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Sterile inflammation induces vasculopathy and chronic lung injury in murine sickle cell disease
Sterile inflammation induces vasculopathy and chronic lung injury in murine sickle cell disease
Sickle cell disease (SCD) is a chronic, devastating family of closely related disease conditions affecting nearly 100,000 ...
Corrigendum to “Clozapine-N-oxide protects dopaminergic neurons against rotenone-induced neurotoxicity by preventing ferritinophagy-mediated ferroptosis” [Free Radic. Biol. Med. 212 (2024) 384–402]
Corrigendum to “Clozapine-N-oxide protects dopaminergic neurons against rotenone-induced neurotoxicity by preventing ferritinophagy-mediated ferroptosis” [Free Radic. Biol. Med. 212 (2024) 384–402]
Volume 215, March 2024, Page 1Author links open overlay panelQingquan Sun a b, Yan Wang c, Liyan Hou d, Sheng Li a, Jau-Sh...
Revising the nomenclature for vitamin E requires agreement on its vitamin function
Revising the nomenclature for vitamin E requires agreement on its vitamin function
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Vitamin E: Not only a single stereoisomer
Vitamin E: Not only a single stereoisomer
The recent position paper by Azzi et al. [1] in this journal opens a discussion forum dedicated to a scientific debate on ...
The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E −/− mice
The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E −/− mice
Atherosclerosis, a complex disease that involves the accumulation of lipids, chronic inflammation, and vascular remodeling...
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta
Diabetes significantly elevates the susceptibility to various cardiovascular disorders, encompassing macrovascular complic...
Are age-related neurodegenerative diseases caused by a lack of the diet-derived compound ergothioneine?
Are age-related neurodegenerative diseases caused by a lack of the diet-derived compound ergothioneine?
We propose that the diet-derived compound ergothioneine (ET) is an important nutrient in the human body, especially for ma...
Redox organization of living systems
Redox organization of living systems
Redox organization governs an underlying simplicity in living systems. Critically, redox reactions enable the essential ch...
TIGAR reduces neuronal ferroptosis by inhibiting succinate dehydrogenase activity in cerebral ischemia
TIGAR reduces neuronal ferroptosis by inhibiting succinate dehydrogenase activity in cerebral ischemia
Stroke is currently the third leading cause of death and severe long-term disability worldwide, and the number of new and ...
mtDNA regulates cGAS-STING signaling pathway in adenomyosis
mtDNA regulates cGAS-STING signaling pathway in adenomyosis
Adenomyosis (AM) has become a prevalent and challenging disease due to the constant rise in its incidence rate over recent...
Modern optical approaches in redox biology: Genetically encoded sensors and Raman spectroscopy
Modern optical approaches in redox biology: Genetically encoded sensors and Raman spectroscopy
The field of redox biology has always been a significant challenge for analytical chemistry. This is because many redox ac...
Glsirt1-mediated deacetylation of GlCAT regulates intracellular ROS levels, affecting ganoderic acid biosynthesis in Ganoderma lucidum
Glsirt1-mediated deacetylation of GlCAT regulates intracellular ROS levels, affecting ganoderic acid biosynthesis in Ganoderma lucidum
Acetylation of lysine residues in proteins is a dynamically regulated, reversible and evolutionarily conserved posttransla...
Chronic exposure to PM10 induces anxiety-like behavior via exacerbating hippocampal oxidative stress
Chronic exposure to PM10 induces anxiety-like behavior via exacerbating hippocampal oxidative stress
Air pollution is progressively identified as a non-negligible environmental risk factor for mental health [1]. Atmospheric...
Reactive oxygen species augment contractile responses of saphenous artery in 10-15-day-old but not adult rats: Substantial role of NADPH oxidases
Reactive oxygen species augment contractile responses of saphenous artery in 10-15-day-old but not adult rats: Substantial role of NADPH oxidases
Reactive oxygen species (ROS), in addition to their known role in the pathogenesis of many diseases, also have regulatory ...
Changed regulation of granulocyte NADPH oxidase activity in the mouse model of obesity-induced type 2 diabetes mellitus
Changed regulation of granulocyte NADPH oxidase activity in the mouse model of obesity-induced type 2 diabetes mellitus
Obesity-related type 2 diabetes mellitus (T2DM) is characterized by low-grade chronic systemic inflammation, metabolic per...
Photosensitized isomerization of resveratrol: Evaluation of energy and electron transfer pathways
Photosensitized isomerization of resveratrol: Evaluation of energy and electron transfer pathways
More than 50 years ago, it was discovered that 3,5,4′-trihydroxystilbene, known as resveratrol (RSV), was synthesized in p...
Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation
Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation
Parkinson's disease (PD) stands as the second most widespread neurological disorder worldwide, marked by the degeneration ...
Corrigendum to “Effects of dietary inorganic nitrate on blood pressure during and post-exercise recovery: A systematic review and meta-analysis of randomized placebo-controlled trials” [Free Radic. Biol. Med. (2024) 215 25–36]
Corrigendum to “Effects of dietary inorganic nitrate on blood pressure during and post-exercise recovery: A systematic review and meta-analysis of randomized placebo-controlled trials” [Free Radic. Biol. Med. (2024) 215 25–36]
Volume 216, April 2024, Page 23Author links open overlay panelCicero Jonas R. Benjamim a, Leonardo S. Lopes da Silva b, Vi...
Corrigendum to “Activation of TGR5 with INT-777 attenuates oxidative stress and neuronal apoptosis via cAMP/PKCε/ALDH2 pathway after subarachnoid hemorrhage in rats” [Free Radic. Biol. Med. (2019 Nov 1) 143 441–453]
Corrigendum to “Activation of TGR5 with INT-777 attenuates oxidative stress and neuronal apoptosis via cAMP/PKCε/ALDH2 pathway after subarachnoid hemorrhage in rats” [Free Radic. Biol. Med. (2019 Nov 1) 143 441–453]
Volume 216, April 2024, Pages 78-79Author links open overlay panelGang Zuo a b 1, Tongyu Zhang b c 1, Lei Huang b d, Camil...
Unveiling the antioxidant superiority of α-tocopherol: Implications for vitamin E nomenclature and classification
Unveiling the antioxidant superiority of α-tocopherol: Implications for vitamin E nomenclature and classification
Since the discovery of tocopherols a century ago, α-tocopherol has been distinguished for its unique biological functions....
MnO2 nanoparticles trigger hepatic lipotoxicity and mitophagy via mtROS-dependent Hsf1Ser326 phosphorylation
MnO2 nanoparticles trigger hepatic lipotoxicity and mitophagy via mtROS-dependent Hsf1Ser326 phosphorylation
In recent years, nanoparticles have been largely produced and extensively applied in various fields, such as medicine, ani...
In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells
In situ lipid-loading activates peripheral dendritic cell subsets characterized by cellular ROS accumulation but compromises their capacity to prime naïve T cells
Volume 210, January 2024, Pages 406-415Author links open overlay panel, , , , , , , , , , , , Highlights•Hypercholesterole...
Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy
Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy
AbstractBackgroundRecent investigations have proposed a potential causal association between the occurrence of ferroptosis...
STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis
STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis
Autoimmune hepatitis (AIH) is a progressive chronic liver disease characterized by elevated serum transaminases, productio...
Different impact of vitamin D on mitochondrial activity and morphology in normal and malignant keratinocytes, the role of genomic pathway
Different impact of vitamin D on mitochondrial activity and morphology in normal and malignant keratinocytes, the role of genomic pathway
Vitamin D3 (1,25(OH)2D3), is a naturally occurring hormone formed in a UVB-dependent, non-enzymatic reaction from the 7-de...
Astrocyte-derived hepcidin aggravates neuronal iron accumulation after subarachnoid hemorrhage by decreasing neuronal ferroportin1
Astrocyte-derived hepcidin aggravates neuronal iron accumulation after subarachnoid hemorrhage by decreasing neuronal ferroportin1
Subarachnoid hemorrhage (SAH) is a potentially life-threatening neurosurgical emergency accounting for approximately 5 % o...
Selenite ameliorates the ATP hydrolysis of mitochondrial F1FO-ATPase by changing the redox state of thiol groups and impairs the ADP phosphorylation
Selenite ameliorates the ATP hydrolysis of mitochondrial F1FO-ATPase by changing the redox state of thiol groups and impairs the ADP phosphorylation
Selenite as an inorganic form of selenium can affect the redox state of mitochondria by modifying the thiol groups of cyst...
Evaluation of the expression of genes associated with iron metabolism in peripheral blood mononuclear cells from Type 2 diabetes mellitus patients
Evaluation of the expression of genes associated with iron metabolism in peripheral blood mononuclear cells from Type 2 diabetes mellitus patients
Diabetes mellitus, a chronic, metabolic disorder characterized by insulin resistance and impaired glucose homeostasis [1],...
bZIP transcription factor FabR: Redox-dependent mechanism controlling docosahexaenoic acid biosynthesis and H2O2 stress response in Schizochytrium sp.
bZIP transcription factor FabR: Redox-dependent mechanism controlling docosahexaenoic acid biosynthesis and H2O2 stress response in Schizochytrium sp.
Docosahexaenoic acid (DHA, 22:6ω-3), a principal ω-3 polyunsaturated fatty acid (PUFA) of human retina and brain membranes...
Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion
Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion
Hepatic ischemia/reperfusion injury (HIRI) represents a prevalent pathophysiological process that imposes a substantial ec...
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