Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M. A novel DNA virus [TTV] associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun. 1997;241:92–7. https://doi.org/10.1006/bbrc.1997.7765.

Article  CAS  PubMed  Google Scholar 

Biagini, P. Classification of TTV and related viruses [Anelloviruses]. In: Viruses TT, De Villiers EM, Hausen HZ editors. Current topics in microbiology and immunology. Berlin, Heidelberg: Springer Berlin Heidelberg; 2009. vol. 331, p. 21–33. ISBN 978–3–540–70971–8.

Taylor LJ, Keeler EL, Bushman FD, Collman RG. The enigmatic roles of Anelloviridae and Redondoviridae in humans. Curr Opin Virol. 2022;55:101248. https://doi.org/10.1016/j.coviro.2022.101248.

Article  CAS  PubMed  Google Scholar 

Wei Y, Chen M, Yang X, Zhang L, Rao L, Yuan F, et al. Molecular characterization of human Torque teno virus. Biomed Rep. 2015;3:821–6. https://doi.org/10.3892/br.2015.508.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maggi F, Focosi D, Albani M, Lanini L, Vatteroni ML, Petrini M, et al. Role of hematopoietic cells in the maintenance of chronic human Torquetenovirus plasma viremia. J Virol. 2010;84:6891–3. https://doi.org/10.1128/JVI.00273-10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Focosi D, Spezia PG, Macera L, Salvadori S, Navarro D, Lanza M, et al. Assessment of prevalence and load of Torquetenovirus viraemia in a large cohort of healthy blood donors. Clin Microbiol Infect. 2020;26:1406–10. https://doi.org/10.1016/j.cmi.2020.01.011.

Article  CAS  PubMed  Google Scholar 

Focosi D, Spezia PG, Maggi F. The emerging tool of the human anellovirome. Viruses. 2024;16:990. https://doi.org/10.3390/v16060990.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santoro A, Tomino C, Prinzi G, Cardaci V, Fini M, Macera L, et al. Microbiome in chronic obstructive pulmonary disease: role of natural products against microbial pathogens. Curr Med Chem. 2020;27:2931–48. https://doi.org/10.2174/0929867327666191213110551.

Article  CAS  PubMed  Google Scholar 

Kulifaj D, Durgueil-Lariviere B, Meynier F, Munteanu E, Pichon N, Dubé M, et al. Development of a standardized real time PCR for Torque teno viruses [TTV] viral load detection and quantification: a new tool for immune monitoring. J Clin Virol. 2018;105:118–27. https://doi.org/10.1016/j.jcv.2018.06.010.

Article  CAS  PubMed  Google Scholar 

Giacconi R, Maggi F, Macera L, Pistello M, Provinciali M, Giannecchini S, et al. Torquetenovirus [TTV] load is associated with mortality in Italian elderly subjects. Exp Gerontol. 2018;112:103–11. https://doi.org/10.1016/j.exger.2018.09.003.

Article  PubMed  Google Scholar 

Giacconi R, Laffon B, Costa S, Teixeira-Gomes A, Maggi F, Macera L, et al. Association of Torquetenovirus viremia with physical frailty and cognitive impairment in three independent European cohorts. Gerontology. 2023;69:684–93. https://doi.org/10.1159/000528169.

Article  CAS  PubMed  Google Scholar 

Virgin HW, Wherry EJ, Ahmed R. Redefining chronic viral infection. Cell. 2009;138:30–50. https://doi.org/10.1016/j.cell.2009.06.036.

Article  CAS  PubMed  Google Scholar 

Maggi F, Andreoli E, Riente L, Meschi S, Rocchi J, Delle Sedie A, et al. Torquetenovirus in patients with arthritis. Rheumatology. 2007;46(5):885–6.

Article  CAS  PubMed  Google Scholar 

Gergely P, Blazsek A, Dankó K, Ponyi A, Poór G. Detection of TT virus in patients with idiopathic inflammatory myopathies. Ann N Y Acad Sci. 2005;1050:304–13. https://doi.org/10.1196/annals.1313.032.

Article  CAS  PubMed  Google Scholar 

Hultin E, Mühr LSA, Bzhalava Z, Hortlund M, Lagheden C, Sundström P, et al. Viremia preceding multiple sclerosis: two nested case-control studies. Virology. 2018;520:21–9. https://doi.org/10.1016/j.virol.2018.04.006.

Article  CAS  PubMed  Google Scholar 

Minosse C, Spezia PG, Mazzotta V, Matusali G, Meschi S, Colavita F, et al. Assessing Torquetenovirus [TTV] as a biomarker for immune responses to SARS-CoV-2 mRNA vaccines in people living with HIV and healthy individuals. Vaccines. 2025;13:153. https://doi.org/10.3390/vaccines13020153.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gergelyjr P, Pullmann R, Stancato C, Otvosjr L, Koncz A, Blazsek A, et al. Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/P28 endogenous retro-viral autoantigen in patients with systemic lupus erythematosus. Clin Immunol. 2005;116:124–34. https://doi.org/10.1016/j.clim.2005.04.002.

Article  CAS  Google Scholar 

Stincarelli MA, Baj A, Guidotti B, Spezia PG, Novazzi F, Lucenteforte E, et al. Plasma Torquetenovirus [TTV] micrornas and severity of COVID-19. Virol J. 2022;19:79. https://doi.org/10.1186/s12985-022-01812-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reshetnyak VI, Maev IV, Burmistrov AI, Chekmazov IA, Karlovich TI. Torque teno virus in liver diseases: on the way towards unity of view. World J Gastroenterol. 2020;26:1691–707. https://doi.org/10.3748/wjg.v26.i15.1691.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roberto P, Cinti L, Lucente D, Russo G, Lai Q, Micozzi A, et al. TTV and CMV viral load dynamics: which emerges first during immunosuppression? J Med Virol. 2024;96:e29814. https://doi.org/10.1002/jmv.29814.

Article  CAS  PubMed  Google Scholar 

Rivanera D, Lozzi MA, Idili C, Lilli D. Prevalence of TT virus infection in Italian-dialysis patients. Pathol Biol Paris. 2009;57:97–100. https://doi.org/10.1016/j.patbio.2008.07.014.

Article  CAS  PubMed  Google Scholar 

Shibayama T, Masuda G, Ajisawa A, Takahashi M, Nishizawa T, Tsuda F, et al. Inverse relationship between the titre of TT virus DNA and the CD4 cell count in patients infected with HIV. AIDS. 2001;15:563–70. https://doi.org/10.1097/00002030-200103300-00004.

Article  CAS  PubMed  Google Scholar 

Borkosky SS, Whitley C, Kopp-Schneider A, Zur Hausen H, de Villiers E-M. Epstein-Barr virus stimulates Torque teno virus replication: a possible relationship to multiple sclerosis. PLoS One. 2012;7:e32160. https://doi.org/10.1371/journal.pone.0032160.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haloschan M, Bettesch R, Görzer I, Weseslindtner L, Kundi M, Puchhammer-Stöckl E. TTV DNA plasma load and its association with age, gender, and HCMV IgG serostatus in healthy adults. AGE. 2014;36:9716. https://doi.org/10.1007/s11357-014-9716-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sabbaghian M, Gheitasi H, Shekarchi AA, Tavakoli A, Poortahmasebi V. The mysterious anelloviruses: investigating its role in human diseases. BMC Microbiol. 2024;24:40. https://doi.org/10.1186/s12866-024-03187-7.

Article  PubMed  PubMed Central  Google Scholar 

Russo P, Milani F, Limongi D, Prezioso C, Novazzi F, Ferrante FD, et al. The effect of torque teno virus [TTV] infection on clinical outcomes, genomic integrity, and mortality in COPD patients. Mech Ageing Dev. 2025;224:112024. https://doi.org/10.1016/j.mad.2024.112024.

Article  CAS  PubMed  Google Scholar 

Russo P, Lamonaca P, Milic M, Rojas E, Prinzi G, Cardaci V, Vitiello L, Proietti S, Santoro A, Tomino C, Fini M, Bonassi S. Biomarkers of DNA damage in COPD patients undergoing pulmonary rehabilitation: Integrating clinical parameters with genomic profiling. Mutat Res Genet Toxicol Environ Mutagen. 2019;843:111–117. https://doi.org/10.1016/j.mrgentox.2019.04.003.

Ali S, Fevery J, Peerlinck K, Verslype C, Schelstraete R, Gyselinck F, et al. TTV infection and its relation to serum transaminases in apparently healthy blood donors and in patients with clotting disorders who have been investigated previously for hepatitis C virus and GBV‐C/HGV infection in Belgium. J Med Virol. 2002;66:561–6. https://doi.org/10.1002/jmv.2181.

Article  PubMed