D. Ponti, The nucleolus: A central hub for ribosome biogenesis and cellular regulatory signals. Int. J. Mol. Sci. 26(9), 4174 (2025)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A.R. Elhamamsy, B.J. Metge, H.A. Alsheikh et al., Ribosome biogenesis: A central player in cancer metastasis and therapeutic resistance. Cancer Res. 82(13), 2344–2353 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

E. Hurt, J. Cheng, J. Baβler et al., SnapShot: eukaryotic ribosome biogenesis I. Cell. 186(10), 2282–2282e1 (2023)

Article  CAS  PubMed  Google Scholar 

V. Sirri, S. Urcuqui-Inchima, P. Roussel et al., Nucleolus: the fascinating nuclear body. Histochem. Cell. Biol. 129(1), 13–31 (2008)

Article  CAS  PubMed  Google Scholar 

M.C. Lafita-Navarro, M. Conacci-Sorrell, Nucleolar stress: from development to cancer. Semin Cell. Dev. Biol. 136, 64–74 (2023)

Article  CAS  PubMed  Google Scholar 

X. Zhou, W.J. Liao, J.M. Liao, P. Liao, H. Lu, Ribosomal proteins: functions beyond the ribosome. J. Mol. Cell. Biol. 7, 92–104 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.S. Lindström, J. Bartek, A. Maya-Mendoza, p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways. Cell. Death Differ. 29, 972–982 (2022)

Article  PubMed  PubMed Central  Google Scholar 

H.F. Horn, K.H. Vousden, Coping with stress: multiple ways to activate p53. Oncogene. 26, 1306–1316 (2007)

Article  CAS  PubMed  Google Scholar 

M.L. Truitt, D. Ruggero, New frontiers in translational control of the cancer genome. Nat. Rev. Cancer. 16, 288–304 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.C. Lafita-Navarro, N. Venkateswaran, J.A. Kilgore, S. Kanji, J. Han, S. Barnes et al., Inhibition of the de Novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells. PLoS Genet. 16, e1009117 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Hafner, M.L. Bulyk, A. Jambhekar, G. Lahav, The multiple mechanisms that regulate p53 activity and cell fate. Nat. Rev. Mol. Cell. Biol. 20, 199–210 (2019)

Article  CAS  PubMed  Google Scholar 

R. Schulz-Heddergott, U.M. Moll, Gain-of-Function (GOF) mutant p53 as actionable therapeutic target. Cancers (Basel) 2018; 10

A.J. Levine, p53: 800 million years of evolution and 40 years of discovery. Nat. Rev. Cancer. 20, 471–480 (2020)

Article  CAS  PubMed  Google Scholar 

M. Konopleva, G. Martinelli, N. Daver, C. Papayannidis, A. Wei, B. Higgins et al., MDM2 inhibition: an important step forward in cancer therapy. Leukemia. 34, 2858–2874 (2020)

Article  PubMed  Google Scholar 

S. Gomes, M. Leão, L. Raimundo, H. Ramos, J. Soares, L. Saraiva, p53 family interactions and yeast: together in anticancer therapy. Drug Discov Today. 21, 616–624 (2016)

Article  CAS  PubMed  Google Scholar 

N. Guaragnella, V. Palermo, A. Galli, L. Moro, C. Mazzoni, S. Giannattasio, The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2. FEMS Yeast Res. 14, 2–16 (2014)

Article  CAS  PubMed  Google Scholar 

M.H. Brodsky, B.T. Weinert, G. Tsang, Y.S. Rong, N.M. McGinnis, K.G. Golic et al., Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol. Cell. Biol. 24, 1219–1231 (2004)

Article  CAS  PubMed  PubMed Central  Google Scholar 

F. Gómez-Herreros, de L. Miguel-Jiménez, M. Morillo-Huesca, L. Delgado-Ramos, M.C. Muñoz-Centeno, S. Chávez, TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress. Nucleic Acids Res. 40, 6508–6519 (2012)

Article  PubMed  PubMed Central  Google Scholar 

F. Gómez-Herreros, O. Rodríguez-Galán, M. Morillo-Huesca, D. Maya, M. Arista-Romero, de la J. Cruz et al., Balanced production of ribosome components is required for proper G1/S transition in Saccharomyces cerevisiae. J. Biol. Chem. 288, 31689–31700 (2013)

Article  PubMed  PubMed Central  Google Scholar 

X. Yuan, Y. Zhou, E. Casanova, M. Chai, E. Kiss, H.J. Gröne et al., Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol. Cell. 19, 77–87 (2005)

Article  CAS  PubMed  Google Scholar 

J. Chen, L.A. Stark, Insights into the relationship between nucleolar stress and the NF-κB pathway. Trends Genet. 35, 768–780 (2019)

Article  CAS  PubMed  Google Scholar 

A. Repenning, D. Happel, C. Bouchard, M. Meixner, Y. Verel-Yilmaz, H. Raifer et al., PRMT1 promotes the tumor suppressor function of p14(ARF) and is indicative for pancreatic cancer prognosis. Embo j. 40, e106777 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Pecoraro, M. Pagano, G. Russo, A. Russo, Ribosome biogenesis and cancer: overview on ribosomal proteins. Int. J. Mol. Sci. 2021; 22

F. Moraga, F. Aquea, Composition of the SAGA complex in plants and its role in controlling gene expression in response to abiotic stresses. Front. Plant. Sci. 6, 865 (2015)

Article  PubMed  PubMed Central  Google Scholar 

G. Lang, J. Bonnet, D. Umlauf, K. Karmodiya, J. Koffler, M. Stierle et al., The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements. Mol. Cell. Biol. 31, 3734–3744 (2011)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Pfab, A. Bruckmann, J. Nazet, R. Merkl, K.D. Grasser, The adaptor protein ENY2 is a component of the deubiquitination module of the Arabidopsis SAGA transcriptional Co-activator complex but not of the TREX-2 complex. J. Mol. Biol. 430, 1479–1494 (2018)

Article  CAS  PubMed  Google Scholar 

X. Li, C.W. Seidel, L.T. Szerszen, J.J. Lange, J.L. Workman, S.M. Abmayr, Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in drosophila gene expression and development. Genes Dev. 31, 1588–1600 (2017)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. Galán, E. García-Oliver, C. Nuño-Cabanes, L. Rubinstein, M. Kupiec, S. Rodríguez-Navarro, The evolutionarily conserved factor Sus1/ENY2 plays a role in telomere length maintenance. Curr. Genet. 64, 635–644 (2018)

Article  PubMed  Google Scholar 

De C. Marco, P. Zoppoli, N. Rinaldo, S. Morganella, M. Morello, V. Zuccalà et al., Genome-wide analysis of copy number alterations led to the characterisation of PDCD10 as oncogene in ovarian cancer. Transl Oncol. 14, 101013 (2021)

Article  PubMed  PubMed Central  Google Scholar 

J.H. Li, Y.F. Tao, C.H. Shen, R.D. Li, Z. Wang, H. Xing et al., Integrated multi-omics analysis identifies ENY2 as a predictor of recurrence and a regulator of telomere maintenance in hepatocellular carcinoma. Front. Oncol. 12, 939948 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

G. Xie, H. Yang, D. Ma, Y. Sun, H. Chen, X. Hu et al., Integration of whole-genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple-negative breast cancer. Int. J. Cancer. 145, 2850–2860 (2019)

Article  CAS  PubMed