Quantitative sleep EEG identifies CSF core biomarker-related subgroups in Alzheimer’s disease

Masters CL, Bateman R, Blennow K, Rowe CC, Sperling RA, Cummings JL. Alzheimer’s disease. Nat Rev Dis Primers. 2015;1(1):1–18.

Article  Google Scholar 

Alzheimer’s Association. 2025 Alzheimer’s disease facts and figures. Alzheim Dementia. 2025;21(5):e70235. Published online 2025 Apr 29. https://doi.org/10.1002/alz.70235.

Zhang J, Zhang Y, Wang J, Xia Y, Zhang J, Chen L. Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies. Signal Transduct Target Ther. 2024;9(1):211.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunn B, Hyman BT, et al. Revised criteria for diagnosis and staging of Alzheimer’s disease. Alzheim Dementia. 2024;20(7):1399–415. https://doi.org/10.1002/alz.14587.

Article  Google Scholar 

Tan CC, Yu JT, Tan L. Biomarkers for preclinical Alzheimer’s disease. J Alzheimers Dis. 2014;42(4):1051–69.

Article  CAS  PubMed  Google Scholar 

Chetty CA, Bhardwaj H, Kumar GP, Devanand T, Sekhar CA, Aktürk T, et al. EEG biomarkers in Alzheimer’s and prodromal Alzheimer’s: a comprehensive analysis of spectral and connectivity features. Alzheim Res Therapy. 2024;16(1):236.

Article  CAS  Google Scholar 

Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheim Dementia. 2018;14(4):535–62.

Article  Google Scholar 

Cedazo-Minguez A, Winblad B. Biomarkers for Alzheimer’s disease and other forms of dementia: clinical needs, limitations and future aspects. Exp Gerontol. 2010;45(1):5–14.

Article  CAS  PubMed  Google Scholar 

Rossini PM, Di Iorio R, Vecchio F, Anfossi M, Babiloni C, Bozzali M, et al. Early diagnosis of Alzheimer’s disease: the role of biomarkers including advanced EEG signal analysis. Report from the IFCN-sponsored panel of experts. Clinical Neurophysiol. 2020;131(6):1287–1310.

Romanella S, Roe D, Tatti E, Cappon D, Paciorek R, Testani E, et al. The sleep side of aging and Alzheimer’s disease. Sleep Med. 2021;77:209–25.

Article  CAS  PubMed  Google Scholar 

Mander BA, Marks SM, Vogel JW, Rao V, Lu B, Saletin JM, et al. \(\beta \)-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation. Nat Neurosci. 2015;18(7):1051–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mander BA, Winer JR, Jagust WJ, Walker MP. Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer’s Disease? Trends Neurosci. 2016;39(8):552–66. https://doi.org/10.1016/j.tins.2016.05.002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petit D, Gagnon JF, Fantini ML, Ferini-Strambi L, Montplaisir J. Sleep and quantitative EEG in neurodegenerative disorders. J Psychosom Res. 2004;56(5):487–96.

Article  PubMed  Google Scholar 

Vickers JC, Dickson TC, Adlard PA, Saunders HL, King CE, McCormack G. The cause of neuronal degeneration in Alzheimer’s disease. Prog Neurobiol. 2000;60(2):139–65.

Article  CAS  PubMed  Google Scholar 

Verret L, Mann EO, Hang GB. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell. 2012;149(3):708–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghorbanian P, Devilbiss DM, Hess T, Bernstein A, Simon AJ, Ashrafiuon H. Exploration of EEG features of Alzheimer’s disease using continuous wavelet transform. Med Biol Eng Comput. 2015;53(9):843–55.

Article  PubMed  Google Scholar 

Jeong J. EEG dynamics in patients with Alzheimer’s disease. Clin Neurophysiol. 2004;115(7):1490–505.

Article  PubMed  Google Scholar 

Holth JK, Fritschi SK, Wang C, Pedersen NP, Cirrito JR, Mahan TE, et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science. 2019;363(6429):880–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lucey BP, McCullough A, Landsness EC, Toedebusch CD, McLeland JS, Zaza AM, et al. Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease. Sci Transl Med. 2019;11(474):eaau6550. Erratum in: Sci Transl Med. (2020) 8;12(525).

Buzsáki G. Rhythms of the brain. Oxford University Press; 2012.

Thakor NV, Tong S. Advances in quantitative electroencephalogram analysis methods. Annual Rev Biomed Eng. 2004;6:453–495. PMID: 15255777. https://doi.org/10.1146/annurev.bioeng.5.040202.121601.

Mander BA, Winer JR, Walker MP. Sleep: a novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer’s disease? Trends Neurosci. 2015;38(8):527–35.

Google Scholar 

Abásolo D, Hornero R, Espino P, Álvarez D, Poza J. Entropy analysis of the EEG background activity in Alzheimer’s disease patients. Physiol Measurem. 2006;27(3):241–253. Epub 2006 Jan 13, PMID: 16462011. https://doi.org/10.1088/0967-3334/27/3/003.

Azami H, Moguilner S, Penagos H, Sarkis RA, Arnold SE, Gomperts SN, et al. EEG entropy in REM sleep as a physiologic biomarker in early clinical stages of Alzheimer’s disease. J Alzheim Dis. 2023;91(4):1557–1572. PMID: 36641682; PMCID: PMC10039707. https://doi.org/10.3233/JAD-221152.

Gallego-Viñarás L, Michela-Gaeta A, Pinol-Ripoll G, Barbé F, Olmos PM, Muñoz-Barrutia A. Calibration Methods for Alzheimer Disease Detection. In: 2024 IEEE 34th International Workshop on Machine Learning for Signal Processing (MLSP). IEEE; 2024. p. 1–6.

Abásolo D, Hornero R, Gómez C, García M, López M. Analysis of EEG background activity in Alzheimer’s disease patients with Lempel-Ziv complexity and central tendency measure. Med Eng Phys. 2006;28(4):315–22.

Article  PubMed  Google Scholar 

Cassani R, Estarellas M, San-Martin R. Electroencephalographic biomarkers of Alzheimer’s disease: A review. NeuroImage: Clinical. 2018;19:518–534.

Babiloni C, Blinowska K, Bonanni L, Cichocki A, De Haan W, Del Percio C, et al. What electrophysiology tells us about Alzheimer’s disease: a window into the synchronization and connectivity of brain neurons. Neurobiol Aging. 2020;85:58–73.

Article  PubMed  Google Scholar 

Roy Y, Banville H, Albuquerque I, Gramfort A, Falk TH, Faubert J. Deep learning-based electroencephalography analysis: a systematic review. J Neural Eng. 2019;16(5):051001. https://doi.org/10.1088/1741-2552/ab260c.

Article  PubMed  Google Scholar 

Bzdok D, Altman N, Krzywinski M. Statistics versus machine learning. Nat Methods. 2018;15(4):233–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gemein LA, Schirrmeister RT, Chrabąszcz P, Wilson D, Boedecker J, Schulze-Bonhage A, et al. Machine-learning-based diagnostics of EEG pathology. Neuroimage. 2020;220:117021.

Article  PubMed  Google Scholar 

Goldstein CA, Berry RB, Kent DT, Kristo DA, Seixas AA, Redline S, et al. Artificial intelligence in sleep medicine: background and implications for clinicians. J Clin Sleep Med. 2020;16(4):609–18.

Article  PubMed  PubMed Central  Google Scholar 

Al-Nuaimi AH, Blūma M, Al-Juboori SS, Eke CS, Jammeh E, Sun L, et al. Robust EEG based biomarkers to detect Alzheimer’s disease. Brain Sci. 2021;11(8):1026.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheim Dementia J Alzheim Assoc. 2011;7(3):263–9. https://doi.org/10.1016/j.jalz.2011.03.005.

Article  Google Scholar 

Lobo A, Saz P, Marcos G, et al. Revalidación y normalización del mini-examen cognoscitivo (primera version en castellano del mini-mental status examination) en la población general geriátrica. Med Clin. 1999;112:767–74. https://doi.org/10.1016/S0025-7753(05)70654-4.

Article  CAS  Google Scholar 

Tombaugh TN, McIntyre NJ. The Mini-Mental State Examination: A Comprehensive Review. J Am Geriatr Soc. 1992;40:922–35.

Article  CAS  PubMed  Google Scholar 

Liguori C, Chiaravalloti A, Izzi F, Nuccetelli M, Bernardini S, Schillaci O, et al. Sleep apnoeas may represent a reversible risk factor for amyloid-\(\beta \) pathology. Brain. 2017;140(12):e75–e75.

Article  PubMed  Google Scholar 

Ortega RL, Dakterzada F, Arias A, Blasco E, Naudí A, Garcia FP, et al. Usefulness of CSF biomarkers in predicting the progression of Amnesic and nonamnesic mild cognitive impairment to Alzheimer’s disease. Curr Aging Sci. 2019;12:35–42. https://doi.org/10.2174/1874609812666190112095430.

Article  CAS  PubMed  Google Scholar 

Targa A, Dakterzada F, Benítez I, López R, Pujol M, Dalmases M, et al. Decrease in sleep depth is associated with higher cerebrospinal fluid neurofilament light levels in patients with Alzheimer’s disease. Sleep. 2021;44(2):zsaa147. PMID: 32766837. https://doi.org/10.1093/sleep/zsaa147.

Dhiman K, Villemagne VL, Fowler C, Bourgeat P, Li QX, Collins S, et al. Cerebrospinal Fluid Neurofilament Light Predicts Risk of Dementia Onset in Cognitively Healthy Individuals and Rate of Cognitive Decline in Mild Cognitive Impairment: A Prospective Longitudinal Study. Biomedicines. 2022;10(5):1045. https://doi.org/10.3390/biomedicines10051045.

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