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Pathology of Methylation, Demethylation, and Methylated DNA Binding Machinery
Pathology of Methylation, Demethylation, and Methylated DNA Binding Machinery
Along with genetic factors, epigenetic factors have been convincingly demonstrated to determine the development of patholo...
Application of Surface-Enhanced Raman Scattering for RNA Detection
Application of Surface-Enhanced Raman Scattering for RNA Detection
The detection of specific RNA molecules is a critical task for modern molecular diagnostics of infectious, oncological, an...
Functional and Structural Features of RecA and RAD51 Recombinases in the Contexts of Antibiotic Resistance of Pathogenic Bacteria and Therapy of Cancer
Functional and Structural Features of RecA and RAD51 Recombinases in the Contexts of Antibiotic Resistance of Pathogenic Bacteria and Therapy of Cancer
The RecA and RAD51 proteins are pivotal enzymes in homologous recombination in bacteria and eukaryotic cells. The proteins...
Allosteric Effects Upon Binding of Proteins and Antibiotics on DNA: History and the Present
Allosteric Effects Upon Binding of Proteins and Antibiotics on DNA: History and the Present
In the 1970s, it was discovered that isotherms of antibiotic binding to DNA indicate interactions between adsorbed molecul...
Thiophene-Hybridized Thiazole Scaffolds: Synthesis, Spectroscopic Characterization, DFT-Based NLO, NBO Property Exploration, Anticancer Screening and Molecular Docking Studies
Thiophene-Hybridized Thiazole Scaffolds: Synthesis, Spectroscopic Characterization, DFT-Based NLO, NBO Property Exploration, Anticancer Screening and Molecular Docking Studies
In this study, thiophene core linked to thiazole skeleton derivatives 4(a–e) were designed and synthesized via a mul...
Selective and Non-Selective Pharmacological Activation of Hypoxia-Inducible Factor Differentially Modulate Cancer Progression of Hepatocellular Carcinoma Cell Line HepG2
Selective and Non-Selective Pharmacological Activation of Hypoxia-Inducible Factor Differentially Modulate Cancer Progression of Hepatocellular Carcinoma Cell Line HepG2
Cellular adaptation to hypoxia is mediated by hypoxia-inducible factor (HIF), a transcription factor primarily regulated b...
Cystine in Formulation Promotes the Migration and Invasion of Colon Cancer Cells with Microsatellite Instability via mTORC1 Signaling
Cystine in Formulation Promotes the Migration and Invasion of Colon Cancer Cells with Microsatellite Instability via mTORC1 Signaling
While cystine in parenteral nutrition has been reported to accelerate tumor growth and chemoresistance in colon cancer, it...
Optimization of Plant Recombinant Lectin Production Using a Transient Expression System in
Optimization of Plant Recombinant Lectin Production Using a Transient Expression System in
Lectins are proteins capable of specifically recognizing and reversibly binding carbohydrates, but they lack enzymatic act...
M6A-Modification of SLC31A1 mRNA Promotes Cuproptosis in Unexplained Recurrent Spontaneous Abortion
M6A-Modification of SLC31A1 mRNA Promotes Cuproptosis in Unexplained Recurrent Spontaneous Abortion
Unexplained recurrent spontaneous abortion (URSA) involves aberrant trophoblast cell death. Cuproptosis, a newly identifie...
Glial Progenitor Cell Therapy Improves Mitochondrial Function in the Hippocampus of 5xFAD Mice, but Does Not Restore the Multiscale Structure of Behavioral Stress Response
Glial Progenitor Cell Therapy Improves Mitochondrial Function in the Hippocampus of 5xFAD Mice, but Does Not Restore the Multiscale Structure of Behavioral Stress Response
Cell therapy is increasingly used to treat a variety of medical conditions, including cancer, immune system disorders, and...
Biochip for Determination of 92 Human Y-Chromosome Haplogroups by SNP Markers and Frequency Distribution of These Haplogroups in Slavic Population of European Russia
Biochip for Determination of 92 Human Y-Chromosome Haplogroups by SNP Markers and Frequency Distribution of These Haplogroups in Slavic Population of European Russia
A method utilizing hydrogel biological microchips was developed to genotype markers of human Y-chromosome haplogroups. Wit...
GLUT8- and AMPK-Dependent Autophagy Signaling in the Mechanism of the Neuroprotective Action of Trehalose
GLUT8- and AMPK-Dependent Autophagy Signaling in the Mechanism of the Neuroprotective Action of Trehalose
Trehalose disaccharide has a stable neuroprotective effect used in inhibiting experimental neurodegeneration. However, the...
microRNA in the Realization of Molecular Mechanisms of Lymphocyte Development and Their Malignant Transformation
microRNA in the Realization of Molecular Mechanisms of Lymphocyte Development and Their Malignant Transformation
The immune system consists of a diverse range of cell types, each performing its specific function. T-lymphocytes, B-lymph...
Gene and Cell Technologies for Treatment of Brain Malignancies
Gene and Cell Technologies for Treatment of Brain Malignancies
Brain malignancies, such as glioblastoma, remain one of the most aggressive and difficult-to-treat cancers because of thei...
Expression of Nonstructural Protein 1 of the Tick-Borne Encephalitis Virus Stimulates the Secretion of Extracellular Vesicles Capable of Activating IL-1β Production
Expression of Nonstructural Protein 1 of the Tick-Borne Encephalitis Virus Stimulates the Secretion of Extracellular Vesicles Capable of Activating IL-1β Production
Despite active research, so far the detailed mechanisms of TBEV pathogenesis have not been fully disclosed. Recently, extr...
Small Nucleolar RNAs and Long Non-Coding RNAs of the SNHG Family in the Pathogenesis of Ovarian Cancer
Small Nucleolar RNAs and Long Non-Coding RNAs of the SNHG Family in the Pathogenesis of Ovarian Cancer
The discovery of a class of long noncoding RNAs (lncRNAs), including lncRNAs of the small nucleolar RNA (snoRNA) host gene...
Immobilization of Protein Macromolecules in Biochip Cells Made of Various Polymers
Immobilization of Protein Macromolecules in Biochip Cells Made of Various Polymers
Microarrays with immobilized protein probes are used to analyze protein samples. Selection of materials for biochip fabric...
Needle-Free Jet-Delivered mRNA-Vaccine Encoding Influenza A(H1N1)pdm09 Hemagglutinin Protects Mice from Lethal Virus Infection
Needle-Free Jet-Delivered mRNA-Vaccine Encoding Influenza A(H1N1)pdm09 Hemagglutinin Protects Mice from Lethal Virus Infection
Seasonal influenza is an acute respiratory illness caused by the influenza A and B viruses that circulate worldwide. Due t...
IFNγ Upregulating miR-1291 Promotes Cell Proliferation and Enhances Phosphorylation of the JAK/STAT Signaling Pathway by Targeting SOCS3 in HepG2 Cells
IFNγ Upregulating miR-1291 Promotes Cell Proliferation and Enhances Phosphorylation of the JAK/STAT Signaling Pathway by Targeting SOCS3 in HepG2 Cells
Liver cancer represents the third leading cause of cancer-related mortality globally, with hepatocellular carcinoma (HCC) ...
Chrysin Boosts the Cell Death and Anticancer Actions of Doxorubicin by Stimulating the TRPM2 Channel in Glioblastoma Cells
Chrysin Boosts the Cell Death and Anticancer Actions of Doxorubicin by Stimulating the TRPM2 Channel in Glioblastoma Cells
The prognosis for glioblastoma multiforme (GBM), the adult brain and spinal cord tumour with the poorest prognosis, has no...
STM2457 is Therapeutic for Idiopathic Pulmonary Fibrosis by Inhibiting the METTL3-CTGF Signaling Axis
STM2457 is Therapeutic for Idiopathic Pulmonary Fibrosis by Inhibiting the METTL3-CTGF Signaling Axis
Methyltransferase-like 3 (METTL3) is integral in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The METTL3 antag...
Effects of Various Factors on Transcription Activity of Transposons in Oyster
Effects of Various Factors on Transcription Activity of Transposons in Oyster
The pogo superfamily is one of the most common groups of DNA transposons. Ten pogo transposons are known to occur in the g...
Transcriptomic Profile of the Trastuzumab-Resistant Breast Cancer Cell Line BT-474
Transcriptomic Profile of the Trastuzumab-Resistant Breast Cancer Cell Line BT-474
The development of resistance to trastuzumab in HER2-positive breast cancer is a serious clinical problem that limits the ...
DNA Double-Strand Break Repair System by a Mechanism of Non-Homologous End Joining Provides Resistance to DNA-Damaging and Oxidizing Stresses in the Yeast
DNA Double-Strand Break Repair System by a Mechanism of Non-Homologous End Joining Provides Resistance to DNA-Damaging and Oxidizing Stresses in the Yeast
The unconventional halotolerant yeast Debaryomyces hansenii is of great importance in biotechnology and the food industry,...
Error Correction Techniques in Synthetic Oligonucleotides and Synthetic DNA
Error Correction Techniques in Synthetic Oligonucleotides and Synthetic DNA
Methods for correcting errors in synthetic oligonucleotides and genetic constructs derived from them are described. Method...
Assembly of a Complex of an Immature 30S Ribosomal Subunit and the Era GTPase Maturation Factor from In Vitro for Structural Studies
Assembly of a Complex of an Immature 30S Ribosomal Subunit and the Era GTPase Maturation Factor from In Vitro for Structural Studies
Era GTPase of Staphylococcus aureus is a ribosome maturation factor. Era GTPase is involved in the late stages of small (3...
CG10543 Protein Is Involved in the Regulation of Transcription of Ecdysone-Dependent Genes
CG10543 Protein Is Involved in the Regulation of Transcription of Ecdysone-Dependent Genes
Despite increasing data on the properties of the origins of replication, the molecular mechanisms underlying the origin re...
Optimization of Production of Recombinant Adeno-Associated Virus Serotype 9
Optimization of Production of Recombinant Adeno-Associated Virus Serotype 9
Vectors based on adeno-associated viruses (AAV) have proven to be a convenient tool for genomic editing. However, for tran...
Regulation of Complement C3 Gene in HepG2 Human Hepatoma Cells under Oxidative Stress
Regulation of Complement C3 Gene in HepG2 Human Hepatoma Cells under Oxidative Stress
Reactive oxygen and nitrogen species accumulate in cells during oxidative stress and cause oxidative damage to various cel...
The CCC Proline Codon Preceding a Stop Codon Modulates Translation Termination in Eukaryotes Depending on the Molecular Context
The CCC Proline Codon Preceding a Stop Codon Modulates Translation Termination in Eukaryotes Depending on the Molecular Context
In bacteria, glycine and proline codons, located upstream of stop codons, suppress translation termination. However, the e...
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