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Plasma metabolomic and inflammatory profiles associated with low physical function in heart failure: an integrated cardiac–metabolic–muscular phenotype
Plasma metabolomic and inflammatory profiles associated with low physical function in heart failure: an integrated cardiac–metabolic–muscular phenotype
Dysregulated metabolomic profiles (dysmetabolism) have been observed in patients with heart failure (HF). In this study, w...
TTV virome marks immune exhaustion, α7nAChR alteration, and mortality in elderly patients with severe COPD
TTV virome marks immune exhaustion, α7nAChR alteration, and mortality in elderly patients with severe COPD
Torque teno virus (TTV) viremia, part of the human virome, is emerging as a dynamic marker of immune competence, yet its l...
Interaction of moderate-to-vigorous physical activity and brain amyloid accumulation on longitudinal cognitive change
Interaction of moderate-to-vigorous physical activity and brain amyloid accumulation on longitudinal cognitive change
Amyloid β (Aβ)–related cognitive decline is a key target for dementia prevention; however, the intensity-d...
Epileptiform discharges in neurodegenerative diseases linked to atrophy but not associated with iron depositions
Epileptiform discharges in neurodegenerative diseases linked to atrophy but not associated with iron depositions
Epileptiform discharges in Alzheimer’s disease (AD) and Lewy body dementia (DLB) may be associated with cognitive de...
Telomere length dynamics do not predict subclinical atherosclerosis progression over a six-year period
Telomere length dynamics do not predict subclinical atherosclerosis progression over a six-year period
Subclinical atherosclerosis (SA) burden and progression are independently associated with all-cause mortality. However, mo...
Multimorbidity as a predictor of mortality in companion dogs
Multimorbidity as a predictor of mortality in companion dogs
Multimorbidity, the presence of two or more conditions, is associated with a higher risk of death as individuals age. Howe...
The role of cellular senescence in immune-metabolic features and prognosis of ovarian cancer: an integrated analysis based on single-cell sequencing and multi-omics data
The role of cellular senescence in immune-metabolic features and prognosis of ovarian cancer: an integrated analysis based on single-cell sequencing and multi-omics data
Ovarian cancer is characterized by a high recurrence rate, and platinum resistance often contributes to poor patient outco...
Association of high-intensity evening light exposure with risk of incident age-related macular degeneration, cataract, and glaucoma: a prospective cohort study of 82,826 participants
Association of high-intensity evening light exposure with risk of incident age-related macular degeneration, cataract, and glaucoma: a prospective cohort study of 82,826 participants
Excessive artificial light at night (ALAN) disrupts circadian rhythms and may accelerate ocular aging; however, personal o...
Andes virus and the aging host: lessons from the 2026 outbreak and a framework for age-related disease severity
Andes virus and the aging host: lessons from the 2026 outbreak and a framework for age-related disease severity
Andes virus (ANDV) is the most virulent New World orthohantavirus, responsible for hantavirus cardiopulmonary syndrome (HC...
Age and sex dependent shift in murine gut microbiome reveals pathological links to host cardiovascular and metabolic pathways
Age and sex dependent shift in murine gut microbiome reveals pathological links to host cardiovascular and metabolic pathways
The gut microbiome undergoes dynamic, sex-dependent changes across the lifespan. However, comprehensive studies examining ...
Quantitative sleep EEG identifies CSF core biomarker-related subgroups in Alzheimer’s disease
Quantitative sleep EEG identifies CSF core biomarker-related subgroups in Alzheimer’s disease
Early detection and biological characterization of Alzheimer’s disease (AD) remain challenging, as current diagnosti...
Combating Alzheimer’s through sleep and exercise (CASE): A study protocol
Combating Alzheimer’s through sleep and exercise (CASE): A study protocol
Dementia affects over 55 million people worldwide, with Alzheimer’s disease (AD) comprising most cases. Because cura...
Associations of cardiorespiratory fitness with structural brain networks in ageing: insights from The Maastricht Study
Associations of cardiorespiratory fitness with structural brain networks in ageing: insights from The Maastricht Study
Higher cardiorespiratory fitness (CRF) has been linked to healthier brain ageing, which includes preservation of white mat...
Expected lifespan and healthspan among rural and urban individuals in Java, Indonesia
Expected lifespan and healthspan among rural and urban individuals in Java, Indonesia
In Indonesia, adults living in rural areas have a longer life expectancy than their urban counterparts. Beyond observed lo...
Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation
Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation
Alzheimer's disease (AD) is a complex neurodegenerative disorder. Current therapeutic approaches targeting a single pa...
Neurovascular decoupling and compensatory network recruitment during speech perception in aging: evidence from EEG-fNIRS
Neurovascular decoupling and compensatory network recruitment during speech perception in aging: evidence from EEG-fNIRS
Age-related decline in speech perception is a prominent challenge in auditory aging, especially under noise conditions. Ho...
Health insurance, healthcare access, and their roles in the association between blood lead levels and epigenetic aging in United States adults
Health insurance, healthcare access, and their roles in the association between blood lead levels and epigenetic aging in United States adults
Lead exposure remains a significant public health problem, and even within current standards, most individuals have limite...
In memoriam: Thomas Eugene Johnson
In memoriam: Thomas Eugene Johnson
The alternative text for this image may have been generated using AI.Tom (as he was k...
Cognitive trajectories and mortality risk in older adults: a 9-year follow-up study
Cognitive trajectories and mortality risk in older adults: a 9-year follow-up study
Cognitive decline is a central feature of aging and a major determinant of disability and mortality. Understanding cogniti...
Usability Insights From Nursing Home Residents On a New Hip Protector Design in Singapore: a Feasibility Study
Usability Insights From Nursing Home Residents On a New Hip Protector Design in Singapore: a Feasibility Study
Older adults residing in nursing homes face an increased risk of falls leading to hip fractures, resulting in a reduced qu...
Using Welfare Technology To Increase Activity in Nursing Homes: Effects of the ‘Touch & Play’ Activity Screen for People with a Diagnosis of Dementia
Using Welfare Technology To Increase Activity in Nursing Homes: Effects of the ‘Touch & Play’ Activity Screen for People with a Diagnosis of Dementia
This study evaluated the effectiveness of the Touch & Play interactive activity screen as welfare technology to en...
Exploring Ageism and Age Norms among Older Adults in Urban India
Exploring Ageism and Age Norms among Older Adults in Urban India
The UN Decade of Healthy Ageing plan of action has identified combating ageism and challenging negative and restrictive at...
Accessing the Hard and Soft Infrastructure of Residential Care Services for Older Adults in Japan: Implications for Post-Growth East Asia
Accessing the Hard and Soft Infrastructure of Residential Care Services for Older Adults in Japan: Implications for Post-Growth East Asia
Globally, populations are getting older. Japan is at the forefront of addressing the challenges posed by population ageing...
Social Networks and Mental Health: A Study of Older Adults in Rural Bihar, India
Social Networks and Mental Health: A Study of Older Adults in Rural Bihar, India
With record high population growth in India, the number of older adults has significantly increased. In Bihar (a state in ...
Bodily Disconnection in Older Adults Residing in Nursing Homes: The Relationship between Bodily Disconnection, Depressive Symptoms and Meaning in Life
Bodily Disconnection in Older Adults Residing in Nursing Homes: The Relationship between Bodily Disconnection, Depressive Symptoms and Meaning in Life
To examine the relationship between bodily disconnection and two indicators of late life well-being – depressive sym...
Spanish Electronic and Paper Version of the Comprehensive Frailty Assessment Instrument (CFAI): a Cross-Cultural Adaptation
Spanish Electronic and Paper Version of the Comprehensive Frailty Assessment Instrument (CFAI): a Cross-Cultural Adaptation
Frailty is a dynamic and potentially reversible state that precedes and predicts adverse health outcomes. However, there i...
Factors Affecting ICT Access and Use of Older Adults and Caregivers in the State of Qatar
Factors Affecting ICT Access and Use of Older Adults and Caregivers in the State of Qatar
Despite the growing importance of the older population in the Arab region, initiatives to facilitate their Information and...
Effect of Multimodal Cognitive Intervention in Older Adults with Mild Cognitive Impairment: A Meta-analysis of Randomized Controlled Trials
Effect of Multimodal Cognitive Intervention in Older Adults with Mild Cognitive Impairment: A Meta-analysis of Randomized Controlled Trials
Nonpharmacological interventions benefit individuals with mild cognitive impairment (MCI), but the synergistic benefits of...
The Validity of Measures in Specific Training According to BaLance Evaluation (STABLE) – An Exercise-based Approach to Balance Rehabilitation for Older Adults at Risk of Falling
The Validity of Measures in Specific Training According to BaLance Evaluation (STABLE) – An Exercise-based Approach to Balance Rehabilitation for Older Adults at Risk of Falling
Falls are a leading cause of injury and premature death among older adults. Specific Training According to BaLance Evaluat...
Incidence and Risk Factors of Postoperative Urinary Retention in Gynecologic Surgery: A Systematic Review and Meta-Analysis
Incidence and Risk Factors of Postoperative Urinary Retention in Gynecologic Surgery: A Systematic Review and Meta-Analysis
To estimate the incidence of postoperative urinary retention following gynecologic surgery and summarize associated risk f...
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