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A Bioimaging Study of Zr-Bintrafusp Alfa PET Scans in Patients with Advanced or Metastatic NSCLC Receiving Bintrafusp Alfa Alone or in Combination with Chemotherapy
A Bioimaging Study of Zr-Bintrafusp Alfa PET Scans in Patients with Advanced or Metastatic NSCLC Receiving Bintrafusp Alfa Alone or in Combination with Chemotherapy
Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the human transfor...
Enhanced Fluorescence of Near-Infrared Anti-CEA Antibodies for Visualizing Colorectal Cancers Using Modified Heptamethine Cyanines
Enhanced Fluorescence of Near-Infrared Anti-CEA Antibodies for Visualizing Colorectal Cancers Using Modified Heptamethine Cyanines
The clinical success of fluorescence-guided surgery is dependent on tumor-specific probes that can achieve high tumor-to-b...
Exploration of the Feasibility of One-Day Dual-Low-Activity Ga-DOTATATE and F-FDG PET/MR in Patients with Neuroendocrine Neoplasms
Exploration of the Feasibility of One-Day Dual-Low-Activity Ga-DOTATATE and F-FDG PET/MR in Patients with Neuroendocrine Neoplasms
The standard 2-day dual-tracer PET protocol provides more information but is time consuming. Thus, this study aimed to val...
Theranostic and Radionuclide-based Treatment Approaches for Radioiodine-refractory Thyroid Cancer: From Biology to Clinical Application
Theranostic and Radionuclide-based Treatment Approaches for Radioiodine-refractory Thyroid Cancer: From Biology to Clinical Application
When differentiated thyroid cancer stops taking up radioiodine, treatment becomes significantly more challenging, and the ...
Template-Directed RIG-I Agonist Assembly for Image-guided Targeted Cancer Immunotherapy
Template-Directed RIG-I Agonist Assembly for Image-guided Targeted Cancer Immunotherapy
Tumor-specific immunotherapies selectively target tumor cells with reduced toxicity compared to conventional treatments. P...
Imaging vascular characteristics and glycolytic metabolism of glioblastoma in a chick embryo model using H MRI and [F]FDG-PET
Imaging vascular characteristics and glycolytic metabolism of glioblastoma in a chick embryo model using H MRI and [F]FDG-PET
To assess hypoxia-associated host-tumour vascular adaptations and glycolytic metabolism in the chick chorioallantoic membr...
Value of Multitracer Imaging in Hepatocellular Carcinomas with Different Metastatic Potential
Value of Multitracer Imaging in Hepatocellular Carcinomas with Different Metastatic Potential
Hepatocellular carcinoma (HCC) shows marked heterogeneity and varying metastatic potential, challenging prognosis and trea...
Engineering Anti-MMP-9 Peptide-Modified Nanoparticles for Precision MRI Diagnosis of Endometriosis
Engineering Anti-MMP-9 Peptide-Modified Nanoparticles for Precision MRI Diagnosis of Endometriosis
Endometriosis diagnosis is often limited by the resolution of conventional imaging techniques (ultrasound/non-targeted MRI...
Design of a Bifunctional pHLIP-RGD Scaffold for Site-Specific [Tc] Tc Labeling: Radiochemical Evaluation and Proof-of-Concept Tumor Targeting
Design of a Bifunctional pHLIP-RGD Scaffold for Site-Specific [Tc] Tc Labeling: Radiochemical Evaluation and Proof-of-Concept Tumor Targeting
To develop a novel molecular scaffold designed for dual targeting via site-specific [99mTc] Tc labeling, we repor...
Sonodynamic Therapy-Enhanced Immunotherapy for Triple-Negative Breast Cancer: Mechanistic Advances, Nanoplatform Strategies, and Clinical Prospects
Sonodynamic Therapy-Enhanced Immunotherapy for Triple-Negative Breast Cancer: Mechanistic Advances, Nanoplatform Strategies, and Clinical Prospects
Triple-negative breast cancer (TNBC) remains a major clinical challenge owing to its inherent resistance to treatment, imm...
Malignant Pleural Mesothelioma (MPM) Evaluation with [C]-Methionine PET/CT Before and After Talc Pleurodesis
Malignant Pleural Mesothelioma (MPM) Evaluation with [C]-Methionine PET/CT Before and After Talc Pleurodesis
Malignant pleural mesothelioma (MPM) poses an imaging challenge that requires special attention, especially in patients wh...
Value of Imaging Parameters of [F]FDG PET/CT and Serological Indices in Predicting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma
Value of Imaging Parameters of [F]FDG PET/CT and Serological Indices in Predicting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma
This study aimed to evaluate the value of [18F]FDG PET/CT parameters and serological indices in predicting lymph node meta...
Photoacoustic Imaging of Muscle Tissue Oxygenation as a Noninvasive Biomarker in Mouse Models of Sickle Cell Disease
Photoacoustic Imaging of Muscle Tissue Oxygenation as a Noninvasive Biomarker in Mouse Models of Sickle Cell Disease
To develop and validate photoacoustic imaging (PAI) as a method to assess hemoglobin counts and muscle tissue oxygen satur...
Magnetically Controlled Nanocarriers for Site-Specific Drug Delivery and Theranostics in Cancer Precision Medicine
Magnetically Controlled Nanocarriers for Site-Specific Drug Delivery and Theranostics in Cancer Precision Medicine
The growing demand for precision oncology has intensified interest in magnetically controlled nanocarriers (MCNCs) as vers...
The Binding of the High Affinity Radioligand Fallypride to the D2-dopamine Receptor is Sensitive to Injected Mass – a PET Study in Rodents
The Binding of the High Affinity Radioligand Fallypride to the D2-dopamine Receptor is Sensitive to Injected Mass – a PET Study in Rodents
Fallypride is a widely used high affinity radioligand for quantification of D2-dopamine receptor binding in small animal P...
Comparison of [F]FDG and [F]PSMA-1007 PET/CT in the Evaluation of Muscle-Invasive Bladder Cancer: A Pilot Feasibility Study
Comparison of [F]FDG and [F]PSMA-1007 PET/CT in the Evaluation of Muscle-Invasive Bladder Cancer: A Pilot Feasibility Study
To compare the diagnostic performance of [18F]FDG and [18F]PSMA‑1007 PET/CT for detecting primary tumors, regional l...
Astrocyte Activation Persists after Recovery of Myelin and Motor Deficits in the Cuprizone Model: a Longitudinal PET and CNS Tissue Analysis Study
Astrocyte Activation Persists after Recovery of Myelin and Motor Deficits in the Cuprizone Model: a Longitudinal PET and CNS Tissue Analysis Study
The cuprizone (CPZ) mouse model for multiple sclerosis enables researchers to investigate the underlying mechanisms of dem...
Comparison of [F]DPA-814 with [F]DPA-714 for TSPO Imaging in an Experimental Model
Comparison of [F]DPA-814 with [F]DPA-714 for TSPO Imaging in an Experimental Model
[18F]DPA-714 is a valuable tracer for studying (neuro)inflammation, with well-characterized tracer kinetics and an establi...
Preclinical Study of Radiolabeled LyP-1 for Detecting Sunitinib-induced Changes in the Tumor Microenvironment and Synergistic Antitumor Effects in Triple-negative Breast Cancer
Preclinical Study of Radiolabeled LyP-1 for Detecting Sunitinib-induced Changes in the Tumor Microenvironment and Synergistic Antitumor Effects in Triple-negative Breast Cancer
Sunitinib is an anti-angiogenic drug that can induce drug resistance characterized by hypoxia. We aimed to synthesize two ...
Diagnostic Value of [F]-FDG and [ Ga]-FAPI-04 PET/MRI for Lymph Node Metastasis in Papillary Thyroid Cancer
Diagnostic Value of [F]-FDG and [ Ga]-FAPI-04 PET/MRI for Lymph Node Metastasis in Papillary Thyroid Cancer
This study aimed to evaluate the diagnostic value of [18F]-FDG PET/MRI for the diagnosis of neck lymph node metastasis (LN...
Positive Protective Effects of Sigma-1 Receptor Stimulation with Fluvoxamine after Myocardial Ischemia and Reperfusion in Rats
Positive Protective Effects of Sigma-1 Receptor Stimulation with Fluvoxamine after Myocardial Ischemia and Reperfusion in Rats
The sigma-1 receptor (Sig-1R) plays diverse roles in regulating Endoplasmic Reticulum (ER) stress, calcium handling, and i...
Combining Dopamine Transporter and Amyloid PET Tracer: A Preclinical Study on Dual-Target Imaging
Combining Dopamine Transporter and Amyloid PET Tracer: A Preclinical Study on Dual-Target Imaging
This study aimed to evaluate the feasibility and diagnostic utility of a dual-target positron emission tomography (PET) im...
Local Infusing Antiplatelet Microspheres to Prevent Thrombosis Post-PCI: a Feasibility Study in Rabbit Aorta
Local Infusing Antiplatelet Microspheres to Prevent Thrombosis Post-PCI: a Feasibility Study in Rabbit Aorta
After percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) is required to prevent thrombosis, but sy...
Development and Evaluation of a Vinyl Sulfone-Based Fluorine-18 Labeling Method for Constructing PSMA-targeted Prostate Cancer Imaging Agents
Development and Evaluation of a Vinyl Sulfone-Based Fluorine-18 Labeling Method for Constructing PSMA-targeted Prostate Cancer Imaging Agents
Since prostate-specific membrane antigen (PSMA) is widely expressed in nearly all stages of prostate cancer (PCa), PSMA tr...
PET Study of S1PR1 Expression in Rodent Model of Myocardial Infarction
PET Study of S1PR1 Expression in Rodent Model of Myocardial Infarction
Acute myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. Sphingosine-1-phosphate (S1P) is...
In vivo Multimodal Magnetic Particle Imaging for Early Detection of Ischemic Stroke in Tree Shrews
In vivo Multimodal Magnetic Particle Imaging for Early Detection of Ischemic Stroke in Tree Shrews
Ischemic stroke is a significant threat to human life and health, and timely diagnosis is essential for improving patient ...
Enhancing the Half-Life of ODAP-Urea Based Radioligands by Incorporating Albumin-Binding Moieties
Enhancing the Half-Life of ODAP-Urea Based Radioligands by Incorporating Albumin-Binding Moieties
Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) is a promising approach to treating me...
Reengineered Anti-CD4 Cys-diabody Variants for Zr-immunoPET of CD4 T Cells in Immunocompetent Mice
Reengineered Anti-CD4 Cys-diabody Variants for Zr-immunoPET of CD4 T Cells in Immunocompetent Mice
CD4+ T cells (T helper and T reg) play an important role in the immune system and are influential in autoimmune diseases (...
CREBBP Mutation as a Culprit for Negative SSTR2 PET in Neuroendocrine Tumors
CREBBP Mutation as a Culprit for Negative SSTR2 PET in Neuroendocrine Tumors
This study aimed to elucidate the molecular and genetic factors contributing to negative 68Ga-DOTATATE PET imaging in neur...
Fibrotic Disease: from Signaling Pathways and Biomarkers to Molecular Imaging
Fibrotic Disease: from Signaling Pathways and Biomarkers to Molecular Imaging
Fibrotic diseases are characterized by excessive accumulation of extracellular matrix (ECM) components following tissue in...
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