P300-Mediated ARRB1 Lactylation Promotes Mitochondrial Dysfunction and Neuronal Apoptosis in Subarachnoid Hemorrhage Via Upregulating S100A9

Zhang A, Liu Y, Wang X, Xu H, Fang C, Yuan L, Wang K, Zheng J, Qi Y, Chen S et al (2023) Clinical potential of immunotherapies in subarachnoid hemorrhage treatment: mechanistic dissection of innate and adaptive immune responses. Aging Dis 14:1533–1554

Article  PubMed  PubMed Central  Google Scholar 

Sangami Pugazenthi AJN, David C, Lauzier AV, Lele A, Huguenard R, Dhar GJ, Zipfel (2024) Umeshkumar Athiraman: Conditioning-based therapeutics for aneurysmal subarachnoid hemorrhage - A critical review. J Cereb Blood Flow Metab 44:317–332

Article  PubMed  Google Scholar 

Tian Q, Liu S, Han SM, Zhang W, Qin XY, Chen JH, Liu CL, Guo YJ, Li MC (2023) The mechanism and relevant mediators associated with neuronal apoptosis and potential therapeutic targets in subarachnoid hemorrhage. Neural Regen Res 18:244–252

CAS  PubMed  Google Scholar 

Wang XY, Wu F, Zhan RY, Zhou HJ (2022) Inflammatory role of microglia in brain injury caused by subarachnoid hemorrhage. Front Cell Neurosci 16:956185

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Z, Zhang A, Liu Y, Hu X, Fang Y, Wang X, Luo Y, Lenahan C, Chen S (2022) New mechanisms and targets of subarachnoid hemorrhage: A focus on mitochondria. Curr Neuropharmacol 20:1278–1296

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xin Q, Wang H, Li Q, Liu S, Qu K, Liu C, Zhang J (2022) Lactylation: a passing fad or the future of posttranslational modification. Inflammation 45:1419–1429

Article  CAS  PubMed  Google Scholar 

Dai SK, Liu PP, Li X, Jiao LF, Teng ZQ, Liu CM (2022) Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development. Development 149

Pan RY, He L, Zhang J, Liu X, Liao Y, Gao J, Liao Y, Yan Y, Li Q, Zhou X et al (2022) Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease. Cell Metab 34:634–648e636

Article  CAS  PubMed  Google Scholar 

Hagihara H, Shoji H, Otabi H, Toyoda A, Katoh K, Namihira M, Miyakawa T (2021) Protein lactylation induced by neural excitation. Cell Rep 37:109820

Article  CAS  PubMed  Google Scholar 

Yang C, Zhao X, Zhou W, Li Q, Lazarovici P, Zheng W (2024) Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2 pathway. J Transl Med 22:844

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weng W, He Z, Ma Z, Huang J, Han Y, Feng Q, Qi W, Peng Y, Wang J, Gu J et al (2025) Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury. Cell Death Differ 32:530–545

Article  CAS  PubMed  Google Scholar 

Li J, Shi X, Xu J, Wang K, Hou F, Luan X, Chen L (2025) Aldehyde dehydrogenase 2 lactylation aggravates mitochondrial dysfunction by disrupting PHB2 mediated mitophagy in acute kidney injury. Adv Sci (Weinh) 12:e2411943

Article  PubMed  Google Scholar 

Kallifatidis G, Mamouni K, Lokeshwar BL (2020) The role of beta-Arrestins in regulating stem cell phenotypes in normal and tumorigenic cells. Int J Mol Sci 21

Abballe L, Alfano V, Antonacci C, Cefalo MG, Cacchione A, Del Baldo G, Pezzullo M, Po A, Moretti M, Mastronuzzi A et al (2023) beta-arrestin1-E2F1-ac axis regulates physiological apoptosis and cell cycle exit in cellular models of early postnatal cerebellum. Front Cell Dev Biol 11:990711

Article  PubMed  PubMed Central  Google Scholar 

Zeng Q, Wang K, Zhao Y, Ma Q, Chen Z, Huang W (2023) Effects of the acetyltransferase p300 on tumour regulation from the novel perspective of posttranslational protein modification. Biomolecules 13

Wang X, Fan W, Li N, Ma Y, Yao M, Wang G, He S, Li W, Tan J, Lu Q, Hou S (2023) YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2. Genome Biol 24:87

Article  PubMed  PubMed Central  Google Scholar 

Xiong XY, Pan XR, Luo XX, Wang YF, Zhang XX, Yang SH, Zhong ZQ, Liu C, Chen Q, Wang PF et al (2024) Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation. Theranostics 14:4297–4317

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang N, Zhang Y, Xu J, Wang P, Wu B, Lu S, Lu X, You S, Huang X, Li M et al (2023) alpha-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure. Cell Res 33:679–698

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie L, Wang Y, Chen Z (2022) Early growth response protein 1 knockdown alleviates the cerebral injury in rats with intracerebral hemorrhage via STAT3/NF-kappaB pathway by reducing RXRalpha acetylation level. Neuroscience 487:120–130

Article  CAS  PubMed  Google Scholar 

Jeong GW, Lee HH, Lee-Kwon W, Kwon HM (2020) Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-kappaB and AP-1. J Neuroinflammation 17:372

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang C, Li Z, Tian K, Meng X, Wang X, Song D, Wang X, Xu T, Sun P, Zhong J et al (2024) LncRNA-Mediated TPI1 and PKM2 promote Self-Renewal and chemoresistance in GBM. Adv Sci (Weinh) 11:e2402600

Article  PubMed  Google Scholar 

Xia P, Ji X, Yan L, Lian S, Chen Z, Luo Y (2024) Roles of S100A8, S100A9 and S100A12 in infection, inflammation and immunity. Immunology 171:365–376

Article  CAS  PubMed  Google Scholar 

Li Y, Chen B, Yang X, Zhang C, Jiao Y, Li P, Liu Y, Li Z, Qiao B, Bond Lau W et al (2019) S100a8/a9 signaling causes mitochondrial dysfunction and cardiomyocyte death in response to ischemic/reperfusion injury. Circulation 140:751–764

Article  CAS  PubMed  Google Scholar 

Zhang J, Ma K, Luo Z, Wang G, Feng Z, Huang Y, Fei K, Liu Y, Xia H, Yuan J, Xiao P (2024) Correction to: combining functional and morphological retinal vascular characteristics achieves high-precision diagnosis of mild non-proliferative diabetic retinopathy. J Transl Med 22:850

Article  PubMed  PubMed Central  Google Scholar 

Yuan B, Zhou XM, You ZQ, Xu WD, Fan JM, Chen SJ, Han YL, Wu Q, Zhang X (2020) Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage. Cell Death Dis 11:76

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Zheng ZV, Lu G, Chan WY, Zhang Y, Wong GKC (2022) Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage. Neural Regen Res 17:1404–1411

Article  CAS  PubMed  Google Scholar 

Zhang J, Zhu Q, Wang J, Peng Z, Zhuang Z, Hang C, Li W (2024) Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage. Neural Regen Res 19:825–832

Article  CAS  PubMed  Google Scholar 

Zhang W, Xu L, Yu Z, Zhang M, Liu J, Zhou J (2023) Inhibition of the Glycolysis prevents the cerebral infarction progression through decreasing the lactylation levels of LCP1. Mol Biotechnol 65:1336–1345

Article  CAS  PubMed  Google Scholar 

Zhang F, Zhou J, Lu P, Zhang X, Yang L, Wu J, Zhang L, Zhang L, Pang J, Xie H et al (2024) Lactylation of histone by BRD4 regulates astrocyte polarization after experimental subarachnoid hemorrhage. J Neuroinflammation 21:186

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Shen X, Zhang Y, Zheng X, Cepeda C, Wang Y, Duan S, Tong X (2023) Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells. Glia 71:1383–1401

Article  PubMed  Google Scholar 

Candelario-Jalil E, Dijkhuizen RM, Magnus T (2022) Neuroinflammation, stroke, Blood-Brain barrier dysfunction, and imaging modalities. Stroke 53:1473–1486

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Wang X, Zho

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