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Effect of Ang II Receptor Inhibition on GSK-3β/CREB/BDNF Signalling in REM Sleep Deprivation-Induced Memory Impairment
Effect of Ang II Receptor Inhibition on GSK-3β/CREB/BDNF Signalling in REM Sleep Deprivation-Induced Memory Impairment
REM (rapid eye movement) sleep deprivation causes serious impairments in hippocampus-dependent learning and memory. This s...
The Anti-proliferative Effects of Anandamide and Oleamide in Glioblastoma Cell Lines Recruit Mitochondrial and PPAR-γ Receptor Modulation
The Anti-proliferative Effects of Anandamide and Oleamide in Glioblastoma Cell Lines Recruit Mitochondrial and PPAR-γ Receptor Modulation
The endocannabinoid anandamide (AEA) and the related metabolite oleamide (ODA) have been demonstrated to possess anti-prol...
The Molecular Signature of Astrocyte Response to Hypoxia Outlines the Metabolic and Cell Survival Mechanisms for Neuroprotection
The Molecular Signature of Astrocyte Response to Hypoxia Outlines the Metabolic and Cell Survival Mechanisms for Neuroprotection
The molecular reprogramming of astrocyte gene expression induced by oxygen deprivation is one of the astrocyte-mediated ne...
Modulating Expression by Kaempferol Alleviates Experimental Autoimmune Encephalomyelitis: Targeting Fpn1-Dependent Ferroptosis and cAMP/CREB/CNTF Signaling
Modulating Expression by Kaempferol Alleviates Experimental Autoimmune Encephalomyelitis: Targeting Fpn1-Dependent Ferroptosis and cAMP/CREB/CNTF Signaling
Multiple sclerosis (MS) is a progressive, immune-mediated demyelinating disorder of the central nervous system (CNS). Kaem...
Serum Aberrant Expression of miR-431-5p and Their Diagnostic Value in Parkinson’s Disease
Serum Aberrant Expression of miR-431-5p and Their Diagnostic Value in Parkinson’s Disease
Non-coding RNA plays an important role in the occurrence and development of Parkinson’s disease (PD). This study onl...
Melatonin Promotes Neurogenesis via the JAK2/STAT3 Pathway in Hypoxic-Ischemic Neonatal Rats
Melatonin Promotes Neurogenesis via the JAK2/STAT3 Pathway in Hypoxic-Ischemic Neonatal Rats
Neonatal hypoxic-ischemic brain damage (HIBD) is a leading cause of neurological dysfunction and long-term disability in n...
1,3,4-Oxadiazole Derivative: A Potential Anti-inflammatory and Antioxidant Agent in Experimental Autoimmune Encephalomyelitis
1,3,4-Oxadiazole Derivative: A Potential Anti-inflammatory and Antioxidant Agent in Experimental Autoimmune Encephalomyelitis
1,3,4-Oxadiazole derivatives have attracted substantial attention as promising therapeutic agents for neurodegenerative di...
Metabolic Alterations Induced by a Seizure-Causing Sodium Channel Mutation and their Partial Normalization by Dietary α-Linolenic Acid in
Metabolic Alterations Induced by a Seizure-Causing Sodium Channel Mutation and their Partial Normalization by Dietary α-Linolenic Acid in
Epilepsy is increasingly recognized as a disorder with prominent metabolic disturbances, but how defined epilepsy-causing ...
Correction: Modulation of the Levels of NMDA Receptor Subunit mRNA and the Bindings of [H]MK-801 in Rat Brain by Chronic Infusion of Subtoxic Dose of MK-801
Correction: Modulation of the Levels of NMDA Receptor Subunit mRNA and the Bindings of [H]MK-801 in Rat Brain by Chronic Infusion of Subtoxic Dose of MK-801
Department of Neuroscience, Medical Research Center, College of Medicine, Ewha Womans University, Mok-dong, Yangchon-ku, S...
EVADR lncRNA Mitigates Neonatal Hypoxic–Ischemic Brain Injury via the miR-145→WNT/β-Catenin Axis and Exhibits Biomarker Potential
EVADR lncRNA Mitigates Neonatal Hypoxic–Ischemic Brain Injury via the miR-145→WNT/β-Catenin Axis and Exhibits Biomarker Potential
Perinatal hypoxic–ischemic injury (HI) upregulated an endogenous retrovirus–derived lncRNA, EVADR, via HIF-1&#...
Exploring the Anticonvulsant and Neuropreventive Effects of Extract in the Pentylenetetrazole-Kindling Model: Analysis of Cognitive Comorbidities Associated with Epilepsy
Exploring the Anticonvulsant and Neuropreventive Effects of Extract in the Pentylenetetrazole-Kindling Model: Analysis of Cognitive Comorbidities Associated with Epilepsy
Oxidative stress associated with neuronal death resulting from excitotoxicity represents a key pathophysiological mechanis...
Nuclear and Cytoplasmic Mouse ID Associated 1 (MIDA1) Protein Varies in Neurons and Astrocytes Across the Different Hippocampal Regions and Exhibits Age-Related Changes
Nuclear and Cytoplasmic Mouse ID Associated 1 (MIDA1) Protein Varies in Neurons and Astrocytes Across the Different Hippocampal Regions and Exhibits Age-Related Changes
Nuclear Mouse ID Associated 1 (MIDA1), also known as Hsp40/DNAJC2 and ZRF1, plays a key role in the establishment of neura...
Exploring the Therapeutic Potential of N-(3,4-dimethoxy phenyl)-6,7-dimethoxyquinazoline-4-amine (TKM01) in Aluminium-Induced Alzheimer’s Disease-Like Model of Zebrafish
Exploring the Therapeutic Potential of N-(3,4-dimethoxy phenyl)-6,7-dimethoxyquinazoline-4-amine (TKM01) in Aluminium-Induced Alzheimer’s Disease-Like Model of Zebrafish
Aluminum (Al), a pervasive environmental neurotoxicant, has been strongly implicated in the onset and progression of Alzhe...
Plasma-Derived Exosomal hsa-miR-3677-3p Induces Ferroptosis in Neurons by Targeting in Perioperative Neurocognitive Disorders After Prostate Surgery
Plasma-Derived Exosomal hsa-miR-3677-3p Induces Ferroptosis in Neurons by Targeting in Perioperative Neurocognitive Disorders After Prostate Surgery
Perioperative neurocognitive disorders (PND) are prevalent complications in elderly patients following surgery, characteri...
Metformin Ameliorates Cognitive Deficits and Neuroinflammation in a Mouse Model of Familial Hypercholesterolemia
Metformin Ameliorates Cognitive Deficits and Neuroinflammation in a Mouse Model of Familial Hypercholesterolemia
Familial hypercholesterolemia (FH), caused by mutations in the low-density lipoprotein receptor (LDLr) gene, has been incr...
Harnessing Endogenous Neural Stem Cells: A New Frontier in Spinal Cord Injury Repair
Harnessing Endogenous Neural Stem Cells: A New Frontier in Spinal Cord Injury Repair
Spinal cord injury (SCI), a serious neurological condition caused by trauma, inflammation, infection, or vascular diseases...
Noninvasive Focused Ultrasound as a Safe Modulator of Calcium-Dependent Neurochemical Signalling in Primary Cortical Cultures
Noninvasive Focused Ultrasound as a Safe Modulator of Calcium-Dependent Neurochemical Signalling in Primary Cortical Cultures
Focused ultrasound stimulation (FUS) is a promising non-invasive neuromodulation technique that can influence neuronal act...
The Cell-Specific Effects of the Human Remyelination-Promoting rHIgM22 on Sphingolipid Metabolism in Cultured Glial Cells
The Cell-Specific Effects of the Human Remyelination-Promoting rHIgM22 on Sphingolipid Metabolism in Cultured Glial Cells
Demyelinating diseases are heterogeneous in their etiology, clinical course, and manifestations. In the long run, however,...
Protective Effect of FABP5 Against 6-OHDA Induced Parkinson’s Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway
Protective Effect of FABP5 Against 6-OHDA Induced Parkinson’s Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway
Mitochondrial dysfunction of neurons is an important feature of Parkinson’s disease (PD). Fatty acid binding protein...
Attenuates Cognitive Deficits in Alzheimer’s Disease by Reducing Oxidative Stress Via the SIRT1/PGC-1α Signaling Pathway
Attenuates Cognitive Deficits in Alzheimer’s Disease by Reducing Oxidative Stress Via the SIRT1/PGC-1α Signaling Pathway
Emerging evidence suggests that probiotics may have a significant impact on the regulation of mitochondrial oxidative stre...
P300-Mediated ARRB1 Lactylation Promotes Mitochondrial Dysfunction and Neuronal Apoptosis in Subarachnoid Hemorrhage Via Upregulating S100A9
P300-Mediated ARRB1 Lactylation Promotes Mitochondrial Dysfunction and Neuronal Apoptosis in Subarachnoid Hemorrhage Via Upregulating S100A9
Background: Lactylation, a novel lactate-derived posttranslational modification, has been demonstrated to be linked with b...
Neuroprotective Effects of Tectoridin in HO-Induced Oxidative Stress and an Amyloid-Infused Rat Model of Alzheimer’s Disease
Neuroprotective Effects of Tectoridin in HO-Induced Oxidative Stress and an Amyloid-Infused Rat Model of Alzheimer’s Disease
This study aims to examine the effects of tectoridin in both in vitro and in vivo models of Alzheimer’s disease. In ...
miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice
miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice
Recently, a growing body of research has shown that microRNAs (miRNAs) are crucial in the pathophysiological mechanisms of...
The Power of Neuroglia in Driving Brain Function
The Power of Neuroglia in Driving Brain Function
Neuroglial cells are essential regulators of central nervous system (CNS) function in development, brain function, and dis...
Ropivacaine Mediates Mitochondrial Dysfunction and Ca Oscillations Attenuation in OPCs Leading to Developmental Spinal Dysmyelination by Inhibiting Akt Signaling
Ropivacaine Mediates Mitochondrial Dysfunction and Ca Oscillations Attenuation in OPCs Leading to Developmental Spinal Dysmyelination by Inhibiting Akt Signaling
Local anesthetics may induce spinal cord neurotoxicity. Our previous work demonstrated that intrathecal ropivacaine admini...
Low-Intensity Physical Exercise is Associated with Improved Myelination and Reduced Microglial Activation in a Cuprizone-Induced Demyelination Model
Low-Intensity Physical Exercise is Associated with Improved Myelination and Reduced Microglial Activation in a Cuprizone-Induced Demyelination Model
Demyelinating diseases like multiple sclerosis cause damage to the myelin sheath, leading to neurological problems. While ...
Prevents Nicotine Addiction in Pubescent Adolescent Rats: Evidence on Dopaminergic, Cholinergic, BDNF and Neuroinflammatory Pathways
Prevents Nicotine Addiction in Pubescent Adolescent Rats: Evidence on Dopaminergic, Cholinergic, BDNF and Neuroinflammatory Pathways
Graptophyllum grandulosum (G. grandulosum) is a plant of the Acanthaceae family found in the Littoral region of Cameroon. ...
Dragon’s Blood Modulates Disulfidptosis-Related Genes to Alleviate Ischemic Brain Injury in Mice
Dragon’s Blood Modulates Disulfidptosis-Related Genes to Alleviate Ischemic Brain Injury in Mice
Dragon’s Blood (DB), a natural resin extracted from Dracaena cochinchinensis, exhibits anti-inflammatory and neuropr...
The Neuroprotective Impact of Agomelatine in Preserving Brain Tissue Molecular Structure Against Alzheimer’s Disease Etiology
The Neuroprotective Impact of Agomelatine in Preserving Brain Tissue Molecular Structure Against Alzheimer’s Disease Etiology
This study investigates the therapeutic advantages of agomelatine in the context of Alzheimer’s disease (AD) using a...
Low-Dose Lipopolysaccharide Alleviates Neuronal Apoptosis and Oxidative Stress in Rats with Spinal Cord Injury by Inducing Nrf2 m6A Methylation Modification via Suppressing ALKBH5
Low-Dose Lipopolysaccharide Alleviates Neuronal Apoptosis and Oxidative Stress in Rats with Spinal Cord Injury by Inducing Nrf2 m6A Methylation Modification via Suppressing ALKBH5
This work reported the neuronal protection of low-dose lipopolysaccharide (LD-LPS) after spinal cord injury (SCI). SCI rat...
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