Huang X-F, Ma S-F, Jiang X-H, Song R-J, Li M, Zhang J, Quan T-JS, Wang HW-R, Yu A-Y He li (2024) Causes and global, regional, and National burdens of traumatic brain injury from 1990 to 2019 Chin J Traumatol 27(6):311–322. https://doi.org/10.1016/j.cjtee.2024.03.007. (https://www.sciencedirect.com/science/article/pii/S1008127524000348)
Wu L et al (1 Jan 2025) Global, regional, and national burdens of mild traumatic brain injuries from 1990 to 2019: findings from the Global Burden of Disease Study 2019 - a cross-sectional study. Int J Surg 111(1):160-170
Shao F et al (25 Mar 2022) Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain Injury-Induced neurodegeneration. Front Aging Neurosci 14:825086.
Bodnar CN, Watson JB, Higgins EK, Quan N, Bachstetter AD (2021) Inflammatory regulation of CNS barriers after traumatic brain injury: A Tale directed by Interleukin-1. Front Immunol 12:688254
Article CAS PubMed PubMed Central Google Scholar
Ashina H, Iljazi A, Al-Khazali HM, Christensen CE, Amin FM, Ashina M, Schytz HW (2020) Hypersensitivity to calcitonin Gene-Related peptide in Post-Traumatic headache. Ann Neurol 88(6):1220–1228
Article CAS PubMed Google Scholar
Thapa K et al (2021) Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets. J Mol Neuroscience: MN Vol 71(9):1725–1742
Taylor J, Orr E, Lesha AH, Kramer A, Cecia JE (2024) Dugan BSSL einhaus,traumatic brain injury: a comprehensive review of biomechanics and molecular pathophysiology,world neurosurgery World Neurosurg 185:74–88. https://doi.org/10.1016/j.wneu.2024.01.084. (https://www.sciencedirect.com/science/article/pii/S1878875024000950)
Yen HC, Chuang HJ, Hsiao WL, Tsai YC, Hsu PM, Chen WS, Han YY (2024) Assessing the impact of early progressive mobilization on moderate-to-severe traumatic brain injury: a randomized controlled trial. Crit Care 28(1):172. https://doi.org/10.1186/s13054-024-04940-0PMID: 38778416; PMCID: PMC11112875
Article PubMed PubMed Central Google Scholar
Roberts I, Shakur-Still H, Aeron-Thomas A, Beaumont D, Belli A, Brenner A, Cargill M, Chaudhri R, Douglas N, Frimley L, Gilliam C, Geer A, Jamal Z, Jooma R, Mansukhani R, Miners A, Pott J, Prowse D, Shokunbi T, Williams J (2021) Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT. Health Technol Assess 25(26):1–76
Article PubMed PubMed Central Google Scholar
Zhang X, Huang X, Hang D et al (2024) Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury. Sci Adv 10(2):eadj4260
Article CAS PubMed PubMed Central Google Scholar
Gravandi MM, Fakhri S, Zarneshan SN, Yarmohammadi A, Khan H (2021) Flavonoids modulate AMPK/PGC-1α and interconnected pathways toward potential neuroprotective activities. Metab Brain Dis 36(7):1501–1521
Article CAS PubMed Google Scholar
Roskoski R (2012) ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol Res 66(2):105–143
Article CAS PubMed Google Scholar
Martin-Vega A, Cobb MH (2023) Navigating the ERK1/2 MAPK cascade. Biomolecules 13(10):1555
Article CAS PubMed PubMed Central Google Scholar
Ullah R, Yin Q, Snell AH, Wan L (2022) RAF-MEK-ERK pathway in cancer evolution and treatment. Semin Cancer Biol 85:123–154
Article CAS PubMed Google Scholar
Gallo S, Vitacolonna A, Bonzano A, Comoglio P, Crepaldi T (2019) ERK: A key player in the pathophysiology of cardiac hypertrophy. Int J Mol Sci 20(9):2164
Article CAS PubMed PubMed Central Google Scholar
An N, Peng J, He G, Fan X, Li F, Chen H (2018) Involvement of activation of Mitogen-Activated protein kinase (MAPK)/Extracellular Signal-Regulated kinase (ERK) signaling pathway in proliferation of urethral plate fibroblasts in Finasteride-Induced rat hypospadias. Med Sci Monit 24:8984–8992
Article CAS PubMed PubMed Central Google Scholar
Zhang HJ, Liao HY, Bai DY, Wang ZQ, Xie XW (2021) MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration. Biomed Pharmacother 143:112170
Article CAS PubMed Google Scholar
Wen X, Jiao L, Tan H (2022) MAPK/ERK pathway as a central regulator in vertebrate organ regeneration. Int J Mol Sci 23(3):1464
Article CAS PubMed PubMed Central Google Scholar
Muñoz-Maldonado C, Zimmer Y, Medová M (2019) A comparative analysis of individual RAS mutations in Cancer biology. Front Oncol 9:1088
Article PubMed PubMed Central Google Scholar
Roskoski R Jr (2021) Blockade of mutant RAS oncogenic signaling with a special emphasis on KRAS. Pharmacol Res 172:105806
Article CAS PubMed Google Scholar
Chabot T, Cheraud Y, Fleury F (2021) Relationships between DNA repair and RTK-mediated signaling pathways. Biochim Biophys Acta Rev Cancer 1875(1):188495
Article CAS PubMed Google Scholar
Li X, Xie Z, Zhou Q et al (2024) TGN-020 alleviate inflammation and apoptosis after cerebral Ischemia-Reperfusion injury in mice through glymphatic and ERK1/2 signaling pathway. Mol Neurobiol 61(2):1175–1186
Article CAS PubMed Google Scholar
Xu X, Zhi T, Chao H, Jiang K, Liu Y, Bao Z, Liang F, Wang D, Li Z, Liu N Jing Ji (2018) ERK1/2/mTOR/Stat3 pathway-mediated autophagy alleviates traumatic brain injury-induced acute lung injury. Biochim Biophys Acta Mol Basis Dis 1864(5 Pt A):1663–1674.https://doi.org/10.1016/j.bbadis.2018.02.011
25, Liu T, Wang Q, Du Z, Yin L, Li J, Meng X, Xue D. The trigger for pancreatic disease: NLRP3 inflammasome. Cell Death Discov. 9(1):246. doi:, Galino J, Zhu N, Allen S, Birchmeier C, Bennett DL (2023) Sustained MAPK/ERK Activation in Adult Schwann Cells Impairs Nerve Repair. J Neurosci Off J Soc Neurosci. 2018;38(3):679–690
Seo JH, Maki T, Maeda M, Miyamoto N, Liang AC, Hayakawa K, Pham LD, Suwa F, Taguchi A, Matsuyama T, Ihara M, Kim KW, Lo EH, Arai K (2014) Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-β signaling. PLoS ONE 9(7):e103174
Article PubMed PubMed Central Google Scholar
Peipei Cheng I, Alberts X, Li (2013) The role of ERK1/2 in the regulation of proliferation and differentiation of astrocytes in developing brain,international. Int J Dev Neurosci 31(8):783–789. https://doi.org/10.1016/j.ijdevneu.2013.09.008
Alanazi MM, Havranek T, Bakos J, Cubeddu LX, Castejon AM (2020) Cell proliferation and anti-oxidant effects of oxytocin and oxytocin receptors: role of extracellular signal-regulating kinase in astrocyte-like cells. Endocr Regul. 54(3):172–182. https://doi.org/10.2478/enr-2020-0020. PMID: 32857718
Menon MB, Dhamija S (2018) Beclin 1 Phosphorylation - at the center of autophagy regulation. Front Cell Dev Biol 6:137
Article PubMed PubMed Central Google Scholar
Vikram Jadhav A, Roy K, Kaur AK, Rai S, Rustagi S (2024) Recent advances in nanomaterial-based drug delivery systems. Nano-Struct Nano-Objects 37:101103. https://doi.org/10.1016/j.nanoso.2024.101103
Malarkannan S (2020) Molecular mechanisms of FasL-mediated ‘reverse-signaling’. Mol Immunol 127:31–37
Article CAS PubMed PubMed Central Google Scholar
Van Opdenbosch N, Lamkanfi M (2019) Caspases in cell death, inflammation, and disease. Immunity 50(6):1352–1364
Article PubMed PubMed Central Google Scholar
Yan Z, He JL, Guo L, Zhang HJ, Zhang SL, Zhang J, Wen YJ, Cao CZ, Wang J, Wang J, Zhang MS, Liang F (2017) Activation of caspase-12 at early stage contributes to cardiomyocyte apoptosis in trauma-induced secondary cardiac injury. Sheng Li Xue Bao 69(4):367–377 PMID: 28825094
Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC (2018) Neuronal cell death. Physiol Rev 98(2):813–880. https://doi.org/10.1152/physrev.00011.2017PMID: 29488822; PMCID: PMC5966715
Article CAS PubMed PubMed Central Google Scholar
Akamatsu Y, Hanafy KA (2020) Cell death and recovery in traumatic brain injury. Neurotherapeutics 17(2):446–456
Article PubMed PubMed Central Google Scholar
Vk DK (2021) G, N G. Intrinsic and extrinsic pathways of apoptosis: role in cancer development and prognosis. Adv Protein Chem Struct Biol 125
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91(4):479–489
Article CAS PubMed Google Scholar
Yuan Y, Ding D, Zhang N, Xia Z, Wang J, Yang H, Guo F, Li B (2018) TNF-α induces autophagy through ERK1/2 pathway to regulate apoptosis in neonatal necrotizing Enterocolitis model cells IEC-6. Cell Cycle 17(11):1390–1402 Epub 2018 Jul 23. PMID: 29950141; PMCID: PMC6110600
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