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Protective Effect of FABP5 Against 6-OHDA Induced Parkinson’s Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway
Protective Effect of FABP5 Against 6-OHDA Induced Parkinson’s Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway
Mitochondrial dysfunction of neurons is an important feature of Parkinson’s disease (PD). Fatty acid binding protein...
Attenuates Cognitive Deficits in Alzheimer’s Disease by Reducing Oxidative Stress Via the SIRT1/PGC-1α Signaling Pathway
Attenuates Cognitive Deficits in Alzheimer’s Disease by Reducing Oxidative Stress Via the SIRT1/PGC-1α Signaling Pathway
Emerging evidence suggests that probiotics may have a significant impact on the regulation of mitochondrial oxidative stre...
P300-Mediated ARRB1 Lactylation Promotes Mitochondrial Dysfunction and Neuronal Apoptosis in Subarachnoid Hemorrhage Via Upregulating S100A9
P300-Mediated ARRB1 Lactylation Promotes Mitochondrial Dysfunction and Neuronal Apoptosis in Subarachnoid Hemorrhage Via Upregulating S100A9
Background: Lactylation, a novel lactate-derived posttranslational modification, has been demonstrated to be linked with b...
Neuroprotective Effects of Tectoridin in HO-Induced Oxidative Stress and an Amyloid-Infused Rat Model of Alzheimer’s Disease
Neuroprotective Effects of Tectoridin in HO-Induced Oxidative Stress and an Amyloid-Infused Rat Model of Alzheimer’s Disease
This study aims to examine the effects of tectoridin in both in vitro and in vivo models of Alzheimer’s disease. In ...
miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice
miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice
Recently, a growing body of research has shown that microRNAs (miRNAs) are crucial in the pathophysiological mechanisms of...
The Power of Neuroglia in Driving Brain Function
The Power of Neuroglia in Driving Brain Function
Neuroglial cells are essential regulators of central nervous system (CNS) function in development, brain function, and dis...
Ropivacaine Mediates Mitochondrial Dysfunction and Ca Oscillations Attenuation in OPCs Leading to Developmental Spinal Dysmyelination by Inhibiting Akt Signaling
Ropivacaine Mediates Mitochondrial Dysfunction and Ca Oscillations Attenuation in OPCs Leading to Developmental Spinal Dysmyelination by Inhibiting Akt Signaling
Local anesthetics may induce spinal cord neurotoxicity. Our previous work demonstrated that intrathecal ropivacaine admini...
Low-Intensity Physical Exercise is Associated with Improved Myelination and Reduced Microglial Activation in a Cuprizone-Induced Demyelination Model
Low-Intensity Physical Exercise is Associated with Improved Myelination and Reduced Microglial Activation in a Cuprizone-Induced Demyelination Model
Demyelinating diseases like multiple sclerosis cause damage to the myelin sheath, leading to neurological problems. While ...
Prevents Nicotine Addiction in Pubescent Adolescent Rats: Evidence on Dopaminergic, Cholinergic, BDNF and Neuroinflammatory Pathways
Prevents Nicotine Addiction in Pubescent Adolescent Rats: Evidence on Dopaminergic, Cholinergic, BDNF and Neuroinflammatory Pathways
Graptophyllum grandulosum (G. grandulosum) is a plant of the Acanthaceae family found in the Littoral region of Cameroon. ...
Dragon’s Blood Modulates Disulfidptosis-Related Genes to Alleviate Ischemic Brain Injury in Mice
Dragon’s Blood Modulates Disulfidptosis-Related Genes to Alleviate Ischemic Brain Injury in Mice
Dragon’s Blood (DB), a natural resin extracted from Dracaena cochinchinensis, exhibits anti-inflammatory and neuropr...
The Neuroprotective Impact of Agomelatine in Preserving Brain Tissue Molecular Structure Against Alzheimer’s Disease Etiology
The Neuroprotective Impact of Agomelatine in Preserving Brain Tissue Molecular Structure Against Alzheimer’s Disease Etiology
This study investigates the therapeutic advantages of agomelatine in the context of Alzheimer’s disease (AD) using a...
Low-Dose Lipopolysaccharide Alleviates Neuronal Apoptosis and Oxidative Stress in Rats with Spinal Cord Injury by Inducing Nrf2 m6A Methylation Modification via Suppressing ALKBH5
Low-Dose Lipopolysaccharide Alleviates Neuronal Apoptosis and Oxidative Stress in Rats with Spinal Cord Injury by Inducing Nrf2 m6A Methylation Modification via Suppressing ALKBH5
This work reported the neuronal protection of low-dose lipopolysaccharide (LD-LPS) after spinal cord injury (SCI). SCI rat...
Exploration of Willd for Alzheimer’s Disease Through Integrated Metabolomics and Network Pharmacology Analyses Targeting BACE1 Protein
Exploration of Willd for Alzheimer’s Disease Through Integrated Metabolomics and Network Pharmacology Analyses Targeting BACE1 Protein
Asparagus racemosus Willd, an Ayurvedic medicine, is known for its antioxidant, antiviral, immune-boosting, and neuro-nutr...
Advances in ERK Signaling Pathway in Traumatic Brain Injury: Mechanisms and Therapeutic Potential
Advances in ERK Signaling Pathway in Traumatic Brain Injury: Mechanisms and Therapeutic Potential
Traumatic brain injury (TBI) stands as one of the leading global causes of disability and mortality. Its pathological prog...
Agonism of MT and MT Receptor Mitigates Oxidative Insult, Neuroinflammation, and Cerebral Injury in Cadmium Chloride Treated Animals
Agonism of MT and MT Receptor Mitigates Oxidative Insult, Neuroinflammation, and Cerebral Injury in Cadmium Chloride Treated Animals
Cadmium (Cd), the stronger neurodegenerating heavy metal, provokes oxidative insult and disturbances in the brain. This st...
From RIPK1 to Necroptosis: Pathogenic Mechanisms in Neurodegenerative Diseases
From RIPK1 to Necroptosis: Pathogenic Mechanisms in Neurodegenerative Diseases
Receptor-interacting protein kinase 1 (RIPK1)-mediated necroptosis, a newly identified mode of regulated cell death, repre...
Stabilization and Reduced Cytotoxicity of Amyloid Beta Aggregates in the Presence of Catechol Neurotransmitters
Stabilization and Reduced Cytotoxicity of Amyloid Beta Aggregates in the Presence of Catechol Neurotransmitters
Oligomeric aggregates of the amyloid-beta (Aβ) peptide have been implicated as the toxic species for Alzheimer’...
A Comprehensive Review of Essential Oils and Their Pharmacological Activities in Neurological Disorders: Exploring Neuroprotective Potential
A Comprehensive Review of Essential Oils and Their Pharmacological Activities in Neurological Disorders: Exploring Neuroprotective Potential
Numerous studies have demonstrated essential oils’ diverse chemical compositions and pharmacological properties enco...
Increased Expression of KNa1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury
Increased Expression of KNa1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury
Recent studies have indicated that functional abnormalities in the KNa1.2 channel are linked to epileptic encephalopathies...
Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1β-Induced Iron Regulatory Protein 1
Contrasting Iron Metabolism in Undifferentiated Versus Differentiated MO3.13 Oligodendrocytes via IL-1β-Induced Iron Regulatory Protein 1
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons...
The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity
Aluminum is a known neurotoxin and a major environmental contributor to neurodegenerative diseases such as Alzheimer’...
The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions
The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions
α2-Adrenoreceptors (ARs) are main Gi-protein coupled autoreceptors in sympathetic nerve terminals and targets for dex...
RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury
RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury
Traumatic brain injury (TBI) is a global public safety issue that poses a threat to death, characterized by high fatality ...
Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation
Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation
Morphine (MPH) is widely used for pain management; however, long-term MPH therapy results in antinociceptive tolerance and...
7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia
7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia
Vascular dementia (VD) is a degenerative cerebrovascular disorder associated with progressive cognitive decline. Previous ...
Modulation of Cellular Levels of Adenosine Phosphates and Creatine Phosphate in Cultured Primary Astrocytes
Modulation of Cellular Levels of Adenosine Phosphates and Creatine Phosphate in Cultured Primary Astrocytes
Adenosine triphosphate (ATP) is the main energy currency of all cells, while creatine phosphate (CrP) is considered as a b...
Sulphated Fucooligosaccharide from Sargassum Horneri: Structural Analysis and Anti-Alzheimer Activity
Sulphated Fucooligosaccharide from Sargassum Horneri: Structural Analysis and Anti-Alzheimer Activity
In the present study, sulfated polysaccharides were obtained by digestion of Sargassum horneri and preparation with enzyme...
Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout mice
Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout mice
Astrocytes have key regulatory roles in central nervous system (CNS), integrating metabolic, inflammatory and synaptic res...
Transplantation of Neural Stem Cells-Overexpressed Ku70 Improves Neurological Deficits in a Mice Model of Cerebral Ischemia Stroke
Transplantation of Neural Stem Cells-Overexpressed Ku70 Improves Neurological Deficits in a Mice Model of Cerebral Ischemia Stroke
Cerebral ischemic stroke is a cerebrovascular disease, which is related to DNA damage. Many researches have shown that Ku7...
CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets
CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets
Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in...
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