P.A. Sharp, Split Genes and RNA splicing nobel lecture, (1994)

D. Li, W. Yu, M. Lai, Targeting serine- and arginine-rich splicing factors to rectify aberrant alternative splicing. Elsevier Ltd (Sep 01 2023). https://doi.org/10.1016/j.drudis.2023.103691

E.T. Wang et al., Alternative isoform regulation in human tissue transcriptomes. Nature 456(7221), 470–476 (2008). https://doi.org/10.1038/nature07509

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Tian et al., Aberrant RNA splicing is a primary link between genetic variation and pancreatic cancer risk. Cancer. Res. 82(11), 2084–2096 (2022). https://doi.org/10.1158/0008-5472.CAN-21-4367

Article  CAS  PubMed  Google Scholar 

F.E. Baralle, J. Giudice, Alternative splicing as a regulator of development and tissue identity. Nat. Pub. Group 1 (Jul. 01, 2017). https://doi.org/10.1038/nrm.2017.27

J.L. Hervoso et al., Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia. Am. J. Hum. Genet 111(8), 1573–1587 (2024). https://doi.org/10.1016/j.ajhg.2024.06.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

B.R. Graveley, T. Maniatis, Arginine/serine-rich domains of SR proteins can function as activators of pre-mRNA splicing. Mol. Cell 1(5), 765–771 (1998). https://doi.org/10.1016/S1097-2765(00)80076-3

Article  CAS  PubMed  Google Scholar 

T. Wang et al., Arabidopsis SRPKII family proteins regulate flowering via phosphorylation of SR proteins and effects on gene expression and alternative splicing. New. Phytol. 238(5), 1889–1907 (2023). https://doi.org/10.1111/NPH.18895

Article  CAS  PubMed  Google Scholar 

X. Li, J.L. Manley, Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell 122(3), 365–378 (2005). https://doi.org/10.1016/J.CELL.2005.06.008

Article  CAS  PubMed  Google Scholar 

M. Müller-McNicoll et al., SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export. Genes Dev. 30(5), 553–566 (2016). https://doi.org/10.1101/GAD.276477.115/-/DC1

Article  PubMed  PubMed Central  Google Scholar 

R.E. Wagner, M. Frye, Noncanonical functions of the serine-arginine-rich splicing factor (SR) family of proteins in development and disease. BioEssays 43(4), 2000242 (2021). https://doi.org/10.1002/BIES.202000242

Article  CAS  Google Scholar 

S.M. Cascarina, E.D. Ross, Expansion and functional analysis of the SR-related protein family across the domains of life. RNA 28(10), 1298–1314 (2022). https://doi.org/10.1261/RNA.079170.122/-/DC1

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.X. Du et al., Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1. J. Exp. Clin. Cancer Res. 40 (2021). https://doi.org/10.1186/s13046-021-01978-8

X. Wang et al., SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner. J. Transl. Med 20(1), 1–18 (2022). https://doi.org/10.1186/S12967-022-03399-3/FIGURES/6

Article  PubMed  PubMed Central  Google Scholar 

J. Larrasa-Alonso et al., The SRSF4-GAS5-glucocorticoid receptor axis regulates ventricular hypertrophy. Circ. Res 129(6), 669–683 (2021). https://doi.org/10.1161/CIRCRESAHA.120.318577/SUPPL_FILE/CIRCRES_CIRCRES-2020-318577D_SUPP8.PDF

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Xiong, Y. Chen, W. Wang, J. Sun, Biological function and molecular mechanism of SRSF3 in cancer and beyond. Oncol. Lett 23(1), 21 (2021). https://doi.org/10.3892/OL.2021.13139

Article  PubMed  PubMed Central  Google Scholar 

D. Segovia et al., SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23. Proc. Natl. Acad. Sci. U. S. A. 121(21), e2322974121 (2024). https://doi.org/10.1073/PNAS.2322974121/SUPPL_FILE/PNAS.2322974121.SD01.XLSX

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Bei, J. Xu, SR Proteins in Cancer: function, Regulation, and Small Inhibitor. BioMed. Central. Ltd (2024)https://doi.org/10.1186/s11658-024-00594-6

J.C. Long, J.F. Caceres, The SR Protein Family of Splicing Factors: master Regulators of Gene Expression (2009). https://doi.org/10.1042/BJ20081501

Y. Che, L. Fu, Aberrant expression and regulatory network of splicing factor-SRSF3 in tumors. Ivyspring Int. Publisher (2020). https://doi.org/10.7150/jca.42645

Article  Google Scholar 

N.K. Leclair et al., Poison exon splicing regulates a coordinated network of SR protein expression during differentiation and Tumorigenesis. Mol. Cell 80(4), 648–665.e9 (2020). https://doi.org/10.1016/j.molcel.2020.10.019

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.A. Rahman, A.R. Krainer, O. Abdel-Wahab, SnapShot: splicing alterations in cancer. Cell. Press (2020). https://doi.org/10.1016/j.cell.2019.12.011

Article  Google Scholar 

M. Song, L. Pang, M. Zhang, Y. Qu, K.V. Laster, Z. Dong, Cdc2-like kinases: structure, biological function, and therapeutic targets for diseases. Springer Nature (2023). https://doi.org/10.1038/s41392-023-01409-4

B.E. Aubol et al., Release of SR proteins from CLK1 by SRPK1: a symbiotic kinase System for phosphorylation control of pre-mRNA splicing. Mol. Cell 63(2), 218–228 (2016). https://doi.org/10.1016/J.MOLCEL.2016.05.034

Article  CAS  PubMed  PubMed Central  Google Scholar 

B.E. Aubol, P. Serrano, L. Fattet, K. Wüthrich, J.A. Adams, Molecular interactions connecting the function of the serine-arginine-rich protein SRSF1 to protein phosphatase 1. J. Biol. Chem. 293(43), 16751–16760 (2018). https://doi.org/10.1074/JBC.RA118.004587

Article  CAS  PubMed  PubMed Central  Google Scholar 

K. Jiang et al., Akt2 regulation of Cdc2-like kinases (Clk/Sty), Serine/Arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCβII messenger ribonucleic acid. Endocrinology 150(5), 2087–2097 (2009). https://doi.org/10.1210/EN.2008-0818

X.Y. Zhong, J.H. Ding, J.A. Adams, G. Ghosh, X.D. Fu, Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev. 23(4), 482–495 (2009). https://doi.org/10.1101/GAD.1752109

Article  CAS  PubMed  PubMed Central  Google Scholar 

C.T. Ma, G. Ghosh, X.D. Fu, J.A. Adams, Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1. J. Mol. Biol. 403(3), 386–404 (2010). https://doi.org/10.1016/J.JMB.2010.08.024

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. Chen et al., CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer. J. Hematol. Oncol. 14 (2021). https://doi.org/10.1186/s13045-021-01072-8

Y. Goldtzvik, N. Sen, S.D. Lam, C. Orengo, Protein Diversification Through Post-Translational Modifications, Alternative Splicing, and Gene Duplication. Elsevier Ltd (2023)https://doi.org/10.1016/j.sbi.2023.102640

V. Edmond et al., Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. Embo. J. 30(3), 510–523 (2011). https://doi.org/10.1038/EMBOJ.2010.333/SUPPL_FILE/EMBJ2010333.REVIEWER_COMMENTS.PDF

Article  CAS  PubMed  Google Scholar 

S.C. Larsen et al., Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells. Sci. Signal 9(443). (2016). https://doi.org/10.1126/SCISIGNAL.AAF7329/SUPPL_FILE/9_RS9_TABLES_S1_TO_S5.ZIP

W. Lan, Y. Qiu, Y. Xu, Y. Liu, Y. Miao, Ubiquitination and ubiquitin-like modifications as mediators of alternative pre-mRNA splicing in Arabidopsis thaliana. Front. Plant. Sci. 13, 869870 (2022). https://doi.org/10.3389/FPLS.2022.869870/BIBTEX

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.L. Morales et al., Posttranslational splicing modifications as a key mechanism in cytarabine resistance in acute myeloid leukemia. Leukemia 37(8), 1649–1659 (2023). https://doi.org/10.1038/s41375-023-01963-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y. Long et al., Distinct mechanisms govern the phosphorylation of different SR protein splicing factors. J. Biol. Chem. 294(4), 1312–1327 (2019). https://doi.org/10.1074/jbc.RA118.003392

Article  CAS  PubMed  Google Scholar