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Predatory journals: What can we do to protect their prey?
In this Editorial, representatives of the International Committee of Medical Editors discuss the need for multi-stakeholde...
A consideration of the potential benefits and harms of menopausal hormone treatment
Ming Jun Kuck and Eef Hogervorst consider the data on the safety and potential cognitive effects in later life of midlife ...
Improving transparency in clinical trial reporting
The power to interpret the results of randomised clinical trial results relies on transparent reporting of the study desig...
Correction: Contraception use and pregnancy in women receiving a 2-dose Ebola vaccine in Rwanda: A retrospective analysis of UMURINZI vaccination campaign data
Notice of Republication This article [1] was republished on April 11, 2025, to address an issue ide...
Identification of lysosomal lipolysis as an essential noncanonical mediator of adipocyte fasting and cold-induced lipolysis
Research ArticleEndocrinologyMetabolism Open Access | 10.1172/JCI185340 Yu-Sheng Yeh,1,2 ...
Nonvesicular cholesterol transport in physiology
The absorption of dietary lipids takes place mainly in the proximal small intestine. In the intestinal lumen, cholesterol...
Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance
Research LetterEndocrinologyMetabolism Open Access | 10.1172/JCI187376 Evi J.C. Koene,1,2 ...
Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence
MUC5AC-rich mucus plugs in asthma are tethered to an epithelium that is buckled to form mucosal folds. We used histology ...
Sensing mycobacteria through unconventional pathways
At present, the factors driving the CD4+ bias of CD1b-TMM–restricted cells remain unclear. Interestingly, CD1b-GMM– and C...
Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Ischemic injury to tubular epithelium. The most common form of tubular injury in patients occurs due to renal hypoperfusi...
Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS–mutant cancer models
Research ArticleOncology Open Access | 10.1172/JCI185278 Shihui Shen,1,2 Qiansen Zhang,1 ...
High PRMT5 levels, maintained by KEAP1 inhibition, drive chemoresistance in high-grade serous ovarian cancer
Sex as a biological variable. Our study exclusively examined female mice because the disease modeled is only relevant in ...
Estrogen receptor-α ablation reverses muscle fibrosis and inguinal hernias
Fibroblast-specific ablation of ESR1 prevents herniation in Aromhum mice. All Aromhum mice developed a fibrotic process c...
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis
Research ArticleAutoimmunityImmunology Open Access | 10.1172/JCI185217 Jun Inamo,1,2 Josh...
Macrophages: key conductors behind perivascular inflammation and vascular remodeling in hypoxia-induced pulmonary hypertension
Importantly, further studies that explore alternative CCL2 sources and alternative stimuli beyond hypoxia that contribute...
ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis
Clinical Research and Public HealthEndocrinologyMetabolism Open Access | 10.1172/JCI184740 Aa...
Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models
Research ArticleOncologyVirology Open Access | 10.1172/JCI183745 Deepa Seetharam,1,2 Jay ...
KRAS mutants confer platinum resistance by regulating ALKBH5 posttranslational modifications in lung cancer
KRAS constitutively active mutations are associated with NSCLC platinum resistance. Despite the widespread occurrence of ...
Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension
Research ArticleInflammationVascular biology Open Access | 10.1172/JCI176865 Rahul Kumar,1,2 ...
Oncostatin M silence and neopeptide: the value of exploring patients with rare inherited bone marrow failure
In this issue of the JCI, Garrigue, Kermasson, and colleagues demonstrate that human oncostatin M (OSM) deficiency underl...
Human oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome
Research ArticleGeneticsHematology Open Access | 10.1172/JCI180981 Alexandrine Garrigue,1 ...
ZDHHC18 promotes renal fibrosis development by regulating HRAS palmitoylation
Research ArticleNephrology Open Access | 10.1172/JCI180242 Di Lu,1 Gulibositan Aji,2 ...
Extracranial arteriovenous malformations: towards etiology-based therapeutic management
The unraveling of the major initiating mechanisms for AVM formation has propelled the field to think of targeted molecula...
Challenging the common practice of intravenous fluid administration
Challenging the common practice of intravenous fluid administration
Frost P. Intravenous fluid therapy in adult inpatients. BMJ (Clinical research ed). 2015;350:g7620.Mayerhöfer T, Shaw AD, ...
Mid-term results of intra-articular calcaneal fractures treated with minimally invasive two-point distractor
Mid-term results of intra-articular calcaneal fractures treated with minimally invasive two-point distractor
Displaced intra-articular calcaneal fractures are a complication-ridden injury to treat and there are various tre...
Myeloid sarcoma of the heart—A clinicopathological correlation
Myeloid sarcoma of the heart—A clinicopathological correlation
A 63-year-old woman with a history of acute myeloid leukemia followed by stem cell transplantation prese...
Associations of malnutrition factors with dysphagia mediated by ADL among nursing home residents
Associations of malnutrition factors with dysphagia mediated by ADL among nursing home residents
The potential link between malnutrition and dysphagia along with its underlying mechanisms remains unknown. This study aim...
A comic that explains palliative care: how patients experience comic-based educational material
A comic that explains palliative care: how patients experience comic-based educational material
The aim of this study was to create a patient-centered comic on palliative care with and for patients admitted to...
In memoriam Univ.-Prof. Dr. Fritz Sterz (1956–2024)
In memoriam Univ.-Prof. Dr. Fritz Sterz (1956–2024)
The medical community mourns the loss of a true pioneer in emergency medicine and res...
Nunavimmi puvakkut kaggutimik aanniaqarniq: Qanuilirqitaa? Lung cancer in Nunavik: How are we doing? A retrospective matched cohort study [Research]
Nunavimmi puvakkut kaggutimik aanniaqarniq: Qanuilirqitaa? Lung cancer in Nunavik: How are we doing? A retrospective matched cohort study [Research]
AbstractBackground: Whether Inuit in Canada experience disparities in lung cancer survival remains unknown. When requiring...
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