Functional and Structural Features of RecA and RAD51 Recombinases in the Contexts of Antibiotic Resistance of Pathogenic Bacteria and Therapy of Cancer

Ambekar S.S., Hattur S.S., Bule P.B. 2017. DNA: Damage and repair mechanisms in humans. Global J. Pharm. Sci. 3, 555613.

Van Der Veen S., Tang C.M. 2015. The BER necessities: The repair of DNA damage in human-adapted bacterial pathogens. Nat. Rev. Microbiol. 13, 83–94.

Article  CAS  Google Scholar 

Zahradka K., Slade D., Bailone A., Sommer S., Averbeck D., Petranovic M., Lindner A.B., Radman M. 2006. Reassembly of shattered chromosomes in Deinococcus radiodurans. Nature. 443, 569–573.

Article  CAS  PubMed  Google Scholar 

Mehta A., Haber J.E. 2014. Sources of DNA double-strand breaks and models of recombinational DNA repair. Cold Spring Harbor Perspect. Biol. 6, a016428.

Article  Google Scholar 

Kowalczykowski S.C. 2015. An overview of the molecular mechanisms of recombinational DNA repair. Cold Spring Harbor Perspect. Biol. 7, a016410.

Article  Google Scholar 

Lusetti S.L., Cox M.M. 2002. The bacterial RecA protein and the recombinational DNA repair of stalled replication forks. Annu. Rev. Biochem. 71, 71–100.

Article  CAS  PubMed  Google Scholar 

Bianco P.R., Lu Y. 2021. Single-molecule insight into stalled replication fork rescue in Escherichia coli. Nucleic Acids Res. 49, 4220–4238.

Article  CAS  PubMed Central  Google Scholar 

Sun Y., McCorvie T.J., Yates L.A., Zhang X. 2020. Structural basis of homologous recombination. Cell. Mol. Life Sci. 77, 3–18.

Article  CAS  PubMed  Google Scholar 

Godin S.K., Sullivan M.R., Bernstein K.A. 2016. Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication. Biochem. Cell Biol. 94, 407–418.

Article  CAS  PubMed Central  Google Scholar 

Yang S., Yu X., Seitz E.M., Kowalczykowski S.C., Egelman E.H. 2001. Archaeal RadA protein binds DNA as both helical filaments and octameric rings. J. Mol. Biol. 314, 1077–1085.

Article  CAS  PubMed  Google Scholar 

Kaushik V., Tiwari M., Tiwari V. 2022. Interaction of RecA mediated SOS response with bacterial persistence, biofilm formation, and host response. Int. J. Biol. Macromol. 217, 931–943.

Article  CAS  PubMed  Google Scholar 

Kowalczykowski S.C., Eggleston A.K. 1994. Homologous pairing and DNA strand-exchange proteins. Annu. Rev. Biochem. 63, 991–1043.

Article  CAS  PubMed  Google Scholar 

Hegner M., Smith S.B., Bustamante C. 1999. Polymerization and mechanical properties of single RecA–DNA filaments. Proc. Natl. Acad. Sci. U. S. A. 96, 10109–10114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Le S., Serrano E., Kawamura R., Carrasco B., Yan J., Alonso J.C. 2017. Bacillus subtilis RecA with DprA–SsbA antagonizes RecX function during natural transformation. Nucleic Acids Res. 45, 8873–8885.

Article  CAS  PubMed Central  Google Scholar 

Inagaki S., Matsumoto-Nakano M., Fujita K., Nagayama K., Funao J., Ooshima T. 2009. Effects of recombinase A deficiency on biofilm formation by Streptococcus mutans. Oral Microbiol. Immunol. 24, 104–108.

Article  CAS  PubMed  Google Scholar 

Crane J.K., Alvarado C.L., Sutton M.D. 2021. Role of the SOS response in the generation of antibiotic resistance in vivo. Antimicrob. Agents Chemother. 65, 00013–00021.https://doi.org/10.1128/aac

Article  Google Scholar 

Roca A.I., Cox M.M., Brenner S.L. 1990. The RecA protein: structure and function. Crit. Rev. Biochem. Mol. Biol. 25, 415–456.

Article  CAS  Google Scholar 

Rocha E.P.C., Cornet E., Michel B. 2005. Comparative and evolutionary analysis of the bacterial homologous recombination systems. PLoS Genet. 1, e15.

Article  PubMed  PubMed Central  Google Scholar 

Andersson S.G., Zomorodipour A., Andersson J.O., Sicheritz-Pontén T., Alsmark U.C.M., Podowski R.M., Näslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. 1998. The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature. 396, 133–140.

Article  CAS  PubMed  Google Scholar 

Zhang D., Fan H., McClarty G., Brunham R. 1995. Identification of the Chlamydia trachomatis RecA-encoding gene. Infect. Immun. 63, 676–680.

Article  CAS  PubMed  Google Scholar 

Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A., Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G., Kelley J.M. 1995. The minimal gene complement of Mycoplasma genitalium. Science. 270, 397–404.

Article  CAS  PubMed  Google Scholar 

Carvalho F.M., Fonseca M.M., De Medeiros S.B., Scortecci K.C., Blaha C.A.G., Agnez-Lima L.F. 2005. DNA repair in reduced genome: The Mycoplasma model. Gene. 360, 111–119.

Article  CAS  PubMed  Google Scholar 

Kreuzer K.N. 2013. DNA damage responses in prokaryotes: Regulating gene expression, modulating growth patterns, and manipulating replication forks. Cold Spring Harbor Perspect. Biol. 5, a012674.

Article  Google Scholar 

Hua Y., Narumi I., Gao G., Tian B., Satoh K., Kitayama S., Shen B. 2003. PprI: A general switch responsible for extreme radioresistance of Deinococcus radiodurans. Biochem. Biophys. Res. Commun. 306, 354–360.

Article  CAS  PubMed  Google Scholar 

Sugiman-Marangos S., Junop M.S. 2010. The structure of DdrB from Deinococcus: A new fold for single-stranded DNA binding proteins. Nucleic Acids Res. 38, 3432–3440.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu F., Li N., Zhang Y. 2023. The radioresistant and survival mechanisms of Deinococcus radiodurans. Radiat. Med. Prot. 4, 70–79.

Article  CAS  Google Scholar 

de la Tour C.B., Boisnard S., Norais C., Toueille M., Bentchikou E., Vannier F., Cox M.M., Sommer S., Servant P. 2011. The deinococcal DdrB protein is involved in an early step of DNA double strand break repair and in plasmid transformation through its single-strand annealing activity. DNA Repair. 10, 1223–1231.

Article  Google Scholar 

LA C.S. 2023. Bacterial resistance, a current crisis. Rev. Esp. Salud Publica. 97, e202302013–e202302013.

Google Scholar 

Aggarwal R., Mahajan P., Pandiya S., Bajaj A., Verma S.K., Yadav P., Kharat A.S., Khan A.U., Dua M., Johri A.K. 2024. Antibiotic resistance: a global crisis, problems and solutions. Crit. Rev. Microbiol. 50, 896–921.

Article  CAS  PubMed  Google Scholar 

Olsufyeva E.N. 2024. History of the creation of a new generation of antibiotics of the group of polycyclic glycopeptides. Mol. Biol. 58, 980–1002.

Article  CAS  Google Scholar 

Ling Z., Yin W., Shen Z., Wang Y., Shen J., Walsh T.R. 2020. Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9. J. Antimicrob. Chemother. 75, 3087–3095.

Article  CAS  Google Scholar 

Thi T.D., López E., Rodríguez-Rojas A., Rodríguez-Beltrán J., Couce A., Guelfo J.R., Castañeda-García A., Blázquez J. 2011. Effect of recA inactivation on mutagenesis of Escherichia coli exposed to sublethal concentrations of antimicrobials. J. Antimicrob. Chemother. 66, 531–538.

Article  CAS  PubMed  Google Scholar 

Lin Z., Kong H., Nei M., Ma H. 2006. Origins and evolution of the recA/RAD51 gene family: Evidence for ancient gene duplication and endosymbiotic gene transfer. Proc. Natl. Acad. Sci. U. S. A. 103, 10328–10333.

Article  CAS  PubMed Central  Google Scholar 

Bonilla B., Hengel S.R., Grundy M.K., Bernstein K.A. 2020. RAD51 gene family structure and function. Annu. Rev. Genet. 54, 25–46.

Article  CAS  PubMed Central 

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