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Akt/mTOR pathway-mediated CCNA1 regulation of radiotherapy resistance in nasopharyngeal carcinoma
Akt/mTOR pathway-mediated CCNA1 regulation of radiotherapy resistance in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC), as a cancer type highly sensitive to radiotherapy, has radiation therapy as the preferred ...
Platelets in the tumor microenvironment: potential mediators of immune exclusion and resistance to immune checkpoint inhibitor therapy
Platelets in the tumor microenvironment: potential mediators of immune exclusion and resistance to immune checkpoint inhibitor therapy
Cancer cells employ diverse strategies to evade immune surveillance and resist therapy, including immune exclusion—a...
The moonlighting functions of glycolytic enzymes in tumorigenesis
The moonlighting functions of glycolytic enzymes in tumorigenesis
Glycolysis is a ubiquitous energy-supply process that occurs in virtually all living cells. The phenomenon of aerobic glyc...
Neural-tumor crosstalk and molecular targeting: mechanisms and therapeutic implications in cancer neuroscience
Neural-tumor crosstalk and molecular targeting: mechanisms and therapeutic implications in cancer neuroscience
The nervous system is increasingly recognized as a key regulator of the tumor microenvironment, engaging in bidirectional ...
CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinoma
CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinoma
Diabetes mellitus (DM) affects the occurrence and progression of pancreatic adenocarcinoma (PAAD), but the DM-related immu...
METTL1-mediated mG tRNA modification promotes colorectal cancer progression and liver metastasis via translational regulation
METTL1-mediated mG tRNA modification promotes colorectal cancer progression and liver metastasis via translational regulation
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with colorectal cancer liver metastasis ...
Intratumoral PD-1 CD8 T cells correlate with AFP levels in HCC patients: a brief report
Intratumoral PD-1 CD8 T cells correlate with AFP levels in HCC patients: a brief report
Hepatocellular carcinoma (HCC), the most common primary liver cancer, typically arises in a context of chronic inflammatio...
Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies
Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies
RNA splicing is a fundamental cellular process that transforms precursor messenger RNA (pre-mRNA) into mature messenger RN...
ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses
ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses
The selective induction of nucleolar stress in cancer cells has become a potential anticancer therapy. However, precisely ...
CSRP2 modulates PDGFRA/PI3K/AKT signaling via PRC1 components in glioma
CSRP2 modulates PDGFRA/PI3K/AKT signaling via PRC1 components in glioma
Glioblastoma (GBM) is the most common and aggressive primary brain tumor, characterized by poor prognosis and therapeutic ...
Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour
Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour
Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm molecularly defined by the NAB2::STAT6 gene fusion (GF), an a...
Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway
Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway
Cholesterol dysregulation plays a central role in tumor progression and has emerged as a potential therapeutic target. Its...
Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma
Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma
Glioblastoma (GBM) is the most common adult primary brain tumor for which new therapeutic strategies are desperately neede...
Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma
Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma
Dysregulated cholesterol metabolism has emerged as a crucial driver of hepatocellular carcinoma (HCC) progression and immu...
Discover personalized drug opportunity and optimized tumor-infiltrating lymphocyte therapy for rare cancer: an organoid-based whole-journey clinical mapping study in a neuroendocrine cancer patient
Discover personalized drug opportunity and optimized tumor-infiltrating lymphocyte therapy for rare cancer: an organoid-based whole-journey clinical mapping study in a neuroendocrine cancer patient
Rare cancer patients face dire prognoses due to high malignancy and scarce treatment options, underscoring an imperative f...
Strategies to target PD-1/PD-L1 in the tumor microenvironment
Strategies to target PD-1/PD-L1 in the tumor microenvironment
In recent years, cancer immunotherapy has become one of the most important methods in cancer treatment, which can kill tum...
Barnaculate Carcinoma in Four Patients: Verrucoid Squamous Cell Carcinoma Subtype with and Oncogenic Variants
Barnaculate Carcinoma in Four Patients: Verrucoid Squamous Cell Carcinoma Subtype with and Oncogenic Variants
Well-differentiated squamous cell carcinoma (SCC) in the oral cavity often has limited pleomorphism. Commonly seen in pati...
An Introduction to Pathology Foundation Models
An Introduction to Pathology Foundation Models
Foundation models are a recently described class of machine learning algorithms that use large amounts of data and trainin...
Prognostic Role of Unconventional Tumor Site of Origin in Mucoepidermoid Carcinoma: A Comprehensive Analysis Using the SEER Database
Prognostic Role of Unconventional Tumor Site of Origin in Mucoepidermoid Carcinoma: A Comprehensive Analysis Using the SEER Database
Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, yet prognosis may vary substantially by ...
Oral HPV-Related Epithelial Proliferation during Fingolimod Therapy: First Case Report and Review of the Literature
Oral HPV-Related Epithelial Proliferation during Fingolimod Therapy: First Case Report and Review of the Literature
Fingolimod, an immunomodulatory agent used in the treatment of multiple sclerosis, has been associated with an increased r...
A Case Report of Primitive Myxoid Mesenchymal Tumor of Infancy (PMMTI) with -ITD Genetic Alteration in the Sinonasal Cavity and Review of Literature
A Case Report of Primitive Myxoid Mesenchymal Tumor of Infancy (PMMTI) with -ITD Genetic Alteration in the Sinonasal Cavity and Review of Literature
Primitive myxoid mesenchymal tumor of infancy (PMMTI) is a rare fibroblastic/myofibroblastic neoplasm, mostly occurring in...
β-Human Chorionic Gonadotropin–Secreting Giant Cell Tumor of Bone in the Mandible: Case Report and Comprehensive Literature Review
β-Human Chorionic Gonadotropin–Secreting Giant Cell Tumor of Bone in the Mandible: Case Report and Comprehensive Literature Review
Giant cell tumor of bone (GCTB) is a rare but locally aggressive neoplasm which most commonly arises in the epiphyses of l...
Clinical and Prognostic Factors of Submandibular Gland Malignancies: A SEER-Based Analysis
Clinical and Prognostic Factors of Submandibular Gland Malignancies: A SEER-Based Analysis
While neoplasms of the submandibular gland (SMG) are rare, there is a nearly 50% risk of malignancy and its neoplasms are ...
Proceedings of the 2026 North American Society of Head and Neck Pathology Companion Meeting, San Antonio, TX, March 22, 2026: It’s a Trap!: Diagnostic Pitfalls in Sinonasal Pathology
Proceedings of the 2026 North American Society of Head and Neck Pathology Companion Meeting, San Antonio, TX, March 22, 2026: It’s a Trap!: Diagnostic Pitfalls in Sinonasal Pathology
Sinonasal pathology presents unique diagnostic challenges due to the anatomic complexity of the region, the wide histologi...
p63-Positive Diffuse Large B-cell Lymphoma of Oropharynx: A Treacherous Mimic of HPV-Related Squamous Cell Carcinoma—A Report of Three Cases
p63-Positive Diffuse Large B-cell Lymphoma of Oropharynx: A Treacherous Mimic of HPV-Related Squamous Cell Carcinoma—A Report of Three Cases
Human papillomavirus-associated squamous cell carcinoma is the most common malignant neoplasm of the oropharynx, often exp...
Intraductal Salivary Gland Neoplasms of the Oral Cavity: A Retrospective Case Series with Emphasis on Newly Described Entities
Intraductal Salivary Gland Neoplasms of the Oral Cavity: A Retrospective Case Series with Emphasis on Newly Described Entities
Intraductal salivary gland tumors represent a distinct and intriguing subset of salivary gland neoplasms, characterized by...
Novel Case of a Molecularly Confirmed Low-Grade Fibromyxoid Sarcoma of the Floor of the Mouth and Literature Review
Novel Case of a Molecularly Confirmed Low-Grade Fibromyxoid Sarcoma of the Floor of the Mouth and Literature Review
Low-grade fibromyxoid sarcoma (LGFMS) is a deceptively bland spindle cell neoplasm with malignant potential, most commonly...
Circulating Tumor HPV DNA Kinetics for Squamous Cell Carcinoma of the Lacrimal Sac Treated with Chemoradiotherapy
Circulating Tumor HPV DNA Kinetics for Squamous Cell Carcinoma of the Lacrimal Sac Treated with Chemoradiotherapy
Lacrimal sac squamous cell carcinoma (LSSCC) is the most common tumor of the rare disease subsite of the nasolacrimal syst...
Intraosseous Atypical Verrucopapillary Epithelial Proliferation with Verrucous Carcinoma Features Evolving from a Keratinizing Odontogenic Cyst: Report of an Uncommon Variant and Review of the Literature
Intraosseous Atypical Verrucopapillary Epithelial Proliferation with Verrucous Carcinoma Features Evolving from a Keratinizing Odontogenic Cyst: Report of an Uncommon Variant and Review of the Literature
Developmental odontogenic cysts (DOCs) of the jawbones with overt luminal keratinization, i.e., odontogenic keratocyst (OK...
Mechanistic Insights into Calcium Oxalate Crystals in Aspergillosis of the Maxillary Sinus
Mechanistic Insights into Calcium Oxalate Crystals in Aspergillosis of the Maxillary Sinus
Aspergillus species can induce calcium oxalate crystal deposition, serving as an important diagnostic marker when typical ...
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