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Objective Measures of Physical Activity and Frailty in Ambulatory Adults Aged 85–89 Years in Kawasaki, Japan: A Cross-sectional Study
Objective Measures of Physical Activity and Frailty in Ambulatory Adults Aged 85–89 Years in Kawasaki, Japan: A Cross-sectional Study
While physical activity (PA) can reduce physical frailty, the specific intensity and duration of PA required to prevent fr...
Admission of Older Patients to Geriatric Inpatient Care from the Emergency Department Compared with Admission through Acute Medical Unit: Cost and Length of Stay Outcomes
Admission of Older Patients to Geriatric Inpatient Care from the Emergency Department Compared with Admission through Acute Medical Unit: Cost and Length of Stay Outcomes
To investigate whether direct admission to geriatric inpatient care from the emergency department (EMD) was associated wit...
Most Hospital-Acquired Complications among Older Adults Are Associated with Frailty: The South-Western Sydney Frailty and Hospital-Acquired Complications Study
Most Hospital-Acquired Complications among Older Adults Are Associated with Frailty: The South-Western Sydney Frailty and Hospital-Acquired Complications Study
People live longer, and frailty has become an important problem in the acute hospital setting. Increasingly the associatio...
Blood Pressure Variability and Frailty in End-Stage Kidney Disease
Blood Pressure Variability and Frailty in End-Stage Kidney Disease
High blood pressure variability (BPV) is a predictor of cardiovascular events and all-cause mortality in people with end-s...
Evaluation of Handgrip Strength Asymmetry to Assess Sarcopenia in Older Patients with Chronic Low Back Pain: A Retrospective Cross-Sectional Study
Evaluation of Handgrip Strength Asymmetry to Assess Sarcopenia in Older Patients with Chronic Low Back Pain: A Retrospective Cross-Sectional Study
Handgrip strength (HGS) is a crucial measurement for diagnosing sarcopenia, and HGS asymmetry indicates functional impairm...
Fecal Microbiota Transplantation Modulates Gut Microbiome Composition and Glial Signaling in Brain and Colon of Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis
Fecal Microbiota Transplantation Modulates Gut Microbiome Composition and Glial Signaling in Brain and Colon of Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis
Despite evidence linking the gut microbiome to neuropathic pain (NP), it is not known if altering gut microbiota can allev...
Muscle Strength Matters Most for Risk of Falling Apart from Body Mass Index in Older Adults: A Mediated-Moderation Analysis
Muscle Strength Matters Most for Risk of Falling Apart from Body Mass Index in Older Adults: A Mediated-Moderation Analysis
The primary objective of this study was to analyze the moderating effect of body mass index (BMI) on the association betwe...
Application of a Social Vulnerability Index and Its Associations with Physical Frailty and Disability in a Cross-sectional Study of Older Kenyan Women Living with and without HIV
Application of a Social Vulnerability Index and Its Associations with Physical Frailty and Disability in a Cross-sectional Study of Older Kenyan Women Living with and without HIV
Social vulnerability reflects deficits in social resources that may disproportionally impact older women with HIV (WWH) in...
The Relationship between Leisure Time Physical Activity and Cognitive Function in Older Americans
The Relationship between Leisure Time Physical Activity and Cognitive Function in Older Americans
This study aims to investigate the correlation between leisure-time physical activity (LTPA) and cognitive function in old...
Polyphenol Supplementation and Sarcopenia: A Systematic Review and Meta-Analysis of Clinical Trials
Polyphenol Supplementation and Sarcopenia: A Systematic Review and Meta-Analysis of Clinical Trials
Experimental evidence suggests that polyphenols, a large group of phytochemicals found in fruits and vegetables, may prese...
Exploring the Role of Antibiotics in Hospice Care
Exploring the Role of Antibiotics in Hospice Care
The decision regarding the use of antibiotics in hospice care, whether to initiate, defer, or discontinue therapy, present...
The Saliva and Muscle Study (SaMu): Rationale and Protocol for Associations between Salivary Microbiome and Accelerated Muscle Ageing
The Saliva and Muscle Study (SaMu): Rationale and Protocol for Associations between Salivary Microbiome and Accelerated Muscle Ageing
The gut microbiome is recognized as a pivotal factor in the pathophysiology of sarcopenia—a condition marked by the ...
CD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults
CD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults
The T cell compartment undergoes significant age-related changes, contributing to the decline of the adaptive immune syste...
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study
Immunosenescence, the gradual deterioration of the immune system, is critical for aging-related diseases. However, the lac...
Delayed viral clearance and altered inflammatory responses affect severity of SARS-CoV-2 infection in aged mice
Delayed viral clearance and altered inflammatory responses affect severity of SARS-CoV-2 infection in aged mice
Epidemiological investigations consistently demonstrate an overrepresentation of the elderly in COVID-19 hospitalizations ...
Enhancing flu vaccine responses in older adults: preliminary insights from the ISOLDA study on immunosenescence and antioxidant and anti-inflammatory approaches
Enhancing flu vaccine responses in older adults: preliminary insights from the ISOLDA study on immunosenescence and antioxidant and anti-inflammatory approaches
Aging is frequently characterized by an inadequate primary vaccine response, likely due to immunosenescence and inflamm-ag...
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination
Ageing-associated remodeling of the murine B cell system is accompanied with a reduction of CD19+ B cells such as follicul...
International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus
International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus
Normative ageingEvery individual ages uniquely. Whilst the literature has used terms such as ‘average’ and ‘typical’ agein...
The senolytic ABT-263 improves cognitive functions in middle-aged male, but not female, atherosclerotic LDLr;hApoB mice
The senolytic ABT-263 improves cognitive functions in middle-aged male, but not female, atherosclerotic LDLr;hApoB mice
Accumulation of cerebral senescent cells may compromise the continuum between vascular and neuronal function, leading to d...
Persisting blood–brain barrier disruption following cisplatin treatment in a mouse model of chemotherapy-associated cognitive impairment
Persisting blood–brain barrier disruption following cisplatin treatment in a mouse model of chemotherapy-associated cognitive impairment
Chemotherapy-related cognitive impairment, commonly referred to as “chemobrain,” significantly affects cancer ...
ChatGPT-estimated occupational complexity predicts cognitive outcomes and cortical thickness above and beyond socioeconomic status among older adults
ChatGPT-estimated occupational complexity predicts cognitive outcomes and cortical thickness above and beyond socioeconomic status among older adults
Many aging cohort studies have collected data on participants’ job titles, yet these job titles were seldom analyzed...
Awareness, knowledge, and motivations about lifespan, healthspan, and Healthy Longevity Medicine in the general population: the HEalthy LOngevity (HELO) conceptual framework
Awareness, knowledge, and motivations about lifespan, healthspan, and Healthy Longevity Medicine in the general population: the HEalthy LOngevity (HELO) conceptual framework
The global population is ageing and the gap between lifespan (total years lived) and healthspan (years lived free of disea...
SenSkin™: a human skin-specific cellular senescence gene set
SenSkin™: a human skin-specific cellular senescence gene set
Cellular senescence gene sets have been leveraged to overcome the inadequate sensitivity or specificity of single markers....
Improving care interactions (and training) in nursing homes with artificial intelligence
Improving care interactions (and training) in nursing homes with artificial intelligence
As the population continues to age, nursing homes will increasingly play a key role in caring for dependent individuals. T...
Decoding cognitive aging: how white matter tracts and demographics distinguish potential Super-Agers
Decoding cognitive aging: how white matter tracts and demographics distinguish potential Super-Agers
Most adults experience age-related cognitive decline. However, “Positive-Agers” exhibit superior cognition com...
Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle
Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle
Sarcopenia increases the risk of frailty, morbidity, and mortality in older adults. Resistance exercise training improves ...
Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice
Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice
The hypothalamus has been recognized as a regulator of whole-body aging. Neuropeptide Y (NPY), highly abundant in the cent...
Associations between shift work and biological age acceleration: A population-based study
Associations between shift work and biological age acceleration: A population-based study
This study aimed to examine the associations between shift work and biological age acceleration (BAA) and to explore poten...
Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei differs across the lifespan
Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei differs across the lifespan
Attentional states reflect the changing behavioral relevance of stimuli in one’s environment, having important conse...
Accelerated retinal ageing and multimorbidity in middle-aged and older adults
Accelerated retinal ageing and multimorbidity in middle-aged and older adults
The aim of this study is to investigate the association between retinal age gap and multimorbidity. Retinal age gap was ca...
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