Akt/mTOR pathway-mediated CCNA1 regulation of radiotherapy resistance in nasopharyngeal carcinoma

Y. Liu, S.Y. Ye, S. He et al., Single-cell and Spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma. Nat. Commun. 15(1), 7713 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Q. Liu, H. Wang, Z. Chen et al., Global, regional, and National epidemiology of nasopharyngeal carcinoma in middle-aged and elderly patients from 1990 to 2021. Ageing Res. Rev. 104, 102613 (2025)

Article  CAS  PubMed  Google Scholar 

P. Feng, Y. Wang, N. Liu et al., High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma. Cell. Death Differ. 31(5), 683–696 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Chen, C. Feng, Y. Lan et al., Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma. J. Nanobiotechnol. 23(1), 96 (2025)

Article  Google Scholar 

N. Miao, D. Cao, J. Jin et al., Tumor cell-intrinsic Piezo2 drives radioresistance by impairing CD8 + T cell stemness maintenance. J. Exp. Med. 221(10), e20231486 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

W. Liu, J. Niu, Y. Huo et al., Role of circular RNAs in cancer therapy resistance. Mol. Cancer. 24(1), 55 (2025)

Article  PubMed  PubMed Central  Google Scholar 

X. Li, H. Liu, W. Gao et al., Octadecyl gallate and Lipid-Modified MnSe2 nanoparticles enhance radiosensitivity in esophageal squamous cell carcinoma and promote radioprotection in normal tissues. Adv. Mater. 36(23), e2311291 (2024)

Article  PubMed  Google Scholar 

Z. Shi, C. Hu, X. Zheng, C. Sun, Q. Li, Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cells. Exp. Hematol. Oncol. 13(1), 55 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

X. Cao, Z. Yan, Z. Chen et al., The emerging role of deubiquitinases in radiosensitivity. Int. J. Radiat. Oncol. Biol. Phys. 118(5), 1347–1370 (2024)

Article  PubMed  Google Scholar 

H.Y. Chan, Q. Wang, A. Howie, J. Bucci, P. Graham, Y. Li, Extracellular vesicle biomarkers redefine prostate cancer radiotherapy. Cancer Lett. 616, 217568 (2025)

Article  CAS  PubMed  Google Scholar 

Y. Zhou, Y. Xiao, H. Liu et al., Elevation of H3K27me3 level contributes to the radioresistance of nasopharyngeal carcinoma by inhibiting OAS1 expression. Am. J. Physiol. Cell. Physiol. 326(1), C60–C73 (2024)

Article  PubMed  Google Scholar 

R. Zhang, Y. Shen, X. Zhou et al., Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization. Nat. Commun. 16(1), 890 (2025)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Labbé, M. Chang, B. Saintpierre et al., Loss of miR-200c-3p promotes resistance to radiation therapy via the DNA repair pathway in prostate cancer. Cell. Death Dis. 15(10), 751 (2024)

Article  PubMed  PubMed Central  Google Scholar 

X.L. Wu, Y.N. Guo, Role of cellular senescence genes and immune infiltration in sepsis and sepsis-Induced ARDS based on bioinformatics analysis. J. Inflamm. Res. 17, 9119–9133 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

D. Pu, Y. Xu, H. Yu et al., Comprehensive pan-cancer analysis reveals CDC6 as a potential Immunomodulatory agent and promising therapeutic target in pancreatic cancer. Transl Cancer Res. 13(8), 4096–4112 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. Guo, S. Xing, Z. Wu et al., Leucine restriction ameliorates Fusobacterium nucleatum-driven malignant progression and radioresistance in nasopharyngeal carcinoma. Cell. Rep. Med. 5(10), 101753 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Liao, X. Qing, X. Li et al., TRAF4 regulates ubiquitination-modulated survivin turnover and confers radioresistance. Int. J. Biol. Sci. 20(1), 182–199 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Z.Q. Long, R. Ding, T.Q. Quan et al., Multi-Omics characterization of Genome-Wide abnormal DNA methylation reveals FGF5 as a diagnosis of nasopharyngeal carcinoma recurrence after radiotherapy. Biomolecules. 15(2), 283 (2025)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Rezapour, R. Wesolowski, M.N. Gurcan, Identifying key genes involved in axillary lymph node metastasis in breast cancer using advanced RNA-Seq analysis: A methodological approach with GLMQL and MAS. Int. J. Mol. Sci. 2024. 25(13)

P. Yanatatsaneejit, T. Chalermchai, V. Kerekhanjanarong et al., Promoter hypermethylation of CCNA1, RARRES1, and HRASLS3 in nasopharyngeal carcinoma. Oral Oncol. 44(4), 400–406 (2008)

Article  CAS  PubMed  Google Scholar 

N.M. Gašperov, I. Sabol, P. Planinić et al., Methylated host cell gene promoters and human papillomavirus type 16 and 18 predicting cervical lesions and cancer. PLoS One. 10(6), e0129452 (2015)

Article  Google Scholar 

J. Kuan-Chun, Huang et al., Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells (EUROPEAN JOURNAL OF CANCER, 2016)

Y. Zhan, S. Fan, Multiple mechanisms involving in radioresistance of nasopharyngeal carcinoma. J. Cancer. 11(14), 4193–4204 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y. Guo, Y. Zhang, S.J. Zhang, Y.N. Ma, Y. He, Comprehensive analysis of key genes and MicroRNAs in radioresistant nasopharyngeal carcinoma. BMC Med. Genomics. 12(1), 1–10 (2019)

Article  Google Scholar 

J.N. Moloney, T.G. Cotter, ROS signalling in the biology of cancer. Semin Cell. Dev. Biol. 80, 50–64 (2017)

Article  PubMed  Google Scholar 

K. Iskandar, J. Foo, A. Liew et al., A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execution of colorectal cancer cells upon drug-induced activation of mutant KRAS. Autophagy. 20(6), 1418–1441 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Z. Ling, J. Pan, Z. Zhang et al., Small-molecule molephantin induces apoptosis and mitophagy flux blockage through ROS production in glioblastoma. Cancer Lett. 592, 216927 (2024)

Article  CAS  PubMed  Google Scholar 

W. Li, Q. Zeng, B. Wang et al., Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization. Redox Biol. 76, 103335 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L. Yu, Y. Deng, X. Wang et al., Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in ewing sarcoma. Nat. Commun. 15(1), 5292 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

N. Nuechterlein, A. Shelbourn, F. Szulzewsky et al., Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype. Genes Dev. 38(5–6), 273–288 (2024)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L. Liu, J. Wang, Y. Wang et al., Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization. J. Exp. Clin. Cancer Res. 43(1), 128 (2024)

Article  PubMed  PubMed Central  Google Scholar 

F. Li, K.M. Bondra, H. Wang et al., Dual Inhibition of MAPK and TORC1 signaling retards development of radiation resistance in pediatric BRAFV600E glioma models. Neuro Oncol. 2025

J. Hu, F. Meng, L. Lv et al., GPR37-enhanced ubiquitination of ATP1A1 inhibits tumor progression and radiation resistance in esophageal squamous cell carcinoma. Cell. Death Dis. 15(12), 933 (2024)

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