Ventola CL (2010) Current issues regarding complementary and alternative medicine (CAM) in the United States: Part 1: the widespread use of CAM and the Need for better-informed health care professionals to provide patient counseling. P T 35:461–468

PubMed  PubMed Central  Google Scholar 

Wiesener S, Falkenberg T, Hegyi G, Hok J, Roberti di Sarsina P, Fonnebo V (2012) Legal status and regulation of complementary and alternative medicine in Europe. Forsch Komplementmed 19(Suppl 2):29–36

PubMed  Google Scholar 

Altemimi A, Lakhssassi N, Baharlouei A, Watson DG, Lightfoot DA (2017) Phytochemicals: extraction, isolation, and identification of bioactive compounds from plant extracts. Plants (Basel). https://doi.org/10.3390/plants6040042

Article  PubMed  Google Scholar 

Deolankar SC, Modi PK, Subbannayya Y, Pervaje R, Prasad TSK (2020) Molecular targets from traditional medicines for neuroprotection in human neurodegenerative diseases. OMICS 24:394–403

Article  CAS  PubMed  Google Scholar 

Karthikkeyan G, Pervaje R, Pervaje SK, Prasad TSK, Modi PK (2021) Prevention of MEK-ERK-1/2 hyper-activation underlines the neuroprotective effect of Glycyrrhiza glabra L. (Yashtimadhu) against rotenone-induced cellular and molecular aberrations. J Ethnopharmacol 274:114025

Article  CAS  PubMed  Google Scholar 

Karthikkeyan G, Pervaje R, Subbannayya Y, Patil AH, Modi PK, Prasad TSK (2020) Plant omics: metabolomics and network pharmacology of liquorice, Indian ayurvedic medicine yashtimadhu. OMICS 24:743–755

Article  CAS  PubMed  Google Scholar 

Karthikkeyan G, Prabhu A, Pervaje R, Pervaje SK, Modi PK, Prasad TSK (2021) Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson’s disease model. Data Brief 39:107535

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bopana N, Saxena S (2007) Asparagus racemosus–ethnopharmacological evaluation and conservation needs. J Ethnopharmacol 110:1–15

Article  PubMed  Google Scholar 

Deolankar SC, Najar MA, Ramesh P, Kanichery A, Kudva AK, Raghu SV, Prasad TSK (2023) Discovery of molecular networks of neuroprotection conferred by brahmi extract in Abeta(42)-induced toxicity model of drosophila melanogaster using a quantitative proteomic approach. Mol Neurobiol 60:303–316

Article  CAS  PubMed  Google Scholar 

Karthikkeyan G, Behera SK, Upadhyay SS, Pervaje R, Prasad TSK, Modi PK (2022) Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)-mediated neuroprotection in a rotenone-induced cellular model of Parkinson’s disease by restoring the mTORC1-AMPK1 axis in autophagic regulation. Phytother Res 36:2207–2222

Article  CAS  PubMed  Google Scholar 

Karthikkeyan G, Najar MA, Pervaje R, Pervaje SK, Modi PK, Prasad TSK (2020) Identification of molecular network associated with neuroprotective effects of yashtimadhu (Glycyrrhiza glabra L.) by quantitative proteomics of rotenone-induced parkinson’s disease model. ACS Omega 5:26611–26625

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh R (2016) Asparagus racemosus: a review on its phytochemical and therapeutic potential. Nat Prod Res 30:1896–1908

Article  CAS  PubMed  Google Scholar 

Srivastava PL, Shukla A, Kalunke RM (2018) Comprehensive metabolic and transcriptomic profiling of various tissues provide insights for saponin biosynthesis in the medicinally important Asparagus racemosus. Sci Rep 8:9098

Article  PubMed  PubMed Central  Google Scholar 

Goyal RK, Singh J, Lal H (2003) Asparagus racemosus–an update. Indian J Med Sci 57:408–414

CAS  PubMed  Google Scholar 

Negi JS, Singh P, Joshi GP, Rawat MS, Bisht VK (2010) Chemical constituents of Asparagus. Pharmacogn Rev 4:215–220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaitonde BB, Jetmalani MH (1969) Antioxytocic action of saponin isolated from Asparagus racemosus Willd (Shatavari) on uterine muscle. Arch Int Pharmacodyn Ther 179:121–129

CAS  PubMed  Google Scholar 

Sharma U, Kumar N, Singh B (2012) Furostanol saponin and diphenylpentendiol from the roots of Asparagus racemosus. Nat Prod Commun 7:995–998

CAS  PubMed  Google Scholar 

Boger DL, Mitscher LA, Mullican MD, Drake SD, Kitos P (1985) Antimicrobial and cytotoxic properties of 9,10-dihydrophenanthrenes: structure-activity studies on juncusol. J Med Chem 28:1543–1547

Article  CAS  PubMed  Google Scholar 

Wiboonpun N, Phuwapraisirisan P, Tip-pyang S (2004) Identification of antioxidant compound from Asparagus racemosus. Phytother Res 18:771–773

Article  CAS  PubMed  Google Scholar 

Acharya SR, Acharya NS, Bhangale JO, Shah SK, Pandya SS (2012) Antioxidant and hepatoprotective action of Asparagus racemosus Willd. root extracts. Indian J Exp Biol 50:795–801

CAS  PubMed  Google Scholar 

Singh B, Day CM, Abdella S, Garg S (2024) Alzheimer’s disease current therapies, novel drug delivery systems and future directions for better disease management. J Control Release 367:402–424

Article  CAS  PubMed  Google Scholar 

Rahman A, Hossen MA, Chowdhury MFI, Bari S, Tamanna N, Sultana SS, Haque SN, Al Masud A, Saif-Ur-Rahman KM (2023) Aducanumab for the treatment of Alzheimer’s disease: a systematic review. Psychogeriatrics 23:512–522

Article  PubMed  PubMed Central  Google Scholar 

Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V (1999) Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402:537–540

Article  CAS  PubMed  Google Scholar 

Vassar R, Kovacs DM, Yan R, Wong PC (2009) The beta-secretase enzyme BACE in health and Alzheimer’s disease: regulation, cell biology, function, and therapeutic potential. J Neurosci 29:12787–12794

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (1999) Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735–741

Article  CAS  PubMed  Google Scholar 

Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G (1999) Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 14:419–427

Article  CAS  PubMed  Google Scholar 

Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME (1999) Membrane-anchored aspartyl protease with Alzheimer’s disease beta-secretase activity. Nature 402:533–537

Article  CAS  PubMed  Google Scholar 

Arya R, Paliwal S, Gupta SP, Sharma S, Madan K, Mishra A, Verma K, Chauhan N (2021) In-silico studies and biological activity of potential BACE-1 inhibitors. Comb Chem High Throughput Screen 24:729–736

Article  CAS  PubMed  Google Scholar 

Prati F, Bottegoni G, Bolognesi ML, Cavalli A (2018) BACE-1 inhibitors: from recent single-target molecules to multitarget compounds for alzheimer’s disease. J Med Chem 61:619–637

Article  CAS  PubMed  Google Scholar 

Ferreira JPS, Albuquerque HMT, Cardoso SM, Silva AMS, Silva VLM (2021) Dual-target compounds for Alzheimer’s disease: natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR). Eur J Med Chem 221:113492

Article  CAS  PubMed  Google Scholar