Love S (2006) Demyelinating diseases. J Clin Pathol 59:1151–1159

Article  CAS  PubMed  PubMed Central  Google Scholar 

Höftberger R, Lassmann H (2017) Inflammatory demyelinating diseases of the central nervous system. Handb Clin Neurol 145:263–283

Lassmann H (2001) Classification of demyelinating diseases at the interface between etiology and pathogenesis. Curr Opin Neurol 14:253–258

Article  CAS  PubMed  Google Scholar 

Miller RH, Mi S (2007) Dissecting demyelination. Nat Neurosci 10:1351–1354

Article  CAS  PubMed  Google Scholar 

Neely SA, Williamson JM, Klingseisen A, Zoupi L, Early JJ, Williams A, Lyons DA (2022) New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination. Nat Neurosci 25:415–420

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gruchot J, Weyers V, Göttle P, Förster M, Hartung H-P, Küry P, Kremer D (2019) The molecular basis for remyelination failure in multiple sclerosis. Cells 8:825

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franklin RJM, ffrench-Constant C (2008) Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 9:839–855

Article  CAS  PubMed  Google Scholar 

Zhan J, Mann T, Joost S, Behrangi N, Frank M, Kipp M (2020) The cuprizone model: dos and do nots. Cells. 9:843

Article  PubMed  PubMed Central  Google Scholar 

Vega-Riquer JM, Mendez-Victoriano G, Morales-Luckie RA, Gonzalez-Perez O (2019) Five decades of cuprizone, an updated model to replicate demyelinating diseases. Curr Neuropharmacol 17:129–141

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu H, Yang HJ, McConomy B, Browning R, Li XM (2010) Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics. Front Behav Neurosci 4:8

Sen MK, Almuslehi MSM, Coorssen JR, Mahns DA, Shortland PJ (2020) Behavioural and histological changes in cuprizone-fed mice. Brain Behav Immun 87:508–523

Article  CAS  PubMed  Google Scholar 

Jhelum P, Santos-Nogueira E, Teo W, Haumont A, Lenoël I, Stys PK, David S (2020) Ferroptosis mediates cuprizone-induced loss of oligodendrocytes and demyelination. J Neurosci 40:9327–9341

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ineichen BV, Zhu K, Carlström KE (2021) Axonal mitochondria adjust in size depending on g‐ratio of surrounding myelin during homeostasis and advanced remyelination. J Neurosci Res 99:793–805

Article  CAS  PubMed  Google Scholar 

Kashani IR, Chavoshi H, Pasbakhsh P, Hassani M, Omidi A, Mahmoudi R, Beyer C, Zendedel A (2017) Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum. Iran J Basic Med Sci 20:886–893

PubMed  PubMed Central  Google Scholar 

Gudi V, Gingele S, Skripuletz T, Stangel M (2014) Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned. Frontiers in cellular neuroscience. 8:73.

Leo H, Kipp M (2022) Remyelination in multiple sclerosis: findings in the cuprizone model. Int J Mol Sci 23:16093

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhan J, Nepomuk F, Kaddatz H, Rühling S, Frenz J, Denecke B, Amor S, Ponsaerts P, Hochstrasser T, Kipp M (2021) Focal white matter lesions induce long-lasting axonal degeneration, neuroinflammation and behavioral deficits. Neurobiol Dis 155:105371

Article  CAS  PubMed  Google Scholar 

Manrique-hoyos N, Ju T, Grønborg M, Kreutzfeldt M, Schedensack M, Kuhlmann T, Schrick C, Bru W, Urlaub H (2012) Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis. Ann Neurol. 71:227–44

Article  PubMed  Google Scholar 

Mercier O, Quilichini PP, Magalon K, Gil F, Ghestem A, Richard F, Boudier T, Cayre M, Durbec P (2024) Transient demyelination causes long-term cognitive impairment, myelin alteration and network synchrony defects. Glia. 72:960–981.

Article  PubMed  Google Scholar 

Bauckneht M, Capitanio S, Raffa S, Roccatagliata L, Pardini M, Lapucci C, Marini C, Sambuceti G, Inglese M, Gallo P, Cecchin D, Nobili F, Morbelli S (2019) Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers. EJNMMI Radiopharm Chem 4:6

Sinnecker T, Kuchling J, Dusek P, Dörr J, Niendorf T, Paul F, Wuerfel J (2015) Ultrahigh field MRI in clinical neuroimmunology: a potential contribution to improved diagnostics and personalised disease management. EPMA J 6:16

Article  PubMed  PubMed Central  Google Scholar 

Duclos V, Iep A, Gomez L, Goldfarb L, Besson FL (2021) PET molecular imaging: a holistic review of current practice and emerging perspectives for diagnosis, therapeutic evaluation and prognosis in clinical oncology. Int J Mol Sci 22:4159

Article  CAS  PubMed  PubMed Central  Google Scholar 

van der Weijden CWJ, Meilof JF, van der Hoorn A, Zhu J, Wu C, Wang Y, Willemsen ATM, Dierckx RAJO, Lammertsma AA, de Vries EFJ (2022) Quantitative assessment of myelin density using [11C]MeDAS PET in patients with multiple sclerosis: a first-in-human study. Eur J Nucl Med Mol Imaging 49:3492–3507

Article  PubMed  PubMed Central  Google Scholar 

Kreisl WC, Kim M-J, Coughlin JM, Henter ID, Owen DR, Innis RB (2020) PET imaging of neuroinflammation in neurological disorders. Lancet Neurol 19:940–950

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Paula Faria D, De Vries EFJ, Sijbesma JWA, Dierckx RAJO, Buchpiguel CA, Copray S (2014) PET imaging of demyelination and remyelination in the cuprizone mouse model for multiple sclerosis: a comparison between [11C]CIC and [11C]MeDAS. Neuroimage 87:395–402

Article  PubMed  Google Scholar 

Guilarte TR, Rodichkin AN, McGlothan JL, Acanda De La Rocha AM, Azzam DJ (2022) Imaging neuroinflammation with TSPO: a new perspective on the cellular sources and subcellular localization. Pharmacol Ther 234:108048

Article  CAS  PubMed  Google Scholar 

Nutma E, Ceyzériat K, Amor S, Tsartsalis S, Millet P, Owen DR, Papadopoulos V, Tournier BB (2021) Cellular sources of TSPO expression in healthy and diseased brain. Eur J Nucl Med Mol Imaging 49:146–163

Article  PubMed  PubMed Central  Google Scholar 

Lee Y, Park Y, Nam H, Lee J-W, Yu S-W (2020) Translocator protein (TSPO): the new story of the old protein in neuroinflammation. BMB Rep 53:20–27

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Paula Faria D, Vlaming MLH, Copray SCVM, Tielen F, Anthonijsz HJA, Sijbesma JWA, Buchpiguel CA, Dierckx RAJO, Van Der Hoorn JWA, De Vries EFJ (2014) PET imaging of disease progression and treatment effects in the experimental autoimmune encephalomyelitis rat model. J Nucl Med 55:1330–1335

Article  PubMed  Google Scholar 

Chauveau F, Becker G, Boutin H (2021) Have (R)-[11C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies. Eur J Nucl Med Mol Imaging 49:201–220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carter RJ, Lione LA, Humby T, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntington’s disease mutation. J Neurosci 19:3248–3257

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sen MK, Mahns DA, Coorssen JR, Shortland PJ (2019) Behavioural phenotypes in the cuprizone model of central nervous system demyelination. Neurosci Biobehav Rev 107:23–46

Article  CAS  PubMed  Google Scholar 

Keijser JN, Van Heuvelen MJG, Nyakas C, Tóth K, Schoemaker RG, Zeinstra E, Van der Zee EA (2017) Whole body vibration improves attention and motor performance in mice depending on the duration of whole body vibration session. Afr J Tradit Complement Altern Med 14:128–134

Article  PubMed