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Diagnostic Value of [F]-FDG and [ Ga]-FAPI-04 PET/MRI for Lymph Node Metastasis in Papillary Thyroid Cancer
Diagnostic Value of [F]-FDG and [ Ga]-FAPI-04 PET/MRI for Lymph Node Metastasis in Papillary Thyroid Cancer
This study aimed to evaluate the diagnostic value of [18F]-FDG PET/MRI for the diagnosis of neck lymph node metastasis (LN...
Positive Protective Effects of Sigma-1 Receptor Stimulation with Fluvoxamine after Myocardial Ischemia and Reperfusion in Rats
Positive Protective Effects of Sigma-1 Receptor Stimulation with Fluvoxamine after Myocardial Ischemia and Reperfusion in Rats
The sigma-1 receptor (Sig-1R) plays diverse roles in regulating Endoplasmic Reticulum (ER) stress, calcium handling, and i...
Combining Dopamine Transporter and Amyloid PET Tracer: A Preclinical Study on Dual-Target Imaging
Combining Dopamine Transporter and Amyloid PET Tracer: A Preclinical Study on Dual-Target Imaging
This study aimed to evaluate the feasibility and diagnostic utility of a dual-target positron emission tomography (PET) im...
Local Infusing Antiplatelet Microspheres to Prevent Thrombosis Post-PCI: a Feasibility Study in Rabbit Aorta
Local Infusing Antiplatelet Microspheres to Prevent Thrombosis Post-PCI: a Feasibility Study in Rabbit Aorta
After percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) is required to prevent thrombosis, but sy...
Development and Evaluation of a Vinyl Sulfone-Based Fluorine-18 Labeling Method for Constructing PSMA-targeted Prostate Cancer Imaging Agents
Development and Evaluation of a Vinyl Sulfone-Based Fluorine-18 Labeling Method for Constructing PSMA-targeted Prostate Cancer Imaging Agents
Since prostate-specific membrane antigen (PSMA) is widely expressed in nearly all stages of prostate cancer (PCa), PSMA tr...
PET Study of S1PR1 Expression in Rodent Model of Myocardial Infarction
PET Study of S1PR1 Expression in Rodent Model of Myocardial Infarction
Acute myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. Sphingosine-1-phosphate (S1P) is...
In vivo Multimodal Magnetic Particle Imaging for Early Detection of Ischemic Stroke in Tree Shrews
In vivo Multimodal Magnetic Particle Imaging for Early Detection of Ischemic Stroke in Tree Shrews
Ischemic stroke is a significant threat to human life and health, and timely diagnosis is essential for improving patient ...
Enhancing the Half-Life of ODAP-Urea Based Radioligands by Incorporating Albumin-Binding Moieties
Enhancing the Half-Life of ODAP-Urea Based Radioligands by Incorporating Albumin-Binding Moieties
Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) is a promising approach to treating me...
Reengineered Anti-CD4 Cys-diabody Variants for Zr-immunoPET of CD4 T Cells in Immunocompetent Mice
Reengineered Anti-CD4 Cys-diabody Variants for Zr-immunoPET of CD4 T Cells in Immunocompetent Mice
CD4+ T cells (T helper and T reg) play an important role in the immune system and are influential in autoimmune diseases (...
CREBBP Mutation as a Culprit for Negative SSTR2 PET in Neuroendocrine Tumors
CREBBP Mutation as a Culprit for Negative SSTR2 PET in Neuroendocrine Tumors
This study aimed to elucidate the molecular and genetic factors contributing to negative 68Ga-DOTATATE PET imaging in neur...
Fibrotic Disease: from Signaling Pathways and Biomarkers to Molecular Imaging
Fibrotic Disease: from Signaling Pathways and Biomarkers to Molecular Imaging
Fibrotic diseases are characterized by excessive accumulation of extracellular matrix (ECM) components following tissue in...
Evaluation of Indocyanine Green Derivatives with Sulfonic Acid and Carboxylic Acid Groups at the Benzoindolenine Moiety for Antibody-Based Tumor Imaging
Evaluation of Indocyanine Green Derivatives with Sulfonic Acid and Carboxylic Acid Groups at the Benzoindolenine Moiety for Antibody-Based Tumor Imaging
In target-specific cancer imaging, antibodies and their fragments are conjugated with fluorescent dyes to work as targetin...
Advances in the Molecular Imaging of Sarcoma: An Emphasis on Metabolic Imaging
Advances in the Molecular Imaging of Sarcoma: An Emphasis on Metabolic Imaging
Sarcomas, malignancies of mesenchymal origin, present significant diagnostic and therapeutic challenges due to their heter...
Tailoring Image Contrast for Cellular Magnetic Resonance Imaging using Gadolinium Chelates and Superparamagnetic Iron Oxide Particles
Tailoring Image Contrast for Cellular Magnetic Resonance Imaging using Gadolinium Chelates and Superparamagnetic Iron Oxide Particles
To investigate magnetic relaxation properties of the tailored contrast using paramagnetic gadolinium (Gd) chelates and sup...
PSMA-1-DOTA Potentially for Effective Targeted Radioligand Therapy of Prostate Cancer
PSMA-1-DOTA Potentially for Effective Targeted Radioligand Therapy of Prostate Cancer
While PSMA-targeted radioligand therapy (RLT) has shown remarkable efficacy for treating end-stage prostate cancer, the &#...
Optimisation of Animal Handing and Timing of 2-deoxy-2-[18F]fluoro-D-glucose PET Tumour Imaging in Mice
Optimisation of Animal Handing and Timing of 2-deoxy-2-[18F]fluoro-D-glucose PET Tumour Imaging in Mice
In humans, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) tumour-to-background contrast continues to increase long after a typ...
Radioimaging Foam Cells Infiltrating Atherosclerotic Plaques in Mice Using 125I-labeled oxLDL as a Radiotracer
Radioimaging Foam Cells Infiltrating Atherosclerotic Plaques in Mice Using 125I-labeled oxLDL as a Radiotracer
Bioimaging such as magnetic resonance is used to monitor atherosclerotic plaques consisting of foam cells, which are deriv...
Comparison Between Prone SPECT-Based Semi-Quantitative Parameters and MBI-Based Semi-Quantitative Parameters in Patients with Locally Advanced Breast Cancer
Comparison Between Prone SPECT-Based Semi-Quantitative Parameters and MBI-Based Semi-Quantitative Parameters in Patients with Locally Advanced Breast Cancer
This study evaluates the semi-quantitative single-photon emission computed tomography (SPECT) parameters of prone SPECT us...
Improved Quantification of MicroPET/CT Imaging Using CT-derived Scaling Factors
Improved Quantification of MicroPET/CT Imaging Using CT-derived Scaling Factors
Combined micro-PET/CT scanners are widely employed to investigate models of brain disorders in rodents using PET-based cor...
In Vivo Mouse Abdominal Oxygen Imaging And Assessment of Subcutaneously Implanted Beta Cell Replacement Devices
In Vivo Mouse Abdominal Oxygen Imaging And Assessment of Subcutaneously Implanted Beta Cell Replacement Devices
Type 1 diabetes (T1D) is an autoimmune disease that leads to the loss of insulin-producing pancreatic beta cells. Beta cel...
First-in-human Evaluation of Safety and Dosimetry of [64Cu]FBP8: A fibrin-binding PET Probe
First-in-human Evaluation of Safety and Dosimetry of [64Cu]FBP8: A fibrin-binding PET Probe
This study presents for the first time in humans the biodistribution, clearance and dosimetry estimates of [64Cu]Fibrin Bi...
Preclinical and Clinical-Scale Magnetic Particle Imaging of Natural Killer Cells: in vitro and ex vivo Demonstration of Cellular Sensitivity, Resolution, and Quantification
Preclinical and Clinical-Scale Magnetic Particle Imaging of Natural Killer Cells: in vitro and ex vivo Demonstration of Cellular Sensitivity, Resolution, and Quantification
Clinical adoption of NK cell immunotherapy is underway for medulloblastoma and osteosarcoma, however there is currently li...
Ex Vivo Human Tissue Functions as a Testing Platform for the Evaluation of a Nerve-Specific Fluorophore
Ex Vivo Human Tissue Functions as a Testing Platform for the Evaluation of a Nerve-Specific Fluorophore
Selecting a nerve-specific lead fluorescent agent for translation in fluorescence-guided surgery is time-consuming and exp...
68Ga-PSMA PET/CT-Based Model Predicts Perineural Invasion of Prostate Cancer with Whole-Mount Sections
68Ga-PSMA PET/CT-Based Model Predicts Perineural Invasion of Prostate Cancer with Whole-Mount Sections
To develop a novel risk model incorporating 68Ga-PSMA PET/CT parameters for prediction of perineural invasion (PNI) of pro...
68Ga-pentixafor PET/CT Is a Supplementary Method for Primary Aldosteronism Subtyping Compared with Adrenal Vein Sampling
68Ga-pentixafor PET/CT Is a Supplementary Method for Primary Aldosteronism Subtyping Compared with Adrenal Vein Sampling
To investigate the diagnostic efficacy of 68Ga-pentixafor positron emission tomography/computed tomography (PET/CT) in pri...
Evaluation of Brain Impairment Using Proton Exchange Rate MRI in a Kainic Acid-Induced Rat Model of Epilepsy
Evaluation of Brain Impairment Using Proton Exchange Rate MRI in a Kainic Acid-Induced Rat Model of Epilepsy
Proton exchange rate (Kex) is a valuable biophysical metric. Kex MRI may augment conventional structural MRI by revealing ...
PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F]TZ4877 in Nonhuman Primates
PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F]TZ4877 in Nonhuman Primates
The sphingosine-1-phosphate receptor-1 (S1PR1) is involved in regulating responses to neuroimmune stimuli. There is a need...
18F-FAPI-42 PET/CT and 18F-FDG PET/CT in Patients with Malignant Digestive System Neoplasms: A Head-to-Head Comparative Study
18F-FAPI-42 PET/CT and 18F-FDG PET/CT in Patients with Malignant Digestive System Neoplasms: A Head-to-Head Comparative Study
Radionuclide-labeled fibroblast activation protein inhibitor (FAPI) is an emerging tumor tracer. We sought to assess the u...
Oral Administration of [18F]MC225 for Quantification of P-glycoprotein Function: A Feasibility Study
Oral Administration of [18F]MC225 for Quantification of P-glycoprotein Function: A Feasibility Study
This preclinical study explored the feasibility of assessing P-glycoprotein (P-gp) function in both brain and gastrointest...
Evaluation of Inflammatory Activity of Extraocular Muscles in Thyroid Associated Orbitopathy by [68Ga]DOTATATE PET/CT
Evaluation of Inflammatory Activity of Extraocular Muscles in Thyroid Associated Orbitopathy by [68Ga]DOTATATE PET/CT
The accurate assessment of inflammatory activity of the extraocular muscles (EOMs) in thyroid associated ophthalmopathy (T...
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