides
Increased resistance to polycyclic glycopeptide antibiotics has become a serious problem for chemotherapy of infections ca...
N-Acetylgalactosamine-Conjugated Antisense Oligonucleotides Designed as Inhibitors of ABCB1: Coping with Multidrug Resistance in Hepatocellular Carcinoma
N-Acetylgalactosamine-Conjugated Antisense Oligonucleotides Designed as Inhibitors of ABCB1: Coping with Multidrug Resistance in Hepatocellular Carcinoma
Cancer-multidrug resistance (MDR) is recognized as one of the barriers to the treatment of advanced hepatocellular carcino...
Synthesis and Antimicrobial Activity of Thiosulfinates and Allicin Analogues
Synthesis and Antimicrobial Activity of Thiosulfinates and Allicin Analogues
Diallyl thiosulfinate (allicin) effectively inhibits the growth of various microorganisms, including antibiotic-resistant ...
Antibiotic Resistance Genes in Cattle Gut Microbiota: Influence of Housing Conditions
Antibiotic Resistance Genes in Cattle Gut Microbiota: Influence of Housing Conditions
Resistance to antimicrobial drugs is an urgent problem not only in public health, but also in animal husbandry. The widesp...
Elucidating the Effects of Aromatic Mutations on the RNA Binding Efficacy of CELF2 Protein
Elucidating the Effects of Aromatic Mutations on the RNA Binding Efficacy of CELF2 Protein
RNA Recognition Motifs (RRMs) are the most common type of protein domain found in eukaryotic RNA-binding proteins (RBPs). ...
Unveiling Neisseria gonorrhoeae Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance
Unveiling Neisseria gonorrhoeae Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance
Despite nearly a century of therapy for gonococcal infection with a variety of antimicrobials, more than 80 million cases ...
Antibiotic Resistance: Threats and Search for Solution
Antibiotic Resistance: Threats and Search for Solution
Antibiotic and, more broadly, antimicrobial resistance is a naturally occurring biological phenomenon and a major public h...
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Triosephosphate Isomerase Inhibition by Resveratrol: A New Mechanism of Anti-Glycolysis in Breast Cancer
Breast cancer cells undergo a process of reprogramming their metabolism for rapid growth and proliferation. One of the mos...
Ras-Related Protein Rab-7a Regulates Glucose Metabolism under Hypoxia by Interacting with Hypoxia-Inducible Factor 1-Alpha in HepG2 Cells
Ras-Related Protein Rab-7a Regulates Glucose Metabolism under Hypoxia by Interacting with Hypoxia-Inducible Factor 1-Alpha in HepG2 Cells
Ras-related protein Rab-7a (RAB7A) is a member of the RAS oncogene superfamily; it plays an important role in vesicle tran...
Distribution of β-Lactamase-Producing Enterobacterales among Patients in Surgical and Therapeutic Departments of a Multidisciplinary Hospital
Distribution of β-Lactamase-Producing Enterobacterales among Patients in Surgical and Therapeutic Departments of a Multidisciplinary Hospital
Adequate empiric therapy is difficult to choose without monitoring the local distribution of antibiotic-resistant bacteria...
CpG Traffic Lights Are Involved in Active DNA Demethylation
CpG Traffic Lights Are Involved in Active DNA Demethylation
DNA methylation is one of the most important mechanisms closely involved in the epigenetic regulation of gene expression. ...
Development of a New Inhibitor of Bacterial Cystathionine γ-Lyase Based on 6-Bromoindole and Aminothiophene
Development of a New Inhibitor of Bacterial Cystathionine γ-Lyase Based on 6-Bromoindole and Aminothiophene
Cystathionine-γ-lyase (CSE) is a key enzyme for H2S generation in the pathogenic bacteria Sta-phylococcus aureus, Pse...
Enzymes of ADP-Heptose Biosynthesis As Targets for the Creation of Broad-Spectrum Antibacterial Drugs
Enzymes of ADP-Heptose Biosynthesis As Targets for the Creation of Broad-Spectrum Antibacterial Drugs
Abstract—Solving the problem of multidrug resistance currently requires the development of nonstandard approaches, s...
Metabolic Heterogeneity of Tumors
Metabolic Heterogeneity of Tumors
Abstract—Currently, much attention in oncology is devoted to the issues of tumor heterogeneity, which creates seriou...
Nitric Oxide(II) in the Biology of Chlorophyta
Nitric Oxide(II) in the Biology of Chlorophyta
Abstract—NO is a gaseous signaling redox-active molecule that functions in various eukaryotes. However, its synthesi...
Regulation of Metabolism and the Role of Redox Factors in the Energy Control of Quiescence and Proliferation of Hematopoietic Cells
Regulation of Metabolism and the Role of Redox Factors in the Energy Control of Quiescence and Proliferation of Hematopoietic Cells
Abstract—One of the key regulators of hematopoietic stem cell (HSC) maintenance is cellular metabolism. Resting HSCs...
Characteristics of δ-Aminolevulinic Acid Dehydratase of the Cold-Water Sponge Halisarca dujardinii
Characteristics of δ-Aminolevulinic Acid Dehydratase of the Cold-Water Sponge Halisarca dujardinii
δ-Aminolevulinic acid dehydratase (ALAD) is a key enzyme of the cytoplasmic heme biosynthesis pathway. The primary st...
Low-Molecular Thiols as a Factor Improving the Sensitivity of Escherichia coli Mutants with Impaired ADP–Heptose Synthesis to Antibiotics
Low-Molecular Thiols as a Factor Improving the Sensitivity of Escherichia coli Mutants with Impaired ADP–Heptose Synthesis to Antibiotics
Abstract—Low molecular-weight thiols as glutathione and cysteine are an important part of the cell’s redox reg...
The Redox-Catalytic Properties of Cobalamins
The Redox-Catalytic Properties of Cobalamins
Abstract—Vitamin B12, or cobalamin, is essential for normal body function and is used in the therapies of different ...
Changes in the Activity of Antioxidant Systems of Escherichia coli under Phosphate Starvation
Changes in the Activity of Antioxidant Systems of Escherichia coli under Phosphate Starvation
Abstract—Changes in the activity of antioxidant systems in Escherichia coli during phosphate starvation have been st...
The Antioxidant and Geroprotective Properties of an Extract of Mountain Ash (Sorbus aucuparia L.) Fruits
The Antioxidant and Geroprotective Properties of an Extract of Mountain Ash (Sorbus aucuparia L.) Fruits
Abstract—Plant polyphenols are characterized by a wide range of biological activities, including antioxidant propert...
Protein Repeats Show Clade-Specific Volatility in Aves
Protein Repeats Show Clade-Specific Volatility in Aves
Protein repeats are a source of rapid evolutionary and functional novelty. Repeats are crucial in development, neurogenesi...
Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction
Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction
Abstract—Ischemia–reperfusion is a cascade of complex and interrelated pathological processes underlying many ...
Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease
Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease
Peripheral blood biomarkers are of particular importance to diagnose certain diseases including coronary artery disease (C...
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