X. Jin, Z. Demere, K. Nair, A. Ali, G.B. Ferraro, T. Natoli, A. Deik, L. Petronio, A.A. Tang, C. Zhu, L. Wang, D. Rosenberg, V. Mangena, J. Roth, K. Chung, R.K. Jain, C.B. Clish, M.G. Vander Heiden, T.R. Golub, A metastasis map of human cancer cell lines. Nature 588, 331–336 (2020)

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

S. Valastyan, R.A. Weinberg, Tumor metastasis: molecular insights and evolving paradigms. Cell 147, 275–292 (2011)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. SenGupta, C.A. Parent, J.E. Bear, The principles of directed cell migration. Nat. Rev. Mol. Cell Biol. 22, 529–547 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L.M. Machesky, H.R. Tang, Actin-based protrusions: promoters or inhibitors of cancer invasion? Cancer Cell 16, 5–7 (2009)

Article  CAS  PubMed  Google Scholar 

D.A. Cruz Walma, Z. Chen, A.N. Bullock, K.M. Yamada, Ubiquitin ligases: guardians of mammalian development. Nat. Rev. Mol. Cell Biol. 23(5), 350–367 (2022)

C. Pohl, I. Dikic, Cellular quality control by the ubiquitin-proteasome system and autophagy. Science 366, 818–822 (2019)

Article  CAS  PubMed  ADS  Google Scholar 

T.E.T. Mevissen, D. Komander, Mechanisms of deubiquitinase specificity and regulation. Annu. Rev. Biochem. 86, 159–192 (2017)

Article  CAS  PubMed  Google Scholar 

M.J. Clague, S. Urbé, D. Komander, Breaking the chains: deubiquitylating enzyme specificity begets function. Nat Rev Mol Cell Biol 20, 338–352 (2019)

Article  CAS  PubMed  Google Scholar 

K.P. Lai, J. Chen, W.K.F. Tse, Role of deubiquitinases in human cancers: potential targeted therapy. Int. J. Mol. Sci. 21 (2020)

Z. Xiao, P. Zhang, L. Ma, The role of deubiquitinases in breast cancer. Cancer Metastasis Rev. 35, 589–600 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

T. Bonacci, M.J. Emanuele, Dissenting degradation: deubiquitinases in cell cycle and cancer. Semin. Cancer Biol. 67, 145–158 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.T. Islam, F. Chen, H. Chen, The oncogenic role of ubiquitin specific peptidase (USP8) and its signaling pathways targeting for cancer therapeutics. Arch. Biochem. Biophys. 701, 108811 (2021)

Article  CAS  PubMed  Google Scholar 

B. Artegiani, L. van Voorthuijsen, R.G.H. Lindeboom, D. Seinstra, I. Heo, P. Tapia, C. López-Iglesias, D. Postrach, T. Dayton, R. Oka, H. Hu, R. van Boxtel, J.H. van Es, J. Offerhaus, P.J. Peters, J. van Rheenen, M. Vermeulen, H. Clevers, Probing the tumor suppressor function of BAP1 in CRISPR-engineered human liver organoids. Cell Stem Cell 24, 927–943.e926 (2019)

Article  CAS  PubMed  Google Scholar 

M. Murtaza, L.A. Jolly, J. Gecz, S.A. Wood, La FAM fatale: USP9X in development and disease. Cell Mol. Life Sci. 72, 2075–2089 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L. Masclef, O. Ahmed, B. Estavoyer, B. Larrivée, N. Labrecque, A. Nijnik, E.B. Affar, Roles and mechanisms of BAP1 deubiquitinase in tumor suppression. Cell Death Differ. 28, 606–625 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.R. Testa, M. Cheung, J. Pei, J.E. Below, Y. Tan, E. Sementino, N.J. Cox, A.U. Dogan, H.I. Pass, S. Trusa, M. Hesdorffer, M. Nasu, A. Powers, Z. Rivera, S. Comertpay, M. Tanji, G. Gaudino, H. Yang, M. Carbone, Germline BAP1 mutations predispose to malignant mesothelioma. Nat. Genet. 43, 1022–1025 (2011)

Article  CAS  PubMed  PubMed Central  Google Scholar 

G.Z. Qiu, W. Sun, M.Z. Jin, J. Lin, P.G. Lu, W.L. Jin, The bad seed gardener: deubiquitinases in the cancer stem-cell signaling network and therapeutic resistance. Pharmacol. Ther. 172, 127–138 (2017)

Article  CAS  PubMed  Google Scholar 

M. He, Z. Zhou, G. Wu, Q. Chen, Y. Wan, Emerging role of DUBs in tumor metastasis and apoptosis: therapeutic implication. Pharmacol. Ther. 177, 96–107 (2017)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. He, H.J. Lee, S. Saha, D. Ruan, H. Guo, C.H. Chan, Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy. Cell Death Dis. 10, 285 (2019)

Article  PubMed  PubMed Central  Google Scholar 

J. Kim, F. Alavi Naini, Y. Sun, L. Ma, Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin. Am. J. Cancer Res. 8, 1823–1836 (2018)

CAS  PubMed  PubMed Central  Google Scholar 

W. Huang, X. Liu, Y. Zhang, M. Deng, G. Li, G. Chen, L. Yu, L. Jin, T. Liu, Y. Wang, Y. Chen, USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2α. J. Cell Physiol. 237(4), 2211–2219 (2022)

Article  CAS  PubMed  Google Scholar 

D. Duan, M. Shang, Y. Han, J. Liu, J. Liu, S.H. Kong, J. Hou, B. Huang, J. Lu, Y. Zhang, EZH2-CCF-cGAS axis promotes breast cancer metastasis. Int. J. Mol. Sci. 23(3), 1788 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Liu, J. Feng, L. Li, L. Lin, J. Ji, C. Lin, L. Liu, N. Zhang, D. Duan, Z. Li, B. Huang, Y. Zhang, J. Lu, Arginine methylation-dependent LSD1 stability promotes invasion and metastasis of breast cancer. EMBO Rep. 21, e48597 (2020)

Article  CAS  PubMed  Google Scholar 

L. Zhang, F. Zhou, Y. Drabsch, R. Gao, B.E. Snaar-Jagalska, C. Mickanin, H. Huang, K.A. Sheppard, J.A. Porter, C.X. Lu, P. ten Dijke, USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor. Nat. Cell Biol. 14, 717–726 (2012)

Article  CAS  PubMed  Google Scholar 

P.J. Eichhorn, L. Rodón, A. Gonzàlez-Juncà, A. Dirac, M. Gili, E. Martínez-Sáez, C. Aura, I. Barba, V. Peg, A. Prat, I. Cuartas, J. Jimenez, D. García-Dorado, J. Sahuquillo, R. Bernards, J. Baselga, J. Seoane, USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat. Med. 18, 429–435 (2012)

Article  CAS  PubMed  Google Scholar 

S. Liu, R. González-Prieto, M. Zhang, P.P. Geurink, R. Kooij, P.V. Iyengar, M. van Dinther, E. Bos, X. Zhang, S.E. Le Dévédec, B. van de Water, R.I. Koning, H.J. Zhu, W.E. Mesker, A.C.O. Vertegaal, H. Ovaa, L. Zhang, J.W.M. Martens, P. Ten Dijke, Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis. Clin. Cancer Res. 26, 1460–1473 (2020)

Article  CAS  PubMed  Google Scholar 

D. Kim, A. Hong, H.I. Park, W.H. Shin, L. Yoo, S.J. Jeon, K.C. Chung, Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells. J. Cell Physiol. 232, 3664–3676 (2017)

Article  CAS  PubMed  Google Scholar 

J. Qin, Z. Zhou, W. Chen, C. Wang, H. Zhang, G. Ge, M. Shao, D. You, Z. Fan, H. Xia, R. Liu, C. Chen, BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5. Nat. Commun. 6, 8471 (2015)

Article  CAS  PubMed  ADS  Google Scholar 

G. Lambies, M. Miceli, C. Martínez-Guillamon, R. Olivera-Salguero, R. Peña, C.P. Frías, I. Calderón, B.S. Atanassov, S.Y.R. Dent, J. Arribas, A. García de Herreros, V.M. Díaz, TGFβ-activated USP27X deubiquitinase regulates cell migration and chemoresistance via stabilization of Snail1. Cancer Res. 79, 33–46 (2019)

Article  CAS  PubMed  Google Scholar 

T. Liu, J. Yu, M. Deng, Y. Yin, H. Zhang, K. Luo, B. Qin, Y. Li, C. Wu, T. Ren, Y. Han, P. Yin, J. Kim, S. Lee, J. Lin, L. Zhang, J. Zhang, S. Nowsheen, L. Wang, J. Boughey, M.P. Goetz, J. Yuan, Z. Lou, CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. Nat. Commun. 8, 13923 (2017)

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

H. Zou, H. Chen, Z. Zhou, Y. Wan, Z. Liu, ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4. Cancer Lett. 467, 19–28 (2019)

Article  CAS  PubMed  Google Scholar 

L. Zhang, J. Qiang, X. Yang, D. Wang, A.U. Rehman, X. He, W. Chen, D. Sheng, L. Zhou, Y.Z. Jiang, T. Li, Y. Du, J. Feng, X. Hu, J. Zhang, X.C. Hu, Z.M. Shao, S. Liu, IL1R2 blockade suppresses breast tumorigenesis and progression by impairing USP15-dependent BMI1 stability. Adv. Sci. (Weinh.) 7, 1901728 (2020)

CAS  PubMed  Google Scholar 

Z. Zhang, Y. Fan, F. Xie, H. Zhou, K. Jin, L. Shao, W. Shi, P. Fang, B. Yang, H. van Dam, P. Ten Dijke, X. Zheng, X. Yan, J. Jia, M. Zheng, J. Jin, C. Ding, S. Ye, F. Zhou, L. Zhang, Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. Nat. Commun. 8, 2116 (2017)

Article  PubMed  PubMed Central  ADS  Google Scholar 

Z. Zhang, J. Li, Y. Ou, G. Yang, K. Deng, Q. Wang, Z. Wang, W. Wang, Q. Zhang, H. Wang, W. Sun, P. Sun, S. Yang, CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism. Signal Transduct. Target. Ther. 5, 25 (2020)

Article