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Comprehensive computational analysis of deleterious nsSNPs in PTEN gene for structural and functional insights
Single nucleotide polymorphisms (SNPs) are pivotal in understanding the genetic basis of complex disorders. Among them, no...
Gene co-expression network analysis reveals relationship between leukocyte fraction and genomic instability in dedifferentiated liposarcoma
Dedifferentiated Liposarcoma (DDLPS) is one of the common subtypes of liposarcoma that is considered a highly malignant ca...
Breast cancer susceptibility is associated with Cyclin D1 single nucleotide polymorphisms in Iran: A case-control study
Breast cancer (BC) is the main cause of cancer-related death in women worldwide. We evaluated the association between the ...
The importance of TP53 status in cancer therapy: The example of chronic lymphocytic leukemia
The TP53 gene encodes the tumor suppressor protein p53, which plays a critical role in genomic stability and cell cycle re...
Comment on: IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study
Dear Editor,I recently read an elegant study by Abdalla1 and Hamdan (2025) published in the Molecular Biology Research Com...
The effect of chemotherapeutic agents on epidermal neural crest stem cells
Human Epidermal Neural Crest Stem Cells (hEPI-NCSCs), as a transient population of multipotent migratory stem cells can di...
Clinical relevance of plasma-derived exosomal long non-coding RNAs (lncRNAs) CCAT1 and XIST in colorectal cancer patients
The expression level of exosomal long non-coding RNAs (lncRNAs) can be relevant for clinical diagnostic approaches. The ob...
Investigation methylation status of tumor suppressor gene NR4A1 and NR4A3 and frequency of rs1569686 polymorphism of DNMT3B gene in patients with acute myeloid leukemia
Acute myeloid leukemia (AML) is the most frequent type of leukemia among adults. Investigating AML heterogeneity based on ...
Pathogenic variants of BUB1 and BUBR1 genes are not prioritized in screening tests of couples with aborted aneuploid fetuses
Chromosome aberrations certainly aneuploidie are the cause of the majority of spontaneous abortions in humans. BUB1 (buddi...
Computational analysis of Ayurvedic herbs to explore their potential role as anti-cervical cancer agents
Cervical cancer is one of the common types of cancer in women. Treatment regimens include use of chemotherapy but it leads...
Effect of 30-day Ramadan fasting on autophagy pathway and metabolic health outcome in healthy individuals
During Ramadan, Muslims fast to spiritually prepare their bodies and spirits. The autophagy pathway restores cellular home...
A review on diabetes and oral cancer: Molecular links and implications
Diabetes mellitus has been linked to an increased risk of oral cancer, with hyperglycemia and chronic inflammation contrib...
Allele and genotype frequencies of β-lactoglobulin gene using PCR-RFLP in Algerian local cattle populations
Milk protein genetic polymorphisms are associated with economically important traits in dairy cattle. The objective of thi...
In-silico structural analysis of Heterocephalus glaber amyloid beta: an anti-Alzheimer's peptide
Heterocephalus glaber, known as the Naked mole-rat, has an extraordinary immunity to Alzheimer's disease. The patholo...
MicroRNAs targeting CDKN2A gene as a potential prognostic marker in head and neck squamous cell carcinoma
Epigenetic factors are known to markedly influence the functions of a gene by modification of transcripts, via methylation...
Evaluation of Beclin1 and mTOR genes and p62 protein expression in breast tumor tissues of Iranian patients
Autophagy is a cellular process that plays a major role in the fate of tumor cells. Understanding the role of autophagy in...
Arginine to glutamine mutation in the substrate binding region impaired the isopentenyl activity of Mycobacterium tuberculosis MiaA
tRNAs act as adaptors during protein synthesis and are chemically modified post-transcriptionally for their structural sta...
The importance of examining the Hardy-Weinberg Equilibrium in genetic association studies
No abstract
A comparison of phylogenetic and distance-based approaches for the distinction of genetically closed species, Draba rimarum (Rech.f.) A.R. Khosravi & A. Eslami-Farouji, and Draba aucheri Boiss. (Brassicaceae) as a case study
Circumscribing species boundries is necessary in systematic plant biology. Even a mistake in delimiting taxa may lead to i...
Human BKV large T genome detection in prostate cancer and benign prostatic hyperplasia tissue samples by nested PCR: A case-control study
Human BK polyomavirus (BKPyV) is a latent infectious agent in the genitourinary tract associated with hemorrhagic cystitis...
Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
The most often diagnosed and fatal malignancy in women is breast cancer. The International Agency for Research on Cancer (...
Genetic association between rs1695 in glutathione S-transferase P1 and risk of periodontitis: a pilot study
The present study aims to determine the association between a genetic polymorphism of GSTP1 (rs1695) and the risk of perio...
Evaluating the association of rs6983267 polymorphism of the CCAT2 gene with thyroid cancer susceptibility in the Iranian Azeri population
Thyroid cancer is the most common malignancy of the endocrine system. LncRNAs play critical role in various cellular proce...
Using several pseudo amino acid composition types and different machine learning algorithms to classify and predict archaeal phospholipases
Phospholipases, as important lipolytic enzymes, have diverse industrial applications. Regarding the stability of extremoph...
The effect of RORA (RAR-Related Orphan Receptor Alpha) receptors on litter size in Akkaraman sheep breed
In this study, the relationship between RORA 23bp indel genotype and allele frequency with twin pregnancy, fertility, live...
Structural arrangement of the active back-to-back dimer in N-glycosylated ErbB receptors is regulated by heterodimerization
The human epidermal growth factor receptor (EGFR/ErbB) family consists of four members (ErbB1-4) and belongs to the superf...
Detection of Hepatozoon spp. in dogs in Shiraz, southern Iran and its effects on the hematological alterations
Canine hepatozoonosis is a tick-transmitted apicomplexan infection caused by two species of Hepatozoon, H. canis, and H. a...
The effect of Annexin A5 overexpression on invasiveness and expression of the genes involved in epithelial-mesenchymal transition of HCT 116 cell line
Epithelial-to-mesenchymal transition (EMT) plays a critical role in colorectal cancer (CRC) metastasis. In the present stu...
Molecular mimicry and COVID-19: Potential implications for global fertility
There has been a concerning increase in the incidence of autoimmune diseases following SARS-CoV-2 infection, with molecula...
Genetic alterations in MED12 promote castration-resistant prostate cancer through modulation of GLI3 signaling
Prostate cancer is a disease that depends on androgenic stimulation and is thus commonly treated with androgen deprivation...
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