Luo X-Q, Li A, Yang X, Xiao X, Hu R, Wang T-W, Dou X-Y, Yang D-J, Dong Z (2018) Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular Dementia rats via cannabinoid receptor 2. Chin Med 13:1–17

Article  Google Scholar 

Eyileten C, Kaplon-Cieslicka A, Mirowska-Guzel D, Malek L, Postula M (2017) Antidiabetic effect of brain-derived neurotrophic factor and its association with inflammation in type 2 diabetes mellitus. J Diabetes Res 2017:2823671

Article  PubMed  PubMed Central  Google Scholar 

Venkat P, Culmone L, Chopp M, Landschoot-Ward J, Wang F, Zacharek A, Chen J (2020) HUCBC Treatment improves cognitive outcome in rats with vascular Dementia. Front Aging Neurosci 12:258

Article  PubMed  PubMed Central  Google Scholar 

Zhang Z-Y, Liu Z, Deng H-H, Chen Q (2018) Effects of acupuncture on vascular Dementia (VD) animal models: a systematic review and meta-analysis. BMC Complement Altern Med 18:1–10

Article  Google Scholar 

Zhang Y, Wang LL, Wu Y, Wang N, Wang SM, Zhang B, Shi CG, Zhang SC (2016) Paeoniflorin attenuates hippocampal damage in a rat model of vascular Dementia. Exp Ther Med 12:3729–3734

Article  CAS  PubMed  PubMed Central  Google Scholar 

Erkinjuntti T, Roman G, Gauthier S, Feldman H, Rockwood K (2004) Emerging therapies for vascular Dementia and vascular cognitive impairment. Stroke 35:1010–1017

Article  CAS  PubMed  Google Scholar 

Baskys A, Cheng J-x (2012) Pharmacological prevention and treatment of vascular Dementia: approaches and perspectives. Exp Gerontol 47:887–891

Article  CAS  PubMed  Google Scholar 

Miranda M, Morici JF, Zanoni MB, Bekinschtein P (2019) Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain. Front Cell Neurosci 13:363

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhen Y-F, Liu X-Y, Zhou D-H, Du X, Yin G, Zhang Y, Fang H, Xu G, Soares JC, Zhang XY (2018) Cognition, serum BDNF levels, and BDNF Val66Met polymorphism in type 2 Diabetes patients and healthy controls. Oncotarget 9:3653

Article  PubMed  Google Scholar 

Wang D-P, Yin H, Lin Q, Fang S-P, Shen J-H, Wu Y-F, Su S-H, Hai J (2019) Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. Naunyn-Schmiedeberg Arch Pharmacol 392:1277–1284

Article  CAS  Google Scholar 

Wan Q, Ma X, Zhang Z-J, Sun T, Xia F, Zhao G, Wu Y-M (2017) Ginsenoside reduces cognitive impairment during chronic cerebral hypoperfusion through brain-derived neurotrophic factor regulated by epigenetic modulation. Mol Neurobiol 54:2889–2900

Article  CAS  PubMed  Google Scholar 

Weissmiller AM, Wu C (2012) Current advances in using neurotrophic factors to treat neurodegenerative disorders. Transl Neurodegen 1:1–9

Google Scholar 

Liu C, Chan CB, Ye K (2016) 7, 8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders. Transl Neurodegen 5:1–9

Google Scholar 

Wu C-H, Hung T-H, Chen C-C, Ke C-H, Lee C-Y, Wang P-Y, Chen S-F (2014) Post-injury treatment with 7, 8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling. PLoS ONE 9:e113397

Article  PubMed  PubMed Central  Google Scholar 

Agrawal R, Noble E, Tyagi E, Zhuang Y, Ying Z, Gomez-Pinilla F (2015) Flavonoid derivative 7, 8-DHF attenuates TBI pathology via TrkB activation. Biochim Biophys Acta Mol Basis Dis 1852:862–872

Article  CAS  Google Scholar 

Pandey SN, Mohit K, Dwivedi DK, Priyansha C, Mangala L, Ashok J (2020) 7, 8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence. Psychopharmacology 237:1827–1840

Article  CAS  PubMed  Google Scholar 

Tan Y, Nie S, Zhu W, Liu F, Guo H, Chu J, Cao XB, Jiang X, Zhang Y, Li Y (2016) 7, 8-dihydroxyflavone ameliorates cognitive impairment by inhibiting expression of tau pathology in ApoE-knockout mice. Front Aging Neurosci 8:287

Article  PubMed  PubMed Central  Google Scholar 

Zeng Y, Lv F, Li L, Yu H, Dong M, Fu Q (2012) 7, 8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. J Neurochem 122:800–811

Article  CAS  PubMed  Google Scholar 

Castello NA, Nguyen MH, Tran JD, Cheng D, Green KN, LaFerla FM (2014) 7, 8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss. PLoS ONE 9:e91453

Article  PubMed  PubMed Central  Google Scholar 

Kwon KJ, Kim MK, Lee EJ, Kim JN, Choi B-R, Kim SY, Cho KS, Han J-S, Kim HY, Shin CY (2014) Effects of Donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular Dementia. J Neurol Sci 347:66–77

Article  CAS  PubMed  Google Scholar 

Dhaliwal N, Dhaliwal J, Singh A, Chopra K (2021) Dimethyl fumarate attenuates 2-VO-induced vascular Dementia via activating the Nrf2 signaling pathway in rats. Inflammopharmacology 29:537–547

Article  CAS  PubMed  Google Scholar 

Akhtar A, Dhaliwal J, Sah SP (2021) 7, 8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer’s disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance. Psychopharmacology 238:1–19

Article  Google Scholar 

Jian W-x, Zhang Z, Zhan J-h, Chu S-f, Peng Y, Zhao M, Wang Q, Chen N-h (2020) Donepezil attenuates vascular Dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation. Acta Pharmacol Sin 41:588–598

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sachdeva AK, Chopra K (2015) Lycopene abrogates Aβ (1–42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer’s Disease. J Nutr Biochem 26:736–744

Article  CAS  PubMed  Google Scholar 

Wills E (1965) Mechanisms of lipid peroxide formation in tissues role of metals and haematin proteins in the catalysis of the oxidation of unsaturated fatty acids. Biochim Biophys Acta Lipids Lipid Metab 98:238–251

Article  CAS  Google Scholar 

Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A-G, Ahn B-W, Shaltiel S, Stadtman ER (1990) Determination of carbonyl content in oxidatively modified proteins. Methods in enzymology. Elsevier, Amsterdam, pp 464–478

Google Scholar 

Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–77

Article  CAS  PubMed  Google Scholar 

Kono Y (1978) Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 186:189–195

Article  CAS  PubMed  Google Scholar 

Lawrence RA, Burk RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71:952–958

Article  CAS  PubMed  Google Scholar 

Ellman GL, Courtney KD, Andres V Jr, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95

Article  CAS  PubMed  Google Scholar 

Bernt E, Bergmeyer HU (1974) l-Glutamate UV-assay with gutamate dehydrogenase and NAD. Methods of enzymatic analysis. Elsevier, Amsterdam, pp 1704–1715

Chapter  Google Scholar 

Yadav M, Parle M, Jindal DK, Sharma N (2018) Potential effect of spermidine on GABA, dopamine, acetylcholinesterase, oxidative stress and proinflammatory cytokines to diminish ketamine-induced psychotic symptoms in rats. Biomed Pharmacother 98:207–213

Article  CAS  PubMed  Google Scholar 

Naik B, Nirwane A, Majumdar A (2017) Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats. Cog Neurodyn 11:35–49

Article  Google Scholar 

Liu D-d, Yuan X, Chu S-f, Chen C, Ren Q, Luo P, Lin M-y, Wang S-s, Zhu T-b, Zhang D-m (2019) CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular Dementia in rats through a Nrf2-mediated antioxidant responses. Acta Pharmacol Sin 40:425–440

Article  PubMed  Google Scholar 

Sohn E, Kim YJ, Lim H-S, Kim B-Y, Jeong S-J (2019) Hwangryunhaedok-Tang exerts neuropreventive effect on memory impairment by reducing cholinergic system dysfunction and inflammatory response in a vascular Dementia rat model. Molecules 24:343

Article  PubMed  PubMed Central  Google Scholar 

Hu Y, Yang Y, Zhang M, Deng M, Zhang J-J (2017) Intermittent fasting pretreatment prevents cognitive impairment in a rat model of chronic cerebral hypoperfusion. J Nutr 147:1437–1445

Article  CAS  PubMed  Google Scholar 

Zhu X, Tian J, Sun S, Dong Q, Zhang F, Zhang X (2016) (-)-SCR1693 protects against memory impairment and hippocampal damage in a chronic cerebral hypoperfusion rat model. Sci Rep 6:28908

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhuvanendran S, Bakar SNS, Kumari Y, Othman I, Shaikh MF, Hassan Z (2019) Embelin improves the spatial memory and hippocampal long-term potentiation in a rat model of chronic cerebral hypoperfusion. Sci Rep 9:1–11

Article  CAS