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Expression of Nonstructural Protein 1 of the Tick-Borne Encephalitis Virus Stimulates the Secretion of Extracellular Vesicles Capable of Activating IL-1β Production
Expression of Nonstructural Protein 1 of the Tick-Borne Encephalitis Virus Stimulates the Secretion of Extracellular Vesicles Capable of Activating IL-1β Production
Despite active research, so far the detailed mechanisms of TBEV pathogenesis have not been fully disclosed. Recently, extr...
Small Nucleolar RNAs and Long Non-Coding RNAs of the SNHG Family in the Pathogenesis of Ovarian Cancer
Small Nucleolar RNAs and Long Non-Coding RNAs of the SNHG Family in the Pathogenesis of Ovarian Cancer
The discovery of a class of long noncoding RNAs (lncRNAs), including lncRNAs of the small nucleolar RNA (snoRNA) host gene...
Immobilization of Protein Macromolecules in Biochip Cells Made of Various Polymers
Immobilization of Protein Macromolecules in Biochip Cells Made of Various Polymers
Microarrays with immobilized protein probes are used to analyze protein samples. Selection of materials for biochip fabric...
Needle-Free Jet-Delivered mRNA-Vaccine Encoding Influenza A(H1N1)pdm09 Hemagglutinin Protects Mice from Lethal Virus Infection
Needle-Free Jet-Delivered mRNA-Vaccine Encoding Influenza A(H1N1)pdm09 Hemagglutinin Protects Mice from Lethal Virus Infection
Seasonal influenza is an acute respiratory illness caused by the influenza A and B viruses that circulate worldwide. Due t...
IFNγ Upregulating miR-1291 Promotes Cell Proliferation and Enhances Phosphorylation of the JAK/STAT Signaling Pathway by Targeting SOCS3 in HepG2 Cells
IFNγ Upregulating miR-1291 Promotes Cell Proliferation and Enhances Phosphorylation of the JAK/STAT Signaling Pathway by Targeting SOCS3 in HepG2 Cells
Liver cancer represents the third leading cause of cancer-related mortality globally, with hepatocellular carcinoma (HCC) ...
Chrysin Boosts the Cell Death and Anticancer Actions of Doxorubicin by Stimulating the TRPM2 Channel in Glioblastoma Cells
Chrysin Boosts the Cell Death and Anticancer Actions of Doxorubicin by Stimulating the TRPM2 Channel in Glioblastoma Cells
The prognosis for glioblastoma multiforme (GBM), the adult brain and spinal cord tumour with the poorest prognosis, has no...
STM2457 is Therapeutic for Idiopathic Pulmonary Fibrosis by Inhibiting the METTL3-CTGF Signaling Axis
STM2457 is Therapeutic for Idiopathic Pulmonary Fibrosis by Inhibiting the METTL3-CTGF Signaling Axis
Methyltransferase-like 3 (METTL3) is integral in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The METTL3 antag...
Effects of Various Factors on Transcription Activity of Transposons in Oyster
Effects of Various Factors on Transcription Activity of Transposons in Oyster
The pogo superfamily is one of the most common groups of DNA transposons. Ten pogo transposons are known to occur in the g...
Transcriptomic Profile of the Trastuzumab-Resistant Breast Cancer Cell Line BT-474
Transcriptomic Profile of the Trastuzumab-Resistant Breast Cancer Cell Line BT-474
The development of resistance to trastuzumab in HER2-positive breast cancer is a serious clinical problem that limits the ...
DNA Double-Strand Break Repair System by a Mechanism of Non-Homologous End Joining Provides Resistance to DNA-Damaging and Oxidizing Stresses in the Yeast
DNA Double-Strand Break Repair System by a Mechanism of Non-Homologous End Joining Provides Resistance to DNA-Damaging and Oxidizing Stresses in the Yeast
The unconventional halotolerant yeast Debaryomyces hansenii is of great importance in biotechnology and the food industry,...
Error Correction Techniques in Synthetic Oligonucleotides and Synthetic DNA
Error Correction Techniques in Synthetic Oligonucleotides and Synthetic DNA
Methods for correcting errors in synthetic oligonucleotides and genetic constructs derived from them are described. Method...
Assembly of a Complex of an Immature 30S Ribosomal Subunit and the Era GTPase Maturation Factor from In Vitro for Structural Studies
Assembly of a Complex of an Immature 30S Ribosomal Subunit and the Era GTPase Maturation Factor from In Vitro for Structural Studies
Era GTPase of Staphylococcus aureus is a ribosome maturation factor. Era GTPase is involved in the late stages of small (3...
CG10543 Protein Is Involved in the Regulation of Transcription of Ecdysone-Dependent Genes
CG10543 Protein Is Involved in the Regulation of Transcription of Ecdysone-Dependent Genes
Despite increasing data on the properties of the origins of replication, the molecular mechanisms underlying the origin re...
Optimization of Production of Recombinant Adeno-Associated Virus Serotype 9
Optimization of Production of Recombinant Adeno-Associated Virus Serotype 9
Vectors based on adeno-associated viruses (AAV) have proven to be a convenient tool for genomic editing. However, for tran...
Regulation of Complement C3 Gene in HepG2 Human Hepatoma Cells under Oxidative Stress
Regulation of Complement C3 Gene in HepG2 Human Hepatoma Cells under Oxidative Stress
Reactive oxygen and nitrogen species accumulate in cells during oxidative stress and cause oxidative damage to various cel...
The CCC Proline Codon Preceding a Stop Codon Modulates Translation Termination in Eukaryotes Depending on the Molecular Context
The CCC Proline Codon Preceding a Stop Codon Modulates Translation Termination in Eukaryotes Depending on the Molecular Context
In bacteria, glycine and proline codons, located upstream of stop codons, suppress translation termination. However, the e...
In Vitro Reconstitution of the 50S Ribosomal Subunit–GTP-Binding Factor YsxC Complex for Structural Studies
In Vitro Reconstitution of the 50S Ribosomal Subunit–GTP-Binding Factor YsxC Complex for Structural Studies
Proper assembly and maturation of ribosomal subunits are critical processes that ensure functional activity, translation e...
Surface-Enhanced Raman Scattering to Improve the Sensitivity of the MTT Assay
Surface-Enhanced Raman Scattering to Improve the Sensitivity of the MTT Assay
Currently, empirical therapy regimens are often used in the treatment of infectious diseases that are not based on data on...
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
Silencing of the S-Phase Kinase-Associated Protein 2 Gene (SKP2) Inhibits Proliferation and Migration of Hepatocellular Carcinoma Cells
SKP2 gene is an independent prognostic factor in some diseases and a potential oncogene. The molecular mechanism underlyin...
Cytotoxic Effects of the Combination of Pam3CSK4 with Carfilzomib, Ixazomib, and Venetoclax in Human Multiple Myeloma Cells
Cytotoxic Effects of the Combination of Pam3CSK4 with Carfilzomib, Ixazomib, and Venetoclax in Human Multiple Myeloma Cells
Proteasome inhibitors (PIs) are effective in the treatment of multiple myeloma (MM), which is a plasma cell malignancy. Di...
Unraveling Cancer Progression in Oral Squamous Cell Carcinoma through Regulatory Network Analysis; miRNA-Target Gene Interaction
Unraveling Cancer Progression in Oral Squamous Cell Carcinoma through Regulatory Network Analysis; miRNA-Target Gene Interaction
Dysregulation of microRNAs (miRs) plays an essential role in tumor progression of oral squamous cell carcinoma (OSCC) thro...
Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1
Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by Upregulating the Expression of SIRT1
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Considerable research...
Toxicity Study of the Pharmacological Pair of Encapsulated Citrobacter freundii C115H Methionine γ-Lyase/Methiin
Toxicity Study of the Pharmacological Pair of Encapsulated Citrobacter freundii C115H Methionine γ-Lyase/Methiin
Acute and subchronic toxicity of the pharmacological pair based on encapsulated Citrobacter freundii C115H methionine ^...
History of the Creation of a New Generation of Antibiotics of the Group of Polycyclic Glycopeptides
History of the Creation of a New Generation of Antibiotics of the Group of Polycyclic Glycopeptides
Increased resistance to polycyclic glycopeptide antibiotics has become a serious problem for chemotherapy of infections ca...
N-Acetylgalactosamine-Conjugated Antisense Oligonucleotides Designed as Inhibitors of ABCB1: Coping with Multidrug Resistance in Hepatocellular Carcinoma
N-Acetylgalactosamine-Conjugated Antisense Oligonucleotides Designed as Inhibitors of ABCB1: Coping with Multidrug Resistance in Hepatocellular Carcinoma
Cancer-multidrug resistance (MDR) is recognized as one of the barriers to the treatment of advanced hepatocellular carcino...
Synthesis and Antimicrobial Activity of Thiosulfinates and Allicin Analogues
Synthesis and Antimicrobial Activity of Thiosulfinates and Allicin Analogues
Diallyl thiosulfinate (allicin) effectively inhibits the growth of various microorganisms, including antibiotic-resistant ...
Antibiotic Resistance Genes in Cattle Gut Microbiota: Influence of Housing Conditions
Antibiotic Resistance Genes in Cattle Gut Microbiota: Influence of Housing Conditions
Resistance to antimicrobial drugs is an urgent problem not only in public health, but also in animal husbandry. The widesp...
Elucidating the Effects of Aromatic Mutations on the RNA Binding Efficacy of CELF2 Protein
Elucidating the Effects of Aromatic Mutations on the RNA Binding Efficacy of CELF2 Protein
RNA Recognition Motifs (RRMs) are the most common type of protein domain found in eukaryotic RNA-binding proteins (RBPs). ...
Unveiling Neisseria gonorrhoeae Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance
Unveiling Neisseria gonorrhoeae Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance
Despite nearly a century of therapy for gonococcal infection with a variety of antimicrobials, more than 80 million cases ...
Antibiotic Resistance: Threats and Search for Solution
Antibiotic Resistance: Threats and Search for Solution
Antibiotic and, more broadly, antimicrobial resistance is a naturally occurring biological phenomenon and a major public h...
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