Fluyau D, Charton TE (2022) Drug addiction. StatPearlspublishing, pp 1–18

WHO (2022) The world drug problem from a public health perspective. Seventy-fifth World Health Assembly, Geneva

Google Scholar 

Christopher JL, Aravkin AY, Zheng P, Abbafati C, Abbas KM, KangevariM A (2020) Burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study. Lancet 396:1223–1249

Article  Google Scholar 

Metuge CE, Dzudie A, Ebasoe PV, Assob NJC, Ngowe M, Njang E, Mabouna S, Eyoum C (2021) Prevalence and factors associated with substance use among students in tertiary institutions in Buea Cameroon. Pan African Med J 41(103):1–3

Google Scholar 

Samaila A, Abdulkadir B (2018) Pathophysiology of substance abuse: a review. Int J Sci Res 7(1):1013–1018

Google Scholar 

Gipson CD, Reissner KJ, Kupchik YM, Smith AC, Stankeviciute N, Simon HME, Kalivas PW (2013) Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc Natl Acad Sci USA 110(22):9124–9129

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adeluyi A, Guerin L, Fisher ML, Galloway A, Cole RA, Chan SL, Wyatt MD, Davis SW, Freeman LR, Ortinski P, Turner JR (2019) Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal. Sci Adv 5(7031):1–11

Google Scholar 

Kohno M, Link J, Dennis LE, McCreadya H, Huckans M, HoffmanWF LJM (2020) Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies. Pharmacol Biochem Behav 179:34–42

Article  Google Scholar 

Sherafat Y, Bautista M, Fowler CD (2021) Multidimensional Intersection of Nicotine, Gene Expression and Behavior. Front Behav Neurosci 15(649129):1–11

Google Scholar 

Volkow ND, Michaelides M, Baler R (2019) The neuroscience of drug reward and addiction. Physiol Rev 99:2115–2140

Article  CAS  PubMed  PubMed Central  Google Scholar 

Postma M (2021) An investigation into the effects of Sceletiumtortuosumin a methamphetamine addiction model in Sprague Dawley rats Master of sciences in Pharmacology, North-West University, pp 21–50

Njoroge MW (2018) Review on treatment of substance use disorders. J Addict Res Ther 9(353):3–5

Google Scholar 

Dumore NG, Janrao MU, Taksande BG, Aglawe MM, Kotagale NR (2019) Effects of withania somnifera nicotine induced conditioned place preference in mice. Pharmacogn J 11(1):43–47

Article  CAS  Google Scholar 

Gadhvi KV, Rai PD, Lavhale MS, Mishra SH (2020) Development and evaluation of a novel herbal formula for tobacco cessation in nicotine addicted rat model. Indian J Exp Biol 58:381–388

CAS  Google Scholar 

Nielsen BE, Bermudez I, Bouzat C (2019) Flavonoids as positive allosteric modulators of α7 nicotinic receptor. Neuropharmacology 160(107794):4–10

Google Scholar 

Aboulaghras S, Sahib N, Bakrim S, Benali T, Charfi S, Guaouguaou F, El Omari N, Gallo M, Montesano D, Zengin G, Taghzouti K, Bouyahya A (2022) Health benefits and pharmacological aspect of chrysoeriol. Pharmaceuticals 15(973):5–10

Google Scholar 

Xie Y, Chen L, Chen J (2024) Luteolin blocks dopaminergic neuron degeneration and shifts microglial M1/M2 polarization by inhibiting Toll like receptor 4. Authorea Preprints

Pahaye DB, Ngo Bum EN, Taïwé GS, Ngoupaye GT, Sidiki N, Moto FCO, Kouemou N, Njapdounke SJK, Nkantchoua G, Kandeda A, Omam JPO (2017) Neuroprotective and antiamnesic effects of mitragyna inermis willd (rubiaceae) on scopolamine-induced memory impairment in mice. Behav Neurol 1:5952897

Google Scholar 

Iñiguez SD, Warren BL, Parise E, Alcantara LF, Schuh B, Maffeo ML, Manojlovic Z, Bolaños CA (2009) Nicotine exposure during adolescence induces a depression like state in adulthood. Neuropsychopharmacology 34(6):1609–1624

Article  PubMed  Google Scholar 

Natarajan R, Wright JW, Harding JW (2011) Nicotine-induced conditioned place preference in adolescent rats. Pharmacol Biochem Behav 99:519–523

Article  CAS  PubMed  Google Scholar 

Schlumfjf M, Lichtentensteiger W, Langermann H, Waster PG, Hefti F (1974) A fluoremetricmicromethod for the simultaneous determination of serotonin, noradrenaline and dopamine in milligram amounts of brain tissue. Biochem Pharmacol 23:2337–2446

Google Scholar 

Ngoupaye GT, Pahaye DB, Ngondi J, Moto FCO, Ngo Bum E (2017) Gladiolus daleniilyophilisate reverses scopolamine induced amnesia and reduces oxidative stress in rat brain. Biomed Pharmacother 91:350–357

Article  PubMed  Google Scholar 

Hestrin S (1949) The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. J Biol Chem 180(1):249–261

Article  CAS  PubMed  Google Scholar 

Chang C, Yang M, Chern WH, J, (2002) Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal 10:178–182

CAS  Google Scholar 

Ramde-Tiendrebeogo A, Tibiri A, Hilou A, Lompo M, Millogo-Kone H, Nacoulma OG, Guissou IP (2012) Antioxidative and antibacterial activities of phenolic compounds from Ficus sue Forssk. Int J Biol Chem Sci 6(1):328–336

Google Scholar 

Ngoupaye GT, Adassi MB, Foutsop AF, Noungoua CM, Yaya J, Kom TD, Ngo Bum E (2021) Anticonvulsant effect and acute toxicity study of the aqueous lyophilized extract of four medicinal plants of Cameroon: Malvaviscusarboreus, Alchemilla kiwuensis and mixture of Drymariacordata and Markhamia lutea. Adv Tradit Med: 1–15

Daws SE, Black YD, Naydenov AV, Vassoler FR, Hanlin RP, Konrad C (2011) Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood. Biol Psych 70(6):583–592

Article  Google Scholar 

Chen Y, Kuo T, Huang EY, Hoffer BJ, Kao J, Chou Y, Chiang Y, Miller J (2018) Nicotine-induced conditional place preference is affected by head injury: correlation with dopamine release in the nucleus accumbens shell. Int J Neuropsychopharmacol 21(10):949–961

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karel P, Van der Toorn A, VanderschurenL GC, SadighiAlvandi M, RenemanL DR, Verheij MMM, Homberg JR (2020) Ultrahigh-resolution MRI reveals structural brain differences in serotonin transporter knockout rats after sucrose and cocaine self-administration. Addict Biol 25(1):12722

Article  Google Scholar 

Lee HJ, Ortiz DM, Sayson LV, Kim M, Cheong JH, Kim HJ (2024) Ameliorating effects of Acanthopanaxkoreanum extract and components on nicotine dependence and withdrawal symptoms. Addict Biol 29(2):133–160

Article  Google Scholar 

Gavini K, Yang E, Parameshwaran K (2021) Developmental nicotine exposure impairs memory and reduces acetylcholine levels in the hippocampus of mice. Brain Res Bull 176:1–7

Article  CAS  PubMed  Google Scholar 

Ortells O, Barrantes GE (2010) Tobacco addiction: a biochemical model of nicotine dependence. Med Hypoth 74:884–894

Article  CAS  Google Scholar 

Tagousop NC, Tamokou J, Ekom ES, Ngnokam D, Voutquenne-Nazabadioko L (2018) Antimicrobial activities of flavonoid glycosides from Graptophyllum grandulosum and their mechanism of antibacterial action. Complem Altern Med 18(252):2–9

Google Scholar 

Wilar G, ShinodaY ST, Fukunaga K (2019) Crucial role of dopamine D2 receptor signaling in nicotine-induced conditioned place preference. Mol Neurobiol 56(12):7911–7928

Article  CAS  PubMed  Google Scholar 

Liu W, Cui X, Zhong Y, Ma R, Liu B, Xia Y (2023) Phenolic metabolites as therapeutic in inflammation and neoplasms: molecular pathways explaining their efficacy. Pharmacol Res 193:106812

Article  CAS  PubMed  Google Scholar 

Meireles M, Moura E, Vieira-Coelho MA, Santos-Buelga C, Gonzalez-Manzano S, Dueñas M, Calhau C (2016) Flavonoids as dopaminergic neuromodulators. Mol Nutr Food Res 60(3):495–501

Article  CAS  PubMed  Google Scholar 

OECD (2008) Acute toxicity-dose adjustment method. OECD Guideline Test Chem 1(4):1–14

Google Scholar