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Akt/mTOR pathway-mediated CCNA1 regulation of radiotherapy resistance in nasopharyngeal carcinoma
Akt/mTOR pathway-mediated CCNA1 regulation of radiotherapy resistance in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC), as a cancer type highly sensitive to radiotherapy, has radiation therapy as the preferred ...
Platelets in the tumor microenvironment: potential mediators of immune exclusion and resistance to immune checkpoint inhibitor therapy
Platelets in the tumor microenvironment: potential mediators of immune exclusion and resistance to immune checkpoint inhibitor therapy
Cancer cells employ diverse strategies to evade immune surveillance and resist therapy, including immune exclusion—a...
The moonlighting functions of glycolytic enzymes in tumorigenesis
The moonlighting functions of glycolytic enzymes in tumorigenesis
Glycolysis is a ubiquitous energy-supply process that occurs in virtually all living cells. The phenomenon of aerobic glyc...
Neural-tumor crosstalk and molecular targeting: mechanisms and therapeutic implications in cancer neuroscience
Neural-tumor crosstalk and molecular targeting: mechanisms and therapeutic implications in cancer neuroscience
The nervous system is increasingly recognized as a key regulator of the tumor microenvironment, engaging in bidirectional ...
CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinoma
CXCL12 derived from cancer-associated fibroblasts mediates dysfunctional intratumoral adaptive immunity in diabetic pancreatic adenocarcinoma
Diabetes mellitus (DM) affects the occurrence and progression of pancreatic adenocarcinoma (PAAD), but the DM-related immu...
METTL1-mediated mG tRNA modification promotes colorectal cancer progression and liver metastasis via translational regulation
METTL1-mediated mG tRNA modification promotes colorectal cancer progression and liver metastasis via translational regulation
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with colorectal cancer liver metastasis ...
Intratumoral PD-1 CD8 T cells correlate with AFP levels in HCC patients: a brief report
Intratumoral PD-1 CD8 T cells correlate with AFP levels in HCC patients: a brief report
Hepatocellular carcinoma (HCC), the most common primary liver cancer, typically arises in a context of chronic inflammatio...
Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies
Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies
RNA splicing is a fundamental cellular process that transforms precursor messenger RNA (pre-mRNA) into mature messenger RN...
ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses
ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses
The selective induction of nucleolar stress in cancer cells has become a potential anticancer therapy. However, precisely ...
CSRP2 modulates PDGFRA/PI3K/AKT signaling via PRC1 components in glioma
CSRP2 modulates PDGFRA/PI3K/AKT signaling via PRC1 components in glioma
Glioblastoma (GBM) is the most common and aggressive primary brain tumor, characterized by poor prognosis and therapeutic ...
Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour
Hippo signalling pathway mediates oncogenic properties of NAB2::STAT6 in solitary fibrous tumour
Solitary fibrous tumour (SFT) is a rare mesenchymal neoplasm molecularly defined by the NAB2::STAT6 gene fusion (GF), an a...
Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway
Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway
Cholesterol dysregulation plays a central role in tumor progression and has emerged as a potential therapeutic target. Its...
Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma
Disconnect between in vitro and in vivo efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma
Glioblastoma (GBM) is the most common adult primary brain tumor for which new therapeutic strategies are desperately neede...
Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma
Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma
Dysregulated cholesterol metabolism has emerged as a crucial driver of hepatocellular carcinoma (HCC) progression and immu...
Discover personalized drug opportunity and optimized tumor-infiltrating lymphocyte therapy for rare cancer: an organoid-based whole-journey clinical mapping study in a neuroendocrine cancer patient
Discover personalized drug opportunity and optimized tumor-infiltrating lymphocyte therapy for rare cancer: an organoid-based whole-journey clinical mapping study in a neuroendocrine cancer patient
Rare cancer patients face dire prognoses due to high malignancy and scarce treatment options, underscoring an imperative f...
Strategies to target PD-1/PD-L1 in the tumor microenvironment
Strategies to target PD-1/PD-L1 in the tumor microenvironment
In recent years, cancer immunotherapy has become one of the most important methods in cancer treatment, which can kill tum...
Targeting MEK/COX-2 axis improve immunotherapy efficacy in dMMR colorectal cancer with PIK3CA overexpression
Targeting MEK/COX-2 axis improve immunotherapy efficacy in dMMR colorectal cancer with PIK3CA overexpression
PIK3CA mutation or overexpression is associated with immunotherapy resistance in multiple cancer types, but is also parado...
OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination
OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination
Dysregulated ubiquitination modification occupies a pivotal role in hepatocellular carcinoma (HCC) tumorigenesis and progr...
A novel risk score system based on immune subtypes for identifying optimal mRNA vaccination population in hepatocellular carcinoma
A novel risk score system based on immune subtypes for identifying optimal mRNA vaccination population in hepatocellular carcinoma
Although mRNA vaccines have shown certain clinical benefits in multiple malignancies, their therapeutic efficacies against...
DNA-methylome-derived epigenetic fingerprint as an immunophenotype indicator of durable clinical immunotherapeutic benefits in head and neck squamous cell carcinoma
DNA-methylome-derived epigenetic fingerprint as an immunophenotype indicator of durable clinical immunotherapeutic benefits in head and neck squamous cell carcinoma
Cancer immunotherapy provides durable response and improves survival in a subset of head and neck squamous cell carcinoma ...
Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Microbial dysbiosis is considered as a hallmark of colorectal cancer (CRC). Trimethylamine-N-oxide (TMAO) as a gut microbi...
Pathological response and tumor stroma immunogenic features predict long-term survival in non-small cell lung cancer after neoadjuvant chemotherapy
Pathological response and tumor stroma immunogenic features predict long-term survival in non-small cell lung cancer after neoadjuvant chemotherapy
Major pathological response (MPR) has become a surrogate endpoint for overall survival (OS) in non-small cell lung cancer ...
Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
Metastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion ...
Repaglinide restrains HCC development and progression by targeting FOXO3/lumican/p53 axis
Repaglinide restrains HCC development and progression by targeting FOXO3/lumican/p53 axis
The recent focus on the roles of N-linked glycoproteins in carcinogenesis across various malignancies has prompted our exp...
O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency
O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency
Glucose not only provides energy for tumor cells, but also provides various biomolecules that are essential for their surv...
PIN1 promotes the metastasis of cholangiocarcinoma cells by RACK1-mediated phosphorylation of ANXA2
PIN1 promotes the metastasis of cholangiocarcinoma cells by RACK1-mediated phosphorylation of ANXA2
Cholangiocarcinoma (CCA), a primary hepatobiliary malignancy, is characterized by a poor prognosis and a lack of effective...
GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer
GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer
Growth differentiating Factor 15 (GDF15) is linked to several cancers, but its effect on chemoresistance in colorectal can...
Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma
Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma
Sunitinib is a recommended drug for metastatic renal cell carcinoma (RCC). However, the therapeutic potential of sunitinib...
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
Tumor-associated macrophages (TAMs) are associated with unfavorable patient prognosis in many cancer types. However, TAMs ...
The predictive significance of chromobox family members in prostate cancer in humans
The predictive significance of chromobox family members in prostate cancer in humans
The Chromobox (CBX) family proteins are crucial elements of the epigenetic regulatory machinery and play a significant rol...
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