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A Bioimaging Study of Zr-Bintrafusp Alfa PET Scans in Patients with Advanced or Metastatic NSCLC Receiving Bintrafusp Alfa Alone or in Combination with Chemotherapy

Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the human transfor...

Molecular Imaging And Biology

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Enhanced Fluorescence of Near-Infrared Anti-CEA Antibodies for Visualizing Colorectal Cancers Using Modified Heptamethine Cyanines

The clinical success of fluorescence-guided surgery is dependent on tumor-specific probes that can achieve high tumor-to-b...

Molecular Imaging And Biology

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Exploration of the Feasibility of One-Day Dual-Low-Activity Ga-DOTATATE and F-FDG PET/MR in Patients with Neuroendocrine Neoplasms

The standard 2-day dual-tracer PET protocol provides more information but is time consuming. Thus, this study aimed to val...

Molecular Imaging And Biology

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$Theranostic and Radionuclide-based Treatment Approaches for Radioiodine-refractory Thyroid Cancer: From Biology to Clinical Application$

Theranostic and Radionuclide-based Treatment Approaches for Radioiodine-refractory Thyroid Cancer: From Biology to Clinical Application

When differentiated thyroid cancer stops taking up radioiodine, treatment becomes significantly more challenging, and the ...

Molecular Imaging And Biology

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Template-Directed RIG-I Agonist Assembly for Image-guided Targeted Cancer Immunotherapy

Tumor-specific immunotherapies selectively target tumor cells with reduced toxicity compared to conventional treatments. P...

Molecular Imaging And Biology

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Imaging vascular characteristics and glycolytic metabolism of glioblastoma in a chick embryo model using H MRI and [F]FDG-PET

To assess hypoxia-associated host-tumour vascular adaptations and glycolytic metabolism in the chick chorioallantoic membr...

Molecular Imaging And Biology

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Value of Multitracer Imaging in Hepatocellular Carcinomas with Different Metastatic Potential

Hepatocellular carcinoma (HCC) shows marked heterogeneity and varying metastatic potential, challenging prognosis and trea...

Molecular Imaging And Biology

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Engineering Anti-MMP-9 Peptide-Modified Nanoparticles for Precision MRI Diagnosis of Endometriosis

Endometriosis diagnosis is often limited by the resolution of conventional imaging techniques (ultrasound/non-targeted MRI...

Molecular Imaging And Biology

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Design of a Bifunctional pHLIP-RGD Scaffold for Site-Specific [Tc] Tc Labeling: Radiochemical Evaluation and Proof-of-Concept Tumor Targeting

To develop a novel molecular scaffold designed for dual targeting via site-specific [99mTc] Tc labeling, we repor...

Molecular Imaging And Biology

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Sonodynamic Therapy-Enhanced Immunotherapy for Triple-Negative Breast Cancer: Mechanistic Advances, Nanoplatform Strategies, and Clinical Prospects

Triple-negative breast cancer (TNBC) remains a major clinical challenge owing to its inherent resistance to treatment, imm...

Molecular Imaging And Biology

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Malignant Pleural Mesothelioma (MPM) Evaluation with [C]-Methionine PET/CT Before and After Talc Pleurodesis

Malignant pleural mesothelioma (MPM) poses an imaging challenge that requires special attention, especially in patients wh...

Molecular Imaging And Biology

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Value of Imaging Parameters of [F]FDG PET/CT and Serological Indices in Predicting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma

This study aimed to evaluate the value of [18F]FDG PET/CT parameters and serological indices in predicting lymph node meta...

Molecular Imaging And Biology

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Photoacoustic Imaging of Muscle Tissue Oxygenation as a Noninvasive Biomarker in Mouse Models of Sickle Cell Disease

To develop and validate photoacoustic imaging (PAI) as a method to assess hemoglobin counts and muscle tissue oxygen satur...

Molecular Imaging And Biology

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Magnetically Controlled Nanocarriers for Site-Specific Drug Delivery and Theranostics in Cancer Precision Medicine

The growing demand for precision oncology has intensified interest in magnetically controlled nanocarriers (MCNCs) as vers...

Molecular Imaging And Biology

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The Binding of the High Affinity Radioligand Fallypride to the D2-dopamine Receptor is Sensitive to Injected Mass – a PET Study in Rodents

Fallypride is a widely used high affinity radioligand for quantification of D2-dopamine receptor binding in small animal P...

Molecular Imaging And Biology

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Comparison of [F]FDG and [F]PSMA-1007 PET/CT in the Evaluation of Muscle-Invasive Bladder Cancer: A Pilot Feasibility Study

To compare the diagnostic performance of [18F]FDG and [18F]PSMA‑1007 PET/CT for detecting primary tumors, regional l...

Molecular Imaging And Biology

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Astrocyte Activation Persists after Recovery of Myelin and Motor Deficits in the Cuprizone Model: a Longitudinal PET and CNS Tissue Analysis Study

The cuprizone (CPZ) mouse model for multiple sclerosis enables researchers to investigate the underlying mechanisms of dem...

Molecular Imaging And Biology

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Comparison of [F]DPA-814 with [F]DPA-714 for TSPO Imaging in an Experimental Model

[18F]DPA-714 is a valuable tracer for studying (neuro)inflammation, with well-characterized tracer kinetics and an establi...

Molecular Imaging And Biology

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Preclinical Study of Radiolabeled LyP-1 for Detecting Sunitinib-induced Changes in the Tumor Microenvironment and Synergistic Antitumor Effects in Triple-negative Breast Cancer

Sunitinib is an anti-angiogenic drug that can induce drug resistance characterized by hypoxia. We aimed to synthesize two ...

Molecular Imaging And Biology

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Dose-aware diffusion model for 3D PET image denoising: Multi-institutional validation with reader study and real low-dose data

Medical Image Analysis

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GCN combined with snake convolution for enhanced topological perception in thrombotic hepatic portal vein segmentation

Medical Image Analysis

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Functional imaging constrained diffusion for brain PET synthesis from structural MRI

Medical Image Analysis

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Ultrasound Localization Microscopy Learned from power doppler by uncertainty frequency density estimation and semantic consistency awareness

Medical Image Analysis

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Predicting neoadjuvant therapy response in breast cancer from preoperative biopsy via spatial–semantic–differential learning and interpretable clinicopathological-guided fusion

Medical Image Analysis

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Harmonization in magnetic resonance imaging: A survey of acquisition, image-level, and feature-level methods

Medical Image Analysis

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NeuroGT: Biophysically grounded graph transformers for self-supervised representation learning of neuronal morphology

Medical Image Analysis

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Prediction of post-stroke brain swelling using biomechanical modelling and deep neural networks

Medical Image Analysis

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PRIME: Phase reversed interleaved multi-Echo acquisition enables highly accelerated distortion-corrected diffusion MRI

Medical Image Analysis

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OOD-SEG: Exploiting out-of-distribution detection techniques for learning image segmentation from sparse multi-class positive-only annotations

Medical Image Analysis

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Foundational model-based geometric consistency monocular depth estimation framework for colonoscopy

Medical Image Analysis

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