Bala S et al (2014) 1, 3, 4-Oxadiazole derivatives: synthesis, characterization, antimicrobial potential, and computational studies. Biomed Res Int 2014(1):172791

PubMed Central  PubMed  Google Scholar 

Bhardwaj N et al (2009) Syntheses, evaluation and characterization of some 1, 3, 4-oxadiazoles as antimicrobial agents. J Chem 6(4):1133–1138

Article  CAS  Google Scholar 

Chaudhary T, Upadhyay PK, Kataria R (2023) Anti-inflammatory and antimicrobial potential of 1, 3, 4-oxadiazoles and its derivatives: a review. Curr Org Synth 21(8):1014–1020

Article  Google Scholar 

Chaudhary T, Upadhyay PK, Kataria R (2024) Anti-inflammatory and antimicrobial potential of 1, 3, 4-oxadiazoles and its derivatives: a review. Curr Org Synth 21(8):1014–1020

Article  CAS  PubMed  Google Scholar 

Farzan M et al (2024) The emerging role of the microglia triggering receptor expressed on myeloid cells (TREM) 2 in multiple sclerosis. Exp Neurol 384:115071

Article  PubMed  Google Scholar 

McGinley MP, Goldschmidt CH, Rae-Grant AD (2021) Diagnosis and treatment of multiple sclerosis: a review. JAMA 325(8):765–779

Article  CAS  PubMed  Google Scholar 

Voskuhl RR, MacKenzie-Graham A (2022) Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis. Front Mol Neurosci 15:1024058

Article  PubMed Central  CAS  PubMed  Google Scholar 

Haki M et al (2024) Review of multiple sclerosis: epidemiology, etiology, pathophysiology, and treatment. Medicine (Baltimore) 103(8):e37297

Article  CAS  PubMed  Google Scholar 

Ghasemi N, Razavi S, Nikzad E (2017) Multiple sclerosis: pathogenesis, symptoms, diagnoses and cell-based therapy. Cell J 19:1–10

PubMed  Google Scholar 

Gustavsen S et al (2021) The association of selected multiple sclerosis symptoms with disability and quality of life: a large Danish self-report survey. BMC Neurol 21:1–12

Article  Google Scholar 

Hauser, S.L. (1994), Multiple sclerosis and other demyelinating diseases. Harrison’s principles of internal medicine, 2287.

Upadhayay S, Mehan S (2021) Targeting Nrf2/HO-1 anti-oxidant signaling pathway in the progression of multiple sclerosis and influences on neurological dysfunctions. Brain Disord 3:100019

Article  CAS  Google Scholar 

Mc Guire C et al (2013) Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology. Trends Mol Med 19(10):604–613

Article  CAS  PubMed  Google Scholar 

Wang J et al (2024) Recent progress and applications of small molecule inhibitors of Keap1–Nrf2 axis for neurodegenerative diseases. Eur J Med Chem 264:115998

Article  CAS  PubMed  Google Scholar 

Leibowitz SM, Yan J (2016) NF-κB pathways in the pathogenesis of multiple sclerosis and the therapeutic implications. Front Mol Neurosci 9:84

Article  PubMed Central  PubMed  Google Scholar 

Sivandzade F et al (2019) NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches. Redox Biol 21:101059

Article  CAS  PubMed  Google Scholar 

Binder MD et al (2023) HLA-DRB1* 15: 01 and the MERTK gene interact to selectively influence the profile of MERTK-expressing monocytes in both health and MS. Neurol Neuroimmunol Neuroinflam 11(2):e200190

Article  Google Scholar 

Rommer PS et al (2019) Immunological aspects of approved MS therapeutics. Front Immunol 10:1564

Article  PubMed Central  CAS  PubMed  Google Scholar 

Ontaneda D, Di Capua D (2012) Benefits versus risks of latest therapies in multiple sclerosis: a perspective review. Ther Adv Drug Saf 3(6):291–303

Article  PubMed Central  PubMed  Google Scholar 

Robinson AP et al (2014) The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment. Handb Clin Neurol 122:173–189

Article  PubMed Central  PubMed  Google Scholar 

Bukhari A et al (2021) Novel oxadiazole derivatives as potent inhibitors of α-amylase and α-glucosidase enzymes: synthesis, in vitro evaluation, and molecular docking studies. Iran J Basic Med Sci 24(12):1632

PubMed Central  PubMed  Google Scholar 

Zainab SR et al (2024) Safety assessment of novel oxadiazole derivatives in acute and sub-acute toxicity studies. Naunyn Schmiedeberg’s Arch Pharmacol. https://doi.org/10.1007/s00210-024-03474-0

Article  Google Scholar 

Khan A et al (2021) Withametelin, a novel phytosterol, alleviates neurological symptoms in EAE mouse model of multiple sclerosis via modulation of Nrf2/HO-1 and TLR4/NF-κB signaling. Neurochem Int 151:105211

Article  CAS  PubMed  Google Scholar 

Kan Q-C et al (2017) Matrine treatment blocks NogoA-induced neural inhibitory signaling pathway in ongoing experimental autoimmune encephalomyelitis. Mol Neurobiol 54:8404–8418

Article  CAS  PubMed  Google Scholar 

Dhandapani R et al (2018) Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons. Nat Commun 9(1):1640

Article  PubMed Central  PubMed  Google Scholar 

Khalid S et al (2018) Antihyperalgesic properties of honokiol in inflammatory pain models by targeting of NF-κB and Nrf2 signaling. Front Pharmacol 9:140

Article  PubMed Central  PubMed  Google Scholar 

Yalcin I et al (2009) Differentiating thermal allodynia and hyperalgesia using dynamic hot and cold plate in rodents. J Pain 10(7):767–773

Article  PubMed  Google Scholar 

Deacon RM (2013) Measuring the strength of mice. J Vis Exp 76:2610

Google Scholar 

Kraeuter A-K, Guest PC, Sarnyai Z (2019) The open field test for measuring locomotor activity and anxiety-like behavior. Pre-clinical models: techniques and protocols. Springer, Cham, pp 99–103

Chapter  Google Scholar 

Mazhar MU et al (2024) Immunostimulant, hepatoprotective, and nephroprotective potential of Bacillus subtilis (NMCC-path-14) in comparison to dexamethasone in alleviating CFA-induced arthritis. Naunyn Schmiedebergs Arch Pharmacol 397(5):3275–3299

Article  CAS  PubMed  Google Scholar 

Moron MS, Depierre JW, Mannervik B (1979) Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochimica et biophysica acta (BBA)-general subjects 582(1):67–78

Article  CAS  PubMed  Google Scholar 

Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351–358

Article  CAS  PubMed  Google Scholar 

Ghosh P et al (2024) Estimating nitric oxide (NO) from MDSCs by Griess method. Methods in Cell Biology. Elsevier, pp 149–158

Google Scholar 

Peter SC et al (2019) Encyclopedia of bioinformatics and computational biology. In: Ranganathan S, Grib-skov M, Nakai K, Schönbach C (eds) Protein Domain Prediction. Elsevier, Amsterdam, pp 661–676

Google Scholar 

Mathur N et al (2024) In silico docking: protocols for computational exploration of molecular interactions. Unravelling Molecular Docking-From Theory to Practice. IntechOpen, London

Google Scholar 

Halgren TA (1996) Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94. J Comput Chem 17(5–6):490–519

Article  CAS  Google Scholar 

Motoc I et al (1986) Three‐dimensional quantitative structure‐activity relationships i. General approach to the pharmacophore model validation. Quant Struct Act Relat 5(3):99–105

Article  CAS  Google Scholar 

Abraham MJ et al (2015) GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX 1:19–25